Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction

Circulation

Volumn 120, Issue SUPPL. 1, 2009, Pages

  Deuse, Tobias ^a,e   Peter, Christoph ^b   Fedak, Paul W M ^d   Doyle, Tim ^c   Reichenspurner, Hermann ^e   Zimmermann, Wolfram H ^f   Eschenhagen, Thomas ^f   Stein, William ^a   Wu, Joseph C ^b   Robbins, Robert C ^a   Schrepfer, Sonja ^a,c,e  

^a Departments of Cardiothoracic Surgery   (Canada)

^b Department of Cardiovascular Medicine ^*  (Canada)

^c STANFORD UNIVERSITY   (United States)

^d LIBIN CARDIOVASCULAR INSTITUTE OF ALBERTA   (Canada)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Apoptosis; Gene therapy; Myocardial infarction; Remodeling

Indexed keywords

CYTOKINE; LACTATE DEHYDROGENASE; PROTEIN KINASE B; SCATTER FACTOR; VASCULOTROPIN; VASCULOTROPIN A;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME RELEASE; GENE TRANSFER; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; GENE THERAPY; GENETICS; HEART INFARCTION; HORIZONTAL GENE TRANSFER; MESENCHYMAL STEM CELL TRANSPLANTATION; PHYSIOLOGY;

ANIMALS; CYTOKINES; GENE THERAPY; GENE TRANSFER, HORIZONTAL; HEPATOCYTE GROWTH FACTOR; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; MICE, INBRED BALB C; MYOCARDIAL INFARCTION; PROTO-ONCOGENE PROTEINS C-AKT; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR FUNCTION, LEFT;

EID: 70349784481     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.843680     Document Type: Article

References (28)

1. 1. Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, Zhang JJ, Chunhua RZ, Liao LM, Lin S, Sun JP. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol. 2004;94:92-95. (Pubitemid 38813459)
2. 2. Katritsis DG, Sotiropoulou PA, Karvouni E, Karabinos I, Korovesis S, Perez SA, Voridis EM, Papamichail M. Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheter Cardiovasc Interv. 2005;65: 321-329. (Pubitemid 40898172)
3. 3. Reinecke H, Murry CE. Taking the death toll after cardiomyocyte grafting: a reminder of the importance of quantitative biology. J Mol Cell. Cardiol. 2002;34:251-253. (Pubitemid 37162417)
4. Fedak PWM. Paracrine effects of cell transplantation: modifying ventricular remodeling in the failing heart. Semin Thorac Cardiovasc Surg. 2008;20:87-93.
5. Schrepfer S, Deuse T, Reichenspumer H, Robbins R, Pelletier M. Stem cell transplantation for the ischemic myocardium: answering the basic questions of bone marrow stromal cell migration, homing, and survival [abstract]. J Heart Lung Transplant. 2008;27:S321.
6. 6. Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspumer H, Robbins RC, Pelletier MP. Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells. Stem. Cells Dev. 2007;16: 105-107. (Pubitemid 46362595)
7. Coelen RJ, Jose DG, May JT. The effect of hexadimethrine bromide (polybrene) on the infection of the primate retroviruses SSV 1/SS.AV 1 and BaEV. Arch Virol. 1983;75:307-311.
8. 8. Sorgi FL, Bhattacharya S, Huang L. Protamine sulfate enhances lipidmediated gene transfer. Gene Ther. 1997;4:961-968. (Pubitemid 27437722)
9. 9. Tiefenbacher CP, Ebert M, Niroomand F, Batkai S, Tillmanns H, Zimmermann R, Kübler W. Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart. Pflugers Arch. 1997;433:563-570. (Pubitemid 27093116)
10. 10. Jenkins DE, Oei Y, Hornig YS, Yu S-F, Dusich J, Purchio T, Contag PR. Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis. Clin Exp Metastasis. 2003;20: 733-744. (Pubitemid 38019275)
11. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med. 1991; 324:1-8.
12. 12. Zimmermann WH, Fink C, Kralisch D, Remmers U, Weil J, Eschenhagen T. Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. Biotechnol Bioeng. 2000;68:106-114. (Pubitemid 30163499)
13. Pearl J, Wu JC. Seeing is believing: tracking cells to determine the effects of cell transplantation. Semin Thorac Cardiovasc Surg. 2008; 20:102-109.
14. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 2008;376: 419-422.
15. 15. Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh. K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemiareperfusion injury in mouse heart. Circulation. 2000;101:660-667. (Pubitemid 30094738)
16. 16. Miao W, Luo Z, Kitsis RN, Walsh K. Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemiareperfusion injury in vivo. J Mol Cell Cardiol. 2000;32:2397-2402. (Pubitemid 32039789)
17. 17. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 2001;104:330-335. (Pubitemid 32666956)
18. Sussman M. "AKT'ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Trends Cardiovasc Med. 2007; 17:235-240.
19. 19. Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana F, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term, survival. Circ Res. 2005;97:663-673. (Pubitemid 41416335)
20. 20. Duan H, Wu C, Wu D, Lu Y, Liu H, Ha X, Zhang Q, Wang H, Jia X, Wang L. Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor. Mol Ther. 2003;8:467-474. (Pubitemid 37161468)
21. 21. Jayasankar V, Woo YJ, Bish LT, Pirolli TJ, Chatterjee S, Berry MF, Burdick J, Gardner TJ, Sweeney HL. Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure. Circulation. 2003; 108(suppl 1):II-230-II-236. (Pubitemid 37099960)
22. 22. Ruixing Y, Dezhai Y, Hai W, Kai H, Xianghong W, Yuming C. Intramyocardial injection of vascular endothelial growth factor gene improves cardiac performance and inhibits cardiomyocyte apoptosis. Eur J Heart Fail. 2007;9:343-351. (Pubitemid 46441972)
23. 23. Hao X, Mansson-Broberg A, Grinnemo K-H, Siddiqui AJ, Dellgren G, Brodin LA, Sylven C. Myocardial angiogenesis after plasmid or adenoviral VEGF-A(165) gene transfer in rat myocardial infarction model. Cardiovasc Res. 2007;73:481-487. (Pubitemid 46084927)
24. 24. Leor J, Quinones MJ, Patterson M, Kedes L, Kloner RA. Adenovirusmediated gene transfer into infarcted myocardium: feasibility, timing, and. location, of expression. J Mol Cell Cardiol. 1996;28:2057-2067. (Pubitemid 26370954)
25. Tomita S, Mickle DAG, Weisel RD, Jia Z-Q, Tumiati LC, Allidina Y, Liu P, Li R-K. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg. 2002;123:1132-1140.
26. 26. Kamihata H, Matsubara H, Nishiue T, Fujiyama S, Amano K, Iba O, Imada T, Iwasaka T. Improvement of collateral perfusion and regional function by implantation of peripheral blood mononuclear cells into ischemic hibernating myocardium.. Arterioscler Thromb Vase Biol. 2002; 22:1804-1810. (Pubitemid 35315765)
27. 27. Gao F, He T, Wang H, Yu S, Yi D, Liu W, Cai Z. A promising strategy for the treatment of ischemic heart disease: mesenchymal stem cellmediated vascular endothelial growth factor gene transfer in rats. Can J Cardiol. 2007;23:891-898. (Pubitemid 350011270)
28. 28. Gallo MP, Ramella R, Alloatti G, Penna C, Pagliaro P, Marcantoni A, Bonafe F, Losano G, Levi R. Limited plasticity of mesenchymal stem cells cocultured with adult cardiomyocytes. J Cell Biochem. 2007;100: 86-99. (Pubitemid 44958181)