Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart

Pflugers Archiv European Journal of Physiology

Volumn 433, Issue 5, 1997, Pages 563-570

  Tiefenbacher, Christiane P ^a   Ebert, Martin ^a   Niroomand, Feraydoon ^a   Batkai, Sandor ^a   Tillmanns, Harald ^b   Zimmermann, Rainer ^a   Kübler, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Elastase; Myeloperoxidase; MyocardiaI blood flow; Myocardial infarction; Myocardial stunning; Neutrophils; Regional myocardial function

Indexed keywords

ELAFIN; ELASTASE; ELASTASE INHIBITOR; MYELOPEROXIDASE; N [4 [(4 CHLOROPHENYLSULFONYL)AMINOCARBONYL]BENZOYL]VALYLPROLYLVALYL TRIFLUOROMETHYL KETONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INTRAVENOUS DRUG ADMINISTRATION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STUNNED HEART MUSCLE;

ANIMALS; CORONARY CIRCULATION; FEMALE; LEUKOCYTE ELASTASE; MYOCARDIAL INFARCTION; MYOCARDIUM; NEUTROPHILS; OLIGOPEPTIDES; PEROXIDASE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PROTEINS; RATS; RATS, WISTAR; SERINE PROTEINASE INHIBITORS;

EID: 0031044218     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050315     Document Type: Article

References (30)

1. Aukland K, Bower BF, Berliner RW (1964) Measurement of local blood flow with hydrogen gas. Circ Res 14:164-187
2. Bassingthwaighte JB, Strandell T, Donald DE (1968) Estimation of coronary blood flow by washout of diffusible indicators. Circ Res 23:259-78
3. Bolli R (1988) Oxygen-derived free radicals and postischaemic myocardial dysfunction ("stunned myocardium"). J Am Coll Cardiol 12:239-249
4. Campbell EJ, Senior RM, MCDonald JA, Cox DL (1982) Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro. J Clin Invest 7:845-852
5. Deanfield JE, Selwyn AP, Chiechia S, Maseri A, Ribeiro P, Rikler S, Morgan M (1983) Myocardial ischaemia during daily life in patients with stable angina: its relation to symptoms and heart rate changes. Lancet 2:753-758
6. Dinerman JL, Mehta JL, Saldeen TGP, Emerson S, Wallin R, Davda R, Davidson A (1990) Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction. J Am Coll Cardiol 15:1559-1563
7. Go Lo, Murry CE, Richard VJ, Jennings RB, Weischedel GR, Reimer KA (1988) Myocardial neutrophil accumulation during reperfusion after reversible or irreversible ischaemia injury. Am J Physiol 255:H1188-1198
8. Harlan JM, Killen PD, Harker LA, Striker GE (1981) Neutrophil-mediated endothelial injury in vitro. Mechanisms of cell detachment. J Clin Invest 68:1394-1403
9. Hartley CJ, Latson LA, Michael LH, Seidel CL, Lewis RM, Entman ML (1983) Doppler measurement of myocardial thickening with a single epicardial transducer. Am J Physiol 245:H1066-H1072
10. Havemann K, Gramse M (1984) Physiology and pathophysiology of neutral proteinases of human granulocytes. Adv Exp Med Biol 167:1-20
11. Heyndrickx IR, Millard RW, McRitchie RJ, Maroko PR, Vatner SF (1975) Regional myocardial, functional and electrophysiological alterations after brief coronary occlusion in conscious dogs. J Clin Invest 56:978-985
12. Huber AR, Weiss SJ (1989) Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall. J Clin Invest 83: 1122-1136
13. Immen W, Granger DN, Meininger CJ, Schelling ME, Granger HJ, Kvietys PR (1990) Anoxia-reoxygenation-induced, neutrophil-mediated endothelial cell injury: role of elastase. Am J Physiol 259:H925-H931
14. Jennings RB, Reimer KA (1983) Factors involved in salvaging ischemic myocardium: effects of reperfusion of arterial blood. Circulation 68:125-136
15. Lucchesi BR (1990) Modulation of leukocyte-mediated myocardial reperfusion injury. Annu Rev Physiol 52:561-576
16. McMurdo L, Thiemermann C, Vane JR (1994) The effects of the endothelin ETA receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischaemia and reperfusion. Br J Pharmacol 112:75-80
17. Mehta JL, Nichols WW, Nicolini FA, Hendricks J, Donnelly WW, Saldeen TG (1994) Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog. Cardiovasc Res 28:947-956
18. Myers ML, Bolli R, Lekich RF, Hartley CJ, Roberts R (1985) Enhancement of recovery of myocardiul function by oxygen free-radical scavengers after reversible regional ischaemia. Circulation 72:915-921
19. Neumann F-J, Tiefenbacher C, Mohler T, Ott I, Parekh N, Steinhausen M, Tillmanns H (1991) Decreased myocardial blood flow after repetitive ischemia and reperfusion of the rat heart: cause or consequence of myocardial stunning? (abstract) Circulation 84(suppl.II):II-656
20. Nicolini FA, Mehta JL, Nichols WW, Donnelly WH, Luostarinen R, Saldeen TGP (1991) Leukocyte elastase inhibition and t-PA induced coronary artery thrombolysis in dogs: beneficial effects on myocardial histology. Am Heart J 122:1245-1251
21. Rosengren S, Arfors KE (1990) Neutrophil-mediated vascular leakage is not suppressed by leukocyte elastase inhibitors. Am J Physiol H1288-H1294
22. Sakka SG, Wallbridge DR, Heusch G (1996) Methods tor the measurement of coronary blood flow and myxocardial perfusion. Basic Res Cardiol 91:155-178
23. Sirsjö A, Nykinder G, Lewis DH (1988) Myeloperoxidase as a measure of polymorphonuclear leukocyte (PNML) content in ischaemic-reperfused rat skeletal muscle (abstract). Int J Microcirc Clin Exp 7:192
24. Smedly LA, Tonnesen MG, Sandhaus RA, Haslett C, Guthrie LA, Johnston RB Jr, Henson PM, Worthen GS (1986) Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elatase. J Clin Invest 77:1233-1243
25. Tiefenbacher CP, Neumann FJ, Parekh N, Amann K, Tillmanns H, Rauch B, Kübler W (1995) Preservation of myocardial blod flow by calcium antagonists does not prevent attenuation of regional myocardial function after repetitive brief periods of myocardial ischaemia in the rat heart. Eur Heart Journal 16:1057-1063
26. Wiedow O, Schroeder J-M, Gregory H, Young J, Christophers E (1990) Elafin: An elastase-specific inhibitor of human skin. J Biol Chem 265:14791-14795
27. Williams JC, Falcone J-M, Knee C, Stein RL, Strimpler AM, Reaves B, Giles RE, Krell RD (1991) Biological characterization of ICI 200,880 and ICI 200,355: novel inhibitors of human neutrophil elastase. Am Rev Respir Dis 144:875-883
28. Woodman RC, Reinhardt PH, Kanwar S, Johnston FL, Kubes P (1993) Effects of human neutrophil elastase (HNE) on neutrophil function in vitro and in inflamed microvessels. Blood 82:2188-2195
29. Yee TT, Suematsu M, Ohashi KL, DeLano FA, Kawabata K, Schmid-Schoenbein GW (1993) Role of elastase in neutrophil adhesion and migration in vivo (abstract). Fed Am Soc Exp Biol J 7:A907I
30. Zimmermann BJ, Granger DJ (1990) Reperfusion-induced leukocyte infiltration: role of elastase. Am J Physiol 259: H390-H394