Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4528-4538

  Aytaç, S Peri ^a   Tozkoparan, Birsen ^a   Kaynak, F Betül ^a   Aktay, Göknur ^b   Göktaş, Özgür ^b   Ünüvar, Songül ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b INONU UNIVERSITY   (Turkey)

Author keywords

Aminomercaptotriazoles; Analgesic anti inflammatory activity; Antioxidant activity; Triazolothiadiazines

Indexed keywords

3 (3,4,5 TRIMETHOXYPHENYLMETHYL) 6 (4 CHLOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 (3,4,5 TRIMETHOXYPHENYLMETHYL) 6 (4 FLUOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 (3,4,5 TRIMETHOXYPHENYLMETHYL) 6 PHENYL 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 (4 METHOXYPHENYLMETHYL) 6 (4 CHLOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 (4 METHOXYPHENYLMETHYL) 6 (4 FLUOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 (4 METHOXYPHENYLMETHYL) 6 PHENYL 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL] 6 (4 CHLOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL] 6 (4 FLUOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL] 6 PHENYL 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 [2 (4 METHOXYPHENYL)ETHYL] 6 (4 CHLOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 [2 (4 METHOXYPHENYL)ETHYL] 6 (4 FLUOROPHENYL) 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 3 [2 (4 METHOXYPHENYL)ETHYL] 6 PHENYL 7H 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZINE; 4 AMINO 3 (3,4,5 TRIMETHOXYPHENYLMETHYL) 1,2,4 TRIAZOLE 5 THIONE; 4 AMINO 3 (4 METHOXYPHENYLMETHYL) 1,2,4 TRIAZOLE 5 THIONE; 4 AMINO 3 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL] 1,2,4 TRIAZOLE 5 THIONE; 4 AMINO 3 [2 (4 METHOXYPHENYL)ETHYL)] 1,2,4 TRIAZOLE 5 THIONE; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; INDOMETACIN; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; LIPID PEROXIDATION; MOUSE; NONHUMAN; PAW EDEMA; ULCEROGENESIS; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CARRAGEENAN; EDEMA; FEMALE; MALE; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PAIN MEASUREMENT; THIADIAZINES; TRIAZOLES; ULCER;

EID: 70349777308     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.026     Document Type: Article

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