Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6h)-ones and their novel Michael addition products with anti-inflammatory activities

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 6, 2001, Pages 470-477

  Tozkoparan, B ^a   Aktay, G ^a   Yesilada, E ^a   Ertan, M ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

CAS 53 86 1; Indometacin; Thiazolo 3,2 b 1,2,4 triazole derivatives, anti inflammatory activity, synthesis

Indexed keywords

2 METHYL 6 (ALPHA AMINOBENZYL)THIAZOLO[3,2 B] 1,2,4 TRIAZOL 5 OL DERIVATIVE; INDOMETACIN; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; INFLAMMATION; MALE; MOUSE; NONHUMAN; SPECTROSCOPY; ULCEROGENESIS;

EID: 0034951052     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300065     Document Type: Article

References (15)

1. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs
2. Synthesis and antiinflammatory activities of 3-(3,5-Di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones
3. Pharmacological properties of a new antiinflammatory compound, α-(3,5-Di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone (KME-4), and its inhibitory effects on prostaglandin synthetase and 5-lipoxygenase
4. Studies on styrene derivatives. 1. Synthesis and antiinflammatory activities of α-benzylidene-γ-butyrolactone derivatives
5. Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyxclooxygenase-2-inhibitors. 1. Thiazolone and oxazolone series
6. Synthesis and biological activity of 6-ylidene-thiazolidino[3,2-b]-1,2,4-triazol-5-ones
7. Design of 5-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, 1,3,4-oxadiazoles, and -1,2,4-triazoles as orally active, nonulcerogenic antiinflammatory agents
8. Synthese und eigenschaften von 5-(4,6-Diphenyl-pyrimidin-2-yl)-1,2,4-triazolin-3-thion und seinen derivaten
9. Synthesis and biological evaluation of thiazolo-triazole derivatives
10. Synthesis of carboxyalkylthiotriazoles and bicyclic derivatives with anti-inflammatory and analgesic activity
11. Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-(6H)-ones
12. Synthesis and evaluation of antiinflammatory activity of the thiazolo[3,2-b]-1,2,4-triazole-(6H)-ones and their Michael addition products
13. Oriental medicines. Part 75. Studies on the constituents of ephedra. 18. Antiinflammatory actions of ephedrines in acute inflammations
14. 6-Benzylidene-2-(2-chlorophenyl)thiazolo[3,2-b]-1,2,4-triazole-(6H)-one
15. Condensed heterocyclic compounds: Synthesis and antiinflammatory activity of novel thiazolo[3,2-a]pyrimidines