Defining the mechanisms that underlie cortical hyperexcitability in amyotrophic lateral sclerosis

Experimental Neurology

Volumn 220, Issue 1, 2009, Pages 177-182

  Vucic, Steve ^a   Cheah, Benjamin C ^b   Kiernan, Matthew C ^b  

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

ALS; Intracortical facilitation; Intracortical inhibition

Indexed keywords

ADULT; AGED; AMPLITUDE MODULATION; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; CONDITIONING; DEGENERATION; EVOKED MUSCLE RESPONSE; EXCITATION; FEMALE; HAND MUSCLE; HUMAN; MALE; MOTOR PERFORMANCE; NEUROPROTECTION; PERIPHERAL NERVE; PRIORITY JOURNAL; STIMULUS RESPONSE;

ACTION POTENTIALS; ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; CEREBRAL CORTEX; ELECTROMAGNETIC FIELDS; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HUMANS; INTERNEURONS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS; PYRAMIDAL CELLS; PYRAMIDAL TRACTS; SYNAPTIC TRANSMISSION; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 70349748799     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.08.017     Document Type: Article

References (40)

1. Abbruzzese G., Assini A., Buccolieri A., Schieppati M., and Trompetto C. Comparison of intracortical inhibition and facilitation in distal and proximal arm muscles in humans. J. Physiol. (Lond) 514 (1999) 895-903
2. Bensimon G., Lacomblez L., and Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N. Engl. J. Med. 330 (1994) 585-591
3. Brooks B.R., Miller R.G., Swash M., and Munsat T.L. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph. Lateral. Scler. Other Mot. Neuron Disord. 1 (2000) 293-299
4. Bruijn L.I., Beal M.F., Becher M.W., Schulz J.B., Wong P.C., Price D.L., and Cleveland D.W. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 7606-7611
5. Cedarbaum J.M., Stambler N., Malta E., Fuller C., Hilt D., Thurmond B., and Nakanishi A. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J. Neurol. Sci. 169 (1999) 13-21
6. Chen R., Cros D., Curra A., Di Lazzaro V., Lefaucheur J.P., Magistris M.R., Mills K., Rosler K.M., Triggs W.J., Ugawa Y., and Ziemann U. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin. Neurophysiol. 119 (2008) 504-532
7. Cudkowicz M., Qureshi M., and Shefner J. Measures and markers in amyotrophic lateral sclerosis. NeuroRx 1 (2004) 273-283
8. de Carvalho M., and Swash M. Nerve conduction studies in amyotrophic lateral sclerosis. Muscle Nerve 23 (2000) 344-352
9. Di Lazzaro V., Restuccia D., Oliviero A., Profice P., Ferrara L., Insola A., Mazzone P., Tonali P., and Rothwell J.C. Magnetic transcranial stimulation at intensities below active motor threshold activates intracortical inhibitory circuits. Exp. Brain Res. 119 (1998) 265-268
10. Eisen A., Kim S., and Pant B. Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron?. Muscle Nerve 15 (1992) 219-224
11. Fisher R.J., Nakamura Y., Bestmann S., Rothwell J.C., and Bostock H. Two phases of intracortical inhibition revealed by transcranial magnetic threshold tracking. Exp. Brain Res. 143 (2002) 240-248
12. Gibb S.L., Boston-Howes W., Lavina Z.S., Gustincich S., Brown Jr. R.H., Pasinelli P., and Trotti D. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. J. Biol. Chem. 282 (2007) 32480-32490
13. Hanajima R., Ugawa Y., Terao Y., Enomoto H., Shiio Y., Mochizuki H., Furubayashi T., Uesugi H., Iwata N.K., and Kanazawa I. Mechanisms of intracortical I-wave facilitation elicited with paired-pulse magnetic stimulation in humans. J. Physiol. (Lond) 538 (2002) 253-261
14. Kanai K., Kuwabara S., Arai K., Sung J.Y., Ogawara K., and Hattori T. Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. Brain 126 (2003) 965-973
15. Kujirai T., Caramia M.D., Rothwell J.C., Day B.L., Thompson P.D., Ferbert A., Wroe S., Asselman P., and Marsden C.D. Corticocortical inhibition in human motor cortex. J. Physiol. (Lond) 471 (1993) 501-519
16. Lacomblez L., Bensimon G., Leigh P.N., Guillet P., and Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet 347 (1996) 1425-1431
17. MacKinnon C.D., Gilley E.A., Weis-McNulty A., and Simuni T. Pathways mediating abnormal intracortical inhibition in Parkinson's disease. Ann. Neurol. 58 (2005) 516-524
18. Medical Research Council. Aid to the examination of the peripheral nervous system (1976), Her Majesty's Stationary Office, London
19. Mills K.R., and Murray N.M. Electrical stimulation over the human vertebral column: which neural elements are excited?. Electroencephalogr. Clin. Neurophysiol. 63 (1986) 582-589
20. Nihei K., McKee A.C., and Kowall N.W. Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol. 86 (1993) 55-64
21. Roshan L., Paradiso G.O., and Chen R. Two phases of short-interval intracortical inhibition. Exp. Brain Res. 151 (2003) 330-337
22. Rowland L.P., and Shneider N.A. Amyotrophic lateral sclerosis. N. Engl. J. Med. 344 (2001) 1688-1700
23. Stefan K., Kunesch E., Benecke R., and Classen J. Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis. Ann. Neurol. 49 (2001) 536-539
24. Strafella A.P., and Paus T. Cerebral blood-flow changes induced by paired-pulse transcranial magnetic stimulation of the primary motor cortex. J. Neurophysiol. 85 (2001) 2624-2629
25. Stys P.K. General mechanisms of axonal damage and its prevention. J. Neurol. Sci. 233 (2005) 3-13
26. Turner M.R., Cagnin A., Turkheimer F.E., Miller C.C., Shaw C.E., Brooks D.J., Leigh P.N., and Banati R.B. Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol. Dis. 15 (2004) 601-609
27. van Zundert B., Peuscher M.H., Hynynen M., Chen A., Neve R.L., Brown Jr. R.H., Constantine-Paton M., and Bellingham M.C. Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis. J. Neurosci. 28 (2008) 10864-10874
28. Vucic S., and Kiernan M.C. Flail-limb variant of motor neuron disease has evidence of central and peripheral nerve dysfunction. Amyotroph. Lateral. Scler. Other Mot. Neuron Disord. 6 (2005) 125
29. Vucic S., and Kiernan M.C. Axonal excitability properties in amyotrophic lateral sclerosis. Clin. Neurophysiol. 117 (2006) 1458-1466
30. Vucic S., and Kiernan M.C. Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease. Brain 129 (2006) 2436-2446
31. Vucic S., and Kiernan M.C. Cortical excitability testing distinguishes Kennedy's disease from amyotrophic lateral sclerosis. Clin. Neurophysiol. 119 (2008) 1088-1096
32. Vucic S., and Kiernan M. Pathophysiology of degeneration in familial amyotrophic lateral sclerosis. Curr. Mol. Med. 9 (2009) 255-272
33. Vucic S., Howells J., Trevillion L., and Kiernan M.C. Assessment of cortical excitability using threshold tracking techniques. Muscle Nerve 33 (2006) 477-486
34. Vucic S., Nicholson G.A., and Kiernan M.C. Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis. Brain 131 (2008) 1540-1550
35. Vucic S., Cheah B., Krishnan A.V., Burke D., and Kiernan M.C. The effects of altering conditioning stimulus intensity on short interval intracortical inhibition. Brain Res. 1273 (2009) 39-47
36. Zanette G., Tamburin S., Manganotti P., Refatti N., Forgione A., and Rizzuto N. Changes in motor cortex inhibition over time in patients with amyotrophic lateral sclerosis. J. Neurol. 249 (2002) 1723-1728
37. Zanette G., Manganotti P., Fiaschi A., and Tamburin S. Modulation of motor cortex excitability after upper limb immobilization. Clin. Neurophysiol. 115 (2004) 1264-1275
38. Ziemann U. Cortical threshold and excitability measurements. In: Eisen A. (Ed). Clinical neurophysiology of motor neuron diseases (2004), Handbook of Clinical Neurophysiology. Elsevier, Amsterdam 317-335
39. Ziemann U. TMS and drugs. Clin. Neurophysiol. 115 (2004) 1717-1729
40. Ziemann U., Winter M., Reimers C.D., Reimers K., Tergau F., and Paulus W. Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation. Neurology 49 (1997) 1292-1298