CD117 is not a useful marker for diagnosing atypical fibroxanthoma

American Journal of Dermatopathology

Volumn 31, Issue 7, 2009, Pages 649-652

  Beer, Trevor W ^a   Haig, Dawn ^b  

^a Cutaneous Pathology   (Australia)

^b General Pathology Laboratories   (Australia)

Author keywords

Atypical fibroxanthoma; CD117; Langerhans cells; Mast cells; Tryptase

Indexed keywords

PROTEIN S 100; STEM CELL FACTOR RECEPTOR; T6 ANTIGEN; TRYPTASE;

ADULT; AGED; ARTICLE; ATYPICAL FIBROXANTHOMA; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; FIBROXANTHOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LANGERHANS CELL; MAJOR CLINICAL STUDY; MALE; MAST CELL; MELANOCYTE; PRIORITY JOURNAL; TUMOR CELL;

AGED; AGED, 80 AND OVER; HISTIOCYTOMA, BENIGN FIBROUS; HUMANS; IMMUNOHISTOCHEMISTRY; MAST CELLS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-KIT; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 70349739606     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181a766fa     Document Type: Article

References (16)

1. Beer TW, Lam M, Heenan PH. Fibrous tissue tumors of the skin. In: Elder DE, ed. Lever's Histopathology of the Skin. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2009.
2. Weiss SW, Goldblum JR. Atypical fibroxanthoma. In: Weiss SW and Goldblum JR, eds. Enzinger and Weiss's Soft Tissue Tumors. 5th ed. Mosby; 2008:403-406.
3. Barr KL, Russo JJ, Vincek V. Re: CD117 immunoreactivity in atypical fibroxanthoma. Am J Dermatopathol. 2009;31:96-98.
4. Mathew RA, Schlauder SM, Calder KB, et al. CD117 immunoreactivity in atypical fibroxanthoma. Am J Dermatopathol. 2008;30:34-36.
5. Fernandez-Flores A. Mast cell population in atypical fibroxanthoma as a finding with CD117 immunostaining. Am J Dermatopathol. 2008;30:640-642.
6. Beer TW. CD117 in AFX: tumor or stroma? Am J Dermatopathol. 2008;30:401-402.
7. Arber DA, Tamayo R, Weiss LM. Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disorders. Hum Pathol. 1998;29:498-504. (Pubitemid 28213470)
8. Chan JK. Mesenchymal tumors of the gastrointestinal tract: a paradise for acronyms (STUMP, GIST, GANT, and now GIPACT), implication of c-kit in genesis, and yet another of the many emerging roles of the interstitial cell of Cajal in the pathogenesis of gastrointestinal diseases? Adv Anat Pathol. 1999;6:19-40.
9. Tsuura Y, Hiraki H, Watanabe K, et al. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Virchows Arch. 1994;424:135-141. (Pubitemid 24105555)
10. Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol. 2005;13:205-220. (Pubitemid 41209013)
11. Guler ML, Daniels JA, Abraham SC, et al. Expression of melanoma antigens in epithelioid gastrointestinal stromal tumors: a potential diagnostic pitfall. Arch Pathol Lab Med. 2008;132:1302-1306.
12. Swick BL, Ravdel L, Fitzpatrick JE, et al. Merkel cell carcinoma: evaluation of KIT (CD117) expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene - implications for treatment with imatinib mesylate. J Cutan Pathol. 2007;34:324-329. (Pubitemid 46466095)
13. Horie M, Hatamochi A, Yamazaki S, et al. A case of cutaneous leiomyosarcoma with over expression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? Br J Dermatol. 2006;154:1013-1016.
14. Djordjevic B, Hanna WM. Expression of c-kit in fibroepithelial lesions of the breast is a mast cell phenomenon. Mod Pathol. 2008;21:1238-1245.
15. Kemmerling R, Dietze O, Müller S, et al. Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma. Pathol Res Pract. 2009;205:365-370.
16. Beer TW, Ng LB, Murray K. Mast cells have prognostic value in Merkel cell carcinoma. Am J Dermatopathol. 2008;30:27-30. (Pubitemid 351161626)