Mesenchymal tumors of the gastrointestinal tract: A paradise for acronyms (STUMP, GIST, GANT, and now GIPACT), implication of c-kit in genesis, and yet another of the many emerging roles of the interstitial cell of Cajal in the pathogenesis of gastrointestinal diseases?

Advances in Anatomic Pathology

Volumn 6, Issue 1, 1999, Pages 19-40

  Chan, John K C ^a  

^a QUEEN ELIZABETH HOSPITAL   (Hong Kong)

Author keywords

c kit; Gastrointestinal stromal tumor; Immunohistochemistry; Interstitial cell of Cajal; Intestinal motility disorder; Molecular genetics

Indexed keywords

STEM CELL FACTOR RECEPTOR; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; BIOSYNTHESIS; CYTOLOGY; DIGESTIVE FUNCTION; DIGESTIVE SYSTEM; FEMALE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TUMOR; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MESODERM; METABOLISM; MIDDLE AGED; MUTATION; NOMENCLATURE; PATHOLOGY; PHYSIOLOGY; REVIEW;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DIGESTIVE PHYSIOLOGY; DIGESTIVE SYSTEM; FEMALE; GASTROINTESTINAL DISEASES; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MESODERM; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS C-KIT; TERMINOLOGY; TUMOR MARKERS, BIOLOGICAL;

EID: 0032602423     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/00125480-199901000-00003     Document Type: Note

References (96)

1. Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998;152:1259-69. (Pubitemid 28221878)
2. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ish-iguro S, et al. Gain-of-function mutations of c-kit in human gas-trointestinal stromal tumors. Science 1998;279:577-80. (Pubitemid 28067289)
3. Nakahara M, Isozaki K, Hirota S, Miyagawa JI, Hase-Sawada N, Taniguchi M, et al. A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors. Gastroenterology 1998:115: 1090-5. (Pubitemid 28485599)
4. Nishida T, Hirota S, Taniguchi M, Hashimoto K, Isozaki K, Na-kamura H, et al. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene [letter]. Nat Genet 1998; 19: 323-4.
5. Ashman L. CDl 17 (CD Guide). In: Kishimoto T, Kikutani H, von dem Borne AEGK, Goyert SM, Mason DY, Miyasaka M, et al., eds. Leucocyte Typing VI, White Cell Differentiation Antigens. New York: Garland Publishing, Inc., 1998:1191-2.
6. Ashman LK, Cambareri AC, Nguyen LY, Buhring HJ. CDl 17 Workshop Panel Report. In: Kishimoto T, Kikutani H, von dem Borne AEGK, Goyert SM, Mason DY, Miyasaka M, et al., eds. Leucocyte Typing VI. White Cell Differentiation Antigens. New York: Garland Publishing, Inc., 1997:816-8.
7. Buhring HJ, Ashman LK, Gattei V, Kniep B, Larregina A, Pinto A, et al. Stem-cell factor receptor (pl45[c-kit]) summary report (CDl 17). In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al., eds. Leucocyte Typing V. White Cell Differentiation Antigens. Oxford: Oxford University Press, 1995:1882-8.
8. Chui X, Egami H, Yamashita J, Kurizaki T, Ohmachi H, Yama-moto S, et al. Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues. Br J Cancer 1996;73:1233-6. (Pubitemid 26162338)
9. Montone KT, van Belle P, Elenitsas R, Elder DE. Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression. Mod Pathol 1997;10:939-44. (Pubitemid 27431970)
10. Ohashi A, Funasaka Y, Ueda M, Ichihashi M. c-KIT receptor expression in cutaneous malignant melanoma and benign melanot-ic naevi. Melanoma Res 1996;6:25-30. (Pubitemid 26065018)
11. Bar-Eli M. Molecular mechanisms of melanoma metastasis. J Cell Physiol 1997;173:275-8. (Pubitemid 27481144)
12. Fukuda T, Kamishima T, Tsuura Y, Suzuki T, Kakihara T, Naito M, et al. Expression of the c-kit gene product in normal and neo-plastic mast cells but not in neoplastic basophil/mast cell precur-sors from chronic myelogenous leukaemia. J Pathol 1995;177: 139-46.
13. Horie K, Fujita J, Takakura K, Kanzaki H, Suginami H, Iwai M, et al. The expression of c-kit protein in human adult and fetal tissues. Hum Reprod 1993;8:1955-62. (Pubitemid 23337165)
14. Izquierdo MA, Van der VaIk P, Van Ark-Otte J, Rubio G, Germa-Lluch JR, Ueda R, et al. Differential expression of the c-kit proto-oncogene in germ cell tumours. J Pathol 1995;177:253-8.
15. Lammie A, Drobnjak M, Gerald W, Saad A, Cote R, Cordon-Cardo C. Expression of c-kit and kit ligand proteins in normal human tissues. J Histochem Cytochem 1994;42:1417-25. (Pubitemid 24338014)
16. Rumessen JJ, Mikkelsen HB, Thuneberg L. Ultrastructure of in-terstitial cells of Cajal associated with deep muscular plexus of human small intestine. Gastroenterology 1992;102:56-68.
17. Rumessen JJ, Thuneberg L. Interstitial cells of Cajal in human small intestine. Ultrastructural identification and organization be-tween the main smooth muscle layers. Gastroenterology 1991; 100: 1417-31.
18. Rumessen JJ, Peters S, Thuneberg L. Light- and electron microsco-pial studies of interstitial cells of Cajal and muscle cells at the submucosal border of human colon. Lab Invest 1993;68:481-95. (Pubitemid 23136169)
19. Sandlow JI, Feng HL, Sandra A. Localization and expression of the c-kit receptor protein in human and rodent testis and sperm. Urology 1997;49:494-500. (Pubitemid 27138703)
20. Stanulla M, Weite K, Hadam MR, Pietsch T. Coexpression of stem cell factor and its receptor c-Kit in human malignant glioma cell lines. Acta Neuropathol 1995;89:158-65.
21. Strohmeyer T, Reese D, Press M, Ackermann R, Hartmann M, Slamon D. Expression of the c-kit proto-oncogene and its ligand stem cell factor (SCF) in normal and malignant human testicular tissue. J Urol 1995;153:511-5.
22. Tajima F, Kawatani T, Ishiga K, Nanba E, Kawasaki H. Serum soluble c-kit receptor and expression of c-kit protein and mRNA in acute myeloid leukemia. Eur J Haematol 1998;60:289-96. (Pubitemid 28270753)
23. Tsuura Y, Hiraki H, Watanabe K, Igarashi S, Shimamura K, Fukuda T, et al. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immuno-histochemical study of formalin-fixed, paraffin-embedded tissues. Virchows Arch 1994;424:135-41. (Pubitemid 24105555)
24. Hagger R, Finlayson C, Jeffrey I, Kumar D. Role of the interstitial cells of Cajal in the control of gut motility. Br J Surg 1997;84: 445-50. (Pubitemid 27196279)
25. Thuneberg L. Interstitial cells of Cajal: intestinal pacemaker cells? Adv Anat Embryol Cell Biol 1982;71:1-130.
26. Hanani M, Louzon V, Miller SM, Faussone-Pellegrini MS. Visualization of interstitial cells of Cajal in the mouse colon by vital staining. Cell Tissue Res 1998;292:275-82. (Pubitemid 28230214)
27. Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology 1996;111:492-515. (Pubitemid 26256739)
28. Hagger R, Gharaie S, Finlayson C, Kumar D. Regional and transmural density of interstitial cells of Cajal in human colon and rectum. Am J Physiol 1998;275:G1309-16.
29. Romert P, Mikkelsen HB. c-kit immunoreactive interstitial cells of Cajal in the human small and large intestine. Histochem Cell Biol 1998;109:195-202. (Pubitemid 28114283)
30. Faussone-Pellegrini MS, Pantalone D, Cortesini C. An ultrastructural study of the interstitial cells of Cajal of the human stomach. J Submicrosc Cytol Pathol 1989;21:439-60. (Pubitemid 19185025)
31. Faussone-Pellegrini MS, Pantalone D, Cortesini C. Smooth muscle cells, interstitial cells of Cajal and myenteric plexus interrelationships in the human colon. Acta Anat 1990;139:31-14.
32. Faussone-Pellegrini MS. Histogenesis, structure and relationships of interstitial cells of Cajal (ICC): from morphology to functional interpretation. Eur J Morphol 1992;30:137-48.
33. Jessen H, Thuneberg L. Interstitial cells of Cajal and Auerbach's plexus. A scanning electron microscopical study of guinea-pig small intestine. J Submicrosc Cytol Pathol 1991;23:195-212.
34. Komuro T, Zhou DS. Anti-c-kit protein immunoreactive cells corresponding to the interstitial cells of Cajal in the guinea-pig small intestine. J Auton Nerv Syst 1996;61:169-74. (Pubitemid 26384341)
35. Thomsen L, Robinson TL, Lee JC, Farraway LA, Hughes MJ, Andrews DW, et al. Interstitial cells of Cajal generate a rhythmic pacemaker current. Nat Med 1998;4:848-51. (Pubitemid 28331030)
36. Kluppel M, Huizinga JD, Malysz J, Bernstein A. Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine. Dev Dyn 1998;211:60-71. (Pubitemid 28035812)
37. Lecoin L, Gabella G, Le Douarin N. Origin of the c-kit-positive interstitial cells in the avian bowel. Development 1996;122:725-33. (Pubitemid 26095978)
38. Koh SD, Sanders KM, Ward SM. Spontaneous electrical rhythmicity in cultured interstitial cells of cajal from the murine small intestine. J Physiol (Lond) 1998;513:203-13. (Pubitemid 28528577)
39. Vanderwinden JM, Vanderhaeghen JJ. Keeping up with the Cajal rhythm [News and Views]. Nat Med 1998;4:765-7.
40. Liu LW, Thuneberg L, Huizinga JD. Selective lesioning of interstitial cells of Cajal by methylene blue and light leads to loss of slow waves. Am J Physiol 1994;266:G485-96. (Pubitemid 24115924)
41. Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995;373:347-9.
42. Isozaki K, Hirota S, Nakama A, Miyagawa J, Shinomura Y, Xu Z, et al. Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats. Gastroenterology 1995;109:456-64.
43. Burns AJ, Lomax AE, Torihashi S, Sanders KM, Ward SM. Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci USA 1996;93:12008-13. (Pubitemid 26347239)
44. Ward SM, Morris G, Reese L, Wang XY, Sanders KM. Interstitial cells of Cajal mediate enteric inhibitory neurotransmission in the lower esophageal and pyloric sphincters. Gastroenterology 1998; 115:314-29. (Pubitemid 28363424)
45. Huizinga JD, Thuneberg L, Vanderwinden JM, Rumessen JJ. In-terstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders. Trends Pharmacol Sci 1997; 18:393-403. (Pubitemid 27435062)
46. Nakama A, Hirota S, Okazaki T, Nagano K, Kawano S, Hori M, et al. Disturbed pyloric motility in Ws/Ws mutant rats due to deficiency of c-kit-expressing interstitial cells of Cajal. Pathol Int 1998;48:843-9. (Pubitemid 28512073)
47. Ekblad E, Sjuve R, Arner A, Sundler F. Enteric neuronal plasticity and a reduced number of interstitial cells of Cajal in hypertrophic rat ileum. Gut 1998;42:836-44. (Pubitemid 28277226)
48. Kenny SE, Connell MG, Rintala RJ, Vaillant C, Edgar DH, Lloyd DA. Abnormal colonic interstitial cells of Cajal in children with anorectal malformations. J Pediatr Surg 1998;33:130-2. (Pubitemid 28060399)
49. Campbell F, Hewlett B, Ho J, Hizinga J, Riddell RH. Interstitial cells of Cajal (ICC) are absent or deranged in intestinal pseudoobstruction (abstract). Mod Pathol 1998;11.
50. Isozaki K, Hirota S, Miyagawa J, Taniguchi M, Shinomura Y, Matsuzawa Y. Deficiency of c-kit+ cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol 1997;92:332-4. (Pubitemid 27076488)
51. Yamataka A, Ohshiro K, Kobayashi H, Lane GJ, Yamataka T, Fujiwara T, et al. Abnormal distribution of intestinal pacemaker (C-KIT-positive) cells in an infant with chronic idiopathic intestinal pseudoobstruction. J Pediatr Surg 1998;33:859-62. (Pubitemid 28280813)
52. Kenny SE, Vanderwinden JM, Rintala RJ, Connell MG, Lloyd DA, Vanderhaegen JJ, et al. Delayed maturation of the interstitial cells of Cajal: a new diagnosis for transient neonatal pseudoobstruction. Report of two cases. J Pediatr Surg 1998;33:94-8. (Pubitemid 28060390)
53. Langer JC, Berezin I, Daniel EE. Hypertrophic pyloric stenosis: ultrastructural abnormalities of enteric nerves and the interstitial cells of Cajal. J Pediatr Surg 1995;30:1535-43.
54. Vanderwinden JM, Liu H, De Laet MH, Vanderhaeghen JJ. Study of the interstitial cells of Cajal in infantile hypertrophic pyloric stenosis [published erratum appears in Gastroenterology 1996 Nov;111(5):1403]. Gastroenterology 1996;111:279-88. (Pubitemid 26256715)
55. Yamataka A, Fujiwara T, Kato Y, Okazaki T, Sunagawa M, Miyano T. Lack of intestinal pacemaker (C-KIT-positive) cells in infantile hypertrophic pyloric stenosis. J Pediatr Surg 1996;31:96-8; discussion 98-9.
56. Yamataka A, Kato Y, Tibboel D, Murata Y, Sueyoshi N, Fujimoto T, et al. A lack of intestinal pacemaker (c-kit) in aganglionic bowel of patients with Hirschsprung's disease. J Pediatr Surg 1995;30:441-4.
57. Vanderwinden JM, Rumessen JJ, Liu H, Descamps D, De Laet MH, Vanderhaeghen JJ. Interstitial cells of Cajal in human colon and in Hirschsprung's disease. Gastroenterology 1996;111:901-10.
58. Horisawa M, Watanabe Y, Torihashi S. Distribution of c-Kit immunopositive cells in normal human colon and in Hirschsprung's disease. J Pediatr Surg 1998;33:1209-14. (Pubitemid 28384802)
59. Yamataka A, Ohshiro K, Kobayashi H, Fujiwara T, Sunagawa M, Miyano T. Intestinal pacemaker C-KIT+ cells and synapses in allied Hirschsprung's disorders. J Pediatr Surg 1997;32:1069-74. (Pubitemid 27349027)
60. Rumessen JJ. Ultrastructure of interstitial cells of Cajal at the colonic submuscular border in patients with ulcerative colitis. Gastroenterology 1996;111:1447-55. (Pubitemid 26404207)
61. Hendrickson MR, Kempson RL. Smooth muscle tumours. In: Whitehead R, ed. Gastrointestinal and Oesophageal Pathology. 1st ed. Edinburgh: Churchill Livingstone, 1989:619-28.
62. Appelman HD. Mesenchymal tumors of the gut: historical perspectives, new approaches, new results, and does it make any difference? In: Goldman H, Appelman HD, Kaufman N, eds. Gastrointestinal Pathology. United States and Canadian Academy of Pathology Monographs in Pathology, No. 31. Baltimore: Williams & Wilkins, 1990:220-46.
63. Franquemont DW. Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol 1995;103:41-7.
64. Hjermstad BM, Sobin LH, Helwig EB. Stromal tumors of the gastrointestinal tract: myogenic or neurogenic? [published erratum appears in Am J Surg Pathol 1987 Aug; 11(8):660]. Am J Surg Pathol 1987;11:383-6. (Pubitemid 17071218)
65. Pike AM, Lloyd RV, Appelman HD. Cell markers in gastrointestinal stromal tumors. Hum Pathol 1988;19:830-4.
66. Mazur MT, Clark HB. Gastric stromal tumors, reappraisal of histogenesis. Am J Surg Pathol 1983;7:507-19. (Pubitemid 13021488)
67. Miettinen M, Virolainen M, Maarit Sarlomo R. Gastrointestinal stromal tumors - value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J Surg Pathol 1995;19:207-16.
68. Suster S. Gastrointestinal stromal tumors. Semin Diagn Pathol 1996;13:297-313. (Pubitemid 26399397)
69. Ma CK, Amin MB, Kintanar E, Linden MD, Zarbo RJ. Immunohistologic characterization of gastrointestinal stromal tumors: a study of 82 cases compared with 11 cases of leiomyomas. Mod Pathol 1993;6:139-44.
70. Saul SH, Rast ML, Brooks JJ. The immunohistochemistry of gastrointestinal stromal tumors. Evidence supporting an origin from smooth muscle. Am J Surg Pathol 1987;11:464-73. (Pubitemid 17085832)
71. Ueyama T, Guo KJ, Hashimoto H, Daimaru Y, Enjoji M. A clinicopathologic and immunohistochemical study of gastrointestinal stromal tumors. Cancer 1992;69:947-55.
72. Herrera GA, Cerezo L, Jones JE, Sack J, Grizzle WE, Pollack WJ, et al. Gastrointestinal autonomic nerve tumors. 'Plexosarcomas.' Arch Pathol Lab Med 1989;113:846-53. (Pubitemid 19206384)
73. Isimbaldi G, Santangelo M, Cenacchi G, Cribiu FM, Claren R, Delpiano C, et al. Gastrointestinal autonomic nerve tumor (plexosarcoma): report of a case with fine needle aspiration biopsy and histologic, immunocytochemical and ultrastructural study. Acta Cytol 1998;42:1189-94. (Pubitemid 28460008)
74. Antonioli DA. Gastrointestinal autonomic nerve tumors. Expanding the spectrum of gastrointestinal stromal tumors. Arch Pathol Lab Med 1989;113:831-3. (Pubitemid 19206380)
75. Donner LR. Gastrointestinal autonomic nerve tumor: a common type of gastrointestinal stromal neoplasm. Ultrastruct Pathol 1997; 21:419-24. (Pubitemid 27376665)
76. Dhimes P, Lopez-Carreira M, Ortega-Serrano MP, Garcia-Munoz H, Martinez-Gonzalez MA, Ballestin C. Gastrointestinal autonomic nerve tumours and their separation from other gastrointestinal stromal tumours: an ultrastructural and immunohistochemical study of seven cases. Virchows Arch 1995;426:27-35.
77. Matsumoto K, Min W, Yamada N, Asano G. Gastrointestinal autonomic nerve tumors: immunohistochemical and ultrastructural studies in cases of gastrointestinal stromal tumor. Pathol Int 1997; 47:308-14. (Pubitemid 27194378)
78. Min KW. Gastrointestinal autonomic nerve tumors and skeinoid fibers [letter; comment]. Am J Surg Pathol 1994;18:958-60.
79. Ojanguren I, Ariza A, Navas-Palacios JJ. Gastrointestinal autonomic nerve tumor: further observations regarding an ultrastructural and immunohistochemical analysis of six cases. Hum Pathol 1996;27:1311-8. (Pubitemid 26415325)
80. Segal A, Carello S, Caterina P, Papadimitriou JM, Spagnolo DV. Gastrointestinal autonomic nerve tumors: a clinicopathological, immunohistochemical and ultrastructural study of 10 cases. Pathology 1994;26:439-47.
81. Testino G, Cornaggia M, Capella C. Gastrointestinal autonomic nerve tumours of the duodenum [letter] Ital J Gastroenterol Hepatol 1998;30:448-9. (Pubitemid 28445799)
82. Tsang WYW. Gastrointestinal autonomic nerve (GAN) tumors: an underrecognized group of gastrointestinal stromal neoplasms. Adv Anat Pathol 1994:1:21-8.
83. Lauwers GY, Erlandson RA, Casper ES, Brennan MF, Woodruff JM. Gastrointestinal autonomic nerve tumors. A clinicopathological, immunohistochemical, and ultrastructural study of 12 cases [see comments]. Am J Surg Pathol 1993;17:887-97. (Pubitemid 23245921)
84. Shanks JH, Harris M, Banerjee SS, Eyden BP. Gastrointestinal autonomic nerve tumours: a report of nine cases. Histopathology 1996;29:111-21. (Pubitemid 26264435)
85. Erlandson RA, Klimstra DS, Woodruff JM. Subclassification of gastrointestinal stromal tumors based on evaluation by electron microscopy and immunohistochemistry [see comments]. Ultrastruct Pathol 1996;20:373-93. (Pubitemid 26274488)
86. Miettinen M. Gastrointestinal stromal tumors. An immunohistochemical study of cellular differentiation. Am J Clin Pathol 1988; 89:601-10.
87. Mikhael AI, Bacchi CE, Zarbo RJ, Ma CK, Gown AM. CD34 expression in stromal tumors of the gastrointestinal tract. Appl Immunohistochem 1994;2:89-93.
88. Suster S, Sorace D, Moran CA. Gastrointestinal stromal tumors with prominent myxoid matrix. Clinicopathologic, immunohistochemical, and ultrastructural study of nine cases of a distinctive morphologic variant of myogenic stromal tumor [see comments]. Am J Surg Pathol 1995;19:59-70.
89. Suster S, Fletcher CD. Gastrointestinal stromal tumors with prominent signet-ring cell features [see comments]. Mod Pathol 1996; 9:609-13. (Pubitemid 26227560)
90. Sarlomo-Rikala M, Kovatich AJ, Barusevicius A, Miettinen M. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol 1998;11:728-34. (Pubitemid 28381606)
91. Sircar K, Hewlett B, Riddell RH. Most gastrointestinal stromal tumors (GIST) arise from the interstitial cells of Cajal (ICC) (abstract). Mod Pathol 1998;11:71A.
92. van de Rijn M, Hendrickson MR, Rouse RV. CD34 expression by gastrointestinal tract stromal tumors. Hum Pathol 1994;25:766-71. (Pubitemid 24249234)
93. Marshall JB, Diaz-Arias AA, Bochna GS, Vogele KA. Achalasia due to diffuse esophageal leiomyomatosis and inherited as an autosomal dominant disorder. Report of a family study. Gastroenterology 1990;98:1358-65. (Pubitemid 20143126)
94. El-Omar M, Davies J, Gupta S, Ross H, Thompson R. Leiomyo-sarcoma in leiomyomatosis of the small intestine. Postgrad Med J 1994;70:661-4.
95. Kindblom LG, Meis-Kindblom JM. Interstitial cells of Cajal: pacemaker cells? (Letter). Am J Pathol 1998;153:2009-11.
96. Arber DA, Tamayo R, Weiss LM. Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disorders. Hum Pathol 1998;29:498-504. (Pubitemid 28213470)