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Volumn 131, Issue 38, 2009, Pages 13568-13569

Rapid and efficient induction of an endogenous cell signaling event by subcellular targeting of a synthetic ligand

Author keywords

[No Author keywords available]

Indexed keywords

AGONIST ACTIVITY; CELL SIGNALING; CYTOSOLS; ENDOGENOUS SIGNALING; IN-CELL; INTRACELLULAR SIGNALING; LIGAND MOLECULES; RESEARCH EFFORTS; SPATIAL LOCALIZATION; SPECIFIC LOCATION; SUB-CELLULAR; SUBCELLULAR LOCATION; SUBCELLULAR TARGETING; SYNTHETIC LIGANDS; TARGET PROTEINS;

EID: 70349731661     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja903706t     Document Type: Article
Times cited : (3)

References (20)
  • 9
    • 0842346438 scopus 로고    scopus 로고
    • (b) Pawson, T. Cell 2004, 116, 191.
    • (2004) Cell , vol.116 , pp. 191
    • Pawson, T.1
  • 10
    • 0028832658 scopus 로고
    • The strategy of small-molecule-mediated protein translocation has previously been demonstrated to trigger several signaling pathways through the use of fusion proteins. However, this is the first attempt to activate an endogenous pathway using a localized ligand without modification of the target protein. See: (a)
    • The strategy of small-molecule-mediated protein translocation has previously been demonstrated to trigger several signaling pathways through the use of fusion proteins. However, this is the first attempt to activate an endogenous pathway using a localized ligand without modification of the target protein. See: (a) Holsinger, L. J.; Spencer, D. M.; Austin, D. J.; Schreiber, S. L.; Crabtree, G. R. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 9810.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 9810
    • Holsinger, L.J.1    Spencer, D.M.2    Austin, D.J.3    Schreiber, S.L.4    Crabtree, G.R.5
  • 18
    • 0034597446 scopus 로고    scopus 로고
    • Direct modification of peptide ligands with a lipid anchor may also be an alternative approach for localizing the ligands at the PM. See
    • Direct modification of peptide ligands with a lipid anchor may also be an alternative approach for localizing the ligands at the PM. See: Kadereit, D.; Kuhlmann, J.; Waldmann, H. ChemBioChem 2000, 1, 144.
    • (2000) ChemBioChem , vol.1 , pp. 144
    • Kadereit, D.1    Kuhlmann, J.2    Waldmann, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.