Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases

Neurotoxicity Research

Volumn 16, Issue 1, 2009, Pages 68-76

  Mester, Laszlo ^a   Szabo, Aliz ^a   Atlasz, Tamas ^b   Szabadfi, Krisztina ^b   Reglodi, Dora ^b,c   Kiss, Peter ^b   Racz, Boglarka ^a   Tamas, Andrea ^b   Gallyas, Ferenc ^a   Sumegi, Balazs ^a   Hocsak, Eniko ^a   Gabriel, Robert ^b   Kovacs, Krisztina ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

^c ROSS UNIVERSITY SCHOOL OF MEDICINE   (Dominica)

Author keywords

Antiapoptotic pathways; BCCAO; HO3089; Retinoprotection

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; HO 3089; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT; RETINA DEGENERATION; TISSUE STRUCTURE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BENZIMIDAZOLES; CAROTID ARTERY DISEASES; ENZYME INHIBITORS; MALE; MAP KINASE KINASE 4; ONCOGENE PROTEIN V-AKT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; RETINAL DEGENERATION; SIGNAL TRANSDUCTION; TIME FACTORS;

MURINAE; RATTUS NORVEGICUS;

EID: 70349729991     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12640-009-9049-6     Document Type: Article

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