Retroperitoneal lipomatous tumors without cytologic atypia: Are they lipomas?: A clinicopathologic and molecular study of 19 cases

American Journal of Surgical Pathology

Volumn 33, Issue 10, 2009, Pages 1470-1476

  MacArenco, Ricardo S ^a   Erickson Johnson, Michele ^b   Wang, Xiaoke ^b   Folpe, Andrew A ^b   Rubin, Brian P ^c   Nascimento, Antonio G ^b   Oliveira, Andre M ^b  

^a CIPAX Medicina Diagnostica   (Brazil)

^b MAYO CLINIC   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

HMGA2; Lipoma; MDM2; Molecular genetics; Retroperitoneum; Well differentiated liposarcoma

Indexed keywords

CARBOXYPEPTIDASE; CYCLIN DEPENDENT KINASE 4; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HIGH MOBILITY GROUP A2 PROTEIN; HYBRID PROTEIN; PROTEIN MDM2;

ADULT; AGED; ARTICLE; CANCER SURGERY; CHROMOSOME 12Q; CHROMOSOME ANALYSIS; CHROMOSOME MARKER; CLINICAL ARTICLE; CONTROL GROUP; CONTROLLED STUDY; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; LIPOMA; LIPOSARCOMA; MALE; MOLECULAR GENETICS; PATHOLOGY; PROSPECTIVE STUDY; RETROPERITONEAL TUMOR; TUMOR RECURRENCE; TUMOR VOLUME;

ADULT; AGED; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIPOMA; LIPOSARCOMA; MALE; MIDDLE AGED; RETROPERITONEAL NEOPLASMS; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 70349693694     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181b278bf     Document Type: Article

References (57)

1. Battista S, Fidanza V, Fedele M, et al. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res. 1999;59:4793-4797.
2. Binh MB, Sastre-Garau X, Guillou L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005;29:1340-1347.
3. Binh MB, Garau XS, Guillou L et al. Reproducibility of MDM2 and CDK4 staining in soft tissue tumors. Am J Clin Pathol. 2006; 125:693-697.
4. Bowen A, Gaisie G, Bron K. Retroperitoneal lipoma in children: choosing among diagnostic imaging modalities. Pediatr Radiol. 1982;12:221-225.
5. De Campos Freire G. Right kidney transposition to the left side by huge retroperitoneal lipoma simulating crossed kidney ectopy; diagnosis with translumbar serial aortography. Urol int. 1957; 4:2-8.
6. Deppe G, Malviya VK, Hercule J, et al. Retroperitoneal pelvic lipoma. J Natl Med Assoc. 1985;77:574-576.
7. Drop A, Czekajska-Chehab E, Maciejewski R. Giant retroperitoneal lipomas-radiological case report. Ann Univ Mariae Curie Sklodowska [Med]. 2003;58:142-146.
8. Erickson-Johnson MR, Seys AR, Roth CW, et al. Assessment of Carboxypeptidase M (CPM). Amplification: a surrogate marker for MDM2 amplification in the discrimination of well-differentiated liposarcomas from lipomas. [1190]. Presented at the annual meeting of The American Society of Human Genetics, November 14, 2008. 2008.
9. Foa C, Mainguene C, Dupre F, et al. Rearrangement involving chromosomes 1 and 8 in a retroperitoneal lipoma. Cancer Genet Cytogenet. 2002;133:156-159.
10. Ford JL, Hittner VJ. Retroperitoneal lipomata; report of 2 cases. Wis Med J. 1950;49:915-917.
11. Forte F, Maturo G, Catania A, et al. Retroperitoneal lipoma. Unusual presentation with detrusor instability. Minerva Urol Nefrol. 2002;54:131-133.
12. Friedman AC, Hartman DS, Sherman J, et al. Computed tomography of abdominal fatty masses. Radiology. 1981;139:415-429.
13. Gariepy LB. Retroperitoneal lipomata. J Mich State Med Soc. 1961;1185-1188.
14. Harvard BM. Retroperitoneal lipoma in children: report of case and review of literature. J Urol. 1953;70:159-163.
15. Hayasaka K, Yamada T, Saitoh Y, et al. CT evaluation of primary benign retroperitoneal tumor. Radiat Med. 1994;12:115-120.
16. Ida CM, Wang X, Erickson-Johnson MR, et al. Primary retroperitoneal lipoma: a soft tissue pathology heresy?: report of a case with classic histologic, cytogenetics, and molecular genetic features. Am J Surg Pathol. 2008;32:951-954.
17. Italiano A, Cardot N, Dupre F, et al. Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the missing link between lipomas and liposarcomas? Int J Cancer. 2007;121:308-315.
18. Italiano A, Ebran N, Attias R, et al. NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22. Genes Chromosomes Cancer. 2008;47:971-977.
19. Katz H. A case of retroperitoneal lipoma. S Afr Med J. 1950; 24:917-918.
20. Kempson RL, Fletcher CDM, Evans HL, et al. Lipomatous tumors. In: Josai J, Sobin LH, eds. Tumors of the Soft Tissues. Bethesda, Maryland: Armed Forces Institute of Pathology; 1998.
21. Lane RH, Stephens DH, Reiman HM. Primary retroperitoneal neoplasms: CT findings in 90 cases with clinical and pathologic correlation. AJR Am J Roentgenol. 1989;152:83-89.
22. Lucas DR, Nascimento AG, Sanjay BK, et al. Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases. Am J Clin Pathol. 1994;102:677-683.
23. Martinez CA, Palma RT, Waisberg J. Giant retroperitoneal lipoma: a case report. Arq Gastroenterol. 2003;40:251-255.
24. McCarthy MP, Frogge JD, Delgado R, et al. A large retroperitoneal lipoma. J Urol. 1977;118:478-479.
25. Medeiros F, Erickson-Johnson MR, Keeney GL, et al. Frequency and characterization of HMGA2 and HMGA1 rearrangements in mesenchymal tumors of the lower genital tract. Genes Chromosomes Cancer. 2007;46:981-990.
26. Meza-Zepeda LA, Berner JM, Henriksen J, et al. Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions. Genes Chromosomes Cancer. 2001;31:264-273.
27. Mineau DE, Nixon GW. Retroperitoneal lipoma in a child. Radiology. 1978;126:456.
28. Mitchell EL, Kelsey A, Armstrong G, et al. Ring chromosomes in a retroperitoneal lipoma of childhood. Genes Chromosomes Cancer. 1992;4:89-91.
29. Noehren AH, Goembel TE, Tannhauser s. So-called retroperitoneal lipoma. Ann Surg. 1953;138:779-783.
30. Pai MR, Naik R, Raghuveer CV. Primary retroperitoneal tumors a 25 year study. Indian J Med Sci. 1995;49:139-141.
31. Pedeutour F, Suijkerbuijk RF, Forus A, et al. Complex composition and co-amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcoma. Genes Chromosomes Cancer. 1994;10:85-94.
32. Pedeutour F, Forus A, Coindre JM, et al. Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosomes Cancer. 1999;24:30-41.
33. Peitsidis P, Peitsidou A, Tsekoura V, et al. Management of large retroperitoneal lipoma in a 12-year-old patient. Urology. 2009;73: 797-799.
34. Petit MM, Mols R, Schoenmakers EF, et al. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics. 1996;36:118-129.
35. Pinto VC, Mattos AG, Pimenta E, et al. Retroperitoneal myxolipoma; report of case in a child seven years of age. Pediatrics. 1954;14:11-15.
36. Pumberger W, Wiesbauer P. Radiological case of the month. Retroperitoneal lipoma in a 6-month-old infant. Arch Pediatr Adolesc Med. 1998;152:201-202.
37. Raftopoulos I, Lee T, Byrne MP. Image of the month: retroperitoneal lipoma. Arch Surg. 2002;137:865-866.
38. Regan JS, Sanes S, Maccallum JD. So-called retroperitoneal lipoma: report of seven cases. Ann Surg. 1943;117:110-117.
39. Sandberg AA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: lipoma. Cancer Genet Cytogenet. 2004;150:93-115.
40. Sandberg AA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma. Cancer Genet Cytogenet. 2004;155:1-24.
41. Seymour EQ, Puckette SE Jr. Retroperitoneal lipoma: a case report in an infant. J Urol. 1968;100:165-166.
42. Shaffer LG, Tommerup N. ISCN 2005: an International System for Human Cytogenetic Nomenclature (2005): Recommendations of the International Standing Committee on Human Cytogenetic Nomenclature. Basel: S Karger Publishers Inc. 2007.
43. Sirvent N, Coindre JM, Maire G, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffinembedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31:1476-1489.
44. Storlazzi CT, Mertens F, Domanski H, et al. Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia. Int J Oncol. 2003;23:67-71.
45. Sullivan WG, Wesenberg RL, Lilly JR. Giant retroperitoneal lipoma in children. Pediatrics. 1980;66:123-125.
46. Trahan S, Erickson-Johnson MR, Rodriguez F, et al. Formation of the 12q14-q15 amplicon precedes the development of a welldifferentiated liposarcoma arising from a nonchondroid pulmonary hamartoma. Am J Surg Pathol. 2006;30:1326-1329.
47. Vibits H, Wammen ES, Duun PS. Recurrent benign retroperitoneal lipoma. Rev Med Chir Soc Med Nat Iasi. 1992;96: 107-109.
48. Weaver J, Downs-Kelly E, Goldblum JR, et al. Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol. 2008;21:943-949.
49. Weiss SW, Rao VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of dedifferentiation. Am J Surg Pathol. 1992;16: 1051-1058.
50. Weitzner S, Blumenthal BI, Moynihan PC. Retroperitoneal lipoma in children. J Pediatr Surg. 1979;14:88-90.
51. Willen H, Akerman M, Dal CP, et al. Comparison of chromosomal patterns with clinical features in 165 lipomas: a report of the CHAMP study group. Cancer Genet Cytogenet. 1998;102:46-49.
52. Winer-Muram HT, Muram D. Retroperitoneal lipoma manifested as an adnexal mass. J Tenn Med Assoc. 1988;81:225-226.
53. Winram RG, Ward-McQuaid JN. Retroperitoneal lipoma causing renal displacement. Can J Surg. 1959;2:422-424.
54. Wolk DP, Schuster KM. Retroperitoneal lipoma in a child. J Pediatr Surg. 1972;7:343-344.
55. Yalcin B, Ozturk H, Kismet E, et al. Giant retroperitoneal lipoma in a child. Pediatr Radiol. 2001;31:304.
56. Young LW, Severson MV, Burke EC, et al. Radiological case of the month. Retroperitoneal lipoma in a child. Am J Dis Child. 1980; 134:83-84.
57. Zhang SZ, Yue XH, Liu XM, et al. Giant retroperitoneal pleomorphic lipoma. Am J Surg Pathol. 1987;11:557-562.