메뉴 건너뛰기




Volumn 17, Issue 5, 2009, Pages 400-406

Modeling auditory transducer dynamics

Author keywords

Hearing; Mechanotransduction; Modeling

Indexed keywords

CALCIUM;

EID: 70349680894     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOO.0b013e3283303443     Document Type: Review
Times cited : (5)

References (91)
  • 1
    • 0020633119 scopus 로고
    • Kinetics of the receptor current in bullfrog saccular hair-cells
    • Corey DP, Hudspeth AJ. Kinetics of the receptor current in bullfrog saccular hair-cells. J Neurosci 1983; 3:962-976.
    • (1983) J Neurosci , vol.3 , pp. 962-976
    • Corey, D.P.1    Hudspeth, A.J.2
  • 2
    • 0024433313 scopus 로고
    • How the ear's works work
    • Hudspeth AJ. How the ear's works work. Nature 1989; 341:397-404.
    • (1989) Nature , vol.341 , pp. 397-404
    • Hudspeth, A.J.1
  • 3
    • 49849096118 scopus 로고    scopus 로고
    • Making an effort to listen: Mechanical amplification in the ear
    • Hudspeth AJ. Making an effort to listen: mechanical amplification in the ear. Neuron 2008; 59:530-545.
    • (2008) Neuron , vol.59 , pp. 530-545
    • Hudspeth, A.J.1
  • 5
    • 0018687120 scopus 로고
    • Ionic basis of the receptor potential in a vertebrate hair cell
    • Corey DP, Hudspeth AJ. Ionic basis of the receptor potential in a vertebrate hair cell. Nature 1979; 281:675-677.
    • (1979) Nature , vol.281 , pp. 675-677
    • Corey, D.P.1    Hudspeth, A.J.2
  • 6
    • 33645758509 scopus 로고    scopus 로고
    • Transfer characteristics of the hair cell's afferent synapse
    • Keen EC, Hudspeth AJ. Transfer characteristics of the hair cell's afferent synapse. Proc Natl Acad Sci U S A 2006; 103:5537-5542.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5537-5542
    • Keen, E.C.1    Hudspeth, A.J.2
  • 7
    • 0001166495 scopus 로고
    • Sensitivity, polarity, and conductance change in response of vertebrate hair cells to controlled mechanical stimuli
    • Hudspeth AJ, Corey DP. Sensitivity, polarity, and conductance change in response of vertebrate hair cells to controlled mechanical stimuli. Proc Natl Acad Sci U S A 1977; 74:2407-2411.
    • (1977) Proc Natl Acad Sci U S A , vol.74 , pp. 2407-2411
    • Hudspeth, A.J.1    Corey, D.P.2
  • 8
    • 0022559277 scopus 로고
    • The transduction channel of hair cells from the bull-frog characterized by noise analysis
    • Holton T, Hudspeth AJ. The transduction channel of hair-cells from the bullfrog characterized by noise-analysis. J Physiol (Lond) 1986; 375:195-227. (Pubitemid 16097604)
    • (1986) Journal of Physiology , vol.VOL. 375 , pp. 195-227
    • Holton, T.1    Hudspeth, A.J.2
  • 9
    • 0024002893 scopus 로고
    • Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell
    • Howard J, Hudspeth AJ. Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell. Neuron 1988; 1:189-199.
    • (1988) Neuron , vol.1 , pp. 189-199
    • Howard, J.1    Hudspeth, A.J.2
  • 10
    • 0028031939 scopus 로고
    • Pulling springs to tune transduction: Adaptation by hair cells
    • DOI 10.1016/0896-6273(94)90147-3
    • Hudspeth AJ, Gillespie PG. Pulling springs to tune transduction: adaptation by hair-cells. Neuron 1994; 12:1-9. (Pubitemid 24044382)
    • (1994) Neuron , vol.12 , Issue.1 , pp. 1-9
    • Hudspeth, A.J.1    Gillespie, P.G.2
  • 11
    • 0021179678 scopus 로고
    • Cross-links between stereocilia in the guinea-pig organ of corti, and their possible relation to sensory transduction
    • Pickles JO, Comis SD, Osborne MP. Cross-links between stereocilia in the guinea-pig organ of corti, and their possible relation to sensory transduction. Hear Res 1984; 15:103-112.
    • (1984) Hear Res , vol.15 , pp. 103-112
    • Pickles, J.O.1    Comis, S.D.2    Osborne, M.P.3
  • 12
    • 0034700162 scopus 로고    scopus 로고
    • High-resolution structure of hair-cell tip links
    • Kachar B, Parakkal M, Kurc M, et al. High-resolution structure of hair-cell tip links. Proc Natl Acad Sci U S A 2000; 97:13336-13341.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13336-13341
    • Kachar, B.1    Parakkal, M.2    Kurc, M.3
  • 13
    • 0026326113 scopus 로고
    • Tip-link integrity and mechanical transduction in vertebrate hair cells
    • Assad JA, Shepherd GM, Corey DP. Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron 1991; 7:985-994.
    • (1991) Neuron , vol.7 , pp. 985-994
    • Assad, J.A.1    Shepherd, G.M.2    Corey, D.P.3
  • 14
    • 0028971075 scopus 로고
    • 2+ entry through mechanosensitive channels localizes the site of mechanoelectrical transduction in hair-cells
    • 2+ entry through mechanosensitive channels localizes the site of mechanoelectrical transduction in hair-cells. Proc Natl Acad Sci U S A 1995; 92:10297-10301.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10297-10301
    • Lumpkin, E.A.1    Hudspeth, A.J.2
  • 15
    • 65549128486 scopus 로고    scopus 로고
    • Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging
    • This experimental and computational study observes calcium-induced fluorescence changes in the stereocilia of rat cochlear inner hair cells following step deflections using fast confocal microscopy. Calcium signals are larger in rows with shorter stereocilia than in the row containing the tallest stereocilia. In contrast to previous studies, this indicates that the mechanoelectrical transduction channels are located at the lower ends (instead of at the upper ends or both ends) of the tip links
    • Beurg M, Fettiplace R, Nam J-H, et al. Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging. Nat Neurosci 2009; 12:553-558. This experimental and computational study observes calcium-induced fluorescence changes in the stereocilia of rat cochlear inner hair cells following step deflections using fast confocal microscopy. Calcium signals are larger in rows with shorter stereocilia than in the row containing the tallest stereocilia. In contrast to previous studies, this indicates that the mechanoelectrical transduction channels are located at the lower ends (instead of at the upper ends or both ends) of the tip links.
    • (2009) Nat Neurosci , vol.12 , pp. 553-558
    • Beurg, M.1    Fettiplace, R.2    Nam, J.-H.3
  • 16
    • 17044401714 scopus 로고    scopus 로고
    • In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats
    • Camb
    • Sotomayor M, Corey DP, Schulten K. In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats. Structure (Camb) 2005; 13:669-682.
    • (2005) Structure , vol.13 , pp. 669-682
    • Sotomayor, M.1    Corey, D.P.2    Schulten, K.3
  • 17
    • 45849137475 scopus 로고    scopus 로고
    • 2+ switch in adhesion and elasticity of c-cadherin
    • This study performs a molecular dynamics simulation of mechanical properties of the tip-link protein c-cadherin and their dependence on calcium. C-cadherin behaves consistent with a viscoelastic element, but with very high stiffness (minimum 25 mN/m). This study supports a role for tip links in force transmission, but not as the elastic element forming the gating spring
    • 2+ switch in adhesion and elasticity of c-cadherin. Biophys J 2008; 94:4621-4633. This study performs a molecular dynamics simulation of mechanical properties of the tip-link protein c-cadherin and their dependence on calcium. C-cadherin behaves consistent with a viscoelastic element, but with very high stiffness (minimum 25 mN/m). This study supports a role for tip links in force transmission, but not as the elastic element forming the gating spring.
    • (2008) Biophys J , vol.94 , pp. 4621-4633
    • Sotomayor, M.1    Schulten, K.2
  • 18
    • 0024804277 scopus 로고
    • Activation and adaptation of transducer currents in turtle hair cells
    • Crawford AC, Evans MG, Fettiplace R. Activation and adaptation of transducer currents in turtle hair cells. J Physiol (Lond) 1989; 419:405-434. (Pubitemid 20012026)
    • (1989) Journal of Physiology , vol.419 , pp. 405-434
    • Crawford, A.C.1    Evans, M.G.2    Fettiplace, R.3
  • 19
    • 85087097314 scopus 로고    scopus 로고
    • Hair bundle mechanics at high frequencies: A test of series or parallel transduction
    • Nuttall AL, Ren T, Gillespie P, et al., editors Singapore: World Scientific Publishing Co. Pte. Ltd
    • Karavitaki KD, Corey DP. Hair bundle mechanics at high frequencies: a test of series or parallel transduction. In: Nuttall AL, Ren T, Gillespie P, et al., editors. Auditory mechanisms: processes and models. Singapore: World Scientific Publishing Co. Pte. Ltd; 2006. pp. 286-292.
    • (2006) Auditory Mechanisms: Processes and Models , pp. 286-292
    • Karavitaki, K.D.1    Corey, D.P.2
  • 20
    • 33845877441 scopus 로고    scopus 로고
    • Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels
    • DOI 10.1038/nn1818, PII NN1818
    • Kozlov AS, Risler T, Hudspeth AJ. Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels. Nat Neurosci 2007; 10:87-92. (Pubitemid 46026531)
    • (2007) Nature Neuroscience , vol.10 , Issue.1 , pp. 87-92
    • Kozlov, A.S.1    Risler, T.2    Hudspeth, A.J.3
  • 22
  • 23
    • 58149337280 scopus 로고    scopus 로고
    • How hair cells hear: The molecular basis of hair-cell mechanotransduction
    • Phillips KR, Biswas A, Cyr JL. How hair cells hear: the molecular basis of hair-cell mechanotransduction. Curr Opin Otolaryngol Head Neck Surg 2008; 16:445-451.
    • (2008) Curr Opin Otolaryngol Head Neck Surg , vol.16 , pp. 445-451
    • Phillips, K.R.1    Biswas, A.2    Cyr, J.L.3
  • 24
    • 0023415077 scopus 로고
    • Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus
    • Eatock RA, Corey DP, Hudspeth AJ. Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus. J Neurosci 1987; 7:2821-2836.
    • (1987) J Neurosci , vol.7 , pp. 2821-2836
    • Eatock, R.A.1    Corey, D.P.2    Hudspeth, A.J.3
  • 25
    • 0036180246 scopus 로고    scopus 로고
    • A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells
    • Holt JR, Gillespie SKH, Provance DW, et al. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell 2002; 108:371-381.
    • (2002) Cell , vol.108 , pp. 371-381
    • Holt, J.R.1    Gillespie, S.K.H.2    Provance, D.W.3
  • 26
    • 0345227330 scopus 로고
    • Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrog's saccular hair cell
    • DOI 10.1073/pnas.84.9.3064
    • Howard J, Hudspeth AJ. Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrogs saccular hair cell. Proc Natl Acad Sci U S A 1987; 84:3064-3068. (Pubitemid 17064780)
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.9 , pp. 3064-3068
    • Howard, J.1    Hudspeth, A.J.2
  • 27
    • 0026666397 scopus 로고
    • An active motor model for adaptation by vertebrate haircells
    • Assad JA, Corey DP. An active motor model for adaptation by vertebrate haircells. J Neurosci 1992; 12:3291-3309.
    • (1992) J Neurosci , vol.12 , pp. 3291-3309
    • Assad, J.A.1    Corey, D.P.2
  • 28
    • 0028136466 scopus 로고
    • The extent of adaptation in bullfrog saccular haircells
    • Shepherd GMG, Corey DP. The extent of adaptation in bullfrog saccular haircells. J Neurosci 1994; 14:6217-6229.
    • (1994) J Neurosci , vol.14 , pp. 6217-6229
    • Shepherd, G.M.G.1    Corey, D.P.2
  • 29
    • 0032718959 scopus 로고    scopus 로고
    • Two components of transducer adaptation in auditory hair cells
    • Wu YC, Ricci AJ, Fettiplace R. Two components of transducer adaptation in auditory hair cells. J Neurophysiol 1999; 82:2171-2181.
    • (1999) J Neurophysiol , vol.82 , pp. 2171-2181
    • Wu, Y.C.1    Ricci, A.J.2    Fettiplace, R.3
  • 31
    • 41649107686 scopus 로고    scopus 로고
    • The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells
    • An experimental and computational study reporting that the mechanical nonlinearities observed in rat outer hair cells are strongly reduced in the presence of constant low calcium concentrations. The article uses a finite element simulation of a three-dimensional hair bundle model with a kinetic reclosure scheme and proposes that myosins are not directly involved in force generation and nonlinear mechanics in the outer hair cell
    • Beurg M, Nam J-H, Crawford A, et al. The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells. Biophys J 2008; 94:2639-2653. An experimental and computational study reporting that the mechanical nonlinearities observed in rat outer hair cells are strongly reduced in the presence of constant low calcium concentrations. The article uses a finite element simulation of a three-dimensional hair bundle model with a kinetic reclosure scheme and proposes that myosins are not directly involved in force generation and nonlinear mechanics in the outer hair cell.
    • (2008) Biophys J , vol.94 , pp. 2639-2653
    • Beurg, M.1    Nam, J.-H.2    Crawford, A.3
  • 32
    • 0000289658 scopus 로고
    • Hearing 0.2. the physical basis of the action of the cochlea
    • Gold T. Hearing 0.2. The physical basis of the action of the cochlea. Proc R Soc Lond Ser B Biol Sci 1948; 135:492-498.
    • (1948) Proc R Soc Lond Ser B Biol Sci , vol.135 , pp. 492-498
    • Gold, T.1
  • 33
    • 0034963407 scopus 로고    scopus 로고
    • Mechanics of the mammalian cochlea
    • Robles L, Ruggero MA. Mechanics of the mammalian cochlea. Physiol Rev 2001; 81:1305-1352.
    • (2001) Physiol Rev , vol.81 , pp. 1305-1352
    • Robles, L.1    Ruggero, M.A.2
  • 34
    • 0020692334 scopus 로고
    • An active process in cochlear mechanics
    • Davis H. An active process in cochlear mechanics. Hear Res 1983; 9:79-90.
    • (1983) Hear Res , vol.9 , pp. 79-90
    • Davis, H.1
  • 35
    • 34547485364 scopus 로고    scopus 로고
    • Power amplification in the mammalian cochlea
    • Lukashkin AN, Walling MN, Russell IJ. Power amplification in the mammalian cochlea. Curr Biol 2007; 17:1340-1344.
    • (2007) Curr Biol , vol.17 , pp. 1340-1344
    • Lukashkin, A.N.1    Walling, M.N.2    Russell, I.J.3
  • 36
    • 84870296911 scopus 로고
    • Observations of the vibration of the basilar membrane in squirrel monkeys using the mössbauer technique
    • Rhode WS. Observations of the vibration of the basilar membrane in squirrel monkeys using the mössbauer technique. J Acoust Soc Am 1971; 49:1218-1231.
    • (1971) J Acoust Soc Am , vol.49 , pp. 1218-1231
    • Rhode, W.S.1
  • 38
    • 0023035379 scopus 로고
    • Basilar membrane mechanics at the base of the chinchilla cochlea. I. Input-output functions, tuning curves, and response phases
    • DOI 10.1121/1.394389
    • Robles L, Ruggero MA, Rich NC. Basilar-membrane mechanics at the base of the chinchilla cochlea 0.1. Input-output functions, tuning curves, and response phases. J Acoust Soc Am 1986; 80:1364-1374. (Pubitemid 17183484)
    • (1986) Journal of the Acoustical Society of America , vol.80 , Issue.5 , pp. 1364-1374
    • Robles, L.1    Ruggero, M.A.2    Rich, N.C.3
  • 40
  • 41
    • 14544269417 scopus 로고    scopus 로고
    • Force generation by mammalian hair bundles supports a role in cochlear amplification
    • DOI 10.1038/nature03367
    • Kennedy HJ, Crawford AC, Fettiplace R. Force generation by mammalian hair bundles supports a role in cochlear amplification. Nature 2005; 433:880-883. (Pubitemid 40314898)
    • (2005) Nature , vol.433 , Issue.7028 , pp. 880-883
    • Kennedy, H.J.1    Crawford, A.C.2    Fettiplace, R.3
  • 43
    • 0035807872 scopus 로고    scopus 로고
    • Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process
    • DOI 10.1073/pnas.251530598
    • Martin P, Hudspeth AJ, Jülicher F. Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process. Proc Natl Acad Sci U S A 2001; 98:14380-14385. (Pubitemid 33121400)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.25 , pp. 14380-14385
    • Martin, P.1    Hudspeth, A.J.2    Julicher, F.3
  • 45
    • 0021891154 scopus 로고
    • The mechanical properties of ciliary bundles of turtle cochlear hair cells
    • Crawford AC, Fettiplace R. The mechanical properties of ciliary bundles of turtle cochlear hair cells. J Physiol (Lond) 1985; 364:359-379. (Pubitemid 15067219)
    • (1985) Journal of Physiology , vol.VOL. 364 , pp. 359-379
    • Crawford, A.C.1    Fettiplace, R.2
  • 48
    • 0034728989 scopus 로고    scopus 로고
    • Essential nonlinearities in hearing
    • Eguiluz VM, Ospeck M, Choe Y, et al. Essential nonlinearities in hearing. Phys Rev Lett 2000; 84:5232-5235.
    • (2000) Phys Rev Lett , vol.84 , pp. 5232-5235
    • Eguiluz, V.M.1    Ospeck, M.2    Choe, Y.3
  • 50
    • 0038311801 scopus 로고    scopus 로고
    • Two adaptation processes in auditory hair cells together can provide an active amplifier
    • Vilfan A, Duke T. Two adaptation processes in auditory hair cells together can provide an active amplifier. Biophys J 2003; 85:191-203. (Pubitemid 36753626)
    • (2003) Biophysical Journal , vol.85 , Issue.1 , pp. 191-203
    • Vilfan, A.1    Duke, T.2
  • 51
    • 0038614902 scopus 로고    scopus 로고
    • Spontaneous oscillation by hair bundles of the bullfrog's sacculus
    • Martin P, Bozovic D, Choe Y, et al. Spontaneous oscillation by hair bundles of the bullfrog's sacculus. J Neurosci 2003; 23:4533-4548. (Pubitemid 36706184)
    • (2003) Journal of Neuroscience , vol.23 , Issue.11 , pp. 4533-4548
    • Martin, P.1    Bozovic, D.2    Choe, Y.3    Hudspeth, A.J.4
  • 52
    • 0001417021 scopus 로고
    • The Hopf-bifurcation of two-dimensional systems under the influence of one external noise source
    • Hoffmann KH. The Hopf-bifurcation of two-dimensional systems under the influence of one external noise source. Zeitschrift Fur Physik B-Condensed Matter 1982; 49:245-252.
    • (1982) Zeitschrift fur Physik B-Condensed Matter , vol.49 , pp. 245-252
    • Hoffmann, K.H.1
  • 53
    • 0028897281 scopus 로고
    • Stochastic resonance and the benefits of noise: From ice ages to crayfish and squids
    • Wiesenfeld K, Moss F. Stochastic resonance and the benefits of noise: from ice ages to crayfish and squids. Nature 1995; 373:33-36.
    • (1995) Nature , vol.373 , pp. 33-36
    • Wiesenfeld, K.1    Moss, F.2
  • 54
    • 33644690847 scopus 로고    scopus 로고
    • Mechanoelectrical transduction assisted by Brownian motion: A role for noise in the auditory system
    • Jaramillo F, Wiesenfeld K. Mechanoelectrical transduction assisted by Brownian motion: a role for noise in the auditory system. Nat Neurosci 1998; 1:384-388. (Pubitemid 128418531)
    • (1998) Nature Neuroscience , vol.1 , Issue.5 , pp. 384-388
    • Jaramillo, F.1    Wiesenfeld, K.2
  • 55
    • 0033734923 scopus 로고    scopus 로고
    • Physiological noise level enhances mechanoelectrical transduction in hair cells
    • DOI 10.1016/S0960-0779(99)00123-X
    • Jaramillo F, Wiesenfeld K. Physiological noise level enhances mechanoelectrical transduction in hair cells. Chaos Solitons Fractals 2000; 11:1869-1874. (Pubitemid 30861255)
    • (2000) Chaos, Solitons and Fractals , vol.11 , Issue.12 , pp. 1869-1874
    • Jaramillo, F.1    Wiesenfeld, K.2
  • 58
    • 33645088706 scopus 로고
    • Amplification of small signals via stochastic resonance
    • Jung P, Hanggi P. Amplification of small signals via stochastic resonance. Phys Rev A 1991; 44:8032-8042.
    • (1991) Phys Rev A , vol.44 , pp. 8032-8042
    • Jung, P.1    Hanggi, P.2
  • 59
    • 14644417730 scopus 로고    scopus 로고
    • Self-tuning to the Hopf bifurcation in fluctuating systems
    • DOI 10.1088/0305-4470/38/8/001
    • Balakrishnan J. Self-tuning to the hopf bifurcation in fluctuating systems. J Phys A Math Gen 2005; 38:1627-1652. (Pubitemid 40317066)
    • (2005) Journal of Physics A: Mathematical and General , vol.38 , Issue.8 , pp. 1627-1652
    • Balakrishnan, J.1
  • 60
    • 52049100131 scopus 로고    scopus 로고
    • Transducer-based force generation explains active process in Drosophila hearing
    • This experimental, theoretical, and computational study presents a simple mathematical model that explains the performance of the Drosophila ear. Adapting a simple gating-spring model to the morphology of the fly ear, a large number of experimental results are quantitatively reproduced
    • Nadrowski B, Albert JT, Göpfert MC. Transducer-based force generation explains active process in Drosophila hearing. Curr Biol 2008; 18:1365-1372. This experimental, theoretical, and computational study presents a simple mathematical model that explains the performance of the Drosophila ear. Adapting a simple gating-spring model to the morphology of the fly ear, a large number of experimental results are quantitatively reproduced.
    • (2008) Curr Biol , vol.18 , pp. 1365-1372
    • Nadrowski, B.1    Albert, J.T.2    Göpfert, M.C.3
  • 61
    • 33646131833 scopus 로고    scopus 로고
    • 2+ changes the force sensitivity of the hair-cell transduction channel
    • 2+ changes the force sensitivity of the hair-cell transduction channel. Biophys J 2006; 90:124-139.
    • (2006) Biophys J , vol.90 , pp. 124-139
    • Cheung, E.L.M.1    Corey, D.P.2
  • 62
    • 33947710086 scopus 로고    scopus 로고
    • A virtual hair cell, I: Addition of gating spring theory into a 3-d bundle mechanical model
    • Nam J-H, Cotton JR, Grant W. A virtual hair cell, I: addition of gating spring theory into a 3-d bundle mechanical model. Biophys J 2007; 92:1918-1928.
    • (2007) Biophys J , vol.92 , pp. 1918-1928
    • Nam, J.-H.1    Cotton, J.R.2    Grant, W.3
  • 63
    • 33947691705 scopus 로고    scopus 로고
    • A virtual hair cell, Ii: Evaluation of mechanoelectric transduction parameters
    • Nam J-H, Cotton JR, Grant W. A virtual hair cell, Ii: evaluation of mechanoelectric transduction parameters. Biophys J 2007; 92:1929-1937.
    • (2007) Biophys J , vol.92 , pp. 1929-1937
    • Nam, J.-H.1    Cotton, J.R.2    Grant, W.3
  • 64
    • 58149302947 scopus 로고    scopus 로고
    • Theoretical conditions for high-frequency hair bundle oscillations in auditory hair cells
    • A study performing finite-element simulations of a three-dimensional model of a hair bundle, using the kinetic reclosure scheme of negative feedback to generate oscillations. Oscillation frequencies mainly depend on the speed of calcium kinetics. Loading the bundle with an elastic element representing the tectorial membrane sharpens the response
    • Nam J-H, Fettiplace R. Theoretical conditions for high-frequency hair bundle oscillations in auditory hair cells. Biophys J 2008; 95:4948-4962. A study performing finite-element simulations of a three-dimensional model of a hair bundle, using the kinetic reclosure scheme of negative feedback to generate oscillations. Oscillation frequencies mainly depend on the speed of calcium kinetics. Loading the bundle with an elastic element representing the tectorial membrane sharpens the response.
    • (2008) Biophys J , vol.95 , pp. 4948-4962
    • Nam, J.-H.1    Fettiplace, R.2
  • 66
    • 36849077168 scopus 로고    scopus 로고
    • Unifying the various incarnations of active hair-bundle motility by the vertebrate hair cell
    • DOI 10.1529/biophysj.107.108498
    • Tinevez J-Y, Jülicher F, Martin P. Unifying the various incarnations of active hair-bundle motility by the vertebrate hair cell. Biophys J 2007; 93:4053-4067. (Pubitemid 350223820)
    • (2007) Biophysical Journal , vol.93 , Issue.11 , pp. 4053-4067
    • Tinevez, J.-Y.1    Julicher, F.2    Martin, P.3
  • 67
    • 41649090763 scopus 로고    scopus 로고
    • Two-state approach to stochastic hair bundle dynamics
    • A theoretical and computational study that maps the dynamics of a simple gating-spring model to the Fitzhugh-Nagumo model of neural excitation. It is shown that analytic results for the power spectral density and response function can be derived when the system displays relaxation oscillations and therefore allows for a good separation of timescales, a situation that has been observed in oscillating hair bundles of the bullfrog
    • Clausznitzer D, Lindner B, Julicher F, et al. Two-state approach to stochastic hair bundle dynamics. Phys Rev E 2008; 77:41901-41913. A theoretical and computational study that maps the dynamics of a simple gating-spring model to the Fitzhugh-Nagumo model of neural excitation. It is shown that analytic results for the power spectral density and response function can be derived when the system displays relaxation oscillations and therefore allows for a good separation of timescales, a situation that has been observed in oscillating hair bundles of the bullfrog.
    • (2008) Phys Rev e , vol.77 , pp. 41901-41913
    • Clausznitzer, D.1    Lindner, B.2    Julicher, F.3
  • 68
    • 0000946497 scopus 로고    scopus 로고
    • Spontaneous oscillations of collective molecular motors
    • Jülicher F, Prost J. Spontaneous oscillations of collective molecular motors. Phys Rev Lett 1997; 78:4510-4513. (Pubitemid 127655536)
    • (1997) Physical Review Letters , vol.78 , Issue.23 , pp. 4510-4513
    • Julicher, F.1    Prost, J.2
  • 69
    • 0036932410 scopus 로고    scopus 로고
    • Characterization of adaptation motors in saccular hair cells by fluctuation analysis
    • Frank JE, Markin V, Jaramillo F. Characterization of adaptation motors in saccular hair cells by fluctuation analysis. Biophys J 2002; 83:3188-3201. (Pubitemid 36041938)
    • (2002) Biophysical Journal , vol.83 , Issue.6 , pp. 3188-3201
    • Frank, J.E.1    Markin, V.2    Jaramillo, F.3
  • 70
    • 0021235622 scopus 로고
    • Neurophysiological evidence for a traveling wave in the amphibian inner-ear
    • Hillery CM, Narins PM. Neurophysiological evidence for a traveling wave in the amphibian inner-ear. Science 1984; 225:1037-1039.
    • (1984) Science , vol.225 , pp. 1037-1039
    • Hillery, C.M.1    Narins, P.M.2
  • 71
    • 0030992135 scopus 로고    scopus 로고
    • Phase locking to high frequencies in the auditory nerve and cochlear nucleus magnocellularis of the barn owl, Tyro alba
    • Koppl C. Phase locking to high frequencies in the auditory nerve and cochlear nucleus magnocellularis of the barn owl, Tyto alba. J Neurosci 1997; 17:3312-3321. (Pubitemid 27175842)
    • (1997) Journal of Neuroscience , vol.17 , Issue.9 , pp. 3312-3321
    • Koppl, C.1
  • 72
    • 0037422930 scopus 로고    scopus 로고
    • A wave traveling over a hopf instability shapes the cochlear tuning curve
    • Magnasco MO. A wave traveling over a hopf instability shapes the cochlear tuning curve. Phys Rev Lett 2003; 90:058101.1-058101.4.
    • (2003) Phys Rev Lett , vol.90
    • Magnasco, M.O.1
  • 74
    • 0038388740 scopus 로고    scopus 로고
    • Active traveling wave in the cochlea
    • Duke T, Jülicher F. Active traveling wave in the cochlea. Phys Rev Lett 2003; 90:158101.1-158101.4.
    • (2003) Phys Rev Lett , vol.90
    • Duke, T.1    Jülicher, F.2
  • 75
    • 58149280498 scopus 로고    scopus 로고
    • Frequency clustering in spontaneous otoacoustic emissions from a lizard's ear
    • This theoretical and computational study considers an ensemble of coupled Hopf oscillators that describe the bobtail lizard cochlea. It finds frequency and amplitude characteristics that are consistent with experimental results
    • Vilfan A, Duke T. Frequency clustering in spontaneous otoacoustic emissions from a lizard's ear. Biophys J 2008; 95:4622-4630. This theoretical and computational study considers an ensemble of coupled Hopf oscillators that describe the bobtail lizard cochlea. It finds frequency and amplitude characteristics that are consistent with experimental results.
    • (2008) Biophys J , vol.95 , pp. 4622-4630
    • Vilfan, A.1    Duke, T.2
  • 77
    • 57749094257 scopus 로고    scopus 로고
    • Enhancement of sensitivity gain and frequency tuning by coupling of active hair bundles
    • A theoretical and computational study that investigates the collective effects of elastic coupling between hair bundles. It is found that the amplificatory gain increases approximately 40-fold when 9 x 9 bundles are coupled together, supporting the idea that collective effects of coupled hair bundles might be an important source of amplification in hearing
    • Dierkes K, Lindner B, Jülicher F. Enhancement of sensitivity gain and frequency tuning by coupling of active hair bundles. Proc Natl Acad Sci U S A 2008; 105:18669-18674. A theoretical and computational study that investigates the collective effects of elastic coupling between hair bundles. It is found that the amplificatory gain increases approximately 40-fold when 9 x 9 bundles are coupled together, supporting the idea that collective effects of coupled hair bundles might be an important source of amplification in hearing.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18669-18674
    • Dierkes, K.1    Lindner, B.2    Jülicher, F.3
  • 78
    • 12244307206 scopus 로고    scopus 로고
    • Power gain exhibited by motile mechanosensory neurons in Drosophila ears
    • Göpfert MC, Humphris ADL, Albert JT, et al. Power gain exhibited by motile mechanosensory neurons in Drosophila ears. Proc Natl Acad Sci U S A 2005; 102:325-330.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 325-330
    • Göpfert, M.C.1    Humphris, A.D.L.2    Albert, J.T.3
  • 79
    • 33747585878 scopus 로고    scopus 로고
    • Specification of auditory sensitivity by Drosophila TRP channels
    • DOI 10.1038/nn1735, PII NN1735
    • Göpfert MC, Albert JT, Nadrowski B, et al. Specification of auditory sensitivity by Drosophila trp channels. Nat Neurosci 2006; 9:999-1000. (Pubitemid 44264909)
    • (2006) Nature Neuroscience , vol.9 , Issue.8 , pp. 999-1000
    • Gopfert, M.C.1    Albert, J.T.2    Nadrowski, B.3    Kamikouchi, A.4
  • 80
    • 34249698687 scopus 로고    scopus 로고
    • Mechanical Signatures of Transducer Gating in the Drosophila Ear
    • DOI 10.1016/j.cub.2007.05.004, PII S0960982207013814
    • Albert JT, Nadrowski B, Göpfert MC. Mechanical signatures of transducer gating in the Drosophila ear. Curr Biol 2007; 17:1000-1006. (Pubitemid 46829843)
    • (2007) Current Biology , vol.17 , Issue.11 , pp. 1000-1006
    • Albert, J.T.1    Nadrowski, B.2    Gopfert, M.C.3
  • 81
    • 60849090516 scopus 로고    scopus 로고
    • Level-dependent auditory tuning: Transducer-based active processes in hearing and best-frequency shifts
    • Nadrowski B, Göpfert MC. Level-dependent auditory tuning: transducer-based active processes in hearing and best-frequency shifts. Communicative Integr Biol 2009; 2:7-10.
    • (2009) Communicative Integr Biol , vol.2 , pp. 7-10
    • Nadrowski, B.1    Göpfert, M.C.2
  • 82
    • 33646182603 scopus 로고    scopus 로고
    • Mechanical properties and consequences of stereocilia and extracellular links in vestibular hair bundles
    • Nam J-H, Cotton JR, Peterson EH, et al. Mechanical properties and consequences of stereocilia and extracellular links in vestibular hair bundles. Biophys J 2006; 90:2786-2795.
    • (2006) Biophys J , vol.90 , pp. 2786-2795
    • Nam, J.-H.1    Cotton, J.R.2    Peterson, E.H.3
  • 83
    • 6944233741 scopus 로고    scopus 로고
    • Computational models of hair cell bundle mechanics: III. 3-d utricular bundles
    • Silber J, Cotton J, Nam J-H, et al. Computational models of hair cell bundle mechanics: III. 3-d utricular bundles. Hear Res 2004; 197:112-130.
    • (2004) Hear Res , vol.197 , pp. 112-130
    • Silber, J.1    Cotton, J.2    Nam, J.-H.3
  • 84
    • 6944226474 scopus 로고    scopus 로고
    • Computational models of hair cell bundle mechanics: I. Single stereocilium
    • Cotton J, Grant W. Computational models of hair cell bundle mechanics: I. Single stereocilium. Hear Res 2004; 197:96-104.
    • (2004) Hear Res , vol.197 , pp. 96-104
    • Cotton, J.1    Grant, W.2
  • 85
    • 6944256822 scopus 로고    scopus 로고
    • Computational models of hair cell bundle mechanics: II. Simplified bundle models
    • Cotton J, Grant W. Computational models of hair cell bundle mechanics: II. Simplified bundle models. Hear Res 2004; 197:105-111.
    • (2004) Hear Res , vol.197 , pp. 105-111
    • Cotton, J.1    Grant, W.2
  • 86
    • 0034144670 scopus 로고    scopus 로고
    • A finite element method for mechanical response of hair cell ciliary bundles
    • Cotton JR, Grant JW. A finite element method for mechanical response of hair cell ciliary bundles. J Biomech Eng 2000; 122:44-50.
    • (2000) J Biomech Eng , vol.122 , pp. 44-50
    • Cotton, J.R.1    Grant, J.W.2
  • 87
    • 33645419097 scopus 로고    scopus 로고
    • Effect of fluid forcing on vestibular hair bundles
    • Nam JH, Cotton JR, Grant JW. Effect of fluid forcing on vestibular hair bundles. J Vestib Res 2005; 15:263-278.
    • (2005) J Vestib Res , vol.15 , pp. 263-278
    • Nam, J.H.1    Cotton, J.R.2    Grant, J.W.3
  • 88
    • 23044466148 scopus 로고    scopus 로고
    • Have we found the tip link, transduction channel, and gating spring of the hair cell?
    • Gillespie PG, Dumont RA, Kachar B. Have we found the tip link, transduction channel, and gating spring of the hair cell? Curr Opin Neurobiol 2005; 15:389-396.
    • (2005) Curr Opin Neurobiol , vol.15 , pp. 389-396
    • Gillespie, P.G.1    Dumont, R.A.2    Kachar, B.3
  • 89
    • 55249088375 scopus 로고    scopus 로고
    • Drosophila mechanotransduction: Linking proteins and functions
    • Albert JT, Nadrowski B, Göpfert MC. Drosophila mechanotransduction: linking proteins and functions. Fly 2007; 1:238-241.
    • (2007) Fly , vol.1 , pp. 238-241
    • Albert, J.T.1    Nadrowski, B.2    Göpfert, M.C.3
  • 90
    • 33748896466 scopus 로고    scopus 로고
    • What is the hair cell transduction channel?
    • Corey DP. What is the hair cell transduction channel? J Physiol 2006; 576(Pt 1):23-28.
    • (2006) J Physiol , vol.576 , Issue.PART 1 , pp. 23-28
    • Corey, D.P.1
  • 91
    • 70349703661 scopus 로고    scopus 로고
    • A bio-inspired electromechanical system: Artificial hair cell
    • A theoretical and computational study of a proposed electrical circuit mimicking the hair bundle's oscillatory mechanism in order to detect small amplitude forces in a noisy environment
    • Ahn KH. A bio-inspired electromechanical system: artificial hair cell. Electron Transport In Nanosystems, NATO Science for Peace and Security Series B Physics and Biophysics; 2008. pp. 351-359. A theoretical and computational study of a proposed electrical circuit mimicking the hair bundle's oscillatory mechanism in order to detect small amplitude forces in a noisy environment.
    • (2008) Electron Transport in Nanosystems, NATO Science for Peace and Security Series B Physics and Biophysics , pp. 351-359
    • Ahn, K.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.