Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis

Therapeutic Drug Monitoring

Volumn 31, Issue 5, 2009, Pages 557-565

  Hirt, Déborah ^a,b   Richardet, Jean Philippe ^c   Urien, Saïk ^a,b   Poupon, Joël ^d   Sogni, Philippe ^a   Batteux, Frédéric ^a   Laurent, Alexis ^a,e   Pavlovic, Silvana ^b   Debray, Marcel ^f,g   Treluyer, Jean Marc ^a,b,h   Weill, Bernard ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Paris Descartes University   (France)

^c Hopital Albert Chenevier   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e HENRI MONDOR HOSPITAL   (France)

^f CNRS   (France)

^g INSERM   (France)

^h Institut Cochin   (France)

Author keywords

Acute alcoholic hepatitis; Mangafodipir; Population pharmacodynamics; Population pharmacokinetics

Indexed keywords

BILIRUBIN; MANGAFODIPIR; MANGANESE; METHYLPREDNISOLONE; PREDNISOLONE;

ADULT; AGED; ALCOHOL LIVER DISEASE; ARTICLE; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; MULTICENTER STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTHROMBIN TIME; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ANESTHETICS, LOCAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; EDETIC ACID; ETOPOSIDE; HEPATITIS, ALCOHOLIC; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MANGANESE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MITOXANTRONE; PREDNISONE; PYRIDOXAL PHOSPHATE; VINCRISTINE; YOUNG ADULT;

EID: 70349677372     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e3181affd6d     Document Type: Article

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