Comparison of manganese biodistribution and MR contrast enhancement in rats after intravenous injection of MnDPDP and MnCl2

Acta Radiologica

Volumn 38, Issue 4 PART 2, 1997, Pages 700-707

  Ni, Yicheng ^a   Petre C ^a   Bosmans, H ^a   Miao, Y ^a   Grant, D ^b   Baert, A L ^a   Marchal, G ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b NYCOMED IMAGING AS   (Norway)

Author keywords

Mangafodipir trisodium; Manganese, experimental; MR contrast media, biodistribution

Indexed keywords

CHLORIDE; CONTRAST MEDIUM; DIAGNOSTIC AGENT; DRUG DERIVATIVE; EDETIC ACID; MANGANESE; MANGANESE CHLORIDE; MANGANESE DERIVATIVE; N,N' BIS(PYRIDOXAL 5 PHOSPHATE)ETHYLENEDIAMINE N,N' DIACETIC ACID; N,N'-BIS(PYRIDOXAL-5-PHOSPHATE)ETHYLENEDIAMINE-N,N'-DIACETIC ACID; PYRIDOXAL 5 PHOSPHATE;

ANIMAL; ARTICLE; COMPARATIVE STUDY; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; RANDOMIZATION; RAT; STATISTICS; TIME; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; CHLORIDES; CONTRAST MEDIA; EDETIC ACID; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE IMAGING; MANGANESE; MANGANESE COMPOUNDS; PYRIDOXAL PHOSPHATE; RANDOM ALLOCATION; RATS; RATS, WISTAR; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0031184507     PISSN: 02841851     EISSN: None     Source Type: Journal    
DOI: 10.1080/02841859709172402     Document Type: Review

References (25)

1. BABA Y., LERCH M. M., TANIMOTO A. et al.: Enhancement of pancreas and diagnosis of pancreatitis using manganese dipyridoxyl diphosphate. Invest. Radiol. 29 (1994), 300.
2. BERNARDINO M. E., YOUNG S. W., LEE J. K. T. & WEINREB J. C.: Hepatic MR imaging with Mn-DPDP. Safety, image quality, and sensitivity. Radiology 183 (1992), 53.
3. CHEZMAR J., REDVANLY R. D. & SEWELL C. W.: Uptake of mangafodipir trisodium (MnDPDP) by hepatocellular carcinoma. Correlation with unenhanced imaging findings and histopathologic features. Acad. Radiol. 3 (1996), S413.
4. ELIZONDO G., FRETZ C. J., STARK D. D. et al.: Preclinical evaluation of Mn-DPDP. New paramagnetic hepatobiliary contrast agent for MR imaging. Radiology 178 (1991), 73.
5. GEHL H. B., URHAHN R., BOHNDORF K. et al.: Mn-DPDP in MR imaging of pancreatic adenocarcinoma. Initial clinical experience. Radiology 186 (1993), 795.
6. GRANT D., ZECH K. & HOLTZ E.: Biodistribution and in vivo stability of manganese dipyridoxyl diphosphate in relation to imaging efficacy. Invest. Radiol. 29 (1994), S249.
7. HAMM B., VOGL T. J., BRANDING G. et al.: Focal liver lesions. MR imaging with Mn-DPDP - Initial clinical results in 40 patients. Radiology 182 (1992), 167.
8. HUSTVEDT S. O., GRANT D., SOUTHON T. E. & ZECH K.: Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration. Acta. Radiol. 38 (1997), 690.
9. 2. Acta Radiol. 38 (1997), 740.
10. 2 in dogs with acute ischaemic heart failure. Acta Radiol. 38 (1997), 750.
11. MISSELWITZ B., MÜHLER A. & WEINMANN H. J.: A toxicologic risk for using manganese complexes? A literature survey of existing data through several medical specialties. Invest. Radiol. 30 (1995), 611.
12. MITCHELL D. G., OUTWATER E. K., MATTEUCCI T., RUBIN D. L., CHEZMAR J. L. & SAINI S.: Adrenal gland enhancement at MR imaging with Mn-DPDP. Radiology 194 (1995), 783.
13. NI Y., MARCHAL G., YU J., RUMMENY E., ZHANG X., LODEMAN K.-P. & BAERT A. L.: Experimental liver cancers. Mn-DPDP-enhanced rims in MR-microangiographic-histologic correlation study. Radiology 188 (1993), 45.
14. NI Y, MARCHAL G., ZHANG X. et al.: The uptake of manganese dipyridoxal-diphosphate by chemically induced hepatocellular carcinoma in rats. A correlation between contrast-media-enhanced magnetic resonance imaging, tumor differentiation and vascularization. Invest. Radiol. 28 (1993), 520.
15. ROCKLAGE S. M., CAAHERIS W. P., QUAY S. C., HAHN F. E. & RAYMOND K. N.: Manganese(II) N,N′-dipyridoxylethylene-diamine-NN′-diacetate 5,5′-bis(phosphate). Synthesis and characterization of a paramagnetic chelate for magnetic resonance imaging enhancement. Inorg. Chem. 28 (1989), 477.
16. ROFSKY N. M., WEINREB J. C., BERNARDINO M. E., YOUNG S. T., LEE J. K. T. & NOZ M. E.: Hepatocellular tumors. Characterization with Mn-DPDP-enhanced MR imaging. Radiology 188 (1993), 53.
17. RUMMENY E., EHRENHEIM C., GEHL H. B. et al.: Manganese-DPDP as a hepatobiliary contrast agent in the magnetic resonance imaging of liver tumors. Results of clinical phase II trials in Germany including 141 patients. Invest Radiol. 26 (19919. S142.
18. SARIC M.: Manganese. In: Handbook on the toxicology of metals. Vol. 2, ch. 15, p. 354. Edited by L. Firebug et al. Elsevier Science Publishers B. V., Amsterdam 1986.
19. SOLITHON T. E., GRANT D., BJØRNERUD A. et al.: NMR relaxation studies with MnDPDP. Acta Radiol. 38 (1997), 708.
20. 2+. Magn. Reson. Med. 8 (1988), 293.
21. TORRES C. G., LUNDBY B., TUFTE STERUD A., MCGILL S., GORDON P. B. & STRAND BJERKNES H.: MnDPDP for MR imaging of the liver. Results from the European phase III studies. Acta Radiol. 38 (1997), 631.
22. 2 in the conscious beagle dog. Can. J. Physiol. Pharmacol. 72 (1994), Suppl. 1, p. 186.
23. WANG C., GORDON P. B., HUSTVEDT S. O. et al.: MR imaging properties and pharmacokinetics of MnDPDP in healthy volunteers. Acta Radiol. 38 (1997), 665.
24. WOLF G. L. & BAUM L.: Cardiovascular toxicity and tissue proton Tl response to manganese injection in the dog and rabbit. AJR 141 (1983), 193.
25. YOUNG S. W., BRADLEY B., MULLER H. H. & RUBIN D. L.: Detection of hepatic malignancies using Mn-DPDP (manganese dipyridoxal diphosphate) hepatobiliary contrast agent. Magn. Reson. Imaging 8 (1990), 267.