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Volumn 52, Issue 2, 2009, Pages 162-169

Susceptibility to simian immunodeficiency virus ex vivo predicts outcome of a prime-boost vaccine after SIVmac239 challenge

Author keywords

Correlate of protection; HIV; Immune response; Immunization; In vitro replication

Indexed keywords

GAMMA INTERFERON;

EID: 70349676021     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181b22f4a     Document Type: Article
Times cited : (4)

References (43)
  • 1
    • 33748714805 scopus 로고    scopus 로고
    • Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: Role of SIV-specific CD8+ T cell responses
    • Malkevitch NV, Patterson LJ, Aldrich MK, et al. Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses. Virology. 2006; 353:83-98.
    • (2006) Virology , vol.353 , pp. 83-98
    • Malkevitch, N.V.1    Patterson, L.J.2    Aldrich, M.K.3
  • 2
    • 10744231337 scopus 로고    scopus 로고
    • Boosting of SIV-specific immune responses in rhesus macaques by repeated administration of Ad5hr- SIVenv/rev and Ad5hr-SIVgag recombinants
    • Zhao J, Lou Y, Pinczewski J, et al. Boosting of SIV-specific immune responses in rhesus macaques by repeated administration of Ad5hr- SIVenv/rev and Ad5hr-SIVgag recombinants. Vaccine. 2003;21: 4022-4035.
    • (2003) Vaccine , vol.21 , pp. 4022-4035
    • Zhao, J.1    Lou, Y.2    Pinczewski, J.3
  • 3
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn NM, Forthal DN, Harro CD, et al. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis. 2005;191:654-665.
    • (2005) J Infect Dis. , vol.191 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3
  • 4
    • 0038664390 scopus 로고    scopus 로고
    • Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunode- ficiency virus type 1 gag gene
    • Casimiro DR, Chen L, Fu TM, et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunode- ficiency virus type 1 gag gene. J Virol. 2003;77:6305-6313.
    • (2003) J Virol. , vol.77 , pp. 6305-6313
    • Casimiro, D.R.1    Chen, L.2    Fu, T.M.3
  • 5
    • 0037122719 scopus 로고    scopus 로고
    • Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
    • Shiver JW, Fu TM, Chen L, et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature. 2002;415:331-335.
    • (2002) Nature , vol.415 , pp. 331-335
    • Shiver, J.W.1    Fu, T.M.2    Chen, L.3
  • 6
    • 32544446124 scopus 로고    scopus 로고
    • Reduction of viral loads by multigenic DNA priming and adenovirus boosting in the SIVmacmacaque model
    • Suh YS, Park KS, Sauermann U, et al. Reduction of viral loads by multigenic DNA priming and adenovirus boosting in the SIVmacmacaque model. Vaccine. 2006;24:1811-1820.
    • (2006) Vaccine , vol.24 , pp. 1811-1820
    • Suh, Y.S.1    Park, K.S.2    Sauermann, U.3
  • 7
    • 0035025623 scopus 로고    scopus 로고
    • Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination
    • Barouch DH, Santra S, Kuroda MJ, et al. Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination. J Virol. 2001;75:5151-5158.
    • (2001) J Virol. , vol.75 , pp. 5151-5158
    • Barouch, D.H.1    Santra, S.2    Kuroda, M.J.3
  • 8
    • 33747040210 scopus 로고    scopus 로고
    • Studies on GM-CSF DNA as an adjuvant for neutralizing Ab elicited by a DNA/MVA immunodeficiency virus vaccine
    • Robinson HL, Montefiori DC, Villinger F, et al. Studies on GM-CSF DNA as an adjuvant for neutralizing Ab elicited by a DNA/MVA immunodeficiency virus vaccine. Virology. 2006;352:285-294.
    • (2006) Virology , vol.352 , pp. 285-294
    • Robinson, H.L.1    Montefiori, D.C.2    Villinger, F.3
  • 9
    • 34250327922 scopus 로고    scopus 로고
    • Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses
    • Precopio ML, Betts MR, Parrino J, et al. Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med. 2007;204:1405-1416.
    • (2007) J Exp Med. , vol.204 , pp. 1405-1416
    • Precopio, M.L.1    Betts, M.R.2    Parrino, J.3
  • 10
    • 33646454992 scopus 로고    scopus 로고
    • Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNAand modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes
    • Goonetilleke N, Moore S, Dally L, et al. Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNAand modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes. J Virol. 2006;80:4717-4728.
    • (2006) J Virol. , vol.80 , pp. 4717-4728
    • Goonetilleke, N.1    Moore, S.2    Dally, L.3
  • 11
    • 34547931898 scopus 로고    scopus 로고
    • SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    • Petrovas C, Price DA, Mattapallil J, et al. SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood. 2007;110: 928-936.
    • (2007) Blood , vol.110 , pp. 928-936
    • Petrovas, C.1    Price, D.A.2    Mattapallil, J.3
  • 12
    • 36249005448 scopus 로고    scopus 로고
    • AIDS research. did merck's failed HIV vaccine cause harm?
    • Cohen J. AIDS research. Did Merck's failed HIV vaccine cause harm? Science. 2007;318:1048-1049.
    • (2007) Science , vol.318 , pp. 1048-1049
    • Cohen, J.1
  • 13
    • 34848908400 scopus 로고    scopus 로고
    • A phase 1/2 comparative vaccine trial of the safety and immunogenicity of a CRF01-AE (subtype E) candidate vaccine: ALVAC-HIV (vCP1521) prime with oligomeric gp160 (92TH023/LAI-DID) or bivalent gp120 (CM235/SF2) boost
    • Thongcharoen P, Suriyanon V, Paris RM, et al. A phase 1/2 comparative vaccine trial of the safety and immunogenicity of a CRF01-AE (subtype E) candidate vaccine: ALVAC-HIV (vCP1521) prime with oligomeric gp160 (92TH023/LAI-DID) or bivalent gp120 (CM235/SF2) boost. J Acquir Immune Defic Syndr. 2007;46:48-55.
    • (2007) J Acquir Immune Defic Syndr. , vol.46 , pp. 48-55
    • Thongcharoen, P.1    Suriyanon, V.2    Paris, R.M.3
  • 14
    • 35449000608 scopus 로고    scopus 로고
    • Comparative evaluation of oral and intranasal priming with replication-competent adenovirus 5 host range mutant (Ad5hr)-simian immunodeficiency virus (SIV) recombinant vaccines on immunogenicity and protective efficacy against SIV (mac251)
    • Zhou Q, Hidajat R, Peng B, et al. Comparative evaluation of oral and intranasal priming with replication-competent adenovirus 5 host range mutant (Ad5hr)-simian immunodeficiency virus (SIV) recombinant vaccines on immunogenicity and protective efficacy against SIV (mac251). Vaccine. 2007;25:8021-8035.
    • (2007) Vaccine , vol.25 , pp. 8021-8035
    • Zhou, Q.1    Hidajat, R.2    Peng, B.3
  • 15
    • 33744902339 scopus 로고    scopus 로고
    • Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239
    • Wilson NA, Reed J, Napoe GS, et al. Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J Virol. 2006;80:5875-5885.
    • (2006) J Virol. , vol.80 , pp. 5875-5885
    • Wilson, N.A.1    Reed, J.2    Napoe, G.S.3
  • 16
    • 33846497834 scopus 로고    scopus 로고
    • Not all cytokine-producing CD8+ Tcells suppress simian immunodeficiency virus replication
    • Chung C, Lee W, Loffredo JT, et al. Not all cytokine-producing CD8+ Tcells suppress simian immunodeficiency virus replication. J Virol. 2007; 81:1517-1523.
    • (2007) J Virol. , vol.81 , pp. 1517-1523
    • Chung, C.1    Lee, W.2    Loffredo, J.T.3
  • 17
    • 0026044404 scopus 로고
    • Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism
    • Walker CM, Erickson AL, Hsueh FC, et al. Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism. J Virol. 1991;65: 5921-5927.
    • (1991) J Virol. , vol.65 , pp. 5921-5927
    • Walker, C.M.1    Erickson, A.L.2    Hsueh, F.C.3
  • 18
    • 0022967777 scopus 로고
    • CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication
    • Walker CM, Moody DJ, Stites DP, et al. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science. 1986;234: 1563-1566.
    • (1986) Science , vol.234 , pp. 1563-1566
    • Walker, C.M.1    Moody, D.J.2    Stites, D.P.3
  • 19
    • 0037453012 scopus 로고    scopus 로고
    • The CD8+ cell noncytotoxic anti- HIV response can be blocked by protease inhibitors
    • Mackewicz CE, Craik CS, Levy JA. The CD8+ cell noncytotoxic anti- HIV response can be blocked by protease inhibitors. Proc Natl Acad Sci U S A. 2003;100:3433-3438.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , pp. 3433-3438
    • MacKewicz, C.E.1    Craik, C.S.2    Levy, J.A.3
  • 20
    • 0035895295 scopus 로고    scopus 로고
    • Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection
    • Stranford SA, Ong JC, Martinez-Marino B, et al. Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection. Proc Natl Acad Sci U S A. 2001;98:597-602.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , pp. 597-602
    • Stranford, S.A.1    Ong, J.C.2    Martinez-Marino, B.3
  • 21
    • 33244470928 scopus 로고    scopus 로고
    • CD8+ cell noncytotoxic anti- HIV response: Restoration by HAART in the late stage of infection
    • Torres KJ, Gutierrez F, Espinosa E, et al. CD8+ cell noncytotoxic anti- HIV response: restoration by HAART in the late stage of infection. AIDS Res Hum Retroviruses. 2006;22:144-152.
    • (2006) AIDS Res Hum Retroviruses. , vol.22 , pp. 144-152
    • Torres, K.J.1    Gutierrez, F.2    Espinosa, E.3
  • 22
    • 0036624882 scopus 로고    scopus 로고
    • Relationship of CD8(+) T cell noncytotoxic anti-HIV response to CD4(+) T cell number in untreated asymptomatic HIV-infected individuals
    • Castelli JC, Deeks SG, Shiboski S, et al. Relationship of CD8(+) T cell noncytotoxic anti-HIV response to CD4(+) T cell number in untreated asymptomatic HIV-infected individuals. Blood. 2002;99:4225-4227.
    • (2002) Blood , vol.99 , pp. 4225-4227
    • Castelli, J.C.1    Deeks, S.G.2    Shiboski, S.3
  • 23
    • 0034874290 scopus 로고    scopus 로고
    • Noncytolytic inhibition of X4 virus by bulk CD8(+) cells from human immunodeficiency virus type 1 (HIV-1)-infected persons and HIV-1-specific cytotoxic T lymphocytes is not mediated by beta-chemokines
    • Geiben-Lynn R, Kursar M, Brown NV, et al. Noncytolytic inhibition of X4 virus by bulk CD8(+) cells from human immunodeficiency virus type 1 (HIV-1)-infected persons and HIV-1-specific cytotoxic T lymphocytes is not mediated by beta-chemokines. J Virol. 2001;75:8306-8316.
    • (2001) J Virol. , vol.75 , pp. 8306-8316
    • Geiben-Lynn, R.1    Kursar, M.2    Brown, N.V.3
  • 24
    • 0037122796 scopus 로고    scopus 로고
    • Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
    • Barouch DH, Kunstman J, Kuroda MJ, et al. Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature. 2002;415:335-339.
    • (2002) Nature , vol.415 , pp. 335-339
    • Barouch, D.H.1    Kunstman, J.2    Kuroda, M.J.3
  • 25
    • 2342465557 scopus 로고    scopus 로고
    • Reversion of CTL escape-variant immunodeficiency viruses in vivo
    • Friedrich TC, Dodds EJ, Yant LJ, et al. Reversion of CTL escape-variant immunodeficiency viruses in vivo. Nat Med. 2004;10:275-281.
    • (2004) Nat Med. , vol.10 , pp. 275-281
    • Friedrich, T.C.1    Dodds, E.J.2    Yant, L.J.3
  • 26
    • 0033809451 scopus 로고    scopus 로고
    • Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication
    • Goldstein S, Brown CR, Dehghani H, et al. Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication. J Virol. 2000;74: 9388-9395.
    • (2000) J Virol. , vol.74 , pp. 9388-9395
    • Goldstein, S.1    Brown, C.R.2    Dehghani, H.3
  • 27
    • 0033794835 scopus 로고    scopus 로고
    • The replicative capacity of rhesus macaque peripheral blood mononuclear cells for simian immunodefi- ciency virus in vitro is predictive of the rate of progression to AIDS in vivo
    • Seman AL, Pewen WF, Fresh LF, et al. The replicative capacity of rhesus macaque peripheral blood mononuclear cells for simian immunodefi- ciency virus in vitro is predictive of the rate of progression to AIDS in vivo. J Gen Virol. 2000;81:2441-2449.
    • (2000) J Gen Virol. , vol.81 , pp. 2441-2449
    • Seman, A.L.1    Pewen, W.F.2    Fresh, L.F.3
  • 28
    • 0034073361 scopus 로고    scopus 로고
    • Resistance to human immunodeficiency virus type 1 in vitro as a surrogate of vaccine-induced protective immunity
    • Castillo RC, Arango-Jaramillo S, John R, et al. Resistance to human immunodeficiency virus type 1 in vitro as a surrogate of vaccine-induced protective immunity. J Infect Dis. 2000;181:897-903.
    • (2000) J Infect Dis. , vol.181 , pp. 897-903
    • Castillo, R.C.1    Arango-Jaramillo, S.2    John, R.3
  • 29
    • 58149105397 scopus 로고    scopus 로고
    • Mucosal prior to systemic application of recombinant adenovirus boosting is more immunogenic than systemic application twice but confers similar protection against SIV-challenge in DNA vaccine-primed macaques
    • Schulte R, Suh YS, Sauermann U, et al. Mucosal prior to systemic application of recombinant adenovirus boosting is more immunogenic than systemic application twice but confers similar protection against SIV-challenge in DNA vaccine-primed macaques. Virology. 2009;383: 300-309.
    • (2009) Virology , vol.383 , pp. 300-309
    • Schulte, R.1    Suh, Y.S.2    Sauermann, U.3
  • 30
    • 22144492537 scopus 로고    scopus 로고
    • Rapid and reproducible infectivity end-point titration of virulent phage in a microplate system
    • Fridholm H, Everitt E. Rapid and reproducible infectivity end-point titration of virulent phage in a microplate system. J Virol Methods. 2005; 128:67-71.
    • (2005) J Virol Methods. , vol.128 , pp. 67-71
    • Fridholm, H.1    Everitt, E.2
  • 31
    • 0034284924 scopus 로고    scopus 로고
    • Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: Comparison of one- versus two-enzyme systems
    • Hofmann-Lehmann R, Swenerton RK, Liska V, et al. Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems. AIDS Res Hum Retroviruses. 2000;16:1247-1257.
    • (2000) AIDS Res Hum Retroviruses. , vol.16 , pp. 1247-1257
    • Hofmann-Lehmann, R.1    Swenerton, R.K.2    Liska, V.3
  • 32
    • 24344490275 scopus 로고    scopus 로고
    • A screening assay for detecting CD8+ cell non-cytotoxic anti-HIV responses
    • Killian MS, Ng S, Mackewicz CE, et al. A screening assay for detecting CD8+ cell non-cytotoxic anti-HIV responses. J Immunol Methods. 2005; 304:137-150.
    • (2005) J Immunol Methods. , vol.304 , pp. 137-150
    • Killian, M.S.1    Ng, S.2    MacKewicz, C.E.3
  • 33
    • 34547094849 scopus 로고    scopus 로고
    • Immunogenicity of a DNA prime and recombinant adenovirus boost regime significantly varies between rhesus macaques of chinese and Indian origins
    • Stahl-Hennig C, Suh YS, Park KS, et al. Immunogenicity of a DNA prime and recombinant adenovirus boost regime significantly varies between rhesus macaques of Chinese and Indian origins. J Med Primatol. 2007;36: 195-205.
    • (2007) J Med Primatol. , vol.36 , pp. 195-205
    • Stahl-Hennig, C.1    Suh, Y.S.2    Park, K.S.3
  • 34
    • 0037105530 scopus 로고    scopus 로고
    • MHC class i alleles influence setpoint viral load and survival time in simian immunodeficiency virusinfected rhesus monkeys
    • Muhl T, Krawczak M, Ten Haaft P, et al. MHC class I alleles influence setpoint viral load and survival time in simian immunodeficiency virusinfected rhesus monkeys. J Immunol. 2002;169:3438-3446.
    • (2002) J Immunol. , vol.169 , pp. 3438-3446
    • Muhl, T.1    Krawczak, M.2    Ten Haaft, P.3
  • 35
    • 33744990609 scopus 로고    scopus 로고
    • Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys
    • Letvin NL, Mascola JR, Sun Y, et al. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science. 2006; 312:1530-1533.
    • (2006) Science , vol.312 , pp. 1530-1533
    • Letvin, N.L.1    Mascola, J.R.2    Sun, Y.3
  • 36
    • 0041707676 scopus 로고    scopus 로고
    • Major histocompatibility complex class i alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses
    • O'Connor DH, Mothe BR, Weinfurter JT, et al. Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses. J Virol. 2003; 77:9029-9040.
    • (2003) J Virol. , vol.77 , pp. 9029-9040
    • O'Connor, D.H.1    Mothe, B.R.2    Weinfurter, J.T.3
  • 37
    • 0038379170 scopus 로고    scopus 로고
    • Advantage of rare HLA supertype in HIV disease progression
    • Trachtenberg E, Korber B, Sollars C, et al. Advantage of rare HLA supertype in HIV disease progression. Nat Med. 2003;9:928-935.
    • (2003) Nat Med. , vol.9 , pp. 928-935
    • Trachtenberg, E.1    Korber, B.2    Sollars, C.3
  • 38
    • 33749650756 scopus 로고    scopus 로고
    • Innate anti-viral immunity is associated with the protection elicited by the simian immunodeficiency virus (SIV) live attenuated virus vaccine in cynomolgus monkeys
    • Goletti D, Macchia I, Leone P, et al. Innate anti-viral immunity is associated with the protection elicited by the simian immunodeficiency virus (SIV) live attenuated virus vaccine in cynomolgus monkeys. Med Sci Monit. 2006;12:BR330-BR340.
    • (2006) Med Sci Monit. , vol.12
    • Goletti, D.1    MacChia, I.2    Leone, P.3
  • 39
    • 33745015013 scopus 로고    scopus 로고
    • Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge
    • Mattapallil JJ, Douek DC, Buckler-White A, et al. Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge. J Exp Med. 2006;203:1533-1541.
    • (2006) J Exp Med. , vol.203 , pp. 1533-1541
    • Mattapallil, J.J.1    Douek, D.C.2    Buckler-White, A.3
  • 40
    • 29244455769 scopus 로고    scopus 로고
    • Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with DNA and recombinant adenoviral vaccine vectors expressing Gag
    • Casimiro DR, Wang F, Schleif WA, et al. Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with DNA and recombinant adenoviral vaccine vectors expressing Gag. J Virol. 2005;79:15547-15555.
    • (2005) J Virol. , vol.79 , pp. 15547-15555
    • Casimiro, D.R.1    Wang, F.2    Schleif, W.A.3
  • 41
    • 4444316121 scopus 로고    scopus 로고
    • Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIVenvelope protein
    • Staprans SI, Barry AP, Silvestri G, et al. Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIVenvelope protein. Proc Natl Acad Sci U S A. 2004; 101:13026-13031.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , pp. 13026-13031
    • Staprans, S.I.1    Barry, A.P.2    Silvestri, G.3
  • 42
    • 31144456952 scopus 로고    scopus 로고
    • Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection
    • Kemball CC, Lee ED, Szomolanyi-Tsuda E, et al. Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. J Immunol. 2006;176:1814-1824.
    • (2006) J Immunol. , vol.176 , pp. 1814-1824
    • Kemball, C.C.1    Lee, E.D.2    Szomolanyi-Tsuda, E.3
  • 43
    • 20444411930 scopus 로고    scopus 로고
    • Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection
    • Kemball CC, Lee ED, Vezys V, et al. Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection. J Immunol. 2005;174:7950-7960.
    • (2005) J Immunol. , vol.174 , pp. 7950-7960
    • Kemball, C.C.1    Lee, E.D.2    Vezys, V.3


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