Glomerular epithelial cell injury associated with mutant α-actinin-4

American Journal of Physiology - Renal Physiology

Volumn 297, Issue 4, 2009, Pages

  Cybulsky, Andrey V ^a,c   Takano, Tomoko ^a   Papillon, Joan ^a   Bijian, Krikor ^a   Guillemette, Julie ^a   Kennedy, Chris R J ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Glomerulonephritis; Transgenic mice; Ubiquitin proteasome system

Indexed keywords

ALPHA ACTININ 4; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MUTANT PROTEIN; PROTEASOME; TUNICAMYCIN; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL STRAIN COS1; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS EPITHELIUM; MOUSE; NONHUMAN; PHOSPHORYLATION; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEINURIA; THROMBOCYTE AGGREGATION; TRANSGENE; UBIQUITINATION; UPREGULATION;

EID: 70349648131     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00055.2009     Document Type: Article

References (40)

1. Bence NF, Sampat RM, Kopito RR. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292: 1552-1555, 2001.
2. Bijian K, Takano T, Papillon J, Khadir A, Cybulsky AV. Extracellular matrix regulates glomerular epithelial cell survival and proliferation. Am J Physiol Renal Physiol 286: F255-F266, 2004. (Pubitemid 38141669)
3. Bijian K, Takano T, Papillon J, Le Berre L, Michaud JL, Kennedy CR, Cybulsky AV. The actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells. Am J Physiol Renal Physiol 289: F1313-F1323, 2005. (Pubitemid 41681366)
4. Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J 348: 241-255, 2000.
5. Brodsky JL. The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation). Biochem J 404: 353-363, 2007.
6. Bush KT, Goldberg AL, Nigam SK. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J Biol Chem 272: 9086-9092, 1997.
7. Coers W, Reivinen J, Miettinen A, Huitema S, Vos JT, Salant DJ, Weening JJ. Characterization of a rat glomerular visceral epithelial cell line. Exp Nephrol 4: 184-192, 1996. (Pubitemid 26162140)
8. Cybulsky AV, Bonventre JV, Quigg RJ, Wolfe LS, Salant DJ. Extracellular matrix regulates proliferation and phospholipid turnover in glomerular epithelial cells. Am J Physiol Renal Fluid Electrolyte Physiol 259: F326-F337, 1990.
9. Cybulsky AV, Takano T, Papillon J, Bijian K. Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury. J Biol Chem 280: 24396-24403, 2005. (Pubitemid 40934523)
10. Cybulsky AV, Takano T, Papillon J, Khadir A, Liu J, Peng H. Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells. J Biol Chem 277: 41342-41351, 2002. (Pubitemid 35257434)
11. Dandapani SV, Sugimoto H, Matthews BD, Kolb RJ, Sinha S, Gerszten RE, Zhou J, Ingber DE, Kalluri R, Pollak MR. Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem 282: 467-477, 2007. (Pubitemid 47076665)
12. Fraley TS, Tran TC, Corgan AM, Nash CA, Hao J, Critchley DR, Greenwood JA. Phosphoinositide binding inhibits alpha-actinin bundling activity. J Biol Chem 278: 24039-24045, 2003. (Pubitemid 36830236)
13. Henderson JM, Al-Waheeb S, Weins A, Dandapani SV, Pollak MR. Mice with altered alpha-actinin-4 expression have distinct morphologic patterns of glomerular disease. Kidney Int 73: 741-750, 2008. (Pubitemid 351323257)
14. Honda K, Yamada T, Endo R, Ino Y, Gotoh M, Tsuda H, Yamada Y, Chiba H, Hirohashi S. Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol 140: 1383-1393, 1998. (Pubitemid 28152987)
15. Inagi R, Nangaku M, Onogi H, Ueyama H, Kitao Y, Nakazato K, Ogawa S, Kurokawa K, Couser WG, Miyata T. Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation. Kidney Int 68: 2639-2650, 2005. (Pubitemid 43251010)
16. Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J Clin Invest 110: 1389-1398, 2002. (Pubitemid 35396907)
17. Kim YH, Goyal M, Kurnit D, Wharram B, Wiggins J, Holzman L, Kershaw D, Wiggins R. Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 60: 957-968, 2001. (Pubitemid 34205795)
18. Kopito RR. ER quality control: the cytoplasmic connection. Cell 88: 427-430, 1997.
19. Kos CH, Le TC, Sinha S, Henderson JM, Kim SH, Sugimoto H, Kalluri R, Gerszten RE, Pollak MR. Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest 111: 1683-1690, 2003. (Pubitemid 38057750)
20. Ly J, Alexander M, Quaggin SE. A podocentric view of nephrology. Curr Opin Nephrol Hypertens 13: 299-305, 2004.
21. Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, Wang QC, Pastan I, Fogo AB, Ichikawa I. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J Am Soc Nephrol 16: 1013-1023, 2005. (Pubitemid 41710312)
22. Michaud JL, Chaisson KM, Parks RJ, Kennedy CR. FSGS-associated alpha-actinin-4 (K256E) impairs cytoskeletal dynamics in podocytes. Kidney Int 70: 1054-1061, 2006.
23. Michaud JL, Lemieux LI, Dube M, Vanderhyden BC, Robertson SJ, Kennedy CR. Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin-4. J Am Soc Nephrol 14: 1200-1211, 2003. (Pubitemid 36514662)
24. Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol 13: 3005-3015, 2002.
25. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403: 98-103, 2000. (Pubitemid 30038529)
26. Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355, 2002. (Pubitemid 34615088)
27. Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 83: 253-307, 2003.
28. Ron D. Translational control in the endoplasmic reticulum stress response. J Clin Invest 110: 1383-1388, 2002. (Pubitemid 35396906)
29. Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ. Adaptation to ER stress is mediated by differential stabilities of pro-survival and proapoptotic mRNAs and proteins. PLoS Biol 4: e374, 2006. (Pubitemid 44760017)
30. Sakahira H, Breuer P, Hayer-Hartl MK, Hartl FU. Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity. Proc Natl Acad Sci USA 99, Suppl 4: 16412-16418, 2002. (Pubitemid 35470987)
31. Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 69: 2131-2147, 2006. (Pubitemid 43882099)
32. Sherman MY, Goldberg AL. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29: 15-32, 2001.
33. Weins A, Kenlan P, Herbert S, Le TC, Villegas I, Kaplan BS, Appel GB, Pollak MR. Mutational and biological analysis of alpha-actinin-4 in focal segmental glomerulosclerosis. J Am Soc Nephrol 16: 3694-3701, 2005. (Pubitemid 46211291)
34. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci USA 104: 16080-16085, 2007. (Pubitemid 350099367)
35. Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, Saunders TL, Dysko RC, Kohno K, Holzman LB, Wiggins RC. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 16: 2941-2952, 2005. (Pubitemid 44743492)
36. Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 71: 1205-1214, 2007.
37. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664, 2005. (Pubitemid 41434389)
38. Yao J, Le TC, Kos CH, Henderson JM, Allen PG, Denker BM, Pollak MR. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol 2: e167, 2004. (Pubitemid 39234444)
39. Yoneda T, Urano F, Ron D. Transmission of proteotoxicity across cellular compartments. Genes Dev 16: 1307-1313, 2002. (Pubitemid 34615084)
40. Yoshida H. ER stress and diseases. FEBS J 274: 630-658, 2007.