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Volumn 133, Issue 12, 2009, Pages 472-478

Present role of homocysteine in clinical medicine;Homocisteína en la clínica humana

Author keywords

Atherothrombosis; Folate deficiency; Homocystinuria; Hyperhomocysteinemia; Vitamin B12 deficiency

Indexed keywords

ACETYLSALICYLIC ACID; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PYRIDOXINE;

EID: 70349613423     PISSN: 00257753     EISSN: 15788989     Source Type: Journal    
DOI: 10.1016/j.medcli.2008.11.032     Document Type: Short Survey
Times cited : (1)

References (61)
  • 1
    • 17344392565 scopus 로고    scopus 로고
    • Significado clínico de la homocisteína
    • C. Aguirre, and M.V. Egurbide Significado clínico de la homocisteína Rev Clin Esp 201 2001 25 27
    • (2001) Rev Clin Esp , vol.201 , pp. 25-27
    • Aguirre, C.1    Egurbide, M.V.2
  • 3
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arterioesclerosis
    • K.S. McCully Vascular pathology of homocysteinemia: implications for the pathogenesis of arterioesclerosis Am J Pathol 56 1969 111 128
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 5
    • 0032817731 scopus 로고    scopus 로고
    • Homocysteine: Cholesterol of the 90s?
    • L.J. Langman, and D.E. Cole Homocysteine: cholesterol of the 90s? Clin Chim Acta 286 1999 63 80
    • (1999) Clin Chim Acta , vol.286 , pp. 63-80
    • Langman, L.J.1    Cole, D.E.2
  • 7
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • DOI 10.1146/annurev.nutr.19.1.217
    • J. Selhub Homocysteine metabolism Annu Rev Nutr 19 1999 217 246 (Pubitemid 29380603)
    • (1999) Annual Review of Nutrition , vol.19 , pp. 217-246
    • Selhub, J.1
  • 8
    • 0031988993 scopus 로고    scopus 로고
    • Determinants of plasma homocysteine
    • H.J. Blom Determinants of plasma homocysteine Am J Clin Nutr 67 1998 188 189
    • (1998) Am J Clin Nutr , vol.67 , pp. 188-189
    • Blom, H.J.1
  • 9
    • 0029974036 scopus 로고    scopus 로고
    • Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥ 40 micromol/liter). the hordaland homocysteine study
    • A.B. Guttormsen, P.M. Ueland, I. Nesthus, O. Nygard, J. Schneede, S.E. Vollset, and H. Refsum Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 micromol/liter) - the Hordaland homocysteine study J Clin Invest 98 1996 2174 2183 (Pubitemid 26376307)
    • (1996) Journal of Clinical Investigation , vol.98 , Issue.9 , pp. 2174-2183
    • Guttormsen, A.B.1    Ueland, P.M.2    Nesthus, I.3    Nygard, O.4    Schneede, J.5    Vollset, S.E.6    Refsum, H.7
  • 10
    • 0030811925 scopus 로고    scopus 로고
    • Genetic predisposition to hyperhomocysteinemia: Deficiency of methylenetetrahydrofolate reductase (MTHFR)
    • R. Rozen Genetic predisposition to hyperhomocysteinemia: deficiency of methilenetetrahydrofolate reductase (MTHFR) Thromb Haemost 78 1997 523 526 (Pubitemid 27289296)
    • (1997) Thrombosis and Haemostasis , vol.78 , Issue.1 , pp. 523-526
    • Rozen, R.1
  • 13
    • 0035960326 scopus 로고    scopus 로고
    • Intervalos de referencia poblacional y determinantes de la homocisteína plasmática
    • (Barc)
    • J.I. Pijoan Zubizarreta, I. Irigoien Garbizu, and C. Aguirre Errasti Intervalos de referencia poblacional y determinantes de la homocisteína plasmática Med Clic (Barc) 117 2001 487 491
    • (2001) Med Clic , vol.117 , pp. 487-491
    • Pijoan Zubizarreta, J.I.1    Irigoien Garbizu, I.2    Aguirre Errasti, C.3
  • 15
  • 18
    • 0021894152 scopus 로고
    • The natural history of homocystinura due to cystathionine beta-synthase deficiency
    • S.H. Mudd, F. Skovby, H.L. Levy, K.D. Pettigrew, B. Wilcken, and R.E. Pyeritz The natural history of homocystinuria due to cystathionine beta-synthase deficiency Am J Hum Genet 37 1985 1 31 (Pubitemid 15138674)
    • (1985) American Journal of Human Genetics , vol.37 , Issue.1 , pp. 1-31
    • Mudd, S.H.1    Skovby, F.2    Levy, H.L.3
  • 20
    • 3042621191 scopus 로고    scopus 로고
    • Ocular axial length in homocystinuria patients with and without ocular changes: Effects of early treatment and biochemical control
    • DOI 10.1016/j.jaapos.2004.01.010, PII S1091853104000345
    • A. Mulvihill, M. O'Keeffe, S. Yap, E. Naughten, P. Howard, and B. Lanigan Ocular axial length in homocistynuria patients with and without ocular changes: effects of early tratmente and biochemical control J AAPOS 8 2004 254 258 (Pubitemid 38833742)
    • (2004) Journal of AAPOS , vol.8 , Issue.3 , pp. 254-258
    • Mulvihill, A.1    O'Keeffe, M.2    Yap, S.3    Naughten, E.4    Howard, P.5    Lanigan, B.6
  • 21
    • 0029808187 scopus 로고    scopus 로고
    • Delay in diagnosis of homocystinuria: Restrospective study of consecutive patients
    • J.R. Cruysberg, G.H. Boers, J.M. Trijbels, and A.F. Deutman Delay in diagnosis of homocystinuria: restrospective study of consecutive patients BMJ 313 1996 1037 1040
    • (1996) BMJ , vol.313 , pp. 1037-1040
    • Cruysberg, J.R.1    Boers, G.H.2    Trijbels, J.M.3    Deutman, A.F.4
  • 22
    • 49849087671 scopus 로고    scopus 로고
    • Adult-onset homocystinuria arteriopathy mimics fibromuscular dysplasia
    • M.P. Chauveheid, O. Lidove, T. Papo, and J.P. Laissy Adult-onset homocystinuria arteriopathy mimics fibromuscular dysplasia Am J Med 121 2008 e5 e6
    • (2008) Am J Med , vol.121
    • Chauveheid, M.P.1    Lidove, O.2    Papo, T.3    Laissy, J.P.4
  • 24
    • 33750620935 scopus 로고    scopus 로고
    • Diagnosis of megaloblastic anaemias
    • S.N. Wickramasinghe Diagnosis of megaloblastic anaemias Blood Rev 20 2006 299 318
    • (2006) Blood Rev , vol.20 , pp. 299-318
    • Wickramasinghe, S.N.1
  • 25
    • 0035978208 scopus 로고    scopus 로고
    • 12
    • (Barc)
    • 12 Med Clin (Barc) 116 2001 457 458
    • (2001) Med Clin , vol.116 , pp. 457-458
    • Aguirre, C.1
  • 26
    • 3142673339 scopus 로고    scopus 로고
    • Vitamin B12 deficiency as a worldwide problem
    • DOI 10.1146/annurev.nutr.24.012003.132440
    • 12 deficiency as a worldwide problem Annu Rev Nutr 24 2004 299 326 (Pubitemid 38938794)
    • (2004) Annual Review of Nutrition , vol.24 , pp. 299-326
    • Stabler, S.P.1    Allen, R.H.2
  • 27
    • 0029891583 scopus 로고    scopus 로고
    • Prevalence of undiagnosed pernicious anemia in the elderly
    • DOI 10.1001/archinte.156.10.1097
    • R. Carmel Prevalence of undiagnosed pernicious anemia in the elderly Arch Intern Med 156 1996 1097 1100 (Pubitemid 26158066)
    • (1996) Archives of Internal Medicine , vol.156 , Issue.10 , pp. 1097-1100
    • Carmel, R.1
  • 29
    • 0037831006 scopus 로고    scopus 로고
    • Vegetarianism and vitamin B-12 (cobalamin) deficiency
    • A.C. Antony Vegetarianism and vitamin B-12 (cobalamin) deficiency Am J Clin Nutr 78 2003 3 6
    • (2003) Am J Clin Nutr , vol.78 , pp. 3-6
    • Antony, A.C.1
  • 32
    • 0029978384 scopus 로고    scopus 로고
    • The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency
    • S.P. Stabler, J. Lindenbaum, and R.H. Allen The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency J Nutr 126 1996 1266S 1272S (Pubitemid 26105670)
    • (1996) Journal of Nutrition , vol.126 , Issue.4 SUPPL.
    • Stabler, S.P.1    Lindenbaum, J.2    Allen, R.H.3
  • 33
    • 33846102164 scopus 로고    scopus 로고
    • Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification
    • M.S. Morris, P.F. Jacques, I.H. Rosenberg, and J. Selhub Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification Am J Clin Nutr 85 2007 193 200 (Pubitemid 46067634)
    • (2007) American Journal of Clinical Nutrition , vol.85 , Issue.1 , pp. 193-200
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 34
    • 0029096398 scopus 로고
    • Cobalamin and folate deficiency in the ederly
    • J.H. Matthews Cobalamin and folate deficiency in the ederly Baillière's Clinical Haematology 8 1995 679 697
    • (1995) Baillière's Clinical Haematology , vol.8 , pp. 679-697
    • Matthews, J.H.1
  • 35
    • 0025331267 scopus 로고
    • Diagnosis of cobalamin deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations
    • DOI 10.1002/ajh.2830340204
    • R.H. Allen, S.P. Stabler, D.G. Savage, and J. Lindenbaum Diagnosis of cobalamin deficiency I: usefulness of serum methylmalonic acid and total homocysteine concentrations Am J Hematol 34 1990 90 98 (Pubitemid 20180100)
    • (1990) American Journal of Hematology , vol.34 , Issue.2 , pp. 90-98
    • Allen, R.H.1    Stabler, S.P.2    Savage, D.G.3    Lindenbaum, J.4
  • 36
    • 0025335524 scopus 로고
    • Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations
    • DOI 10.1002/ajh.2830340205
    • J. Lindenbaum, D.G. Savage, S.P. Stabler, and R.H. Allen Diagnosis of cobalamin deficciency: II Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine concentrations Am J Hematol 34 1990 99 107 (Pubitemid 20180101)
    • (1990) American Journal of Hematology , vol.34 , Issue.2 , pp. 99-107
    • Lindenbaum, J.1    Savage, D.G.2    Stabler, S.P.3    Allen, R.H.4
  • 37
    • 0028223165 scopus 로고
    • Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies
    • DOI 10.1016/0002-9343(94)90149-X
    • D.G. Savage, J. Lindenbaum, S.P. Stabler, and R.H. Allen Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficicencies Am J Med 96 1994 239 246 (Pubitemid 24099223)
    • (1994) American Journal of Medicine , vol.96 , Issue.3 , pp. 239-246
    • Savage, D.G.1    Lindenbaum, J.2    Stabler, S.P.3    Allen, R.H.4
  • 39
    • 0030047397 scopus 로고    scopus 로고
    • Subtle cobalamin deficiency
    • R. Carmel Subtle cobalamin deficiency Ann Intern Med 124 1996 338 340 (Pubitemid 26047462)
    • (1996) Annals of Internal Medicine , vol.124 , Issue.3 , pp. 338-340
    • Carmel, R.1
  • 40
    • 0031583658 scopus 로고    scopus 로고
    • Hiperhomocisteinemia, un nuevo marcador de riesgo vascular: Territorios vasculares afectados, papel en la patogénesis de la arteriosclerosis y la trombosis y tratamiento
    • A. Córdoba Porras, F. Blanco Vaca, and F. González Sastre Hiperhomocisteinemia, un nuevo marcador de riesgo vascular: territorios vasculares afectados, papel en la patogénesis de la arteriosclerosis y la trombosis y tratamiento Med Clin (Barc) 109 1997 715 725 (Pubitemid 128530856)
    • (1997) Medicina Clinica , vol.109 , Issue.18 , pp. 715-725
    • Cordoba Porras, A.1    Blanco Vaca, F.2    Gonzalez Sastre, F.3
  • 41
    • 33747879556 scopus 로고    scopus 로고
    • Homocysteine Hypothesis for Atherothrombotic Cardiovascular Disease. Not Validated
    • DOI 10.1016/j.jacc.2006.04.086, PII S0735109706014665
    • S. Kaul, A.A. Zadeh, and P.K. Shah Homocysteine hypotesis for atherothrombotic cardiovascular disease - not validated J Am Coll Cardiol 48 2006 914 923 (Pubitemid 44292448)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.5 , pp. 914-923
    • Kaul, S.1    Zadeh, A.A.2    Shah, P.K.3
  • 42
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine Studies Collaboration
    • Homocysteine Studies Collaboration Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis JAMA 288 2002 2015 2022
    • (2002) JAMA , vol.288 , pp. 2015-2022
  • 43
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • D.S. Wald, M. Law, and J.K. Morris Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis BMJ 325 2002 1202 1206 (Pubitemid 35398783)
    • (2002) British Medical Journal , vol.325 , Issue.7374 , pp. 1202-1206
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 45
    • 1242339767 scopus 로고    scopus 로고
    • Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: A randomised pilot trial
    • A.H. Liem, A.J. Van Boven, N.J. Veeger, A.J. Withagen, R.M. Robles de Medina, and J.G. Tijssen et al. Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial Int J Cardiol 93 2004 175 179
    • (2004) Int J Cardiol , vol.93 , pp. 175-179
    • Liem, A.H.1    Van Boven, A.J.2    Veeger, N.J.3    Withagen, A.J.4    Robles De Medina, R.M.5    Tijssen, J.G.6
  • 46
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction and death
    • J.F. Toole, M.R. Malinow, L.E. Chambless, J.D. Spence, L.C. Pettigrew, and V.J. Hoeard et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction and death JAMA 291 2004 565 575
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3    Spence, J.D.4    Pettigrew, L.C.5    Hoeard, V.J.6
  • 47
    • 33645796222 scopus 로고    scopus 로고
    • Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • K.H. Bønaa, I. Njølstad, P.M. Ueland, H. Schirmer, A. Tverdal, and T. Steigen et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction N Engl J Med 354 2006 1578 1588
    • (2006) N Engl J Med , vol.354 , pp. 1578-1588
    • Bønaa, K.H.1    Njølstad, I.2    Ueland, P.M.3    Schirmer, H.4    Tverdal, A.5    Steigen, T.6
  • 48
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in vascular disease
    • The Heart Outcomes Prevention Evaluation (HOPE) 2 investigators
    • The Heart Outcomes Prevention Evaluation (HOPE) 2 investigators Homocysteine lowering with folic acid and B vitamins in vascular disease N Engl J Med 354 2006 1567 1577
    • (2006) N Engl J Med , vol.354 , pp. 1567-1577
  • 49
    • 49949101867 scopus 로고    scopus 로고
    • Mortality and cardivascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography
    • M. Ebbing, Ø. Bleie, P.M. Ueland, J.E. Nordehaug, D.W. Nilsen, and S.E. Vollset et al. Mortality and cardivascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography JAMA 300 2008 795 804
    • (2008) JAMA , vol.300 , pp. 795-804
    • Ebbing, M.1    Bleie, Ø.2    Ueland, P.M.3    Nordehaug, J.E.4    Nilsen, D.W.5    Vollset, S.E.6
  • 51
    • 10844230196 scopus 로고    scopus 로고
    • Homocysteine, antiphospholipid antibodies and risk of thrombosis in patients with systemic lupus erythematosus
    • DOI 10.1191/0961203304lu2035oa
    • A. Martínez-Berriotxoa, G. Ruiz-Irastorza, M.V. Egurbide, M. Rueda, and C. Aguirre Homocysteine, antiphospholipid antibodies and risk of thrombosis in patients with systemic lupus erythematosus Lupus 13 2004 927 933 (Pubitemid 39664952)
    • (2004) Lupus , vol.13 , Issue.12 , pp. 927-933
    • Martinez-Berriotxoa, A.1    Ruiz-Irastorza, G.2    Egurbide, M.-V.3    Rueda, M.4    Aguirre, C.5
  • 54
    • 31344459617 scopus 로고    scopus 로고
    • Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
    • B-Vitamin treatment trialists' collaboration
    • B-Vitamin treatment trialists' collaboration Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials Am Heart J 151 2006 282 287
    • (2006) Am Heart J , vol.151 , pp. 282-287
  • 55
    • 40549095695 scopus 로고    scopus 로고
    • Is folic acid good for everyone?
    • A. David, Y.I. Kim, and H. Refsum Is folic acid good for everyone? Am J Clin Nutr 87 2008 517 533
    • (2008) Am J Clin Nutr , vol.87 , pp. 517-533
    • David, A.1    Kim, Y.I.2    Refsum, H.3
  • 56
    • 33645777279 scopus 로고    scopus 로고
    • Homocysteine trials - Clear outcomes for complex reasons
    • J. Loscalzo Homocysteine trials - clear outcomes for complex reasons N Engl J Med 254 2006 1629 1632
    • (2006) N Engl J Med , vol.254 , pp. 1629-1632
    • Loscalzo, J.1
  • 57
    • 0031597388 scopus 로고    scopus 로고
    • 12, and serum total homocysteine levels in confirmed Alzheimer disease
    • R. Clarke, A.D. Smith, K.A. Jobst, H. Refsum, L. Sutton, and P.M. Ueland Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease Arch Neurol 55 1998 1449 1455 (Pubitemid 28525506)
    • (1998) Archives of Neurology , vol.55 , Issue.11 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 60
    • 21744454670 scopus 로고    scopus 로고
    • Homocysteine and folic acid: Implications for pregnancy
    • DOI 10.1055/s-2005-872404
    • S. Daly, A. Cotter, A.E. Mohillo, and J. Scott Homocysteine and folic acid: implications for pregnancy Semin Vasc Med 5 2005 190 200 (Pubitemid 40944294)
    • (2005) Seminars in Vascular Medicine , vol.5 , Issue.2 , pp. 190-200
    • Daly, S.1    Cotter, A.2    Molloy, A.E.3    Scott, J.4


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