메뉴 건너뛰기




Volumn 109, Issue 18, 1997, Pages 715-725

Hiperhomocisteinemia, un nuevo marcador de riesgo vascular: Territorios vasculares afectados, papel en la patogénesis de la arteriosclerosis y la trombosis y tratamiento

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; METHIONINE; VITAMIN;

EID: 0031583658     PISSN: 00257753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (15)

References (156)
  • 2
    • 0000167774 scopus 로고
    • Disorders fo transsulfuration
    • Scriver CR, Beadet AL, Sly WS, Valle D, editores. Nueva York: McGraw-Hill Inc.
    • Mudd SH, Levy HL, Skovy F. Disorders fo transsulfuration. En: Scriver CR, Beadet AL, Sly WS, Valle D, editores. The metabolic molecular bases of inherited diseases. Nueva York: McGraw-Hill Inc., 1995; 1.279-1.327.
    • (1995) The Metabolic Molecular Bases of Inherited Diseases , pp. 1279-1327
    • Mudd, S.H.1    Levy, H.L.2    Skovy, F.3
  • 5
    • 0014310595 scopus 로고
    • Homocystinuria: A clinical and pathological study of nine subjects in six families
    • Carey MC, Donovan DE, Fitzgerald O, McAuley FD. Homocystinuria: a clinical and pathological study of nine subjects in six families. Am J Med 1968; 45: 7-25.
    • (1968) Am J Med , vol.45 , pp. 7-25
    • Carey, M.C.1    Donovan, D.E.2    Fitzgerald, O.3    McAuley, F.D.4
  • 6
    • 10344229550 scopus 로고
    • St. Louis: CV Mosby
    • a ed.). St. Louis: CV Mosby, 1972; 224-281.
    • (1972) a Ed.) , pp. 224-281
    • McKusick, V.A.1
  • 7
    • 76549221821 scopus 로고
    • Homocystinuria: Studies of 20 families with 38 affected members
    • Schimke RN, McKusik VA, Huang T, Pollack AD. Homocystinuria: studies of 20 families with 38 affected members. JAMA 1965; 193: 711-720.
    • (1965) JAMA , vol.193 , pp. 711-720
    • Schimke, R.N.1    McKusik, V.A.2    Huang, T.3    Pollack, A.D.4
  • 8
    • 0000487436 scopus 로고
    • Homocysteine theory of arteriosclerosis. Development and current status
    • Gotto AM Jr, Paoletti R, editores. Nueva York: Raven Press
    • McCully KS. Homocysteine theory of arteriosclerosis. Development and current status. En: Gotto AM Jr, Paoletti R, editores. Atherosclerosis reviews (Vol. 11). Nueva York: Raven Press, 1983; 157-246.
    • (1983) Atherosclerosis Reviews , vol.11 , pp. 157-246
    • McCully, K.S.1
  • 9
    • 0017238445 scopus 로고
    • Grow promotion by homocysteic acid
    • Cloppath P, Smith VC, McCully KS. Grow promotion by homocysteic acid. Science 1976; 192: 372-374.
    • (1976) Science , vol.192 , pp. 372-374
    • Cloppath, P.1    Smith, V.C.2    McCully, K.S.3
  • 10
    • 0022472013 scopus 로고
    • Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator
    • Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest 1986; 77: 1.909-1.916.
    • (1986) J Clin Invest , vol.77 , pp. 1909-1916
    • Rodgers, G.M.1    Kane, W.H.2
  • 11
    • 0014434483 scopus 로고
    • Activation of haegman factor by L-homocysteine
    • Ratnoff OD. Activation of haegman factor by L-homocysteine. Science 1968; 162: 1.007-1.009.
    • (1968) Science , vol.162 , pp. 1007-1009
    • Ratnoff, O.D.1
  • 12
    • 0020055946 scopus 로고
    • Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism
    • Graeber JL, Slott JH, Ulane RE, Schulman JD, Stuart MJ. Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism. Pediatr Res 1982; 16: 490-493.
    • (1982) Pediatr Res , vol.16 , pp. 490-493
    • Graeber, J.L.1    Slott, J.H.2    Ulane, R.E.3    Schulman, J.D.4    Stuart, M.J.5
  • 13
    • 0027247803 scopus 로고
    • Abnormally high thromboxane biosynthesis in homozygous homocystinuris: Evidence for platelet involvement and probucol-sensitive mechanism
    • Di Minno G, Davi G, Margaglione M, Cirillo F, Grandone E, Ciabattoni et al. Abnormally high thromboxane biosynthesis in homozygous homocystinuris: evidence for platelet involvement and probucol-sensitive mechanism. J Clin Invest 1993; 92: 1.400-1.406.
    • (1993) J Clin Invest , vol.92 , pp. 1400-1406
    • Di Minno, G.1    Davi, G.2    Margaglione, M.3    Cirillo, F.4    Grandone, E.5    Ciabattoni6
  • 14
    • 0017197285 scopus 로고
    • Homocystine-induced arteriosclerosis: The role of endothelial cell injury and platelet response in its genesis
    • Harker LA, Ross R, Schter SJ, Scott CR. Homocystine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin Invest 1976; 58: 731-741.
    • (1976) J Clin Invest , vol.58 , pp. 731-741
    • Harker, L.A.1    Ross, R.2    Schter, S.J.3    Scott, C.R.4
  • 15
    • 0016390789 scopus 로고
    • Homocysteinernia: Vascular injury and arterial trhombosis
    • Harker LA, Slichter SJ, Scott CR, Ross R Homocysteinernia: vascular injury and arterial trhombosis. N Engl J Med 1974; 291: 537-543.
    • (1974) N Engl J Med , vol.291 , pp. 537-543
    • Harker, L.A.1    Slichter, S.J.2    Scott, C.R.3    Ross, R.4
  • 16
    • 0027531427 scopus 로고
    • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
    • Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 1993; 91: 308-318.
    • (1993) J Clin Invest , vol.91 , pp. 308-318
    • Stamler, J.S.1    Osborne, J.A.2    Jaraki, O.3    Rabbani, L.E.4    Mullins, M.5    Singel, D.6
  • 17
    • 0025190042 scopus 로고
    • Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
    • Rodgers GM, Conn MT. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood 1990; 75: 895-901.
    • (1990) Blood , vol.75 , pp. 895-901
    • Rodgers, G.M.1    Conn, M.T.2
  • 18
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz SR, Sadler JE. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 1991; 88: 1.906-1.914.
    • (1991) J Clin Invest , vol.88 , pp. 1906-1914
    • Lentz, S.R.1    Sadler, J.E.2
  • 19
    • 0029933176 scopus 로고    scopus 로고
    • Coexistence of heredidary homocystinuria and factor V Leiden-effect on thrombosis
    • Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C et al. Coexistence of heredidary homocystinuria and factor V Leiden-effect on thrombosis. N Engl J Med 1996; 334: 763-768.
    • (1996) N Engl J Med , vol.334 , pp. 763-768
    • Mandel, H.1    Brenner, B.2    Berant, M.3    Rosenberg, N.4    Lanir, N.5    Jakobs, C.6
  • 20
    • 0027515303 scopus 로고
    • Familial cerebrovascular accidents due to concomitant hyperhomocysteinemia and protein C deficiency type 1
    • Franken DG, Vreugdenhil A, Boers GHJ, Verrips A, Bloom HJ, Novakova IRO. Familial cerebrovascular accidents due to concomitant hyperhomocysteinemia and protein C deficiency type 1. Stroke 1993; 24: 1.599-1.600.
    • (1993) Stroke , vol.24 , pp. 1599-1600
    • Franken, D.G.1    Vreugdenhil, A.2    Boers, G.H.J.3    Verrips, A.4    Bloom, H.J.5    Novakova, I.R.O.6
  • 21
  • 23
    • 0027198477 scopus 로고
    • Disorders methionine/homocysteine metabolism in premature vascular disease. Its ocurrence. cofactor therapy, and enzymology
    • Dudman NPB, Wilcken DEL, Wang J, Lyinch JF, Macey D. Lundberg P. Disorders methionine/homocysteine metabolism in premature vascular disease. Its ocurrence. cofactor therapy, and enzymology. Arterioscler Thromb 1993; 13: 1.253-1.260.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1253-1260
    • Dudman, N.P.B.1    Wilcken, D.E.L.2    Wang, J.3    Lyinch, J.F.4    Macey, D.5    Lundberg, P.6
  • 26
    • 0026729430 scopus 로고
    • Hyperhomocysteinemia as a risk factor for stroke
    • Brattström L, Lindgren A. Hyperhomocysteinemia as a risk factor for stroke. Neurol Res 1992; 14: 81-84.
    • (1992) Neurol Res , vol.14 , pp. 81-84
    • Brattström, L.1    Lindgren, A.2
  • 27
    • 0028177431 scopus 로고
    • Effects of age, lipoproteins, and hemostatic parameters on the role of homocyst(e)inemia as a cardivascular risk factor in men
    • Von Eckardstein A, Malinow MR, Upson B, Heinrich J, Schulte H, Schönfeld R et al. Effects of age, lipoproteins, and hemostatic parameters on the role of homocyst(e)inemia as a cardivascular risk factor in men. Arterioscler Thromb 1994; 14: 460-464.
    • (1994) Arterioscler Thromb , vol.14 , pp. 460-464
    • Von Eckardstein, A.1    Malinow, M.R.2    Upson, B.3    Heinrich, J.4    Schulte, H.5    Schönfeld, R.6
  • 29
    • 0025278455 scopus 로고
    • Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke
    • Coull BM, Malinow MR, Beamer N, Sexton G, Nordt F, Pat de Garmo ANP. Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke. Stroke 1990; 21: 572-576.
    • (1990) Stroke , vol.21 , pp. 572-576
    • Coull, B.M.1    Malinow, M.R.2    Beamer, N.3    Sexton, G.4    Nordt, F.5    Pat De Garmo, A.N.P.6
  • 30
    • 0026729430 scopus 로고
    • Hyperhomocysteinemia as a risk factor for stroke
    • Brattström L, Lindgren A. Hyperhomocysteinemia as a risk factor for stroke. Neurol Res 1992; 14: 81-84.
    • (1992) Neurol Res , vol.14 , pp. 81-84
    • Brattström, L.1    Lindgren, A.2
  • 31
    • 0025095390 scopus 로고
    • Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease-effects of pyridoxine and folic acid treatment
    • Brattström L, Israelson B, Norrving B, Bergovist D, Thorne J, Hultberg B et al. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease-effects of pyridoxine and folic acid treatment. Atherosclerosis 1990; 81: 51-60.
    • (1990) Atherosclerosis , vol.81 , pp. 51-60
    • Brattström, L.1    Israelson, B.2    Norrving, B.3    Bergovist, D.4    Thorne, J.5    Hultberg, B.6
  • 32
    • 0024403532 scopus 로고
    • Plasma homocysteine and metionine tolerance in early-onset vascular disease
    • Brattström L, Israelsson B, Hultberg B. Plasma homocysteine and metionine tolerance in early-onset vascular disease. Haemostasis 1989; 19(Supl 1) 35-44.
    • (1989) Haemostasis , vol.19 , Issue.1 SUPL , pp. 35-44
    • Brattström, L.1    Israelsson, B.2    Hultberg, B.3
  • 33
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995; 274: 1.049-1.057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 34
    • 0024391453 scopus 로고
    • Prevalence of hyperhomocystein(e)mia in patients with peripheral arterial occlusive disease
    • Malinow MR, Kang SS, Taylor LM, Wong PWK, Coull B, Inahara T et al. Prevalence of hyperhomocystein(e)mia in patients with peripheral arterial occlusive disease. Circulation 1989; 79: 1.180-1.188.
    • (1989) Circulation , vol.79 , pp. 1180-1188
    • Malinow, M.R.1    Kang, S.S.2    Taylor, L.M.3    Wong, P.W.K.4    Coull, B.5    Inahara, T.6
  • 35
    • 0020541265 scopus 로고
    • Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria
    • Wilcken DEL, Reddy SG, Gupta VJ. Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria. Metabolism 1983; 32: 363-370.
    • (1983) Metabolism , vol.32 , pp. 363-370
    • Wilcken, D.E.L.1    Reddy, S.G.2    Gupta, V.J.3
  • 36
    • 0026552225 scopus 로고
    • Hyperhomocysteinemia in stroke: Prevalence, cause, and relationships to type of stroke and stroke risk factors
    • Brattström L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B et al. Hyperhomocysteinemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors. Eur J Clin Invest 1992; 22: 214-221.
    • (1992) Eur J Clin Invest , vol.22 , pp. 214-221
    • Brattström, L.1    Lindgren, A.2    Israelsson, B.3    Malinow, M.R.4    Norrving, B.5    Upson, B.6
  • 40
    • 0027514869 scopus 로고
    • Cobalamin absorption and serum homocysteine and methylmatonic acid in elderly subjets with low serum cobalamin
    • Joosten E, Pelemans W, Devos P, Lesaffre E, Goossens W, Criel A et al. Cobalamin absorption and serum homocysteine and methylmatonic acid in elderly subjets with low serum cobalamin. Eur J Haematol 1993; 51: 25-30.
    • (1993) Eur J Haematol , vol.51 , pp. 25-30
    • Joosten, E.1    Pelemans, W.2    Devos, P.3    Lesaffre, E.4    Goossens, W.5    Criel, A.6
  • 42
    • 0025331267 scopus 로고
    • Diagnosis of cobalamin deficiency, I: Usefulness of serum methylmalonic acid and total homocysteine concentrations
    • Allen RH, Stabler SP, Savage DG, Lindenbaum J, Diagnosis of cobalamin deficiency, I: usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematology 1990; 34: 90-98.
    • (1990) Am J Hematology , vol.34 , pp. 90-98
    • Allen, R.H.1    Stabler, S.P.2    Savage, D.G.3    Lindenbaum, J.4
  • 43
    • 0000526332 scopus 로고
    • Inherited disorders of cobalamin transport and metabolism
    • En: Scriver CR, Beaudet AL, Sly WS, Valle D, editores. Nueva York: McGraw-Hill Inc.
    • Fenton AW, Rosenberg LE. Inherited disorders of cobalamin transport and metabolism. En: Scriver CR, Beaudet AL, Sly WS, Valle D, editores. The metabolic and molecular bases of inherited disease. Nueva York: McGraw-Hill Inc., 1995; 3.129-3.149.
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 3129-3149
    • Fenton, A.W.1    Rosenberg, L.E.2
  • 44
    • 0000443712 scopus 로고
    • Inherited disorders of folate transport and metabolism
    • En: Scriver CR, Beaudet AL, Sly WS, Valle D, editores. Nueva York: McGraw-Hill Inc.
    • Rosenblatt DS. Inherited disorders of folate transport and metabolism. En: Scriver CR, Beaudet AL, Sly WS, Valle D, editores. The metabolic and molecular bases of inherited disease, Nueva York: McGraw-Hill Inc., 1995: 3.111-3.128.
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 3111-3128
    • Rosenblatt, D.S.1
  • 47
    • 0027330937 scopus 로고
    • Hyperhomocysteinemia: A risk factor in women with unexplained recurrent early pregnancy loss
    • Wouters MG, Boers GH, Bloom HJ, Trijbels FJ, Thomas CM, Borm GF et al. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993; 60: 820-825.
    • (1993) Fertil Steril , vol.60 , pp. 820-825
    • Wouters, M.G.1    Boers, G.H.2    Bloom, H.J.3    Trijbels, F.J.4    Thomas, C.M.5    Borm, G.F.6
  • 49
    • 0025362827 scopus 로고
    • Methionine metabolism in mammals
    • Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem 1990; 1: 228-237.
    • (1990) J Nutr Biochem , vol.1 , pp. 228-237
    • Finkelstein, J.D.1
  • 50
    • 0016722112 scopus 로고
    • Labile methyl balances for normal humans on varios dietary regimens
    • Mudd SH, Poole JR. Labile methyl balances for normal humans on varios dietary regimens. Metabolism 1975; 24: 721-735.
    • (1975) Metabolism , vol.24 , pp. 721-735
    • Mudd, S.H.1    Poole, J.R.2
  • 51
    • 0018934312 scopus 로고
    • Labile methyl group balances in the human the role of sarcosine
    • Mudd SH, Ebert MH, Schriver CR. Labile methyl group balances in the human the role of sarcosine. Metabolism 1980; 29: 707-720.
    • (1980) Metabolism , vol.29 , pp. 707-720
    • Mudd, S.H.1    Ebert, M.H.2    Schriver, C.R.3
  • 52
    • 0023845397 scopus 로고
    • Interrelations between plasma free and protein-bound homocysteine and cysteine in homocystinuria
    • Wiley VC, Dudman NPB, Wilcken DEL. Interrelations between plasma free and protein-bound homocysteine and cysteine in homocystinuria. Metabolism 1988; 37: 191-195.
    • (1988) Metabolism , vol.37 , pp. 191-195
    • Wiley, V.C.1    Dudman, N.P.B.2    Wilcken, D.E.L.3
  • 54
    • 0022339972 scopus 로고
    • Radioenzymic determination of homocysteine in plasma and urine
    • Refsum H, Heiland S, Ueland PM. Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 1985; 31: 624-628.
    • (1985) Clin Chem , vol.31 , pp. 624-628
    • Refsum, H.1    Heiland, S.2    Ueland, P.M.3
  • 55
    • 0018126120 scopus 로고
    • The detection of cysteine-homocysteine mixed disulphide in plasma of normal fasting man
    • Gupta VJ, Wilcken DEL. The detection of cysteine-homocysteine mixed disulphide in plasma of normal fasting man. Eur J Clin Invest 1978; 8: 205-207.
    • (1978) Eur J Clin Invest , vol.8 , pp. 205-207
    • Gupta, V.J.1    Wilcken, D.E.L.2
  • 56
    • 0002647769 scopus 로고    scopus 로고
    • Thermolabile genotype of methylenetetrahydrofolate reductase (MTHFR) and hyperhomocysteinemia in patients with nonhemorrhagic cerebro-vascular disease. The Society for Inborn Errors of Metabolism (SSIEM). Cardiff 34th Annual Symposium. 10th-13th September
    • Córdoba PA, Cirera S, Carrascosa C, Arcelus R, Castellvi A, Rodes M et al. Thermolabile genotype of methylenetetrahydrofolate reductase (MTHFR) and hyperhomocysteinemia in patients with nonhemorrhagic cerebro-vascular disease. The Society for Inborn Errors of Metabolism (SSIEM). Cardiff 34th Annual Symposium. 10th-13th September. J Inherited Metabolic Disease 1996; 19 (Supl 1): 23.
    • (1996) J Inherited Metabolic Disease , vol.19 , Issue.1 SUPL , pp. 23
    • Córdoba, P.A.1    Cirera, S.2    Carrascosa, C.3    Arcelus, R.4    Castellvi, A.5    Rodes, M.6
  • 59
    • 0021993423 scopus 로고
    • Improved identification of heterozygotes for homocystinuria due to cystathionine-synthase deficiency by the combination of methionine loading and enzyme determination in cultures fibroblasts
    • Boers GHJ, Fowler B, Smals AGH, Trijbels FJM, Leermakers AL, Kleijer WJ et al. Improved identification of heterozygotes for homocystinuria due to cystathionine-synthase deficiency by the combination of methionine loading and enzyme determination in cultures fibroblasts. Hum Genet 1985; 69: 164-169.
    • (1985) Hum Genet , vol.69 , pp. 164-169
    • Boers, G.H.J.1    Fowler, B.2    Smals, A.G.H.3    Trijbels, F.J.M.4    Leermakers, A.L.5    Kleijer, W.J.6
  • 61
    • 0000363006 scopus 로고
    • Disorders of transsulfuration
    • Scriver CR, Beadet AL, Sly WS, Valle D, editores. Nueva York: McGraw-Hill
    • a ed.). Vol 1. Nueva York: McGraw-Hill, 1989; 693-734.
    • (1989) a Ed.) , vol.1 , pp. 693-734
    • Mudd, S.H.1    Levy, H.L.2    Skovy, F.3
  • 62
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
    • Kang SS, Zhou J, Wong PWK, Kowalisyn J, Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase Am J Hum Genet 1988; 43: 414-421.
    • (1988) Am J Hum Genet , vol.43 , pp. 414-421
    • Kang, S.S.1    Zhou, J.2    Wong, P.W.K.3    Kowalisyn, J.4    Strokosch, G.5
  • 63
    • 0023832738 scopus 로고
    • 12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthase deficiency
    • 12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthase deficiency. Metabolism 1988; 37: 175-178.
    • (1988) Metabolism , vol.37 , pp. 175-178
    • Brattström, L.1    Israelsson, B.2    Lindgarde, F.3    Hultberg, B.4
  • 64
    • 0023946537 scopus 로고
    • Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis
    • Lindenbaum J, Healton EB, Savage DC, Brust JC, Garrett TJ, Podell ER et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988; 318: 1.720-1.728.
    • (1988) N Engl J Med , vol.318 , pp. 1720-1728
    • Lindenbaum, J.1    Healton, E.B.2    Savage, D.C.3    Brust, J.C.4    Garrett, T.J.5    Podell, E.R.6
  • 65
    • 0025331267 scopus 로고
    • Diagnosis of cobalamin deficiency, I. Usefulness of serum methylmalonic acid and total homocysteine concentratios
    • Allen RH, Stabler SP, Savage DG, Lindenbaum J, Diagnosis of cobalamin deficiency, I. Usefulness of serum methylmalonic acid and total homocysteine concentratios. Am J Hematol 1990; 34: 90-98.
    • (1990) Am J Hematol , vol.34 , pp. 90-98
    • Allen, R.H.1    Stabler, S.P.2    Savage, D.G.3    Lindenbaum, J.4
  • 66
    • 0023870112 scopus 로고
    • Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatographymass spectrometry
    • Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatographymass spectrometry. J Clin Invest 1988; 81: 466-474.
    • (1988) J Clin Invest , vol.81 , pp. 466-474
    • Stabler, S.P.1    Marcell, P.D.2    Podell, E.R.3    Allen, R.H.4    Savage, D.G.5    Lindenbaum, J.6
  • 67
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PWF, Rush D, Rosemberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270: 2.693-2.698.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.F.3    Rush, D.4    Rosemberg, I.H.5
  • 68
    • 0022360797 scopus 로고
    • Methionine intolerance: A possible risk factor for coronary artery disease
    • Murphy-Chutorian DR, Wexman MP, Grieco AJ. Methionine intolerance: a possible risk factor for coronary artery disease. J Am Coll Cardiol 1985; 6: 725-730.
    • (1985) J Am Coll Cardiol , vol.6 , pp. 725-730
    • Murphy-Chutorian, D.R.1    Wexman, M.P.2    Grieco, A.J.3
  • 71
    • 0025094782 scopus 로고
    • Hyperhomocyst(e)inemia in Utah siblings with early coronary disease
    • Williams RR, Malinow MR, Hunt SC. Hyperhomocyst(e)inemia in Utah siblings with early coronary disease. Ccron Artery Dis 1990; 1: 681-685.
    • (1990) Ccron Artery Dis , vol.1 , pp. 681-685
    • Williams, R.R.1    Malinow, M.R.2    Hunt, S.C.3
  • 72
    • 0028217231 scopus 로고
    • The case that hyperhomocysteinemia is a risk factor for coronary artery disease
    • Murphy-Chutorian D, Alderman EL. The case that hyperhomocysteinemia is a risk factor for coronary artery disease. Am J Cardiol 1994; 73: 705-707.
    • (1994) Am J Cardiol , vol.73 , pp. 705-707
    • Murphy-Chutorian, D.1    Alderman, E.L.2
  • 73
    • 0021752123 scopus 로고
    • Moderate homocystinemia-a posible risk factor arteriosclerotic cerebrovascular disease
    • Brattström L, Hardebo JE, Hultberg BL. Moderate homocystinemia-a posible risk factor arteriosclerotic cerebrovascular disease. Stroke 1984; 15: 1.012-1.016.
    • (1984) Stroke , vol.15 , pp. 1012-1016
    • Brattström, L.1    Hardebo, J.E.2    Hultberg, B.L.3
  • 74
    • 0025978325 scopus 로고
    • Total plasma homocysteine determination in subjects with premature cerebral vascular disease
    • Mereau-Richard C, Muller JP, Faivre E, Ardouin P, Rousseaux J, Total plasma homocysteine determination in subjects with premature cerebral vascular disease. Clin Chem 1991; 37: 126.
    • (1991) Clin Chem , vol.37 , pp. 126
    • Mereau-Richard, C.1    Muller, J.P.2    Faivre, E.3    Ardouin, P.4    Rousseaux, J.5
  • 75
    • 0026036480 scopus 로고
    • The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease
    • Taylor LM, Defrang RD, Harris EJ, Porter JM. The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease. J Vasc Surg 1991; 13: 128-136.
    • (1991) J Vasc Surg , vol.13 , pp. 128-136
    • Taylor, L.M.1    Defrang, R.D.2    Harris, E.J.3    Porter, J.M.4
  • 77
    • 0022471265 scopus 로고
    • Protein-bound homocysteine. A possible risk factor for coronary artery disease
    • Kang S, Wong PWK, Cook HY, Norusis M, Messer JV. Protein-bound homocysteine. A possible risk factor for coronary artery disease. J Clin Invest 1986; 77: 1.482-1.486.
    • (1986) J Clin Invest , vol.77 , pp. 1482-1486
    • Kang, S.1    Wong, P.W.K.2    Cook, H.Y.3    Norusis, M.4    Messer, J.V.5
  • 78
    • 0024342063 scopus 로고
    • Plasma homocysteine a risk factor for vascular disease: Plasma levels in healt, disease, and drug therapy
    • Ueland PM, Refsum H. Plasma homocysteine a risk factor for vascular disease: plasma levels in healt, disease, and drug therapy J Lab Clin Med 1989; 114: 473-501.
    • (1989) J Lab Clin Med , vol.114 , pp. 473-501
    • Ueland, P.M.1    Refsum, H.2
  • 79
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995; 346: 1.395-1.398.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 80
    • 0024465521 scopus 로고
    • Plasma sulfhydryl-containig amino acids in patients with cerebral infaction and in hypertensive subjects
    • Araki A, Sako Y, Matsumoto M, Asada T, Kita T. Plasma sulfhydryl-containig amino acids in patients with cerebral infaction and in hypertensive subjects. Atherosclerosis 1989; 79: 139-146.
    • (1989) Atherosclerosis , vol.79 , pp. 139-146
    • Araki, A.1    Sako, Y.2    Matsumoto, M.3    Asada, T.4    Kita, T.5
  • 82
    • 0027523674 scopus 로고
    • Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults
    • Malinow MR, Nieto FJ, Szklo M, Chambless LE, Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. Circulation 1993; 87: 1.107-1.113.
    • (1993) Circulation , vol.87 , pp. 1107-1113
    • Malinow, M.R.1    Nieto, F.J.2    Szklo, M.3    Chambless, L.E.4    Bond, G.5
  • 85
    • 84865895272 scopus 로고
    • Incidencia de hiperhomocisteinemia en pacientes con accidente vascular precoz. VIII congreso Nacional de la Sociedad Espan̄ola de Arteriosclerosis
    • Cordoba A, Castellvi A, Rodés M, Arboix A, Iranzo AS, Piles Marti JL et al. Incidencia de hiperhomocisteinemia en pacientes con accidente vascular precoz. VIII congreso Nacional de la Sociedad Espan̄ola de Arteriosclerosis. Clin Invest Arterioscler 1995; 7 (Supl 1): 50.
    • (1995) Clin Invest Arterioscler , vol.7 , Issue.1 SUPL , pp. 50
    • Cordoba, A.1    Castellvi, A.2    Rodés, M.3    Arboix, A.4    Iranzo, A.S.5    Piles Marti, J.L.6
  • 86
    • 0028807786 scopus 로고
    • Plasma homocysteine in ischemic stroke
    • Laghi PF, Frigerio C, Di Perri T. Plasma homocysteine in ischemic stroke. Stroke 1995; 26: 2.374-2.375.
    • (1995) Stroke , vol.26 , pp. 2374-2375
    • Laghi, P.F.1    Frigerio, C.2    Di Perri, T.3
  • 87
    • 0028100645 scopus 로고
    • Impaired homocysteine metabolism: A risk factor in young adults with atherosclerotic arterial occlusive disease of the leg
    • Aronson DC, Onkenhout W, Raben AMTJ, Oudenhoven FIJ. Impaired homocysteine metabolism: a risk factor in young adults with atherosclerotic arterial occlusive disease of the leg. Br J Surg 1994; 81: 1.114-1.118.
    • (1994) Br J Surg , vol.81 , pp. 1114-1118
    • Aronson, D.C.1    Onkenhout, W.2    Raben, A.M.T.J.3    Oudenhoven, F.I.J.4
  • 90
    • 0027200550 scopus 로고
    • Hyperhomocysteinemia in patients operated for lower extremity ischaemia below the age of 50: Effect of smoking and extent of disease
    • Bergmark C, Manssor MA, Swedenborg J, De Faire U, Svardal AM, Ueland PM. Hyperhomocysteinemia in patients operated for lower extremity ischaemia below the age of 50: effect of smoking and extent of disease. Eur J Vasc Surg 1993; 7: 391-396.
    • (1993) Eur J Vasc Surg , vol.7 , pp. 391-396
    • Bergmark, C.1    Manssor, M.A.2    Swedenborg, J.3    De Faire, U.4    Svardal, A.M.5    Ueland, P.M.6
  • 91
    • 0017284939 scopus 로고
    • The pathogenesis of coronary arteria disease. a possible role for methionine metabolism
    • Wilcken DEL, Wilcken B. The pathogenesis of coronary arteria disease. A possible role for methionine metabolism. J Clin Invest 1976; 57: 1.079-1.082.
    • (1976) J Clin Invest , vol.57 , pp. 1079-1082
    • Wilcken, D.E.L.1    Wilcken, B.2
  • 92
    • 0026034240 scopus 로고
    • Thermolabile methylene tetrahydrofolate reductase: An inherited risk factor coronary artery disease
    • Kang SS, Wong PWK, Susmano A, Sora J, Norusis M, Ruggie N, Thermolabile methylene tetrahydrofolate reductase: an inherited risk factor coronary artery disease. Am J Hum Genet 1991; 48: 536-545.
    • (1991) Am J Hum Genet , vol.48 , pp. 536-545
    • Kang, S.S.1    Wong, P.W.K.2    Susmano, A.3    Sora, J.4    Norusis, M.5    Ruggie, N.6
  • 93
    • 0023892344 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease
    • Kang SS, Wong PWK, Zhou J, Sora J, Lessick M, Ruggie N et al. Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism 1988; 37: 611-613.
    • (1988) Metabolism , vol.37 , pp. 611-613
    • Kang, S.S.1    Wong, P.W.K.2    Zhou, J.3    Sora, J.4    Lessick, M.5    Ruggie, N.6
  • 94
    • 0030006275 scopus 로고    scopus 로고
    • Molecular variant of 5,10-methylenetetrahydrofolate reductase is a risk factor of isquemic heart disease in the japanese population
    • Izumi M, Iwai N, Ohmichi N, Nakamura Y, Shimoike H, Shinoshita M. Molecular variant of 5,10-methylenetetrahydrofolate reductase is a risk factor of isquemic heart disease in the japanese population. Atherosclerosis 1996; 121: 293-294.
    • (1996) Atherosclerosis , vol.121 , pp. 293-294
    • Izumi, M.1    Iwai, N.2    Ohmichi, N.3    Nakamura, Y.4    Shimoike, H.5    Shinoshita, M.6
  • 95
    • 0028210769 scopus 로고
    • Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease
    • Wu LL, Wu J, Hunt SC, James BC, Vicent GM, Williams RR et al. Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease. Clin Chem 1994; 40: 552-561.
    • (1994) Clin Chem , vol.40 , pp. 552-561
    • Wu, L.L.1    Wu, J.2    Hunt, S.C.3    James, B.C.4    Vicent, G.M.5    Williams, R.R.6
  • 96
    • 0029088620 scopus 로고
    • Higher plasma homocyst(e)ine and icreased susceptibility to adverse effects of low folate in early familial coronary artery disease
    • Hopkinns PN, Wu LL, Wu J, Hunt SC, James BC, Vicent GM et al. Higher plasma homocyst(e)ine and icreased susceptibility to adverse effects of low folate in early familial coronary artery disease. Arterioscler Thromb Vasc Biol 1995; 15: 1.314-1.320.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1314-1320
    • Hopkinns, P.N.1    Wu, L.L.2    Wu, J.3    Hunt, S.C.4    James, B.C.5    Vicent, G.M.6
  • 97
    • 0028855901 scopus 로고
    • Hyperhomocysteinemia and low pyridoxal phosphate: Common and independent reversible risk factors for coronary artery disease
    • Robinson K, Mayer EL, Miller DP, Green R, Van Lente F, Gupta A et al. Hyperhomocysteinemia and low pyridoxal phosphate: common and independent reversible risk factors for coronary artery disease. Circulation 1995; 92: 2.825-2.830.
    • (1995) Circulation , vol.92 , pp. 2825-2830
    • Robinson, K.1    Mayer, E.L.2    Miller, D.P.3    Green, R.4    Van Lente, F.5    Gupta, A.6
  • 101
    • 0029116984 scopus 로고
    • Plasma homocysteine levels in patients with deep venous thrombosis
    • Amundsen T, Ueland PM, Waage A. Plasma homocysteine levels in patients with deep venous thrombosis. Arterioscler Thromb Vasc Biol 1995; 15: 1.321-1.323.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1321-1323
    • Amundsen, T.1    Ueland, P.M.2    Waage, A.3
  • 102
    • 0026571546 scopus 로고
    • Intrauterine growth retardation, perinatal death and maternal homocysteine levels
    • Burke G, Robinson K, Refsum H, Stuart B, Drumm J, Graham I. Intrauterine growth retardation, perinatal death and maternal homocysteine levels. N Engl J Med 1992; 326: 69-70.
    • (1992) N Engl J Med , vol.326 , pp. 69-70
    • Burke, G.1    Robinson, K.2    Refsum, H.3    Stuart, B.4    Drumm, J.5    Graham, I.6
  • 103
    • 0024496991 scopus 로고
    • Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults
    • Stary HC. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults Arteriosclerosis 1989; 9 (Supl 1): 19-32.
    • (1989) Arteriosclerosis , vol.9 , Issue.1 SUPL , pp. 19-32
    • Stary, H.C.1
  • 104
    • 0024603895 scopus 로고
    • Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
    • Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320: 915-924.
    • (1989) N Engl J Med , vol.320 , pp. 915-924
    • Steinberg, D.1    Parthasarathy, S.2    Carew, T.E.3    Khoo, J.C.4    Witztum, J.L.5
  • 107
    • 0027314719 scopus 로고
    • Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions
    • Sparrow CP, Oszewski J. Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions. J Lipid Res 1993; 34: 1.219-1.228.
    • (1993) J Lipid Res , vol.34 , pp. 1219-1228
    • Sparrow, C.P.1    Oszewski, J.2
  • 108
    • 0023664723 scopus 로고
    • The role of sulfur-containing aminoacids in Superoxide production and modification of low density lipoprotein by arterial smooth muscle cells
    • Heinecke JW, Rosen H, Suzuki LA, Chait A. The role of sulfur-containing aminoacids in Superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. J Biol Chem 1987; 262: 10.098-10 103.
    • (1987) J Biol Chem , vol.262 , pp. 10098-10103
    • Heinecke, J.W.1    Rosen, H.2    Suzuki, L.A.3    Chait, A.4
  • 109
    • 0021721459 scopus 로고
    • Iron an copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture
    • Hemecke JW, Rosen H, Chait A. Iron an copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. J Clin Invest 1984; 74: 1.890-1.894.
    • (1984) J Clin Invest , vol.74 , pp. 1890-1894
    • Hemecke, J.W.1    Rosen, H.2    Chait, A.3
  • 110
    • 84865895272 scopus 로고
    • Susceptibilidad a la oxidación de las LDL y HDL de pacientes con homocistinuria. VIII congreso Nacional de la Sociedad Espanola de Arteriosclerosis
    • Córdoba A, Sánchez JL, Rodés M, Acevedo S, Bayen E, Castellvi A et al. Susceptibilidad a la oxidación de las LDL y HDL de pacientes con homocistinuria. VIII congreso Nacional de la Sociedad Espanola de Arteriosclerosis. Clin Invest Arterioscler 1995; 7 (Supl 1): 50.
    • (1995) Clin Invest Arterioscler , vol.7 , Issue.1 SUPL , pp. 50
    • Córdoba, A.1    Sánchez, J.L.2    Rodés, M.3    Acevedo, S.4    Bayen, E.5    Castellvi, A.6
  • 111
    • 0029839284 scopus 로고    scopus 로고
    • Susceptibility to oxidation of plasma low and high-density lipoproteins to oxidation in patients with severe hyperhomocysteinemia
    • Córdoba PA, Sánchez QJL. González SF, Ordóñez LLJ, Blanco VF. Susceptibility to oxidation of plasma low and high-density lipoproteins to oxidation in patients with severe hyperhomocysteinemia. J Mol Med 1996; 74: 771-776.
    • (1996) J Mol Med , vol.74 , pp. 771-776
    • Córdoba, P.A.1    Sánchez, Q.J.L.2    González, S.F.3    Ordóñez, L.L.J.4    Blanco, V.F.5
  • 114
  • 115
    • 0026486960 scopus 로고
    • Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein (a) to fibrin: A potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism
    • Harpel PC, Chang VT, Borth W. Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein (a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism. Proc Natl Acad Sci USA 1992; 89: 10.193-10.197.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10193-10197
    • Harpel, P.C.1    Chang, V.T.2    Borth, W.3
  • 116
    • 0026492128 scopus 로고
    • Homocysteine catabolism: Levels os 3 enzymes in cultured human vascular endothelium and their relevance to vascular disease
    • Wang J, Dudman NPB, Wilcken DEL, Lynch JF. Homocysteine catabolism: levels os 3 enzymes in cultured human vascular endothelium and their relevance to vascular disease. Aterosclerosis 1992; 97: 97-106.
    • (1992) Aterosclerosis , vol.97 , pp. 97-106
    • Wang, J.1    Dudman, N.P.B.2    Wilcken, D.E.L.3    Lynch, J.F.4
  • 117
    • 0022552919 scopus 로고
    • Endothelial cell injury due to copper-catalized hydrogen peroxide generation from homocysteine
    • Stakebaum G, Harlan JM. Endothelial cell injury due to copper-catalized hydrogen peroxide generation from homocysteine. J Clin Invest 1986; 77: 1.370-1.376.
    • (1986) J Clin Invest , vol.77 , pp. 1370-1376
    • Stakebaum, G.1    Harlan, J.M.2
  • 118
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond) 1993; 362: 801-809.
    • (1993) Nature (Lond) , vol.362 , pp. 801-809
    • Ross, R.1
  • 119
    • 0025173097 scopus 로고
    • Developmental mechanisms underlying pathology of arteries
    • Schwartz SM, Heimark RL, Majesky MW. Developmental mechanisms underlying pathology of arteries. Physiol Rev 1990; 70: 1.177-1.209.
    • (1990) Physiol Rev , vol.70 , pp. 1177-1209
    • Schwartz, S.M.1    Heimark, R.L.2    Majesky, M.W.3
  • 120
    • 0021041780 scopus 로고
    • Effect of sulfinpyrazone on homocysteine-induced endothelial injury and atherosclerosis in baboons
    • Harker LA, Harlan JM, Ross R. Effect of sulfinpyrazone on homocysteine-induced endothelial injury and atherosclerosis in baboons Circ Res 1983; 53: 731-739.
    • (1983) Circ Res , vol.53 , pp. 731-739
    • Harker, L.A.1    Harlan, J.M.2    Ross, R.3
  • 122
    • 0025677250 scopus 로고
    • Intracellular thiols regulate activation of nuclear factor kB and transcription of human inmunodeficiency virus
    • Staal FJT, Roederer M, Herzenberg LA, Herzenberg LA. Intracellular thiols regulate activation of nuclear factor kB and transcription of human inmunodeficiency virus. Proc Natl Acad Sci USA 1990; 87: 9.943-9.947.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9943-9947
    • Staal, F.J.T.1    Roederer, M.2    Herzenberg, L.A.3    Herzenberg, L.A.4
  • 123
    • 0025666540 scopus 로고
    • Regulation of prolyl endopeptidase activity by the intracellular redox-state
    • Tsukahara T, Ishiura S, Sugita H. Regulation of prolyl endopeptidase activity by the intracellular redox-state. J Bioi Chem 1990; 265: 21.448-21.453.
    • (1990) J Bioi Chem , vol.265 , pp. 21448-21453
    • Tsukahara, T.1    Ishiura, S.2    Sugita, H.3
  • 124
    • 0024516594 scopus 로고
    • Oxidation-reduction and the molecular mechanism of the regulatory RNA-protein interaction
    • Hentze MW, Rouault TA, Harford JB, Klausner RD. Oxidation-reduction and the molecular mechanism of the regulatory RNA-protein interaction. Science 1989; 244: 357-359.
    • (1989) Science , vol.244 , pp. 357-359
    • Hentze, M.W.1    Rouault, T.A.2    Harford, J.B.3    Klausner, R.D.4
  • 125
    • 0018858624 scopus 로고
    • Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury
    • Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res 1980; 18: 113-121.
    • (1980) Thromb Res , vol.18 , pp. 113-121
    • Wall, R.T.1    Harlan, J.M.2    Harker, L.A.3    Striker, G.E.4
  • 126
    • 0016848034 scopus 로고
    • Antithrombin activity in homocystinuria
    • Giannini MJ, Coleman M, Inerfield I. Antithrombin activity in homocystinuria. Lancet 1975; 1: 1.094.
    • (1975) Lancet , vol.1 , pp. 1094
    • Giannini, M.J.1    Coleman, M.2    Inerfield, I.3
  • 127
    • 0023001487 scopus 로고
    • Blood coagulation changes in homocystinuria: Effects of pyridoxine and other specific theraphy
    • Palareti G, Salardi S, Piazzi S, Piazzi S, Leggnani C, Poggi M et al. Blood coagulation changes in homocystinuria: effects of pyridoxine and other specific theraphy. J Pediatr 1986; 109: 1.001-1.006.
    • (1986) J Pediatr , vol.109 , pp. 1001-1006
    • Palareti, G.1    Salardi, S.2    Piazzi, S.3    Piazzi, S.4    Leggnani, C.5    Poggi, M.6
  • 128
    • 0024403531 scopus 로고
    • Lowered antitrombina III activity and other clotting changes in homocystinuria. Effects of a pyridoxine-folate regimen
    • Palareti G, Coccheri S Lowered antitrombina III activity and other clotting changes in homocystinuria. Effects of a pyridoxine-folate regimen. Haemostasis 1989; 19 (Supl 1): 24-28.
    • (1989) Haemostasis , vol.19 , Issue.1 SUPL , pp. 24-28
    • Palareti, G.1    Coccheri, S.2
  • 130
    • 0024245618 scopus 로고
    • Antithrombin III deficiency
    • Beresford CH. Antithrombin III deficiency. Blood Rev 1988; 2: 239-250.
    • (1988) Blood Rev , vol.2 , pp. 239-250
    • Beresford, C.H.1
  • 132
    • 0028567843 scopus 로고
    • Coagulation factors and markers of activation of coagulation in homocystinuria: A study in two siblings
    • Schienle HW, Seitz R, Rohner I, Lerch L, Krumpholz B, Krauss G et al. Coagulation factors and markers of activation of coagulation in homocystinuria: a study in two siblings. Blood Coagul Fibrinolysis 1994; 5: 873-878.
    • (1994) Blood Coagul Fibrinolysis , vol.5 , pp. 873-878
    • Schienle, H.W.1    Seitz, R.2    Rohner, I.3    Lerch, L.4    Krumpholz, B.5    Krauss, G.6
  • 133
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M, Ozawa T, Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest 1993; 92: 1.381-1.386
    • (1993) J Clin Invest , vol.92 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 134
    • 0025063154 scopus 로고
    • Homocysteine uptake by human umbilical vein endothelial cells in culture
    • 1.054
    • Ewadh MJA, Tudball W, Roese FA. Homocysteine uptake by human umbilical vein endothelial cells in culture. Biochim Biophys Acta 1990; 1.054: 263-266.
    • (1990) Biochim Biophys Acta , pp. 263-266
    • Ewadh, M.J.A.1    Tudball, W.2    Roese, F.A.3
  • 135
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • Hajjar KA. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest 1993; 91: 2.873-2.879.
    • (1993) J Clin Invest , vol.91 , pp. 2873-2879
    • Hajjar, K.A.1
  • 136
    • 0026773724 scopus 로고
    • An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin espression in human umbilical vein endothelial cells
    • Hayashi T, Honda G, Suzuki K, An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin espression in human umbilical vein endothelial cells. Blood 1992; 79: 2.930-2.936.
    • (1992) Blood , vol.79 , pp. 2930-2936
    • Hayashi, T.1    Honda, G.2    Suzuki, K.3
  • 137
    • 0028796677 scopus 로고
    • Thrombomodulin and ristocetincofactor in homocystinuria: A study in two siblings
    • Schienle HW, Seitz R, Nawroth P, Rohner I, Lerch L, Krumpholz B et al. Thrombomodulin and ristocetincofactor in homocystinuria: a study in two siblings. Thromb Res 1995; 77: 79-86.
    • (1995) Thromb Res , vol.77 , pp. 79-86
    • Schienle, H.W.1    Seitz, R.2    Nawroth, P.3    Rohner, I.4    Lerch, L.5    Krumpholz, B.6
  • 138
    • 0021251182 scopus 로고
    • Synthesis of coagulation factor V by cultured aortic endothelium
    • Cereveny TJ, Fass DN, Mann KG. Synthesis of coagulation factor V by cultured aortic endothelium. Blood 1984; 63: 1.467-1.474.
    • (1984) Blood , vol.63 , pp. 1467-1474
    • Cereveny, T.J.1    Fass, D.N.2    Mann, K.G.3
  • 139
    • 0023821460 scopus 로고
    • Formation of factor Va by atherosclerotic rabbit aorta mediate factor Xa-catalized prothrombin activation
    • Rodgers GM, Kane WH, Pitas RE. Formation of factor Va by atherosclerotic rabbit aorta mediate factor Xa-catalized prothrombin activation. J Clin Invest 1988; 81: 1.911-1.919.
    • (1988) J Clin Invest , vol.81 , pp. 1911-1919
    • Rodgers, G.M.1    Kane, W.H.2    Pitas, R.E.3
  • 140
    • 0021046842 scopus 로고
    • Prothrombin is activated on vascular endothelial cells by factor Xa and calcium
    • Rodgers GM, Shuman MA. Prothrombin is activated on vascular endothelial cells by factor Xa and calcium. Proc Natl Acad Sci USA 1983; 80: 7.001-7.005.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 7001-7005
    • Rodgers, G.M.1    Shuman, M.A.2
  • 141
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (Lond) 1987; 327: 524-526.
    • (1987) Nature (Lond) , vol.327 , pp. 524-526
    • Palmer, R.M.J.1    Ferrige, A.G.2    Moncada, S.3
  • 142
    • 0023505509 scopus 로고
    • Endotheliumderived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endotheliumderived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84: 9.265-9.269.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 143
    • 0024455055 scopus 로고
    • N-acetyl-cysteine potentiates platelet inhibition by endothelium-derived relaxing factor
    • Stamler JS, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF et al. N-acetyl-cysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res 1989; 65: 789-795.
    • (1989) Circ Res , vol.65 , pp. 789-795
    • Stamler, J.S.1    Mendelsohn, M.E.2    Amarante, P.3    Smick, D.4    Andon, N.5    Davies, P.F.6
  • 144
    • 0026586147 scopus 로고
    • S-nitrosylation of protein with nitric oxide: Synthesis and characterization of biologically active compounds
    • Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T et al. S-nitrosylation of protein with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA 1992; 89: 444-448.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 444-448
    • Stamler, J.S.1    Simon, D.I.2    Osborne, J.A.3    Mullins, M.E.4    Jaraki, O.5    Michel, T.6
  • 145
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer RH, Wilson BD, Gubler DB, Fitzgerald LA, Rodgers GM. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb 1993; 13: 1.327-1.333.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1327-1333
    • Fryer, R.H.1    Wilson, B.D.2    Gubler, D.B.3    Fitzgerald, L.A.4    Rodgers, G.M.5
  • 146
    • 0025359565 scopus 로고
    • Increased prostacyclin biosynthesis in a patient with homocystinuria
    • Van Maldergem L, Capel, Boeynaems JM. Increased prostacyclin biosynthesis in a patient with homocystinuria. Eur J Pediatr 1990; 149: 666-667.
    • (1990) Eur J Pediatr , vol.149 , pp. 666-667
    • Van Maldergem, L.1    Capel2    Boeynaems, J.M.3
  • 148
    • 0023949170 scopus 로고
    • Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency. Possible implications for prevention of vascular disease
    • Wilcken DEL, Dudman NPB, Tyrrell PA, Robertson MR. Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency. Possible implications for prevention of vascular disease. Metabolism 1988; 37: 697-701.
    • (1988) Metabolism , vol.37 , pp. 697-701
    • Wilcken, D.E.L.1    Dudman, N.P.B.2    Tyrrell, P.A.3    Robertson, M.R.4
  • 150
    • 0019825844 scopus 로고
    • Homocysteine in the plasma of renal transplant recipients: Effects of cofactors for methionine metabolism
    • Wilcken DEL, Gupta VJ, Betts AK. Homocysteine in the plasma of renal transplant recipients: effects of cofactors for methionine metabolism. Clin Sci 1981; 61: 743-749.
    • (1981) Clin Sci , vol.61 , pp. 743-749
    • Wilcken, D.E.L.1    Gupta, V.J.2    Betts, A.K.3
  • 152
    • 0024359963 scopus 로고
    • Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency
    • Holme E, Kjellman B, Ronge E. Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency. Arch Dis Child 1989; 64: 1.061-1.064.
    • (1989) Arch Dis Child , vol.64 , pp. 1061-1064
    • Holme, E.1    Kjellman, B.2    Ronge, E.3
  • 153
    • 0028305415 scopus 로고
    • Adverse effects of increased dietary folate. Relation to measures to reduce the incidence of neural tube defects
    • Chanarin I. Adverse effects of increased dietary folate. Relation to measures to reduce the incidence of neural tube defects. Clin Invest Med 1994; 17: 244-252.
    • (1994) Clin Invest Med , vol.17 , pp. 244-252
    • Chanarin, I.1
  • 154
    • 0027426101 scopus 로고
    • Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: Effect of parenteral methylcobalamin treatment
    • Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993; 103: 149-157.
    • (1993) Atherosclerosis , vol.103 , pp. 149-157
    • Araki, A.1    Sako, Y.2    Ito, H.3
  • 155
    • 0024324438 scopus 로고
    • Carriership for homocystinuria in juvenile vascular disease
    • Boers GHJ. Carriership for homocystinuria in juvenile vascular disease. Haemostasis 1989; 19 (Supl 1): 29-34.
    • (1989) Haemostasis , vol.19 , Issue.1 SUPL , pp. 29-34
    • Boers, G.H.J.1
  • 156


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.