Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 4, 2009, Pages

  Schaeffer, Paul J ^a,d   DeSantiago, Jaime ^b   Yang, John ^a   Flagg, Thomas P ^a   Kovacs, Attila ^a   Weinheimer, Carla J ^a   Courtois, Michael ^a   Leone, Teresa C ^a,c   Nichols, Colin G ^a   Bers, Donald M ^b   Kelly, Daniel P ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BURNHAM INSTITUTE   (United States)

^d MIAMI UNIVERSITY   (United States)

Author keywords

Calcium signaling; Cardiac hypertrophy; Cardiac mitochondria; Excitation contraction coupling; Restrictive cardiomyopathy

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCINEURIN; CALCINEURIN B1; FATTY ACID; PHOSPHOLAMBAN; PROTEIN ATP2A2; SERINE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CARDIOMYOPATHY; CONTROLLED STUDY; FATTY ACID OXIDATION; FEMALE; HEART EXCITATION; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HISTOPATHOLOGY; MALE; MITOCHONDRION; MOUSE; MUSCLE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; VASODILATATION;

AGING; ANIMALS; CALCINEURIN; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CARDIOMYOPATHIES; CARDIOTONIC AGENTS; DOBUTAMINE; FATTY ACIDS; GENOTYPE; HEART VENTRICLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXIDATION-REDUCTION; PHENOTYPE; PHOSPHORYLATION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SERINE; SODIUM-CALCIUM EXCHANGER; THREONINE; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 70349610465     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00152.2009     Document Type: Article

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