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Volumn 19, Issue 10, 2009, Pages 790-799

Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders

Author keywords

Anorexia; Eating disorders; HTR3A; HTR3B; Serotonin; Serotonin receptor type 3

Indexed keywords

SEROTONIN 3A RECEPTOR; SEROTONIN 3B RECEPTOR;

EID: 70349560389     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32833132b3     Document Type: Article
Times cited : (39)

References (58)
  • 2
    • 0032535420 scopus 로고    scopus 로고
    • Heritability of binge-eating and broadly defined bulimia nervosa
    • Bulik CM, Sullivan PF, Kendler KS. Heritability of binge-eating and broadly defined bulimia nervosa. Biol Psychiatry 1998; 44:1210-1218.
    • (1998) Biol Psychiatry , vol.44 , pp. 1210-1218
    • Bulik, C.M.1    Sullivan, P.F.2    Kendler, K.S.3
  • 5
    • 17144470045 scopus 로고    scopus 로고
    • A controlled family study of anorexia nervosa and bulimia nervosa: Psychiatric disorders in first-degree relatives and effects of proband comorbidity
    • Lilenfeld LR, Kaye WH, Greeno CG, Merikangas KR, Plotnicov K, Pollice C, et al. A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity. Arch Gen Psychiatry 1998; 55:603-610.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 603-610
    • Lilenfeld, L.R.1    Kaye, W.H.2    Greeno, C.G.3    Merikangas, K.R.4    Plotnicov, K.5    Pollice, C.6
  • 6
    • 0034062205 scopus 로고    scopus 로고
    • Anorexia nervosa and major depression: Shared genetic and environmental risk factors
    • Wade TD, Bulik CM, Neale M, Kendler KS. Anorexia nervosa and major depression: shared genetic and environmental risk factors. Am J Psychiatry 2000; 157:469-471.
    • (2000) Am J Psychiatry , vol.157 , pp. 469-471
    • Wade, T.D.1    Bulik, C.M.2    Neale, M.3    Kendler, K.S.4
  • 7
    • 0034017433 scopus 로고    scopus 로고
    • Controlled family study of anorexia nervosa and bulimia nervosa: Evidence of shared liability and transmission of partial syndromes
    • Strober M, Freeman R, Lampert C, Diamond J, Kaye W. Controlled family study of anorexia nervosa and bulimia nervosa: evidence of shared liability and transmission of partial syndromes. Am J Psychiatry 2000; 157:393-401.
    • (2000) Am J Psychiatry , vol.157 , pp. 393-401
    • Strober, M.1    Freeman, R.2    Lampert, C.3    Diamond, J.4    Kaye, W.5
  • 8
    • 0004235298 scopus 로고
    • American Psychiatric Association Washington DC: American Psychiatric Association
    • American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders. 4th Ed.
  • 10
    • 0029400216 scopus 로고
    • Serotonin, eating behavior, and fat intake
    • Blundell JE, Lawton CL, Halford JC. Serotonin, eating behavior, and fat intake. Obes Res 1995; 3 (Suppl 4):471S-476S.
    • (1995) Obes Res , vol.3 , Issue.SUPPL. 4
    • Blundell, J.E.1    Lawton, C.L.2    Halford, J.C.3
  • 11
    • 0034110321 scopus 로고    scopus 로고
    • Separate systems for serotonin and leptin in appetite control
    • Halford JC, Blundell JE. Separate systems for serotonin and leptin in appetite control. Ann Med 2000; 32:222-232.
    • (2000) Ann Med , vol.32 , pp. 222-232
    • Halford, J.C.1    Blundell, J.E.2
  • 12
    • 0034888327 scopus 로고    scopus 로고
    • Aggression, serotonin, and seasonality
    • Brewerton TD. Aggression, serotonin, and seasonality. Am J Psychiatry 2001; 158:1335-1336.
    • (2001) Am J Psychiatry , vol.158 , pp. 1335-1336
    • Brewerton, T.D.1
  • 13
    • 0030333131 scopus 로고    scopus 로고
    • Brain serotonin, carbohydrate-craving, obesity and depression
    • Wurtman RJ, Wurtman JJ. Brain serotonin, carbohydrate-craving, obesity and depression. Adv Exp Med Biol 1996; 398:35-41.
    • (1996) Adv Exp Med Biol , vol.398 , pp. 35-41
    • Wurtman, R.J.1    Wurtman, J.J.2
  • 14
    • 0029095767 scopus 로고
    • Molecular cloning of human 5-hydroxytryptamine 3 receptor: Heterogeneity in distribution and function among species
    • Miyake A, Mochizuki S, Takemoto Y, Akuzawa S. Molecular cloning of human 5-hydroxytryptamine 3 receptor: heterogeneity in distribution and function among species. Mol Pharmacol 1995; 48:407-416.
    • (1995) Mol Pharmacol , vol.48 , pp. 407-416
    • Miyake, A.1    Mochizuki, S.2    Takemoto, Y.3    Akuzawa, S.4
  • 16
    • 0037835606 scopus 로고    scopus 로고
    • Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E
    • Niesler B, Frank B, Kapeller J, Rappold GA. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene 2003; 310:101-111.
    • (2003) Gene , vol.310 , pp. 101-111
    • Niesler, B.1    Frank, B.2    Kapeller, J.3    Rappold, G.A.4
  • 17
    • 34347253875 scopus 로고    scopus 로고
    • Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
    • Niesler B, Walstab J, Combrink S, Moller D, Kapeller J, Rietdorf J, et al. Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. Mol Pharmacol 2007; 72:8-17.
    • (2007) Mol Pharmacol , vol.72 , pp. 8-17
    • Niesler, B.1    Walstab, J.2    Combrink, S.3    Moller, D.4    Kapeller, J.5    Rietdorf, J.6
  • 18
  • 19
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132:397-414.
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 20
    • 33748922627 scopus 로고    scopus 로고
    • Serotonin 5-HT(3) receptors in the central nervous system
    • Chameau P, van Hooft JA. Serotonin 5-HT(3) receptors in the central nervous system. Cell Tissue Res 2006; 326:573-581.
    • (2006) Cell Tissue Res , Issue.326 , pp. 573-581
    • Chameau, P.1    Van Hooft, J.A.2
  • 21
    • 0025482640 scopus 로고
    • Serotonin3 receptor antagonists block anorectic responses to amino acid imbalance
    • Hammer VA, Gietzen DW, Beverly JL, Rogers QR. Serotonin3 receptor antagonists block anorectic responses to amino acid imbalance. Am J Physiol 1990; 259:R627-R636.
    • (1990) Am J Physiol , vol.259
    • Hammer, V.A.1    Gietzen, D.W.2    Beverly, J.L.3    Rogers, Q.R.4
  • 22
    • 0027972218 scopus 로고
    • Anorectic response to amino acid imbalance: A selective serotonin3 effect?
    • Jiang JC, Gietzen DW. Anorectic response to amino acid imbalance: a selective serotonin3 effect? Pharmacol Biochem Behav 1994; 47:59-63.
    • (1994) Pharmacol Biochem Behav , vol.47 , pp. 59-63
    • Jiang, J.C.1    Gietzen, D.W.2
  • 23
    • 0028278041 scopus 로고
    • Anorectic responses to dietary amino acid imbalance: Effects of vagotomy and tropisetron
    • Washburn BS, Jiang JC, Cummings SL, Dixon K, Gietzen DW. Anorectic responses to dietary amino acid imbalance: effects of vagotomy and tropisetron. Am J Physiol 1994; 266:R1922-R1927.
    • (1994) Am J Physiol , vol.266
    • Washburn, B.S.1    Jiang, J.C.2    Cummings, S.L.3    Dixon, K.4    Gietzen, D.W.5
  • 24
    • 0026604970 scopus 로고
    • Does ondansetron attenuate amphetamine-induced behaviour in human volunteers?
    • Silverstone PH, Johnson B, Cowen PJ. Does ondansetron attenuate amphetamine-induced behaviour in human volunteers? Psychopharmacology (Berl) 1992; 107:140-141.
    • (1992) Psychopharmacology (Berl) , vol.107 , pp. 140-141
    • Silverstone, P.H.1    Johnson, B.2    Cowen, P.J.3
  • 25
    • 12344262523 scopus 로고    scopus 로고
    • Ondansetron, a selective 5-HT3 antagonist, antagonizes methamphetamine-induced anorexia in mice
    • Ginawi OT, Al-Majed AA, Al-Suwailem AK. Ondansetron, a selective 5-HT3 antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol Res 2005; 51:255-259.
    • (2005) Pharmacol Res , vol.51 , pp. 255-259
    • Ginawi, O.T.1    Al-Majed, A.A.2    Al-Suwailem, A.K.3
  • 26
    • 33646358928 scopus 로고    scopus 로고
    • Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms
    • Faris PL, Eckert ED, Kim SW, Meller WH, Pardo JV, Goodale RL, et al. Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms. J Affect Disord 2006; 92:79-90.
    • (2006) J Affect Disord , vol.92 , pp. 79-90
    • Faris, P.L.1    Eckert, E.D.2    Kim, S.W.3    Meller, W.H.4    Pardo, J.V.5    Goodale, R.L.6
  • 28
    • 34548619713 scopus 로고    scopus 로고
    • Eating disorders: An overview of treatment responses and the potential impact of vulnerability genes and endophenotypes
    • Ramoz N, Versini A, Gorwood P. Eating disorders: an overview of treatment responses and the potential impact of vulnerability genes and endophenotypes. Expert Opin Pharmacother 2007; 8:2029-2044.
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 2029-2044
    • Ramoz, N.1    Versini, A.2    Gorwood, P.3
  • 29
    • 8044219683 scopus 로고    scopus 로고
    • Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa
    • Hinney A, Lentes KU, Rosenkranz K, Barth N, Roth H, Ziegler A, et al. Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa. Int J Obes Relat Metab Disord 1997; 21:224-230.
    • (1997) Int J Obes Relat Metab Disord , vol.21 , pp. 224-230
    • Hinney, A.1    Lentes, K.U.2    Rosenkranz, K.3    Barth, N.4    Roth, H.5    Ziegler, A.6
  • 31
    • 35548986357 scopus 로고    scopus 로고
    • Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia
    • Mercader JM, Ribases M, Gratacos M, Gonzalez JR, Bayes M, de Cid R, et al. Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia. Genes Brain Behav 2007; 6:706-716.
    • (2007) Genes Brain Behav , vol.6 , pp. 706-716
    • Mercader, J.M.1    Ribases, M.2    Gratacos, M.3    Gonzalez, J.R.4    Bayes, M.5    De Cid, R.6
  • 32
    • 42449113824 scopus 로고    scopus 로고
    • Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders
    • Mercader JM, Saus E, Aguera Z, Bayes M, Boni C, Carreras A, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet 2008; 17:1234-1244.
    • (2008) Hum Mol Genet , vol.17 , pp. 1234-1244
    • Mercader, J.M.1    Saus, E.2    Aguera, Z.3    Bayes, M.4    Boni, C.5    Carreras, A.6
  • 33
    • 10744223605 scopus 로고    scopus 로고
    • Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type
    • Ribases M, Gratacos M, Armengol L, de Cid R, Badia A, Jimenez L, et al. Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry 2003; 8:745-751.
    • (2003) Mol Psychiatry , vol.8 , pp. 745-751
    • Ribases, M.1    Gratacos, M.2    Armengol, L.3    De Cid, R.4    Badia, A.5    Jimenez, L.6
  • 34
    • 3042736862 scopus 로고    scopus 로고
    • Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations
    • Ribases M, Gratacos M, Fernandez-Aranda F, Bellodi L, Boni C, Anderluh M, et al. Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet 2004; 13:1205-1212.
    • (2004) Hum Mol Genet , vol.13 , pp. 1205-1212
    • Ribases, M.1    Gratacos, M.2    Fernandez-Aranda, F.3    Bellodi, L.4    Boni, C.5    Anderluh, M.6
  • 35
    • 20244381139 scopus 로고    scopus 로고
    • Association of BDNF with restricting anorexia nervosa and minimum body mass index: A family-based association study of eight European populations
    • Ribases M, Gratacos M, Fernandez-Aranda F, Bellodi L, Boni C, Anderluh M, et al. Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur J Hum Genet 2005; 13:428-434.
    • (2005) Eur J Hum Genet , vol.13 , pp. 428-434
    • Ribases, M.1    Gratacos, M.2    Fernandez-Aranda, F.3    Bellodi, L.4    Boni, C.5    Anderluh, M.6
  • 38
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 39
  • 41
    • 0029966556 scopus 로고    scopus 로고
    • Adjusting for multiple testing when reporting research results: The Bonferroni vs. Holm methods
    • Aickin M, Gensler H. Adjusting for multiple testing when reporting research results: the Bonferroni vs. Holm methods. Am J Public Health 1996; 86:726-728.
    • (1996) Am J Public Health , vol.86 , pp. 726-728
    • Aickin, M.1    Gensler, H.2
  • 43
    • 0034118493 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data
    • Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics 2000; 155:945-959.
    • (2000) Genetics , vol.155 , pp. 945-959
    • Pritchard, J.K.1    Stephens, M.2    Donnelly, P.3
  • 44
    • 0034742439 scopus 로고    scopus 로고
    • 0 UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder
    • Niesler B, Flohr T, Nothen MM, Fischer C, Rietschel M, Franzek E, et al. Association between the 50 UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder. Pharmacogenetics 2001; 11:471-475.
    • (2001) Pharmacogenetics , vol.11 , pp. 471-475
    • Niesler, B.1    Flohr, T.2    Nothen, M.M.3    Fischer, C.4    Rietschel, M.5    Franzek, E.6
  • 45
    • 17744374472 scopus 로고    scopus 로고
    • Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients
    • Niesler B, Weiss B, Fischer C, Nothen MM, Propping P, Bondy B, et al. Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients. Pharmacogenetics 2001; 11:21-27.
    • (2001) Pharmacogenetics , vol.11 , pp. 21-27
    • Niesler, B.1    Weiss, B.2    Fischer, C.3    Nothen, M.M.4    Propping, P.5    Bondy, B.6
  • 49
    • 38649128750 scopus 로고    scopus 로고
    • High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor
    • Krzywkowski K, Davies PA, Feinberg-Zadek PL, Brauner-Osborne H, Jensen AA. High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. Proc Natl Acad Sci U S A 2008; 105:722-727.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 722-727
    • Krzywkowski, K.1    Davies, P.A.2    Feinberg-Zadek, P.L.3    Brauner-Osborne, H.4    Jensen, A.A.5
  • 50
    • 53049098052 scopus 로고    scopus 로고
    • Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors
    • Walstab J, Hammer C, Bonisch H, Rappold G, Niesler B. Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors. Pharmacogenet Genomics 2008; 18:793-802.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 793-802
    • Walstab, J.1    Hammer, C.2    Bonisch, H.3    Rappold, G.4    Niesler, B.5
  • 51
    • 33749252329 scopus 로고    scopus 로고
    • The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine
    • Sugai T, Suzuki Y, Sawamura K, Fukui N, Inoue Y, Someya T. The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine. Pharmacogenomics J 2006; 6:351-356.
    • (2006) Pharmacogenomics J , vol.6 , pp. 351-356
    • Sugai, T.1    Suzuki, Y.2    Sawamura, K.3    Fukui, N.4    Inoue, Y.5    Someya, T.6
  • 52
    • 33745698343 scopus 로고    scopus 로고
    • Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression
    • Yamada K, Hattori E, Iwayama Y, Ohnishi T, Ohba H, Toyota T, et al. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biol Psychiatry 2006; 60:192-201.
    • (2006) Biol Psychiatry , vol.60 , pp. 192-201
    • Yamada, K.1    Hattori, E.2    Iwayama, Y.3    Ohnishi, T.4    Ohba, H.5    Toyota, T.6
  • 53
    • 0037868158 scopus 로고    scopus 로고
    • Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients
    • Tremblay PB, Kaiser R, Sezer O, Rosler N, Schelenz C, Possinger K, et al. Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients. J Clin Oncol 2003; 21:2147-2155.
    • (2003) J Clin Oncol , vol.21 , pp. 2147-2155
    • Tremblay, P.B.1    Kaiser, R.2    Sezer, O.3    Rosler, N.4    Schelenz, C.5    Possinger, K.6
  • 54
    • 52949108889 scopus 로고    scopus 로고
    • First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome
    • Kapeller J, Houghton LA, Monnikes H, Walstab J, Moller D, Bonisch H, et al. First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum Mol Genet 2008; 17:2967-2977.
    • (2008) Hum Mol Genet , vol.17 , pp. 2967-2977
    • Kapeller, J.1    Houghton, L.A.2    Monnikes, H.3    Walstab, J.4    Moller, D.5    Bonisch, H.6
  • 55
    • 22044431993 scopus 로고    scopus 로고
    • A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala
    • Iidaka T, Ozaki N, Matsumoto A, Nogawa J, Kinoshita Y, Suzuki T, et al. A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. J Neurosci 2005; 25:6460-6466.
    • (2005) J Neurosci , vol.25 , pp. 6460-6466
    • Iidaka, T.1    Ozaki, N.2    Matsumoto, A.3    Nogawa, J.4    Kinoshita, Y.5    Suzuki, T.6
  • 56
    • 10744223528 scopus 로고    scopus 로고
    • A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women
    • Melke J, Westberg L, Nilsson S, Landen M, Soderstrom H, Baghaei F, et al. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. Arch Gen Psychiatry 2003; 60:1017-1023.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 1017-1023
    • Melke, J.1    Westberg, L.2    Nilsson, S.3    Landen, M.4    Soderstrom, H.5    Baghaei, F.6
  • 57
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160:636-645.
    • (2003) Am J Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2


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