Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms

Journal of Affective Disorders

Volumn 92, Issue 1, 2006, Pages 79-90

  Faris, Patricia L ^a   Eckert, Elke D ^a   Kim, Suck Won ^a   Meller, William H ^a   Pardo, Jose V ^c   Goodale, Robert L ^b   Hartman, Boyd K ^a  

^a Fairview University   (United States)

^b Department of Surgery ^*  (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bulimia nervosa; Depression; Vagal pathophysiology

Indexed keywords

ONDANSETRON; PLACEBO;

ARTICLE; BECK DEPRESSION INVENTORY; BINGE EATING DISORDER; BRAIN CORTEX; BULIMIA; CINGULATE GYRUS; CLINICAL PROTOCOL; CLINICAL TRIAL; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; FRONTAL CORTEX; HUMAN; HYPOTHESIS; LABORATORY; MEAL; NERVE CONDUCTION; NERVE FUNCTION; NEUROTRANSMISSION; ORBITAL CORTEX; PAIN THRESHOLD; PARABRACHIAL NUCLEUS; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SATIETY; SENSORY NERVE CONDUCTION; STATISTICAL SIGNIFICANCE; STOMACH DISTENSION; VAGUS NERVE; VAGUS NERVE STIMULATION; VOMITING;

BULIMIA NERVOSA; DEPRESSION; HUMANS; NEURONS, AFFERENT; ONDANSETRON; PAIN; PAIN MEASUREMENT; SEROTONIN ANTAGONISTS; VAGUS NERVE;

EID: 33646358928     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2005.12.047     Document Type: Article

References (50)

1. Arakawa T., Uno H., Fukuda T., Higuchi K., Kobayashi K., and Kuroke T. New aspects of gastric adaptive relaxation, reflex after food intake for more food: involvement of capsaicin-sensitive sensory nerves and nitric oxide. J. Smooth Muscle Res. 33 (1997) 81-88
2. Blackshaw L.A., and Grundy D. Effects of 5-hydroxytryptamine (5-HT) on the discharge of vagal mechanoreceptors and motility in the upper gastrointestinal tract of the ferret. J. Auton. Nerv. Syst. 45 (1993) 51-59
3. Blundell J. Pharmacological approaches to appetite suppression. Trends Pharmacol. Sci. 12 (1991) 147-157
4. Braun D.L., Sunday S.R., and Halmi K.A. Psychiatric comorbidity in patients with eating disorders. Psychol. Med. 24 (1994) 859-867
5. Daughters R.S., Hartman B.K., Grossman A.W., Marshall A.M., and Faris P.L. Ondansetron attenuates CCK-induced satiety and c-fos labeling in the dorsal medulla. Peptides 22 (2001) 1331-1338
6. Devlin M.J., Walsh B.T., Guss J.L., Kissileff H.R., Liddle R.A., and Petkova E. Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa. Am. J. Clin. Nutr. 65 (1997) 114
7. deZwaan M., Biener D., Bach M., Schneider C., and Stacher G. Relationship between thresholds to thermally and to mechanically induced pain in patients with eating disorders and healthy subjects. Pain 67 (1996) 511-512
8. deZwaan M., Biener D., Wiesnagrotzki S., and Stacher G. Pain sensitivity, alexithymia, and depression in patients with eating disorders; are they related?. J. Psychosom. Res. 41 (1996) 65-70
9. Faris P.L., Raymond N.C., deZwaan M., Howard L.A., Eckert E.D., and Mitchell J.E. Nociceptive, but not tactile thresholds are elevated in bulimia nervosa. Biol. Psychiatry 32 (1992) 462-466
10. Faris P.L., Kim S.W., Meller W.H., Goodale R.L., Hofbauer R.D., Oakman S.A., Howard L.A., Stevens E.R., Eckert E.D., and Hartman B.K. Effect of ondansetron, a 5-HT3 receptor antagonist, on the dynamic association between bulimic behaviors and pain thresholds. Pain 77 (1998) 297-303
11. Faris P.L., Kim S.W., Meller W.H., Goodale R.L., Oakman S.A., Hofbauer R.D., Eckert E.D., and Hartman B.K. Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomized, double-blind trial. Lancet 355 (2000) 792-797
12. Freeman A.J., Cunningham K.T., and Tyers M.B. Selectivity of 5-HT3 antagonists and anti-emetic mechanisms of action. Anticancer Drugs 3 (1992) 79-85
13. Fukui H., Yamamoto M., and Sato S. Vagal afferent fibers and peripheral 5-HT3 receptors mediate cisplatin-induced emesis in dogs. Jpn. J. Pharmacol. 59 (1992) 221-226
14. Galligan J.J. Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons. Behav. Brain Res. 73 (1996) 199-201
15. Geliebter A., Melton P.M., McCray R.S., Gallagher D.R., Gage D., and Hashim S.A. Gastric capacity, gastric emptying, and test-meal intake in normal and bulimic women. Am. J. Clin. Nutr. 56 (1992) 656-661
16. Geracioti Jr. T.D., and Liddle R.A. Impaired cholecystokinin secretion in bulimia nervosa. N. Engl. J. Med. 319 (1988) 683-688
17. Girdler S.S., Koo-Loeb J., Pedersen C.A., Brown H.J., and Maixner W. Blood pressure-related hypoalgesia in bulimia nervosa. Psychosom. Med. 60 (1998) 736-743
18. Granstrom L., and Backman L. Stomach distension in extremely obese and in normal subjects. Acta Chir. Scand. 151 (1985) 367-370
19. Hadigan C.M., Walsh B.T., Devlin M.J., LaChauessee J.L., and Kissileff H.R. Behavioral assessment of satiety in bulimia nervosa. Appetite 18 (1992) 233-241
20. Halmi K.A., and Sunday S.R. Temporal patterns of hunger and fullness ratings and related cognitions in anorexia and bulimia. Appetite 16 (1991) 219-237
21. Herzog D.B., Keller M.B., Sacks N.R., Yeh C.J., and Lavori P.W. Psychiatric comorbidity in treatment-seeking anorexics and bulimics. J. Am. Acad. Child Adolesc. Psych. 31 (1992) 810-818
22. 3H] GR65630, to rat area postrema, vagus nerve, and the brains of several species. Eur. J. Pharmacol. 157 (1989) 157-164
23. Kissileff H.R., Wentzlaff T.H., Guss J.L., Walsh B.T., Devlin M.J., and Thornton J.C. A direct measure of satiety disturbance in patients with bulimia nervosa. Physiol. Behav. 60 (1996) 1077-1085
24. Krahl S.E., Clark K.B., Smith D.C., and Browning R.A. Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. Epilepsia 39 (1998) 709-714
25. Lautenbacher S., Pauls A.M., Strian F., Pirke K.M., and Krieg J.C. Pain perception in patients with eating disorders. Psychosom. Med. 52 (1990) 673-682
26. Lautenbacher S., Barth K., Friess E., Strian F., Pirke K.M., and Krieg J.C. Dieting and pain sensitivity: a validation of clinical findings. Physiol. Behav. 50 (1991) 629-631
27. Lautenbacher S., Pauls A.M., Strian F., Pirke K.M., and Krieg J.C. Pain sensitivity in anorexia nervosa and bulimia nervosa. Biol. Psychiatry 29 (1991) 1-6
28. Li Y., Hao Y., Zhu J., and Owyang C. Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats. Gastroenterology 118 (2000) 1997-2207
29. Ness T.J., Randich A., Fillingim R.B., Faught R.E., and Backensto E.M. Low intensity vagal nerve stimulation lowers human thermal pain thresholds. Pain 86 (2000) 81-85
30. Pauls A.M., Laughtenbacher S., Strian F., Pirke K.M., and Krieg J.C. Assessment of somatosensory indicators of polyneuropathy in patients with eating disorders. Eur. Arch. Psychiatry Clin. Neurosci. 241 (1991) 8-12
31. Phillips R.J., and Powley T.L. Gastric volume detection after selective vagotomies in rats. Am. J. Physiol. 274 (1998) R1626-R1638
32. Randich A., and Maixner W. {D-Ala] Methionine enkephalin-amide reflexively induces antinociception by activating vagal afferents. Pharmacol. Biochem. Behav. 21 (1984) 441-448
33. Ren K., Zhuo M., Randich A., and Gebhart G.F. Vagal afferent stimulation-produced effects on nociception in capsaicin-treated rats. J. Neurophysiol. 69 (1993) 1530-1540
34. Reynolds D.J., Leslie R.A., Grahame-Smith D.G., and Harvey J.M. Localization of 5-HT3 receptor binding sites in human dorsal vagal complex. Eur. J. Pharmacol. 174 (1989) 127-130
35. Reynolds D.J., Barber N.A., Grahame S.D., and Leslie R.A. Cisplatin-evoked induction of c-fox protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-HT3 receptor antagonist granisetron (BRL 43694). Brain Res. 565 (1991) 231-236
36. Rinaman L., Card J.P., Schwaber J.S., and Miselis R.R. Ultrastructural demonstration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat. J. Neurosci. 9 (1989) 1985-1986
37. Rissanen A., Naukkarinen H., Virkkunen M., Rawlings R.R., and Linnoila M. Fluoxetine normalizes increased cardiac vagal tone in bulimia nervosa. J. Clin. Psychopharmacol. 18 (1998) 26-32
38. Robinson P.H., McHugh P.R., Mortan T.H., and Stephenson J.D. Gastric control of food intake. J. Psychosom. Res. 32 (1988) 592-606
39. Rogers R.C., McTigue D.M., and Hermann G.E. Vagal control of digestion: modulation by central neural and peripheral endocrine factors. Neurosci. Biobehav. Rev. 20 (1996) 57-66
40. Rush A.J., George M.S., Sackeim H.A., Marangell L.B., Husain M.M., Giller C., Nahas Z., Haines S., Simpson Jr. R.K., and Goodman R. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multi-center study. Biol. Psychiatry 47 (2000) 276-286
41. Schinkel A.H., Wagenaar E., and van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 97 (1996) 2517-2524
42. Schwartz G.J., and Moran T.H. Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals. Neurosci. Biobehav. Rev. 20 (1996) 47-56
43. Schwartz G.J., Netterville L.A., McHugh P.R., and Moran T.H. Gastric loads potentiate inhibition of food intake produced by cholecystokinin analogue. Am. J. Physiol. 261 (1991) R1141-R1146
44. Simpson K.H., Murphy P., Colthup P.V., and Whelan P. Concentration of ondansetron in cerebrospinal fluid following oral dosing in volunteers. Psychopharmacology 109 (1992) 497-498
45. Skodol A.E., Oldham J.M., Hyler S.E., Kellman H.D., Doidge N., and Davies M. Comorbidity of DSM-III-R eating disorders and personality disorders. Int. J. Eat. Disord. 14 (1993) 403-416
46. Smith G.P. Animal models of human eating disorders. Ann. N.Y. Acad. Sci. 575 (1989) 63-72
47. Stephan E., Pardo J.V., Faris P.L., Hartman B.K., Kim S.W., Ivanov E.H., Daughters R.S., Costello P.A., and Goodale R.L. Functional neuroimaging of gastric distention. J. Gastrointest. Surg. 7 (2003) 740-749
48. Thurston C.L., and Randich A. Quantitative characterization and spinal substrates of antinociception produced by electrical stimulation of the subdiaphragmatic vagus in rats. Pain 44 (1991) 201-210
49. Weigert N., Li Y.Y., Schick R.R., Coy D.H., Classen M., and Schusdziarra V. Role of vagal fibers and bombesin/gastrin-releasing peptide-neurons in distention-induced gastrin release in rats. Regulatory Pept. 69 (1997) 33-40
50. Zhu J.X., Zhu X.Y., Owyang C., and Li Y. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J. Physiol. 530 (2001) 431-442