Enantioselective determination of mexiletine and its metabolites p-hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal-phase liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics

Chirality

Volumn 21, Issue 7, 2009, Pages 648-656

  Godoy, Ana Leonor Pardo ^a   Parisi, Caio Cesar ^a   Marques, Maria Paula ^a   Coelho, Eduardo Barbosa ^a   Lanchote, Vera Lucia ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Enantiomers; LC MS MS; Metabolism; Mexiletine; Pharmacokinetics; Rats

Indexed keywords

4 HYDROXYMEXILETINE; DRUG METABOLITE; HYDROXYMETHYLMEXILETINE; MEXILETINE; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RACEMIC MIXTURE; RAT; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; STEREOCHEMISTRY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA; DRUGS, CHINESE HERBAL; MALE; MASS SPECTROMETRY; MEXILETINE; QUINOXALINES; RATS; RATS, WISTAR; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY;

EID: 70349545874     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20650     Document Type: Article

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