Analysis of enantiomers of chiral phenethylamine drugs by capillary gas chromatography/mass spectrometry/flame-ionization detection and pre-column chiral derivatization

Journal of Biochemical and Biophysical Methods

Volumn 54, Issue 1-3, 2002, Pages 103-113

  Tao, Qiao Feng ^a   Zeng, Su ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b Zhejiang Provincial Institute for Drug Control   (China)

Author keywords

Chiral amine drug; Chiral derivatization; Enantiomers; Gas chromatography

Indexed keywords

AMPHETAMINE; AMPHETAMINE DERIVATIVE; FENFLURAMINE; METHAMPHETAMINE; MEXILETINE; PHENETHYLAMINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CONTROLLED STUDY; DERIVATIZATION; DRUG DETERMINATION; ENANTIOMER; ENANTIOSELECTIVITY; HUMAN; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY;

CHROMATOGRAPHY, GAS; FLAME IONIZATION; MASS SPECTROMETRY; PHENETHYLAMINES; PROLINE; SENSITIVITY AND SPECIFICITY; STAINING AND LABELING; STEREOISOMERISM;

EID: 0037207263     PISSN: 0165022X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-022X(02)00134-3     Document Type: Article

References (7)

1. Rauus A.G., Groen K. Current regulatory (draft) guidance on chiral medicinal products: Canada, EEC, Japan, United States. Chirality. 6:1994;72-75.
2. Yao T.W., Zeng S., Wang T.W., Chen S.Q. Phenotype analysis of cytochrome P450 2C19 in Chinese subjects with mephenytoin S/R enantiomeric ratio in urine measured by chiral GC. Biomed. Chromatogr. 15:2001;9-13.
3. Li X., Zeng S. Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in rat hepatic microsome after chiral derivatization with 2,3,4,6-tetra-O-acetyl-β-D-glycopyranosyl isothiocyanate. J. Chromatogr., B. 742:2000;433-439.
4. Yao T.W., Zhou Q., Zeng S. Stereoselective determination of propafenone enantiomers in transgenic Chinese hamster CHL cells expressing human cytochrome P450. Biomed. Chromatogr. 14:2000;498-501.
5. Zeng S., Zhong J., Pan L. HPLC separation and quantitation of ofloxacin enantiomers in rat microsomes. J. Chromatogr., B. 728:1999;151-155.
6. Yao T.W., Zeng S. Stereoselective determination of p-hydroxyphenylphenylhydantoin enantiomers in rat liver microsomal incubates by RP-HPLC using β-cyclodextrin as chiral mobile phase additives. Biomed. Chromatogr. 15:2001;141-144.
7. S. Zeng, Separation and assay of the enantiomers of some chiral drugs by chiral chromatography. PhD dissertation, Dec. 1999, Zhejiang University.