High-performance liquid chromatographic determination of mexiletine enantiomers in plasma using direct and indirect enantioselective separations

Journal of Chromatography B: Biomedical Applications

Volumn 685, Issue 2, 1996, Pages 281-289

  Lanchote, Vera Lucia ^a   Bonato, Pierina Sueli ^a   Dreossi, Sônia A C ^a   Gonçalves, Paulo V B ^a   Cesarino, Evandro J ^a   Bertucci, Carlo ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Enantiomer separation; Mexiletine

Indexed keywords

MEXILETINE;

ADULT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; ENANTIOMER; EXTRACTION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTERMETHOD COMPARISON; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TECHNIQUE;

ADMINISTRATION, ORAL; ADULT; ANTI-ARRHYTHMIA AGENTS; CAPSULES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCADIAN RHYTHM; CYSTEINE; HUMANS; INDICATORS AND REAGENTS; LINEAR MODELS; MALE; MEXILETINE; NAPHTHALENES; O-PHTHALALDEHYDE; OSMOLAR CONCENTRATION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM;

EID: 0030601749     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00195-8     Document Type: Article

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