The EP1 subtype of prostaglandin E2 receptor: Role in keratinocyte differentiation and expression in non-melanoma skin cancer

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 81, Issue 4, 2009, Pages 279-290

  Konger, R L ^a   Billings, S D ^a   Prall, N C ^a   Katona, T M ^a   DaSilva, S C ^a   Kennedy, C R J ^b   Badve, S ^a   Perkins, S M ^a   LaCelle, P T ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Calcium mobilization; EP1 subtype of prostaglandin E2 receptor; Keratinocyte differentiation; Non melanoma skin cancer

Indexed keywords

CYTOKERATIN; CYTOKERATIN K10; EP1 RECEPTOR; PROSTAGLANDIN E RECEPTOR; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; UNCLASSIFIED DRUG; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; 6-ISOPROPOXY-9-OXOXANTHENE-2-CARBOXYLIC ACID; CALCIUM; PROSTANOID RECEPTOR EP1; XANTHONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL DIFFERENTIATION; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; EPIDERMIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; SECOND MESSENGER; SKIN CANCER; SKIN CELL; SPINDLE CELL CARCINOMA; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CLASSIFICATION; CYTOLOGY; DRUG ANTAGONISM; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN TUMOR; TUMOR CELL CULTURE;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; RECEPTORS, PROSTAGLANDIN E; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TUMOR CELLS, CULTURED; XANTHONES;

EID: 70349509150     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2009.05.025     Document Type: Article

References (49)

1. Jakobsson P.J., Thoren S., Morgenstern R., and Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. USA 96 (1999) 7220-7225
2. Pentland A.P., and Needleman P. Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis. J. Clin. Invest. 77 (1986) 246-251
3. Breyer R.M., Bagdassarian C.K., Myers S.A., and Breyer M.D. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 661-690
4. Hatae N., Sugimoto Y., and Ichikawa A. Prostaglandin receptors: advances in the study of EP3 receptor signaling. J. Biochem. 131 (2002) 781-784
5. Abramovitz M., Adam M., Boie Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim. Biophys. Acta 1483 (2000) 285-293
6. Neufang G., Furstenberger G., Heidt M., Marks F., and Muller-Decker K. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc. Natl. Acad. Sci. USA 98 (2001) 7629-7634
7. Tiano H.F., Loftin C.D., Akunda J., et al. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 62 (2002) 3395-3401
8. Evans C.B., Pillai S., and Goldyne M.E. Endogenous prostaglandin E2 modulates calcium-induced differentiation in human skin keratinocytes. Prostaglandins Leukotrienes Essent. Fatty Acids 49 (1993) 777-781
9. Leong J., Hughes-Fulford M., Rakhlin N., Habib A., Maclouf J., and Goldyne M.E. Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. Exp. Cell Res. 224 (1996) 79-87
10. Konger R.L., Malaviya R., and Pentland A.P. Growth regulation of primary human keratinocytes by prostagandin E receptor EP2 and EP3 subtypes. Biochim. Biophys. Acta 1401 (1998) 221-234
11. Konger R.L., Scott G.A., Landt Y., Ladenson J.H., and Pentland A.P. Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression. Am. J. Pathol. 161 (2002) 2065-2078
12. Brouxhon S., Konger R.L., VanBuskirk J., et al. Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness. J. Invest. Dermatol. 127 (2007) 439-446
13. 3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes. Exp. Dermatol. 14 (2005) 914-922
14. 2, in adult human epidermis. J. Invest. Dermatol. 124 (2005) 965-970
15. Lee J.L., Kim A., Kopelovich L., Bickers D.R., and Athar M. Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. J. Invest. Dermatol. 125 (2005) 818-825
16. 1 subtype. J. Biol. Chem. 268 (1993) 26767-26772
17. Rys-Sikora K.E., Konger R.L., Schoggins J.W., Malaviya R., and Pentland A.P. Coordinate expression of secretory phospholipase A2 and cyclooxygenase-2 in activated human keratinocytes. Am. J. Physiol. Cell Physiol. 278 (2000) C822-C833
18. Konger R.L., and Chan T.C. Epidermal growth factor induces terminal differentiation in human epidermoid carcinoma cells. J. Cell. Physiol. 156 (1993) 515-521
19. Rahal S., McVeigh L.I., Zhang Y., Guan Y., Breyer M.D., and Kennedy C.R.J. Increased severity of renal impairment in nephritic mice lacking the EP1 receptor. Can. J. Physiol. Pharmacol. 84 (2006) 877-885
20. Tripp C.S., Blomme E.A.G., Chinn K.S., Hardy M.M., LaCelle P., and Pentland A.P. Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection. J. Invest. Dermatol. 121 (2003) 853-861
21. Kolly C., Suter M.M., and Muller E.J. Proliferation, cell cycle exit, and onset of terminal differentiation in cultured keratinocytes: pre-programmed pathways in control of C-Myc and notch1 prevail over extracellular calcium signals. J. Invest. Dermatol. 124 (2005) 1014-1025
22. Lee Y.S., Yuspa S.H., and Dlugosz A.A. Differentiation of cultured human epidermal keratinocytes at high cell densities is mediated by endogenous activation of the protein kinase C signaling pathway. J. Invest. Dermatol. 111 (1998) 762-766
23. Narumiya S., Sugimoto Y., and Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79 (1999) 1193-1226
24. Travers J.B., Huff J.C., Rola-Pleszczynski M., Gelfand E.W., Morelli J.G., and Murphy R.C. Identification of functional platelet-activating factor receptors on human keratinocytes. J. Invest. Dermatol. 105 (1995) 816-823
25. 3b for correct sorting to the plasma membrane but not for correct folding. Biochem. J. 350 (2000) 839-847
26. 2 receptor function. Mol. Pharmacol. 56 (1999) 545-551
27. Salahpour A., Bonin H., Bhalla S., Petaja-Repo U., and Bouvier M. Biochemical characterization of b2-adrenergic receptor dimers and oligomers. Biol. Chem. 384 (2003) 117-123
28. Milligan G. G protein-coupled receptor dimerization: function and ligand pharmacology. Mol. Pharmacol. 66 (2004) 1-7
29. Breitwieser G.E. G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling. Circ. Res. 94 (2004) 17-27
30. 1 prostanoid receptor. Mol. Pharmacol. 59 (2001) 1446-1456
31. KaurA. Li P. Adhesive properties of human basal epidermal cells: an analysis of keratinocyte stem cells, transit amplifying cells, and postmitotic differentiating cells. J. Invest. Dermatol. 114 (2000) 413-420
32. Polakowska R.R., Graf B.A., Falciano V., and LaCelle P. Transcription regulatory elements of the first intron control human transglutaminase type I gene expression in epidermal keratinocytes. J. Cell. Biochem. 73 (1999) 355-369
33. Bhattacharya M., Peri K.G., Almazan G., et al. Nuclear localization of prostaglandin E2 receptors. Proc. Natl. Acad. Sci. USA 95 (1998) 15792-15797
34. Bhattacharya M., Varma D.R., and Chemtob S. Nuclear prostaglandin receptors. Gene Ther. Mol. Biol. 4 (1999) 323-338
35. Zhu T., Gobeil F., Vazquez-Tello A., et al. Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. Can. J. Physiol. Pharmacol. 84 (2006) 377-391
36. Gobeil Jr. F., Vazquez-Tello A., Marrache A.M., et al. Nuclear prostaglandin signaling system: biogenesis and actions via heptahelical receptors. Can. J. Physiol. Pharmacol. 81 (2003) 196-204
37. Thorat M.A., Morimiya A., Mehrotra S., Konger R., and Badve S.S. Prostanoid receptor EP1 expression in breast cancer. Mod. Pathol. 21 (2008) 15-21
38. Lord J.T., and Ziboh V.A. Specific binding of prostaglandin E2 to membrane preparations from human skin: receptor modulation by UVB-irradiation and chemical agents. J. Invest. Dermatol. 73 (1979) 373-377
39. Hennings H., Michael D., Cheng C., Steinert P., Holbrook K., and Yuspa S.H. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19 (1980) 245-254
40. van Rodijnen W.F., Korstjens I.J., Legerstee N., ter Wee P.M., and Tangelder G.-J. Direct vasoconstrictor effect of prostaglandin E2 on renal interlobular arteries: role of the EP3 receptor. Am. J. Physiol. Renal. Physiol. 292 (2007) F1094-F1101
41. 2 release from macula densa cells. J. Clin. Invest. 112 (2003) 76-82
42. 2 receptor subtype 1 targeting. J. Clin. Invest. 117 (2007) 2496-2505
43. Tezuka T., and Takahashi T. Human hematoxylin-stainable protein of keratohyalin granules origin. I. Extraction and purification. J. Invest. Dermatol. 89 (1987) 400-404
44. Tober K.L., Thomas-Ahner J.M., Kusewitt D.F., and Oberyszyn T.M. Effects of UVB on E prostanoid receptor expression in murine skin. J. Invest. Dermatol. 127 (2007) 214-221
45. Neumann M., Dulsner E., Furstenberger G., and Muller-Decker K. The expression pattern of prostaglandin E synthase and EP receptor isoforms in normal mouse skin and preinvasive skin neoplasms. Exp. Dermatol. 16 (2007) 445-453
46. Morita I., Schindler M., Regier M.K., et al. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem. 270 (1995) 10902-10908
47. Rangarajan A., Talora C., Mammucari C., et al. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20 (2001) 3427-3436
48. Schlotzer-Schrehardt U., Zenkel M., and Nusing R.M. Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues. Invest. Ophthalmol. Vis. Sci. 43 (2002) 1475-1487
49. Bhattacharya M., Peri K., Ribeiro-da-Silva A., et al. Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope. J. Biol. Chem. 274 (1999) 15719-15724