Importance of the extracellular domain for prostaglandin EP2 receptor function

Molecular Pharmacology

Volumn 56, Issue 3, 1999, Pages 545-551

  Stillman, Brett A ^a   Breyer, Matthew D ^a   Breyer, Richard M ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTANOID;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL STRAIN COS1; CELLULAR DISTRIBUTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

EID: 0032819107     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.3.545     Document Type: Article

References (36)

1. 3 receptor is an essential determinant of ligand selectivity. J Biol Chem 272: 13475-13478.
2. 3 receptor. Mol Pharmacol 51:61-68.
3. 4 subtype is essential for agonist-induced desensitization. Mol Pharmacol 51:343-349.
4. 2 subtype. J Biol Chem 269:11873-11877.
5. Bergwitz C, Gardella TJ, Rlannery MR, Potts JT, Kronenberg HM, Goldring SR and Juppner H (1996) Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. J Biol Chem 271:26469-26472.
6. 2 receptor. J Biol Chem 269:6163-6169.
7. 50) of and enzymatic reaction. Biochem Pharmacol 22:3099-3108.
8. Coleman RA, Smith WL and Narumiya S (1994) International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46:205-229.
9. D'Angelo D, Eubank J, Davis M and Dorn G, II (1996) Mutagenic analysis of platelet thromboxane receptor cysteines. J Biol Chem 271:6233-6240.
10. Dixon RAF, IS S, Candelore MR, Register RB, Scattergood W, Rands E and Strader CD (1987) Structural features required for ligand binding to the β-adrenergic receptor. EMBO J 6:3269-3275.
11. Fong TM, Huang RC and Strader CD (1992a) Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor. J Biol Chem 267:25664-25667.
12. Fong TM, Yu H, Huang RC and Strader CD (1992b) The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides. Biochemistry 31:11806-11811.
13. Frielle T, Daniel KW, Caron MG and Lefkowitz RJ (1988) Structural basis of β-adrenergic receptor subtype specificity studied with chimeric β1/β2-adrenergic receptors. Proc Natl Acad Sci USA 85:9494-9498.
14. 1 subtype. J Biol Chem 268:26767-26772.
15. Gerszten RE, Chen J, Ishii M, Ishii K, Wang L, Nanevicz T, Turck CW, Vu TH and Coughlin SR (1994) Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature (Lond) 368:648-651.
16. Higuchi R. (1989) Using PCR to engineer DNA, in PCR Technology: Principles and Applications for DNA Amplification (H. A. Erlich, ed.) pp 61-70, Stockton Press, New York.
17. 1 receptor. J Biol Chem 269:30953-30959.
18. Honda A, Sugimoto Y, Namba T, Watabe A, Irie A, Negishi M, Narumiya S and Ichikawa A (1993) Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype. J Biol Chem 268:7759-7762.
19. Howl J and Wheatley M (1996) Molecular recognition of peptide and non-peptide ligands by the extracellular domains of neurohypophysial hormone receptors. Biochem J 317:577-582.
20. 3α subtype. Arch Biochem and Biophys 327:161-166.
21. Huang RC, Yu H, Strader CD and Fong TM (1994) Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor. Biochemistry 33:3007-3013.
22. Ji T, Grossmann M and Ji I (1998) G protein coupled receptors: I. Diversity of receptor-ligand interactions. J Biol Chem 273:17299-17302.
23. Kedzie K, Donello J, Krauss H, Regan J and Gil D (1998) A single amino-acid substitution in the EP2 prostaglandin receptor confers responsiveness to prosta-cyclin analogs. Mol Pharmacol 54:584-590.
24. Kobilka BK, Kobilka TS, Daniel K, Regan JW, Caron MG and Lefkowitz RJ (1988) Chimeric α2-β2-adrenergic receptors: Delineation of domains involved in effector coupling and ligand binding specificity. Science (Wash DC) 240:1310-1316.
25. Kolakowski LF (1994) GCRDb: A G-protein-coupled receptor database. Recept Channels 2:1-7.
26. 3 determines G-protein specificity. Nature (Lond) 365:166-170.
27. s through interactions of α-carboxylic acid of agonist and arginine residue of seventh transmembrane domain. J Biol Chem 270:16122-16127.
28. s-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol Pharmacol 60:1031-1037.
29. Pan Y, Wilson P and Gitschier J (1994) The effect of eight V2 vasopressin receptor mutations on stimulation of adenylyl cyclase and binding to vasopressin. J Biol Chem 269:31933-31937.
30. 2 subtype. Mol Pharmacol 46:213-220.
31. 3 receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. J Neurochem 67:212-219.
32. Savarese TM and Fraser CM (1992) In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem J 283:1-19.
33. Schoneberg T, Liu J and Wess J (1995) Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor. J Biol Chem 270:1-7.
34. Stillman B, Audoly L and Breyer RM (1998) A conserved threonine in the second extracellular loop of the human EP2 and EP4 receptors is required for ligand binding. Eur J Pharmacol 357:73-82.
35. Yokota Y, Akazawa C, Ohkubo H and Nakanishi S (1992) Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors. EMBO J 11:3585-3591.
36. 2-adrenergic receptor can modulate receptor/G protein affinity. Mol Pharmacol 53:524-529.