Cholesterol-dependent regulation of adenosine A2A receptor-mediated anion secretion in colon epithelial cells

Experimental Cell Research

Volumn 315, Issue 17, 2009, Pages 3028-3035

  Lam, Rebecca S ^a   Nahirney, Drew ^a   Duszyk, Marek ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anion secretion; Co immunoprecipitation; Colonic epithelia; Short circuit current

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; ANION; CALCIUM CHANNEL; CHOLESTEROL; CYCLIC AMP; FILIPIN; METHYL BETA CYCLODEXTRIN; POTASSIUM CHANNEL; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; ELECTRIC CURRENT; EPITHELIUM CELL; LIPID MEMBRANE; LIPID RAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION;

EID: 70349443679     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.06.005     Document Type: Article

References (49)

1. Gimpl G., Burger K., and Fahrenholz F. Cholesterol as modulator of receptor function. Biochemistry 36 (1997) 10959-10974
2. Niu S.L., Mitchell D.C., and Litman B.J. Manipulation of cholesterol levels in rod disk membranes by methyl-β-cyclodextrin: effects on receptor activation. J. Biol. Chem. 277 (2002) 20139-20145
3. Hinzpeter A., Fritsch J., Borot F., Trudel S., Vieu D.L., Brouillard F., Baudouin-Legros M., Clain J., Edelman A., and Ollero M. Membrane cholesterol content modulates ClC-2 gating and sensitivity to oxidative stress. J. Biol. Chem. 282 (2007) 2423-2432
4. Romanenko V., Fang Y., Byfield F., Travis A.J., Vandenberg C.A., Rothblat G.H., and Levitan I. Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys. J. 87 (2004) 3850-3861
5. Bastiaanse E.M.L., Hold K.M., and Van der Laarse A. The effect of membrane cholesterol content on ion transport processes in plasma membranes. Cardiovasc. Res. 33 (1997) 272-283
6. Edidin M. The state of lipid rafts: from model membranes to cells. Annu. Rev. Biophys. Biomol. Struct. 32 (2003) 257-283
7. Lam R.S., Shaw A.R., and Duszyk M. Membrane cholesterol content modulates activation of BK channels in colonic epithelia. Biochim. Biophys. Acta (BBA) - Biomembr. 1667 (2004) 241-248
8. Bucheimer R.E., and Linden J. Purinergic regulation of epithelial transport. J. Physiol. (Lond.) 555 (2004) 311-321
9. Fredholm B.B., IJzerman A.P., Jacobson K.A., Klotz K.N., and Linden J. International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53 (2001) 527-552
10. Peng Z., Borea P.A., Wilder T., Yee H., Chiriboga L., Blackburn M.R., Azzena G., Resta G., and Cronstein B.N. Adenosine signaling contributes to ethanol-induced fatty liver in mice. J. Clin. Invest. 119 (2009) 582-594
11. Barrett K.E., Huott P.A., Shah S.S., Dharmsathaphorn K., and Wasserman S.I. Differing effects of apical and basolateral adenosine on colonic epithelial cell line T84. Am. J. Physiol. Cell Physiol. 256 (1989) C197-C203
12. Nyce J.W. Insight into adenosine receptor function using antisense and gene-knockout approaches. Trends Pharmacol. Sci. 20 (1999) 79-83
13. Lazarowski E.R., Mason S.J., Clarke L., Harden T.K., and Boucher R.C. Adenosine receptors on human airway epithelia and their relationship to chloride secretion. Br. J. Pharmacol. 106 (1992) 774-782
14. Rugolo M., Mastrocola T., Whorle C., Rasola A., Gruenert D.C., Romeo G., and Galietta L.J. ATP and A1 adenosine receptor agonists mobilize intracellular calcium and activate K+ and Cl- currents in normal and cystic fibrosis airway epithelial cells. J. Biol. Chem. 268 (1993) 24779-24784
15. Warth R., and Barhanin J. Function of K+ channels in the intestinal epithelium. J. Membr. Biol. 193 (2003) 67-78
16. Heitzmann D., and Warth R. Physiology and pathophysiology of potassium channels in gastrointestinal epithelia. Physiol. Rev. 88 (2008) 1119-1182
17. Smith P.L., and Frizzell R.A. Chloride secretion by canine tracheal epithelium: IV. Basolateral membrane K permeability parallels secretion rate. J. Membr. Biol. 77 (1984) 187-199
18. - secretion by α2-adrenergic receptors in mouse colonic epithelium. J. Physiol. (Lond.) 548 (2003) 475-484
19. Duta V., Szkotak A.J., Nahirney D., and Duszyk M. The role of bestrophin in airway epithelial ion transport. FEBS Lett. 577 (2004) 551-554
20. Gao Z., Li Z., Baker S.P., Lasley R.D., Meyer S., Elzein E., Palle V., Zablocki J.A., Blackburn B., and Belardinelli L. Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists. J. Pharmacol. Exp. Ther. 298 (2001) 209-218
21. Drab M., Verkade P., Elger M., Kasper M., Lohn M., Lauterbach B., Menne J., Lindschau C., Mende F., Luft F.C., Schedl A., Haller H., and Kurzchalia T.V. Loss of caveolae, vascular dysfunction, and pulmonary defects in Caveolin-1 gene-disrupted mice. Science 293 (2001) 2449-2452
22. Munro S. Lipid rafts: elusive or illusive?. Cell. 115 (2003) 377-388
23. Simons K., and Vaz W.L.C. Model systems, lipid rafts, and cell membranes. Annu. Rev. Biophys. Biomol. Struct. 33 (2004) 269-295
24. Brown D.A., and Rose J.K. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68 (1992) 533-544
25. Smart E.J., Ying Y.S., Mineo C., and Anderson R.G. A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 10104-10108
26. Davare M.A., Avdonin V., Hall D.D., Peden E.M., Burette A., Weinberg R.J., Horne M.C., Hoshi T., and Hell J.W. A β2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science 293 (2001) 98-101
27. Hansen G.H., Immerdal L., Thorsen E., Niels-Christiansen L.L., Nystrom B.T., Demant E.J.F., and Danielsen E.M. Lipid rafts exist as stable cholesterol-independent microdomains in the brush border membrane of enterocytes. J. Biol. Chem. 276 (2001) 32338-32344
28. Zidovetzki R., and Levitan I. Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochim. Biophys. Acta (BBA) - Biomembr. 1768 (2007) 1311-1324
29. Barenholz Y. Sphingomyelin and cholesterol: from membrane biophysics and rafts to potential medical applications. Subcell Biochem. 37 (2004) 167-215
30. Needham D., and Nunn R.S. Elastic deformation and failure of lipid bilayer membranes containing cholesterol. Biophys. J. 58 (1990) 997-1009
31. Rodal S.K., Skretting G., Garred O., Vilhardt F., van Deurs B., and Sandvig K. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol. Biol. Cell 10 (1999) 961-974
32. Pike L.J., and Casey L. Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking. Biochemistry 41 (2002) 10315-10322
33. Shigematsu S., Watson R.T., Khan A.H., and Pessin J.E. The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4. J. Biol. Chem. 278 (2003) 10683-10690
34. Byfield F.J., Hoffman B.D., Romanenko V., Fang Y., Crocker J.C., and Levitan I. Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. Acta Physiol. 187 (2006) 285-294
35. Sharma D.K., Brown J.C., Choudhury A., Peterson T.E., Holicky E., Marks D.L., Simari R., Parton R.G., and Pagano R.E. Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol. Mol. Biol. Cell 15 (2004) 3114-3122
36. Ying M., Grimmer S., Iversen T.G., Van Deurs B., and Sandvig K. Cholesterol loading induces a block in the exit of VSVG from the TGN. Traffic 4 (2003) 772-784
37. Canals M., Burgueno J., Marcellino D., Cabello N., Canela E.I., Mallol J., Agnati L., Ferre S., Bouvier M., Fuxe K., Ciruela F., Lluis C., and Franco R. Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J. Neurochem. 88 (2004) 726-734
38. Ca3.1 (SK4) and KV7.1 (KCNQ1) channels in mouse colonic Cl- secretion. Acta Physiol. 189 (2007) 251-258
39. Wang H.S., Brown B.S., McKinnon D., and Cohen I. Molecular basis for differential sensitivity of KCNQ and IKs channels to the cognitive enhancer XE991. Mol. Pharmacol. 57 (2000) 1218-1223
40. Rufo P.A., Merlin D., Riegler M., Ferguson-Maltzman M.H., Dickinson B.L., Brugnara C., Alper S.L., and Lencer W.I. The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. J. Clin. Invest. 100 (1997) 3111-3120
41. + channels and membrane fluidity in vascular smooth muscle cells. Pflugers Arch. 415 (1989) 262-268
42. Seifert R., and Dove S. Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities. Mol. Pharmacol. 75 (2009) 13-18
43. Zheng H., Chu J., Qiu Y., Loh H.H., and Law P.Y. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 9421-9426
44. McIntire W.E., MacCleery G., and Garrison J.C. The G protein β subunit is a determinant in the coupling of Gs to the β1-adrenergic and A2a adenosine receptors. J. Biol. Chem. 276 (2001) 15801-15809
45. Davare M.A., Avdonin V., Hall D.D., Peden E.M., Burette A., Weinberg R.J., Horne M.C., Hoshi T., and Hell J.W. A β2 adrenergic receptor signaling complex assembled with the Ca2+ Channel Cav1.2. Science 293 (2001) 98-101
46. Lavine N., Ethier N., Oak J.N., Pei L., Liu F., Trieu P., Rebois R.V., Bouvier M., Hebert T.E., and Van Tol H.H.M. G Protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J. Biol. Chem. 277 (2002) 46010-46019
47. Lu H., Chen C., and Klaassen C. Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice. Drug Metab. Dispos. 32 (2004) 1455-1461
48. Ward J.L., and Tse C.M. Nucleoside transport in human colonic epithelial cell lines: evidence for two Na+-independent 1transport systems in T84 and Caco-2 cells. Biochim. Biophys. Acta (BBA) - Biomembr. 1419 (1999) 15-22
49. Szkotak A.J., Ng A.M.L., Sawicka J., Baldwin S.A., Man S.F.P., Cass C.E., Young J.D., and Duszyk M. Regulation of K+ current in human airway epithelial cells by exogenous and autocrine adenosine. Am. J. Physiol. Cell Physiol. 281 (2001) C1991-C2002