Pathophysiology of anorexia of aging;Physiopathologie de l'anorexie liée à l'âge

Nutrition Clinique et Metabolisme

Volumn 23, Issue 3, 2009, Pages 118-123

  Fetissov, Sergueï O ^a   Petit, André ^a   Déchelotte, Pierre ^a  

^a Faculté de Médecine Pharmacie   (France)

Author keywords

Appetite; Autoantibodies; Food intake; Geriatrics; Gut; Hormones; Microflora; Neuropeptides; Nutrition

Indexed keywords

ALPHA INTERMEDIN; ANABOLIC AGENT; GHRELIN; GROWTH HORMONE; NEUROPEPTIDE Y;

AGING; ANOREXIA; DISEASE PREDISPOSITION; FOOD INTAKE; FRAIL ELDERLY; HUMAN; IMMUNE SYSTEM; INTESTINE FLORA; INTESTINE FUNCTION; MICROBIAL CONTAMINATION; MORTALITY; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 70349437188     PISSN: 09850562     EISSN: 17683092     Source Type: Journal    
DOI: 10.1016/j.nupar.2009.05.001     Document Type: Review

References (75)

1. Aloia J.F., Vaswani A., Ma R., and Flaster E. Aging in women: the four-compartment model of body composition. Metabolism (1996) 45
2. Chumlea W.C., Garry P.J., Hunt W.C., and Rhyne R.L. Distributions of serial changes in stature and weight in a healthy elderly population. Hum Biol 60 (1988) 917-925
3. Sjogren A., Osterberg T., and Steen B. Intake of energy, nutrients and food items in a ten-year cohort comparison and in a six-year longitudinal perspective: a population study of 70- and 76-year-old Swedish people. Age Ageing 23 (1994) 108-112
4. Lesser S., Pauly L., Volkert D., and Stehle P. Nutritional situation of the elderly in Eastern/Baltic and Central/Western Europe: the Ageing Nutrition Project. Ann Nutr Metab 52 Suppl. 1 (2008) 62-71
5. Roberts S.B., Fuss P., Heyman M.B., Evans W.J., Tsay R., Rasmussen H., et al. Control of food intake in older men. JAMA 272 (1994) 1601-1606
6. Morley J.E. Anorexia of aging: physiologic and pathologic. Am J Clin Nutr 66 (1997) 760-773
7. Volkert D., Berner Y.N., Berry E., Cederholm T., Coti Bertrand P., Milne A., et al. ESPEN guidelines on enteral nutrition: Geriatrics. Clin Nutr 25 (2006) 330-360
8. Dey D.K., Rothenberg E., Sundh V., Bosaeus I., and Steen B. Body mass index, weight change and mortality in the elderly. A 15-year longitudinal population study of 70-year-olds. Eur J Clin Nutr 55 (2001) 482-492
9. Mair W., and Dillin A. Aging and survival: the genetics of lifespan extension by dietary restriction. Annu Rev Biochem 77 (2008) 727-754
10. Wolden-Hanson T. Mechanisms of the anorexia of aging in the Brown Norway rat. Physiol Behav 88 (2006) 267-276
11. Gruenewald D.A., Marck B.T., and Matsumoto A.M. Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male Brown Norway rats. Endocrinology 137 (1996) 4460-4467
12. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
13. Berthoud H.-R. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil 20 (2008) 64-72
14. Hillebrand J.J., de Wied D., and Adan R.A. Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides 23 (2002) 2283-2306
15. Kishi T., and Elmquist J.K. Body weight is regulated by the brain: a link between feeding and emotion. Mol Psychiatry 10 (2005) 132-146
16. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
17. Fetissov S.O., Hallman J., Oreland L., af Klinteberg B., Grenbäck E., Hulting A.L., et al. Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients. Proc Natl Acad Sci U S A 99 (2002) 17155-17160
18. Hamze Sinno M, Do Rego JC, Coëffier M, Bole-Feysot C, Ducrotte P, Gilbert D, et al. Regulation of feeding and anxiety by α-MSH reactive autoantibodies. Psychoneuroendocrinology 2008, doi: 10.1016/j.psyneuen.2008.08.021.
19. Fetissov S.O., Hamze Sinno M., Coëffier M., Bole-Feysot C., Ducrotté P., Hökfelt T., et al. Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora. Nutrition 24 (2008) 348-359
20. Sohn E.H., Wolden-Hanson T., Matsumoto A.M., and Testosterone. (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male Brown Norway rats: Contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression. Endocrinology 143 (2002) 954-963
21. Kaneda T., Makino S., Nishiyama M., Asaba K., and Hashimoto K. Differential neuropeptide responses to starvation with ageing. J Neuroendocrinol 13 (2001) 1066-1075
22. Wolden-Hanson T., Marck B.T., and Matsumoto A.M. Blunted hypothalamic neuropeptide gene expression in response to fasting, but preservation of feeding responses to AgRP in aging male Brown Norway rats. Am J Physiol Regul Integr Comp Physiol 287 (2004) R138-R146
23. Pich E.M., Messori B., Zoli M., Ferraguti F., Marrama P., Biagini G., et al. Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats. Brain Res 575 (1992) 265-271
24. Blanton C.A., Horwitz B.A., Blevins J.E., Hamilton J.S., Hernandez E.J., and McDonald R.B. Reduced feeding response to neuropeptide Y in senescent Fischer 344 rats. Am J Physiol Regul Integr Comp Physiol 280 (2001) R1052-R1060
25. Kmiec Z. Central regulation of food intake in ageing. J Physiol Pharmacol 57 Suppl. 6 (2006) 7-16
26. Escobar C.M., Krajewski S.J., Sandoval-Guzman T., Voytko M.L., Rance N.E., and Neuropeptide. Y gene expression is increased in the hypothalamus of older women. J Clin Endocrinol Metab 89 (2004) 2338-2343
27. Taniguchi S., Yanase T., Kurimoto F., Takayanagi R., Haji M., Kurose S., et al. Age-related increase in neuropeptide Y-like immunoreactivity in cerebrospinal fluid in women. Fukuoka Igaku Zasshi 85 (1994) 361-365
28. Walter M.J., Scherrer J.F., Flood J.F., and Morley J.E. Effects of localized injections of neuropeptide Y antibody on motor activity and other behaviors. Peptides 15 (1994) 607-613
29. Cummings D.E., Purnell J.Q., Frayo R.S., Schmidova K., Wisse B.E., and Weigle D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 (2001) 1714-1719
30. Rigamonti A.E., Pincelli A.I., Corra B., Viarengo R., Bonomo S.M., Galimberti D., et al. Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. J Endocrinol 175 (2002) R1-5
31. Kozakowski J., Rabijewski M., and Zgliczynski W. Ghrelin-growth hormone releasing and orexigenic hormone in men declines with age, insulin and with decrease in testosterone concentration. Neuro Endocrinol Lett 29 (2008) 100-106
32. Schutte A.E., Huisman H.W., Schutte R., van Rooyen J.M., Malan L., and Malan N.T. Aging influences the level and functions of fasting plasma ghrelin levels: the POWIRS study. Regul Pept 139 (2007) 65-71
33. Serra-Prat M, Alfaro SR, Palomera E, Casamitjana R, Buquet X, Fernández-Fernández C, et al. Relationship between ghrelin and the metabolic syndrome in the elderly: a longitudinal population-based study. Clinical Endocrinology 2008, DOI: 10.1111/j.1365-2265.2008.03307.x.
34. Yukawa M., Cummings D.E., Matthys C.C., Callahan H.S., Frayo R.S., Spiekerman C.F., et al. Effect of aging on the response of ghrelin to acute weight loss. J Am Geriatr Soc 54 (2006) 648-653
35. Chapman I.M., Bach M.A., Van Cauter E., Farmer M., Krupa D., Taylor A.M., et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab 81 (1996) 4249-4257
36. Broglio F., Benso A., Castiglioni C., Gottero C., Prodam F., Destefanis S., et al. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J Clin Endocrinol Metab 88 (2003) 1537-1542
37. Tschop M., Smiley D.L., and Heiman M.L. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
38. Dimaraki E.V., and Jaffe C.A. Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism. Rev Endocr Metab Disord 7 (2006) 237-249
39. Lanfranco F., Gianotti L., Giordano R., Pellegrino M., Maccario M., and Arvat E. Ageing, growth hormone and physical performance. J Endocrinol Invest 26 (2003) 861-872
40. Kappeler L., Gourdji D., Zizzari P., Bluet-Pajot M.T., and Epelbaum J. Age-associated changes in hypothalamic and pituitary neuroendocrine gene expression in the rat. J Neuroendocrinol 15 (2003) 592-601
41. Ariyasu H., Iwakura H., Yamada G., Nakao K., Kangawa K., and Akamizu T. Efficacy of ghrelin as a therapeutic approach for age-related physiological changes. Endocrinology 149 (2008) 3722-3728
42. Yukawa M., Weigle D.S., Davis C.D., Marck B.T., and Wolden-Hanson T. Peripheral ghrelin treatment stabilizes body weights of senescent male Brown Norway rats at baseline and after surgery. Am J Physiol Regul Integr Comp Physiol 294 (2008) R1453-R1460
43. Bowers C.Y., Granda R., Mohan S., Kuipers J., Baylink D., and Veldhuis J.D. Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women. J Clin Endocrinol Metab 89 (2004) 2290-2300
44. Smith R.G., Sun Y., Jiang H., Albarran-Zeckler R., Timchenko N., and Ghrelin Receptor. (GHS-R1A) agonists show potential as interventive agents during aging. Ann N Y Acad Sci 1119 (2007) 147-164
45. Zorrilla E.P., Iwasaki S., Moss J.A., Chang J., Otsuji J., Inoue K., et al. From the cover: Vaccination against weight gain. Proc Natl Acad Sci U S A 103 (2006) 13226-13231
46. Salles N. Basic mechanisms of the aging gastrointestinal tract. Dig Dis 25 (2007) 112-117
47. Morley J.E. The aging gut: Physiology. Clin Geriatr Med 23 (2007) 757-767
48. Bhutto A., and Morley J.E. The clinical significance of gastrointestinal changes with aging. Curr Opin Clin Nutr Metab Care 11 (2008) 651-660
49. Pilotto A., and Salles N. Helicobacter pylori infection in geriatrics. Helicobacter 7 Suppl. 1 (2002) 56-62
50. Almeida J.A., Kim R., Stoita A., McIver C.J., Kurtovic J., and Riordan S.M. Lactose malabsorption in the elderly: Role of small intestinal bacterial overgrowth. Scand J Gastroenterol 43 (2008) 146-154
51. McEvoy A., Dutton J., and James O.F. Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly. Br Med J (Clin Res Ed) 287 (1983) 789-793
52. Lipski P.S., Kelly P.J., and James O.F.W. Bacterial contamination of the small bowel in elderly people: Is it necessarily pathological?. Age Ageing 21 (1992) 5-12
53. Hopkins M.J., Sharp R., and Macfarlane G.T. Age- and disease-related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 48 (2001) 198-205
54. Pilotto A., and Malfertheiner P. An approach to Helicobacter pylori infection in the elderly. Aliment Pharmacol Ther 16 (2002) 683-691
55. Isomoto H., Nakazato M., Ueno H., Date Y., Nishi Y., Mukae H., et al. Low plasma ghrelin levels in patients with Helicobacter pylori-associated gastritis. Am J Med 117 (2004) 429-432
56. Salles N., Menard A., Georges A., Salzmann M., de Ledinghen V., de Mascarel A., et al. Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients. J Gerontol A Biol Sci Med Sci 61 (2006) 1144-1150
57. Nwokolo C.U., Freshwater D.A., O'Hare P., and Randeva H.S. Plasma ghrelin following cure of Helicobacter pylori. Gut 52 (2003) 637-640
58. Lewis S.J., Potts L.F., Malhotra R., and Mountford R. Small bowel bacterial overgrowth in subjects living in residential care homes. Age Ageing 28 (1999) 181-185
59. Portnoi V.A. Helicobacter pylori infection and anorexia of aging. Arch Intern Med 157 (1997) 269-272
60. Roper J., Francois F., Shue P.L., Mourad M.S., Pei Z., Olivares de Perez A.Z., et al. Leptin and ghrelin in relation to Helicobacter pylori status in adult males. J Clin Endocrinol Metab 93 (2008) 2350-2357
61. Ley R.E., Turnbaugh P.J., Klein S., and Gordon J.I. Microbial ecology: Human gut microbes associated with obesity. Nature 444 (2006) 1022-1023
62. Li M., Wang B., Zhang M., Rantalainen M., Wang S., Zhou H., et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci 105 (2008) 2117-2122
63. Zhou Z.-H., Zhang Y., Hu Y.-F., Wahl L.M., Cisar J.O., and Notkins A.L. The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies. Cell Host Microbe 1 (2007) 51-61
64. Avrameas S. Natural autoantibodies: from "horror autotoxicus" to "gnothi seauton". Immunol Today 12 (1991) 154-159
65. Elkon K., and Casali P. Nature and functions of autoantibodies. Nat Clin Pract Rheumatol 4 (2008) 491-498
66. Oldstone M.B. Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept. Curr Top Microbiol Immunol 296 (2005) 1-17
67. Hamze Sinno M., Gallas S., Coëffier M., Ibrahim A., Breuille D., Déchelotte P., et al. Methotrexate-induced anorexia is associated with alteration of hypothalamic neuropeptide expression and plasma levels of MSH-reactive autoantibodies. 16th Annual Meeting of the Society for the Study of Ingestive Behavior. July 15-19, 2008, Paris, France (2008)
68. Fetissov S.O., Harro J., Jaanisk M., Järv A., Podar I., Allik J., et al. Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Proc Natl Acad Sci U S A 102 (2005) 14865-14870
69. Morley J.E. Anorexia, sarcopenia, and aging. Nutrition 17 (2001) 660-663
70. Hays N.P., and Roberts S.B. The anorexia of aging in humans. Physiol Behav 88 (2006) 257-266
71. Di Francesco V., Fantin F., Omizzolo F., Residori L., Bissoli L., Bosello O., et al. The anorexia of aging. Dig Dis 25 (2007) 129-137
72. Fetissov S.O., and Déchelotte P. The putative role of neuropeptide autoantibodies in anorexia nervosa. Curr Opin Clin Nutr Metab Care 11 (2008) 428-434
73. Fetissov S.O., Hamze Sinno M., Coquerel Q., Do Rego J.C., Coëffier M., Gilbert D., et al. Emerging role of autoantibodies against appetite-regulating neuropeptides in eating disorders. Nutrition 24 (2008) 854-859
74. Fetissov S.O., Hallman J., Nilsson I., Lefvert A.K., Oreland L., and Hökfelt T. Aggressive behavior linked to corticotropin-reactive autoantibodies. Biol Psychiatry 60 (2006) 799-802
75. Roy B.F., Rose J.W., Sunderland T., Morihisa J.M., and Murphy D.L. Antisomatostatin IgG in major depressive disorder. A preliminary study with implications for an autoimmune mechanism of depression. Arch Gen Psychiatry 45 (1988) 924-928