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The easily removable cyclopentylidene protecting groups were essential for an efficient intramolecular acetalization to give the desired heterobicyclic core. First experiments for this key step with the bis-isopropylidene protected analog of 22 snowed that one of the two isopropylidene protecting groups was not cleaved rapidly enough
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The easily removable cyclopentylidene protecting groups were essential for an efficient intramolecular acetalization to give the desired heterobicyclic core. First experiments for this key step with the bis-isopropylidene protected analog of 22 snowed that one of the two isopropylidene protecting groups was not cleaved rapidly enough.
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CCDC 718839 contains the supplementary crystallography data for the structure 27 reported in this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via
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CCDC 718839 contains the supplementary crystallography data for the structure 27 reported in this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data- request/cif.
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