The expression of endotoxic activity in the Limulus test as compared to cytokine production in immune cells

Current Medicinal Chemistry

Volumn 16, Issue 21, 2009, Pages 2653-2660

  Brandenburg, Klaus ^a   Howe, Jörg ^a   Gutsman, Thomas ^a   Garidel, Patrick ^b  

^a RESEARCH CENTER BORSTEL   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Aggregate structure; Endotoxin; Limulus test; Lipid A; LPS

Indexed keywords

(1-3) BETA GLUCAN; ALBUMIN; BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; GLUCAN; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTOFERRIN; LIPID A DERIVATIVE; SERINE PROTEASE ZYMOGEN FACTOR C; SERINE PROTEINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; BACTEREMIA; BLOOD CLOTTING; CELL ASSAY; CHEMICAL MODIFICATION; CLINICAL EVALUATION; COMPLEMENT ACTIVATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; ENDOTOXIN DETECTION; GRAM NEGATIVE BACTERIUM; HUMAN; LIMULUS; LIMULUS AMOEBOCYTE LYSATE TEST; LIMULUS LYSATE TEST; LIMULUS POLYPHEMUS; LIPID ANALYSIS; MONONUCLEAR CELL; NONHUMAN; PROTEIN LIPID INTERACTION; QUANTITATIVE ANALYSIS; REVIEW; SENSITIVITY ANALYSIS; SEPSIS; STRUCTURE ANALYSIS; TOXICITY TESTING; TOXIN ANALYSIS;

ACYLATION; CYTOKINES; ENDOTOXINS; HUMANS; LEUKOCYTES, MONONUCLEAR; LIMULUS TEST; LIPOPOLYSACCHARIDES;

EID: 70349404264     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709788682001     Document Type: Review

References (46)

1. Brade H.; Brade L.; Rietschel E.Th. Structure-activity relationships of bacterial lipopolysaccharides (endotoxins). Zbl. Bakt. Hyg., 1988, 268, 151-179.
2. Rietschel E.T. and Brade H. Bacterial endotoxins. Sci. Am., 1992, 267, 54-61.
3. Marek W, Ozyurt M, Potthast J, Mensing T. Endotoxin-induced airway hyperresponsiveness in rabbits: Contribution of neuropeptides. J. Physiol. Pharmacol., 2008, 59, Suppl 6, 421-432.
4. Levin J. and Bang F.B. Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin. Thromb. Diath. Haemorrh., 1968, 19, 186-197.
5. Levin J.; Bang F.B. A description of cellular coagulation in the Limulus. Bull. Johns. Hopkins. Hosp., 1964, 115, 337-345.
6. Levin J.; Bang F.B. The role of Endotoxin in the extracellular coagulation of Limulus blood. Bull. Johns. Hopkins. Hosp., 1964, 115, 265-274.
7. Iwanaga S.M.T.; Tokunaga F.; Muta T. Molecular mechanism of hemolymph clotting system in Limulus. Thrombosis Res., 1992, 68, 1-32.
8. Tokunaga F.; Miyata T.; Nakamura T.; Morita T.; Kuma K.; Miyata T.; Iwanaga S. Lipopolysaccharide-sensitive serine-protease zymogen (factor C) of horseshoe crab hemocytes. Identification and alignment of proteolytic fragments produced during the activation show that it is a novel type of serine protease. Eur. J. Biochem., 1987, 167, 405-416.
9. Nakamura T.; Tokunaga F.; Morita T.; Iwanaga S. Interaction between lipopolysaccharide and intracellular serine protease zymogen, factor C, from horseshoe crab (Tachypleus tridentatus) hemocytes. J. Biochem., 1988, 103, 370-374.
10. Koshiba T.; Hashii T.; Kawabata S. A structural perspective on the interaction between lipopolysaccharide and factor C, a receptor involved in recognition of Gram-negative bacteria. J. Biol. Chem., 2007, 282, 3962-3967.
11. Bergner A.; Oganessyan V.; Muta T.; Iwanaga S.; Typke D.; Huber R.; Bode W. Crystal structure of a coagulogen, the clotting protein from horseshoe crab: A structural homologue of nerve growth factor. EMBO J., 1996, 15, 6789-6797.
12. Morita T.; Ohtsubo S.; Nakamura T.; Tanaka S.; Iwanaga S.; Ohasei K.; Niwa M. Isolation and biological activities of Limulus antocoagulans (anti-LPS factor) which interacts with lipopolysaccharide (LPS). J. Biochem., 1985, 97, 1611-1620.
13. Hoess A.; Watson S.; Siber G.R.; Liddington R. Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 A resolution. EMBO J., 1993, 12, 3351-3356.
14. Dankesreiter S.; Hoess A.; Schneider-Mergener J.; Wagner H.; Mietke T. Synthetic endotoxin-binding peptides block endotoxin-triggered TNF-α production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock. J. Immunol., 2000, 164, 4804-4811.
15. Andrä J.; Lamata M.; Martinez d.T.; Bartels R.; Koch M.H.; Brandenburg K. Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide. Biochem. Pharmacol., 2004, 68, 1297-1307.
16. Andrä J.; Howe J.; Garidel P.; Rössle M.; Richter W.; Leiva-Leon J.; Moriyon I.; Bartels R.; Gutsmann T.; Brandenburg K. Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: Thermodynamic, biophysical and microbiological analysis. Biochem. J., 2007, 406, 297-307.
17. Tan N.S.; Ho B.; Ding J.L. High-affinity LPS binding domain(s) in recombinant factor C of a horseshoe crab neutralizes LPS-induced lethality. FASEB J., 2000, 14, 859-870.
18. Nakamura T.; Tokunaga F.; Morita T.; Iwanaga S.; Kusumoto S.; Shiba T.; Kobayashi T.; Inoue K. Intracellular serine-protease zymogen, factor C, from horseshoe crab hemocytes. Its activation by synthetic lipid A analogues and acidic phospholipids. Eur. J. Biochem., 1988, 176, 89-94.
19. Takada H.; Kotani S.; Tanaka S.; Ogawa T.; Takahashi I.; Tsujimoto M.; Komuro T.; Shiba T.; Kusumoto S.; Kusunose N. Structural requirements of lipid A species in activation of clotting enzymes from the horseshoe crab, and the human complement cascade. Eur. J. Biochem., 1988, 175, 573-580.
20. Takada H. and Kotani S. Structural requirements of lipid A for endotoxicity and other biological activities. CRC Crit. Rev. Microbiol., 1989, 16, 477-523.
21. Schromm A.B.; Brandenburg K.; Loppnow H.; Moran A.P.; Koch M.H.J.; Rietschel E.Th.; Seydel U. Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion. Eur. J. Biochem., 2000, 267, 2008-2013.
22. Seydel U.; Schromm A.B.; Brade L.; Gronow S.; Andra J.; Müller M.; Koch M.H.; Fukase K.; Kataoka M.; Hashimoto M.; Kusumoto S.; Brandenburg K. Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity. FEBS J., 2005, 272, 327-340.
23. Brandenburg K.; Matsuura M.; Heine H.; Müller M.; Kiso M.; Ishida H.; Koch M.H.J.; Seydel U. Biophysical characterization of triacyl monosaccharide lipid A partial structures in relation to bioactivity. Biophys. J., 2002, 83, 322-333.
24. Matsuura M.; Yamamoto A.; Kojima Y.; Homma J.Y.; Kiso M.; Hasegawa A. Biological activities of chemically synthesized partial structure analogues of lipid A. J. Biochem., 1985, 98, 1229-1237.
25. Stumacher R.J.; Kovnat M.J.; McCabe W.R. Limitations of the usefulness of the Limulus assay for endotoxin. N. Engl. J. Med., 1973, 288, 1261-1264.
26. Ng K.P.; Bhanumathy M.; Ong G.S.Y.; Yong B.H.; Parasakthi N.; Koh M.T.; Siow C.P.; Bosco J. Endotoxin tests in patients with sepsis. J. Endotoxin Res., 1995, 2, 387-393.
27. Bates D.W.; Parsonnet J.; Ketchum P.A.; Miller E.B.; Novitsky T.J.; Sands K.; Hibberd P.L.; Graman P.S.; Lanken P.N.; Schwartz J.S.; Kahn K.; Snydman D.R.; Moore R.; Black E.; Platt R. Limulus amebocyte lysate assay for detection of endotoxin in patients with sepsis syndrome. AMCC Sepsis Project Working Group. Clin. Infect. Dis., 1998, 27, 582-591.
28. Tanaka S. and Iwanaga S. Limulus test for detecting bacterial endotoxins. Meth. Enzymol., 1993, 223, 358-364
29. Ketchum P.A.; Parsonnet J.; Stotts L.S.; Novitsky T.J.; Schlain B.; Bates D.W. Utilization of a chromogenic Limulus amebocyte lysate blood assay in a multi-center study of sepsis. J. Endotoxin Res., 1997, 4, 9-16.
30. Buttenschoen K.; Kornmann M.; Berger D.; Leder G.; Beger H.G.; Vasilescu C. Endotoxemia and endotoxin tolerance in patients with ARDS. Langenbecks Arch. Surg., 2008, 393, 473-478.
31. Dehus O.; Hartung T.; Hermann C. Endotoxin evaluation of eleven lipopolysaccharides by whole blood assay does not always correlate with Limulus amebocyte lysate assay. J. Endotoxin. Res., 2006, 12, 171-180.
32. Novitsky T.J. Limitations of the Limulus amebocyte lysate test in demonstrating circulating lipopolysaccharides. Ann. NY Acad. Sci., 1998, 851, 416-421.
33. Brandenburg K.; Jurgens G.; Andrä J.; Lindner B.; Koch M.H.J.; Blume A.; Garidel P. Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins. Eur. J. Biochem., 2002, 269, 5972-5981.
34. Jürgens G.; Müller M.; Koch M.H.J.; Brandenburg K. Interaction of hemoglobin with enterobacterial lipopolysaccharide and lipid A: Physicochemical characterization and biological activity. Eur. J. Biochem., 2001, 268, 4233-4242.
35. Brandenburg K.; Garidel P.; Andrä J.; Jürgens G.; Müller M.; Blume A.; Koch M.H.J.; Levin J. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. J. Biol. Chem., 2003, 278, 47660-47669.
36. Howe J.; Hammer M.; Alexander C.; Rossle M.; Fournier K.; Mach J.P.; Waelli T.; Gorczynski R.M.; Ulmer A.J.; Zähringer U.; Rietschel E.T.; Brandenburg K. Biophysical characterization of the interaction of endotoxins with hemoglobins. Med. Chem., 2007, 3, 13-20.
37. Seydel U.; Hawkins L.; Schromm A.B.; Heine H.; Scheel O.; Koch M.H.; Brandenburg K. The generalized endotoxic principle. Eur. J. Immunol., 2003, 33, 1586-1592.
38. Brandenburg K.; Hawkins L.; Garidel P.; Andrä J.; Müller M.; Heine H.; Koch M.H.J.; Seydel U. Structural Polymorphism and Endotoxic Activity of Synthetic Phospholipid-like Amphiphiles. Biochemistry, 2004, 43, 4039-4046.
39. Schromm A.B.; Howe J.; Ulmer A.J.; Wiesmuller K.H.; Seyberth T.; Jung G.; Rossle M.; Koch M.H.; Gutsmann T.; Brandenburg K. 2660 Current Medicinal Chemistry, 2009 Vol. 16, No. 21 Brandenburg et al. Physicochemical and biological analysis of synthetic bacterial lipopeptides: Validity of the concept of endotoxic conformation. J. Biol. Chem., 2007, 282, 11030-11037.
40. Jürgens G.; Müller M.; Garidel P.; Koch M.H.J.; Nakakubo H.; Blume A.; Brandenburg K. Investigation into the interaction of recombinant human serum albumin with Re-lipopolysaccharide and lipid A. J. Endotoxin Res., 2002, 8, 115-126.
41. Brandenburg K.; Jürgens G.; Müller M.; Fukuoka S.; Koch M.H.J. Biophysical characterization of lipopolysaccharide and lipid A inactivation by lactoferrin. Biol. Chem., 2001, 382, 1215-1225.
42. Andrä J.; Garidel P.; Majerle A.; Jerala R.; Ridge R.; Paus E.; Novitsky T.; Koch M.H.; Brandenburg K. Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide. Eur. J. Biochem., 2004, 271, 2037-2046.
43. Brandenburg K.; Andrä J.; Müller M.; Koch M.H.J.; Garidel P. Physicochemical properties of bacterial glycopolymers in relation to bioactivity. Carbohydr. Res., 2003, 338, 2477-2489.
44. Mueller M.; Lindner B.; Dedrick R.; Schromm A.B.; Seydel U. Endotoxin: physical requirements for cell activation. J. Endotoxin. Res., 2005, 11, 299-303.
45. Mueller M.; Lindner B.; Kusumoto S.; Fukase K.; Schromm A.B.; Seydel U. Aggregates are the biologically active units of endotoxin. J. Biol. Chem., 2004, 279, 26307-26313.
46. Brandenburg K. and Seydel U. Infrared spectroscopy of glycolipids. Chem. Phys. Lipids, 1998, 96, 23-40.