Type 2a sodium-phosphate co-transporter serves as a histological predictor of renal dysfunction and tubular apical damage in the kidneys of septic mice

Biomedical Research

Volumn 30, Issue 4, 2009, Pages 251-258

  Kamimoto, Miyuki ^a   Mizuno, Shinya ^a   Ohnishi, Hiroyuki ^a   Mizuno Horikawa, Yoko ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; NITROGEN; SODIUM PHOSPHATE COTRANSPORTER 2A; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; KIDNEY DYSFUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; SEPSIS; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING;

ACUTE KIDNEY INJURY; ANIMALS; ANOXIA; BIOLOGICAL MARKERS; FEMALE; GENE EXPRESSION REGULATION; KIDNEY TUBULES, PROXIMAL; LIPOPOLYSACCHARIDES; MICE; SEPSIS; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA;

ANIMALIA; MUS;

EID: 70349402041     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.30.251     Document Type: Article

References (33)

1. Achparaki A, Kotzampassi K, Eleftheriadis E and Foroglou C (1988) Ultrastructural changes of the renal cortex after septic shock in rats. Histol Histopathol 3, 133-146.
2. Barak V, Schwartz A, Kalickman I, Nisman B, Gurman G and Shoenfeld Y (1998) Prevalence of hypophosphatemia in sepsis and infection: the role of cytokines. Am J Med 104, 40-47.
3. Baum M, Schiavi S, Dwarakanath V and Quigley R (2005) Effect of fibroblast growth factor-23 on phophate transport in proximal tubules. Kidney Int 68, 1148-1153.
4. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H and Tenenhouse HS (1998) Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 95, 5372-5377.
5. Bell PD and Navar LG (1982) Relationship between tubuloglomerular feedback responses and perfusate hypotonicity. Kidney Int 22, 234-239.
6. Chen J, Doctor RB and Mandel LJ (1994) Cytoskeletal dissociation of ezrin during renal anoxia: role in microvillar injury. Am J Physiol 267, C784-C795.
7. Gai Q, Hodgson SF, Kao PC, Lennon VA, Klee GG, Zinsmiester AR and Kumar R (1994) Inhibition of renal phosphate transport by a tumor production in a patient with oncogenic osteomalacia. N Engl J Med 330, 1645-1649.
8. + transporters in kidneys of rats with ischemia-induced acute renal failure. Am J Physiol 278, F925-F939.
9. Lameire N, Van Biesen W and Vanholder R (2005) Acute renal failure. Lancet 365, 417-430.
10. Larsson T, Marsell R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Jüppner H and Jonsson KB (2004) Transgenic mice expressing fibroblast growth factor 23 under the control of the alphal(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145, 3084-3086.
11. Mak GZ, Kavanaugh GM, Buschmann MM, Stickley SM, Koch M, Goss KH, Waechter H. Zuk A and Matlin KS (2006) Regulated synthesis and functions of laminin 5 in polarized madin-darby canine kidney epithelial cells. Mol Biol Cell 17, 3664-3677.
12. Mizuno S and Nakamura T (2005) Prevention of neutrophil extravasation by hepatocyte growth factor leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys. Am J Pathol 166, 1895-1905.
13. Ohnishi H, Mizuno S and Nakamura T (2008) Inhibition of tubular cell proliferation by neutralizing endogenous hepatocyte growth factor leads to renal hypoxia and bone marrow-derived cell engraftment in acute renal failure. Am J Physiol 294, F326-F335.
14. Prié D, Huart V, Bakouh N, Planelles G, Dellis O, Gérard B, Hulin P, Benqué-Blanchet F, Silve C, Grandchamp B and Friedlander G (2002) Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter. N Engl J Med 347, 983-991.
15. Razzaque MS and Lanske B (2006) Hypervitaminosis D and premature aging: Lessons learned from Fgf23 and Klotho mutant mice. Trend Mol Med 12, 298-305.
16. Riedler GF and Scheitlin WA (1969) Hypophosphataemia in septicaemia: higher incidence in gram-negative than in gram-positive infections. Br Med J 1, 753-756.
17. Rosenberger C, Rosen S, Paliege A and Heyman SN (2009) Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia. Methods Mol Biol 466, 161-174.
18. Scheinman SJ and Tenenhouse HS (2003) Nephrolithiasis, osteoporosis, and mutations in the type 2a sodium-phosphate cotransporter. N Engl J Med 348, 264-265.
19. Schor N (2002) Acute renal failure and the sepsis syndrome. Kidney Int 61, 764-776.
20. Schrier RW and Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351, 159-169.
21. Segawa H, Yamanaka S, Ohno Y, Onitsuka A, Shiozawa K, Aranami F, Furutani J, Tomoe Y, Ito M, Kuwahata M, Imura A, Nabeshima Y and Miyamoto K (2007) Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. Am J Physiol 292, F769-F779.
22. Shanley PF, Brezis M, Spokes K, Silva P, Epstein FH and Rosen S (1986) Hypoxic injury in the proximal tubule of the isolated perfused rat kidney. Kidney Int 29, 1021-1032.
23. Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T. Fukumoto S, Tomizuka K and Yamashita T (2004) Targeted ablation of fgt23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin-D metabolism. J Clin Invest 113, 561-568.
24. Shor R, Halabe A, Rishver S, Tilis Y, Matas Z, Fux A, Boaz M and Weinstein J (2006) Severe hypophosphatemia in sepsis as a mortality predictor. Ann Clin Lab Sci 36, 67-72.
25. Sutton TA, Fisher CJ and Molitoris BA (2002) Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int 62, 1539-1549.
26. Tenenhouse HS (2007) Phosphate transport: molecular basis, regulation and pathophysiology. J Steroid Biochem Mol Biol 103, 572-577.
27. Toribio RE, Kohn CW, Hardy J and Rosol TJ (2005) Alterations in serum parathyroid hormone and electrolyte concentrations and urinary excretion of electrolytes in horses with induced endotoxemia. J Vet Intern Med 19, 223-231.
28. Varia MA, Calkins-Adams DP, Rinker LH, Kennedy AS, Novotny DB, Fowler WC Jr and Raleigh JA (1998) Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol 71, 270-277.
29. Virkki LV, Biber J, Murer H and Forster IC (2007) Phosphate transporters: a tale of two solute carrier families. Am J Physiol 293, F643-F654.
30. Westberg G, Shultz PJ and Raij L (1994) Exogenous nitric oxide prevents endotoxin-induced glomerular thrombosis in rats. Kidney Int 46, 711-716.
31. Yanada M, Kojima T, Ishiguro K, Nakayama Y, Yamamoto K, Matsushita T, Kadomatsu K, Nishimura M, Muramatsu T and Saito H (2002) Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice. Blood 99, 2455-2458.
32. Yosypiv IV (2009) Renin-angiotensin system-growth factor cross-talk: a novel mechanism for ureteric bud morphogenesis. Pediatr Nephrol 24, 1113-1120.
33. Yu X and White KE (2005) FGF23 and disorders of phosphate homeostasis. Cytokine Growth Factor Rev 16, 221-232.