메뉴 건너뛰기




Volumn 5, Issue 9, 2009, Pages 507-518

Myopathy with statin-fibrate combination therapy: Clinical considerations

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ATORVASTATIN; CERIVASTATIN; CYCLOSPORIN; FENOFIBRATE; FENOFIBRIC ACID; FIBRIC ACID DERIVATIVE; FLUINDOSTATIN; GEMFIBROZIL; GLUCURONOSYLTRANSFERASE 1A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; MIBEFRADIL; PRAVASTATIN; REPAGLINIDE; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL; TRILIPIX; UNCLASSIFIED DRUG;

EID: 70349334010     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2009.151     Document Type: Review
Times cited : (73)

References (122)
  • 1
    • 33645746101 scopus 로고    scopus 로고
    • The role of fibrates in a statin world
    • Bloomfield, H. E. The role of fibrates in a statin world. Arch. Intern. Med. 166, 715-716 (2006).
    • (2006) Arch. Intern. Med. , vol.166 , pp. 715-716
    • Bloomfield, H.E.1
  • 2
    • 70349320632 scopus 로고    scopus 로고
    • bbott. TriCor® (fenofibrate tablets) [online]
    • Abbott. TriCor® (fenofibrate tablets) Us full prescribing information [online], http://www.rxabbott.com/pdf/tricorpi.pdf (2008).
    • (2008) Us Full Prescribing Information
  • 4
    • 68649084061 scopus 로고    scopus 로고
    • Pfizer. Lopid® (gemfibrozil tablets)
    • Pfizer. Lopid® (gemfibrozil tablets) Us full prescribing information [online], http://media.Pfizer.com/files/products/uspi-lopid.pdf (2008).
    • (2008) Us Full Prescribing Information [Online]
  • 5
    • 49949106373 scopus 로고    scopus 로고
    • Pharmacogenomics and drug toxicity
    • Nakamura, Y. Pharmacogenomics and drug toxicity. N. Engl. J. Med. 359, 856-858 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 856-858
    • Nakamura, Y.1
  • 6
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
    • Lazarou, J., Pomeranz, B. H. & Corey, P. N. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 279, 1200-1205 (1998).
    • (1998) JAMA , vol.279 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 7
    • 0023232216 scopus 로고
    • Helsinki Heart study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia: Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick, M. H. et al. Helsinki Heart study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia: safety of treatment, changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med. 317, 1237-1245 (1987).
    • (1987) N. Engl. J. Med. , vol.317 , pp. 1237-1245
    • Frick, M.H.1
  • 8
    • 0018838168 scopus 로고
    • WHO cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: Mortality follow-up. Report of the Committee of Principal investigators
    • [authors listed]
    • [authors listed] WHO cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up. Report of the Committee of Principal investigators Lancet 2 379-385 1980.
    • (1980) Lancet , vol.2 , pp. 379-385
  • 9
    • 0037414218 scopus 로고    scopus 로고
    • Statin-associated myopathy
    • Thompson, P. D., Clarkson, P. & Karas, R. H. Statin-associated myopathy. JAMA 289, 1681-1690 (2003).
    • (2003) JAMA , vol.289 , pp. 1681-1690
    • Thompson, P.D.1    Clarkson, P.2    Karas, R.H.3
  • 10
    • 0036163750 scopus 로고    scopus 로고
    • FDA adverse event reports on statin-associated rhabdomyolysis
    • Omar, M. A. & wilson, J. P. FDA adverse event reports on statin-associated rhabdomyolysis. Ann. Pharmacother. 36, 288-295 (2002).
    • (2002) Ann. Pharmacother , vol.36 , pp. 288-295
    • Omar, M.A.1    Wilson, J.P.2
  • 11
    • 9644252909 scopus 로고    scopus 로고
    • Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs
    • Graham, D. J. et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA 292, 2585-2590 (2004).
    • (2004) JAMA , vol.292 , pp. 2585-2590
    • Graham, D.J.1
  • 12
    • 0037143688 scopus 로고    scopus 로고
    • ACC/AHA/NHLBi Clinical advisory on the use and safety of statins
    • Pasternak, R. C. et al. ACC/AHA/NHLBi Clinical advisory on the use and safety of statins. Circulation 106, 1024-1028 (2002).
    • (2002) Circulation , vol.106 , pp. 1024-1028
    • Pasternak, R.C.1
  • 13
    • 33645889332 scopus 로고    scopus 로고
    • Final conclusions and recommendations of the National Lipid Association statin safety Assessment Task Force
    • McKenney, J. M., Davidson, M. H., Jacobson, T. A., Guyton, J. R. & National Lipid Association statin safety Assessment Task Force. Final conclusions and recommendations of the National Lipid Association statin safety Assessment Task Force. Am. J. Cardiol. 97 (Suppl. 1), s89-s94 (2006).
    • (2006) Am. J. Cardiol. , vol.97 , Issue.SUPPL. 1
    • McKenney, J.M.1    Davidson, M.H.2    Jacobson, T.A.3    Guyton, J.R.4
  • 14
    • 0036787034 scopus 로고    scopus 로고
    • Statin-associated myopathy with normal creatine kinase levels
    • Phillips, P. S. et al. Statin-associated myopathy with normal creatine kinase levels. Ann. Intern. Med. 137, 581-585 (2002).
    • (2002) Ann. Intern. Med. , vol.137 , pp. 581-585
    • Phillips, P.S.1
  • 15
    • 0034924212 scopus 로고    scopus 로고
    • Statin-fibrate combination therapy
    • Shek, A. & Ferrill, M. J. Statin-fibrate combination therapy. Ann. Pharmacother. 35, 908-917 (2001).
    • (2001) Ann. Pharmacother. , vol.35 , pp. 908-917
    • Shek, A.1    Ferrill, M.J.2
  • 16
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • Law, M. & rudnicka, A. R. Statin safety: a systematic review. Am. J. Cardiol. 97 (Suppl. 1), s52-s60 (2006).
    • (2006) Am. J. Cardiol. , vol.97 , Issue.SUPPL. 1
    • Law, M.1    Rudnicka, A.R.2
  • 17
    • 14544278807 scopus 로고    scopus 로고
    • Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization
    • Shanahan, R. L., Kerzee, J. A., Sandhoff, B. G., Carroll, N. M. & Merenich, J. A. Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization. Pharmacotherapy 25, 345-351 (2005).
    • (2005) Pharmacotherapy , vol.25 , pp. 345-351
    • Shanahan, R.L.1    Kerzee, J.A.2    Sandhoff, B.G.3    Carroll, N.M.4    Merenich, J.A.5
  • 18
    • 52049116959 scopus 로고    scopus 로고
    • Clinical characterization and molecular mechanisms of statin myopathy
    • Toth, P. P. , Harper, C. R. & Jacobson, T. A. Clinical characterization and molecular mechanisms of statin myopathy. Expert. Rev. Cardiovasc. Ther. 6, 955-969 (2008).
    • (2008) Expert. Rev. Cardiovasc. Ther. , vol.6 , pp. 955-969
    • Toth, P.P.1    Harper, C.R.2    Jacobson, T.A.3
  • 19
    • 33744523781 scopus 로고    scopus 로고
    • On the mechanisms of statin-induced myopathy
    • Laaksonen, R. On the mechanisms of statin-induced myopathy. Clin. Pharmacol. Ther. 79, 529-531 (2006).
    • (2006) Clin. Pharmacol. Ther. , vol.79 , pp. 529-531
    • Laaksonen, R.1
  • 20
    • 33644790562 scopus 로고    scopus 로고
    • Mechanisms of statin-induced myopathy: A role for the ubiquitin-proteasome pathway Arterioscler
    • Chapman, M. J. & Carrie, A. Mechanisms of statin-induced myopathy: a role for the ubiquitin-proteasome pathway Arterioscler. Thromb. Vasc. Biol. 25, 2441-2444 (2005).
    • (2005) Thromb. Vasc. Biol. , vol.25 , pp. 2441-2444
    • Chapman, M.J.1    Carrie, A.2
  • 21
    • 14844317370 scopus 로고    scopus 로고
    • Regarding the mechanism of statin-induced myopathy
    • Noël, B. Regarding the mechanism of statin-induced myopathy. Am. Heart J. 149, e3 (2005).
    • (2005) Am. Heart J. , vol.149
    • Noël, B.1
  • 22
    • 33746665298 scopus 로고    scopus 로고
    • Genetic risk factors associated with lipid-lowering drug-induced myopathies
    • Vladutiu, G. D. et al. Genetic risk factors associated with lipid-lowering drug-induced myopathies. Muscle Nerve 34, 153-162 (2006).
    • (2006) Muscle Nerve , vol.34 , pp. 153-162
    • Vladutiu, G.D.1
  • 24
    • 0037345750 scopus 로고    scopus 로고
    • Statins unmasking a mitochondrial myopathy: A case report and proposed mechanism of disease
    • Diaczok, B. J. & shali, R. Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease. South Med. J. 96, 318-320 (2003).
    • (2003) South Med. J. , vol.96 , pp. 318-320
    • Diaczok, B.J.1    Shali, R.2
  • 25
    • 0141612021 scopus 로고    scopus 로고
    • Benefit-risk assessment of rosuvastatin 10 to 40 milligrams
    • Brewer, H. B. J R. Benefit-risk assessment of rosuvastatin 10 to 40 milligrams. Am. J. Cardiol. 92 (Suppl. 2), 23-29 (2003).
    • (2003) Am. J. Cardiol. , vol.92 , Issue.SUPPL. 2 , pp. 23-29
    • Brewer, H.B.J.R.1
  • 26
    • 0026689657 scopus 로고
    • Lovastatin/gemfibrozil myopathy: A clinical, histochemical, and ultrastructural study
    • Chucrallah, A., De Girolami, U., Freeman, R. & Federman, M. Lovastatin/gemfibrozil myopathy: a clinical, histochemical, and ultrastructural study. Eur. Neurol. 32, 293-296 (1992).
    • (1992) Eur. Neurol. , vol.32 , pp. 293-296
    • Chucrallah, A.1    De Girolami, U.2    Freeman, R.3    Federman, M.4
  • 27
    • 0025747901 scopus 로고
    • Inhibition of HMG-CoA reductase in mononuclear cells during gemfibrozil treatment
    • Stange, E. F. et al. Inhibition of HMG-CoA reductase in mononuclear cells during gemfibrozil treatment. Atherosclerosis 91, 257-265 (1991).
    • (1991) Atherosclerosis , vol.91 , pp. 257-265
    • Stange, E.F.1
  • 28
    • 0021934636 scopus 로고
    • Fenofibrate treatment inhibits HMG-CoA reductase activity in mononuclear cells from hyperlipoproteinemic patients
    • Schneider, A., Stange, E. F. , Ditschuneit, H. H. & Ditschuneit, H. Fenofibrate treatment inhibits HMG-CoA reductase activity in mononuclear cells from hyperlipoproteinemic patients. Atherosclerosis 56, 257-262 (1985).
    • (1985) Atherosclerosis , vol.56 , pp. 257-262
    • Schneider, A.1    Stange, E.F.2    Ditschuneit, H.H.3    Ditschuneit, H.4
  • 29
    • 26844481019 scopus 로고    scopus 로고
    • Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats
    • Farswan, M., Rathod, S. P. , Upaganlawar, A. B. & semwal, A. Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats. Indian J. Exp. Biol. 43, 845-848 (2005).
    • (2005) Indian J. Exp. Biol. , vol.43 , pp. 845-848
    • Farswan, M.1    Rathod, S.P.2    Upaganlawar, A.B.3    Semwal, A.4
  • 30
    • 18044392731 scopus 로고    scopus 로고
    • Drug-induced myopathies. An overview of the possible mechanisms
    • Owczarek, J., Jasinska, M. & Orszulak-Michalak, D. Drug-induced myopathies. An overview of the possible mechanisms. Pharmacol. Rep. 57, 23-34 (2005).
    • (2005) Pharmacol. Rep. , vol.57 , pp. 23-34
    • Owczarek, J.1    Jasinska, M.2    Orszulak-Michalak, D.3
  • 31
    • 33845306820 scopus 로고    scopus 로고
    • Statin-induced apoptosis and skeletal myopathy
    • Dirks, A. J. & Jones, K. M. Statin-induced apoptosis and skeletal myopathy. Am. J. Physiol. Cell Physiol. 291, C1208-C1212 (2006).
    • (2006) Am. J. Physiol. Cell Physiol. , vol.291
    • Dirks, A.J.1    Jones, K.M.2
  • 32
    • 23944515089 scopus 로고    scopus 로고
    • Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells
    • Sacher, J., Weigl, L., Werner, M., Szegedi, C. & Hohenegger, M. Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. J. Pharmacol. Exp. Ther. 314, 1032-1041 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 1032-1041
    • Sacher, J.1    Weigl, L.2    Werner, M.3    Szegedi, C.4    Hohenegger, M.5
  • 33
    • 0031194174 scopus 로고    scopus 로고
    • Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro
    • Flint, O. P. , Masters, B. A., Gregg, R. E. & Durham, S. K. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicol. Appl. Pharmacol. 145, 91-98 (1997).
    • (1997) Toxicol. Appl. Pharmacol. , vol.145 , pp. 91-98
    • Flint, O.P.1    Masters, B.A.2    Gregg, R.E.3    Durham, S.K.4
  • 34
    • 0030012771 scopus 로고    scopus 로고
    • The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle
    • Laaksonen, R. et al. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am. J. Cardiol. 77, 851-854 (1996).
    • (1996) Am. J. Cardiol. , vol.77 , pp. 851-854
    • Laaksonen, R.1
  • 35
    • 0037318567 scopus 로고    scopus 로고
    • Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation
    • Maeda, T., Kawane, T. & Horiuchi, N. Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology 144, 681-692 (2003).
    • (2003) Endocrinology , vol.144 , pp. 681-692
    • Maeda, T.1    Kawane, T.2    Horiuchi, N.3
  • 36
    • 2442706575 scopus 로고    scopus 로고
    • Atorvastatin prevents rhoC isoprenylation, invasion, and metastasis in human melanoma cells
    • Collisson, E. A. et al. Atorvastatin prevents rhoC isoprenylation, invasion, and metastasis in human melanoma cells. Mol. Cancer Ther. 2, 941-948 (2003).
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 941-948
    • Collisson, E.A.1
  • 37
    • 67651152643 scopus 로고    scopus 로고
    • Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation
    • Maeda, T. & Horiuchi, N. Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. J. Biochem. 145, 771-781 (2009).
    • (2009) J. Biochem. , vol.145 , pp. 771-781
    • Maeda, T.1    Horiuchi, N.2
  • 38
    • 34948842028 scopus 로고    scopus 로고
    • Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells
    • Jantzen, F. et al. Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. J. Physiol. Pharmacol. 58, 503-514 (2007).
    • (2007) J. Physiol. Pharmacol. , vol.58 , pp. 503-514
    • Jantzen, F.1
  • 39
    • 0036192275 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and rho A prenylation
    • Blanco-Colio, L. M. et al. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and rho A prenylation. Atherosclerosis 161, 17-26 (2002).
    • (2002) Atherosclerosis , vol.161 , pp. 17-26
    • Blanco-Colio, L.M.1
  • 40
    • 0033003886 scopus 로고    scopus 로고
    • Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts
    • Mutoh, T. , Kumano, T. , Nakagawa, H. & Kuriyama, M. Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts. FEBS Lett. 444, 85-89 (1999).
    • (1999) FEBS Lett. , vol.444 , pp. 85-89
    • Mutoh, T.1    Kumano, T.2    Nakagawa, H.3    Kuriyama, M.4
  • 41
    • 0037013293 scopus 로고    scopus 로고
    • Inhibition of protein geranylgeranylation and rhoA/rhoA kinase pathway induces apoptosis in human endothelial cells
    • Li, X. et al. Inhibition of protein geranylgeranylation and rhoA/rhoA kinase pathway induces apoptosis in human endothelial cells. J. Biol. Chem. 277, 15309-15316 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 15309-15316
    • Li, X.1
  • 42
    • 32444440805 scopus 로고    scopus 로고
    • Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: A potential therapeutic approach to rheumatoid arthritis
    • Nagashima, T. , Okazaki, H., Yudoh, K., Matsuno, H. & Minota, S. Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. Arthritis Rheum. 54, 579-586 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 579-586
    • Nagashima, T.1    Okazaki, H.2    Yudoh, K.3    Matsuno, H.4    Minota, S.5
  • 43
    • 0041920695 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis
    • Zhong, W. B., Wang, C. Y. , Chang, T. C. & Lee, W. S. Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology 144, 3852-3859 (2003).
    • (2003) Endocrinology , vol.144 , pp. 3852-3859
    • Zhong, W.B.1    Wang, C.Y.2    Chang, T.C.3    Lee, W.S.4
  • 44
    • 0034749404 scopus 로고    scopus 로고
    • 2+ release induced by clofibric acid from the sarcoplasmic reticulum of mouse skeletal muscle fibres
    • Ikemoto, T. & endo, M. Properties of Ca2+ release induced by clofibric acid from the sarcoplasmic reticulum of mouse skeletal muscle fibres. Br. J. Pharmacol. 134, 719-728 (2001). (Pubitemid 33016142)
    • (2001) British Journal of Pharmacology , vol.134 , Issue.4 , pp. 719-728
    • Ikemoto, T.1    Endo, M.2
  • 45
    • 0035823579 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation
    • Rao, R. V. et al. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J. Biol. Chem. 276, 33869-33874 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 33869-33874
    • Rao, R.V.1
  • 46
    • 0033057924 scopus 로고    scopus 로고
    • The effect of peroxisome proliferators on mitochondrial bioenergetics
    • Zhou, S. & wallace, K. B. The effect of peroxisome proliferators on mitochondrial bioenergetics. Toxicol. Sci. 48, 82-89 (1999).
    • (1999) Toxicol. Sci. , vol.48 , pp. 82-89
    • Zhou, S.1    Wallace, K.B.2
  • 47
    • 37049010298 scopus 로고    scopus 로고
    • Novel duplication mutation in the patatin domain of adipose triglyceride lipase (PNPLA2) in neutral lipid storage disease with severe myopathy
    • Akiyama, M. et al. Novel duplication mutation in the patatin domain of adipose triglyceride lipase (PNPLA2) in neutral lipid storage disease with severe myopathy. Muscle Nerve 36, 856-859 (2007).
    • (2007) Muscle Nerve , vol.36 , pp. 856-859
    • Akiyama, M.1
  • 48
    • 56049104881 scopus 로고    scopus 로고
    • Novel mutations in the adipose triglyceride lipase gene causing neutral lipid storage disease with myopathy
    • Campagna, F. et al. Novel mutations in the adipose triglyceride lipase gene causing neutral lipid storage disease with myopathy. Biochem. Biophys. Res. Commun. 377, 843-846 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 843-846
    • Campagna, F.1
  • 50
    • 56149123480 scopus 로고    scopus 로고
    • Genetic determinants of statin-associated myopathy
    • Molokhia, M., Bhatia, S. & Nitsch, D. Genetic determinants of statin-associated myopathy. Per. Med. 5, 481-494 (2008).
    • (2008) Per. Med. , vol.5 , pp. 481-494
    • Molokhia, M.1    Bhatia, S.2    Nitsch, D.3
  • 51
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/sLC21 family: Phylogenetic classification as OATP/sLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch, B. & Meier, P. J. Organic anion transporting polypeptides of the OATP/sLC21 family: phylogenetic classification as OATP/sLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. 447, 653-665 (2004).
    • (2004) Pflugers Arch. , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 52
    • 35548965586 scopus 로고    scopus 로고
    • The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver
    • DOI 10.1124/dmd.107.017269
    • Mano, Y. , Usui, T. & Kamimura, H. The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. Drug Metab. Dispos. 35, 2040-2044 (2007). (Pubitemid 350005193)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.11 , pp. 2040-2044
    • Mano, Y.1    Usui, T.2    Kamimura, H.3
  • 53
    • 34547154774 scopus 로고    scopus 로고
    • Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid
    • Goosen, T. C. et al. Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid. Drug Metab. Dispos. 35, 1315-1324 (2007).
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1315-1324
    • Goosen, T.C.1
  • 54
    • 17644426320 scopus 로고    scopus 로고
    • Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes
    • Prueksaritanont, T. et al. Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes. Pharm. Res. 22, 71-78 (2005).
    • (2005) Pharm. Res. , vol.22 , pp. 71-78
    • Prueksaritanont, T.1
  • 55
    • 23744480403 scopus 로고    scopus 로고
    • Interconversion pharmacokinetics of simvastatin and its hydroxy acid in dogs: Effects of gemfibrozil
    • Prueksaritanont, T. et al. Interconversion pharmacokinetics of simvastatin and its hydroxy acid in dogs: effects of gemfibrozil. Pharm. Res. 22, 1101-1109 (2005).
    • (2005) Pharm. Res. , vol.22 , pp. 1101-1109
    • Prueksaritanont, T.1
  • 56
    • 0036266987 scopus 로고    scopus 로고
    • Mechanistic studies on metabolic interactions between gemfibrozil and statins
    • Prueksaritanont, T. et al. Mechanistic studies on metabolic interactions between gemfibrozil and statins. J. Pharmacol. Exp. Ther. 301, 1042-1051 (2002).
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 1042-1051
    • Prueksaritanont, T.1
  • 57
    • 0036843479 scopus 로고    scopus 로고
    • Effects of fibrates on metabolism of statins in human hepatocytes
    • Prueksaritanont, T. et al. Effects of fibrates on metabolism of statins in human hepatocytes. Drug Metab. Dispos. 30, 1280-1287 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1280-1287
    • Prueksaritanont, T.1
  • 59
    • 0036233667 scopus 로고    scopus 로고
    • Glucuronidation of statins in animals and humans: A novel mechanism of statin lactonization
    • Prueksaritanont, T. et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab. Dispos. 30, 505-512 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 505-512
    • Prueksaritanont, T.1
  • 60
    • 4644301418 scopus 로고    scopus 로고
    • Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP/OATP1B1; SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug-drug interactions between cerivastatin and gemfibrozil
    • Shitara, Y. , Hirano, M., Sato, H. & sugiyama, Y. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP/OATP1B1; sLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interactions between cerivastatin and gemfibrozil. J. Pharmacol. Exp. Ther. 311, 228-236 (2004).
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 61
    • 23044456599 scopus 로고    scopus 로고
    • Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide
    • Niemi, M., Backman, J. T. , Juntti-Patinen, L., Neuvonen, M. & Neuvonen, P. J. Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide. Br. J. Clin. Pharmacol. 60, 208-217 (2005).
    • (2005) Br. J. Clin. Pharmacol. , vol.60 , pp. 208-217
    • Niemi, M.1    Backman, J.T.2    Juntti-Patinen, L.3    Neuvonen, M.4    Neuvonen, P.J.5
  • 62
    • 0036892714 scopus 로고    scopus 로고
    • Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes
    • Wang, J. S., Neuvonen, M., Wen, X., Backman, J. T. & Neuvonen, P. J. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab. Dispos. 30, 1352-1356 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1352-1356
    • Wang, J.S.1    Neuvonen, M.2    Wen, X.3    Backman, J.T.4    Neuvonen, P.J.5
  • 63
    • 70349324850 scopus 로고    scopus 로고
    • VHA Pharmacy Benefits Management-strategic Healthcare Group and The Medical Advisory Panel Statin-Fibrate Report: Focus on Safety [online]
    • VHA Pharmacy Benefits Management-strategic Healthcare Group and The Medical Advisory Panel Statin-Fibrate Report: Focus on Safety [online], http://www.pbm.va.gov/safety%20reports/87ry38statin-fibrate-final.pdf (2004).
    • (2004)
  • 64
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy: A genomewide study
    • SeArCH Collaborative Group. et al.
    • SeArCH Collaborative Group. et al. SLCO1B1 variants and statin-induced myopathy: a genomewide study. N. Engl. J. Med. 359, 789-799 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 789-799
  • 65
    • 34547178337 scopus 로고    scopus 로고
    • Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3
    • Noé, J., Portmann, R., Brun, M. E. & Funk, C. Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab. Dispos. 35, 1308-1314 (2007).
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1308-1314
    • Noé, J.1    Portmann, R.2    Brun, M.E.3    Funk, C.4
  • 66
    • 26644438110 scopus 로고    scopus 로고
    • Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2-and P-glycoprotein-mediated transport
    • Yamazaki, M. et al. Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2-and P-glycoprotein-mediated transport. Xenobiotica 35, 737-753 (2005).
    • (2005) Xenobiotica , vol.35 , pp. 737-753
    • Yamazaki, M.1
  • 67
    • 33745243715 scopus 로고    scopus 로고
    • Drug-drug interaction between pitavastatin and various drugs via OATP1B1
    • Hirano, M., Maeda, K., Shitara, Y. & sugiyama, Y. Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metab. Dispos. 34, 1229-1236 (2006).
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 1229-1236
    • Hirano, M.1    Maeda, K.2    Shitara, Y.3    Sugiyama, Y.4
  • 68
    • 33646536542 scopus 로고    scopus 로고
    • Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression and pharmacogenetics
    • Ho, R. H. et al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression and pharmacogenetics. Gastroenterology 130, 1793-1806 (2006).
    • Gastroenterology , vol.130 , pp. 1793-1806
    • Ho, R.H.1
  • 69
    • 25144494314 scopus 로고    scopus 로고
    • Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells
    • Kopplow, K., Letschert, K., König, J., Walter, B. & Keppler, D. Human hepatobiliary transport of organic anions analyzed by quadruple- transfected cells. Mol. Pharmacol. 68, 1031-1038 (2005).
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1031-1038
    • Kopplow, K.1    Letschert, K.2    König, J.3    Walter, B.4    Keppler, D.5
  • 70
    • 0038171260 scopus 로고    scopus 로고
    • Uptake of rosuvastatin by isolated rat hepatocytes: Comparison with pravastatin
    • Nezasa, K., Higaki, K., Takeuchi, M., Nakano, M. & Koike, M. Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin. Xenobiotica 33, 379-388 (2003).
    • (2003) Xenobiotica , vol.33 , pp. 379-388
    • Nezasa, K.1    Higaki, K.2    Takeuchi, M.3    Nakano, M.4    Koike, M.5
  • 71
    • 0033601257 scopus 로고    scopus 로고
    • A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
    • Hsiang, B. et al. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J. Biol. Chem. 274, 37161-37168 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 37161-37168
    • Hsiang, B.1
  • 72
    • 56149107690 scopus 로고    scopus 로고
    • Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism
    • Kalliokoski, A., Backman, J. T. , Kurkinen, K. J., Neuvonen, P. J. & Niemi, M. Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism. Clin. Pharmacol. Ther. 84, 488-496 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 488-496
    • Kalliokoski, A.1    Backman, J.T.2    Kurkinen, K.J.3    Neuvonen, P.J.4    Niemi, M.5
  • 73
    • 0033678688 scopus 로고    scopus 로고
    • Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion
    • Boyd, R. A. et al. Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. J. Clin. Pharmacol. 40, 91-98 (2000).
    • (2000) J. Clin. Pharmacol. , vol.40 , pp. 91-98
    • Boyd, R.A.1
  • 74
    • 11144354934 scopus 로고    scopus 로고
    • The effect of gemfibrozil on the pharmacokinetics of rosuvastatin
    • Schneck, D. W. et al. The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin. Pharmacol. Ther. 75, 455-463 (2004).
    • (2004) Clin. Pharmacol. Ther. , vol.75 , pp. 455-463
    • Schneck, D.W.1
  • 75
    • 34147133352 scopus 로고    scopus 로고
    • Inhibition of human organic anion transporter 3-mediated pravastatin transport by gemfibrozil and its metabolites in humans
    • Nakagomi-Hagihara, R., Nakai, D. & Tokui, T. Inhibition of human organic anion transporter 3-mediated pravastatin transport by gemfibrozil and its metabolites in humans. Xenobiotica 37, 416-426 (2007).
    • (2007) Xenobiotica , vol.37 , pp. 416-426
    • Nakagomi-Hagihara, R.1    Nakai, D.2    Tokui, T.3
  • 76
    • 34249327766 scopus 로고    scopus 로고
    • Gemfibrozil and its glucuronide inhibit the hepatic uptake of pravastatin mediated by OATP1B1
    • Nakagomi-Hagihara, R., Nakai, D., Tokui, T. , Abe, T. & ikeda, T. Gemfibrozil and its glucuronide inhibit the hepatic uptake of pravastatin mediated by OATP1B1. Xenobiotica 37, 474-486 (2007).
    • (2007) Xenobiotica , vol.37 , pp. 474-486
    • Nakagomi-Hagihara, R.1    Nakai, D.2    Tokui, T.3    Abe, T.4    Ikeda, T.5
  • 77
    • 0141483647 scopus 로고    scopus 로고
    • Combination lipid-lowering therapy with statins: Safety issues in the postcerivastatin era
    • Jacobson, T. A. Combination lipid-lowering therapy with statins: safety issues in the postcerivastatin era. Expert Opin. Drug Saf. 2, 269-286 (2003).
    • (2003) Expert Opin. Drug Saf. , vol.2 , pp. 269-286
    • Jacobson, T.A.1
  • 78
    • 23044464472 scopus 로고    scopus 로고
    • The effects of multiple doses of fenofibrate on the pharmacokinetics of pravastatin and its 3α-hydroxy isomeric metabolite
    • Gustavson, L. E. et al. The effects of multiple doses of fenofibrate on the pharmacokinetics of pravastatin and its 3α-hydroxy isomeric metabolite. J. Clin. Pharmacol. 45, 947-953 (2005).
    • (2005) J. Clin. Pharmacol. , vol.45 , pp. 947-953
    • Gustavson, L.E.1
  • 79
    • 0034145932 scopus 로고    scopus 로고
    • Lack of a clinically significant pharmacokinetic interaction between fenofibrate and pravastatin in healthy volunteers
    • Pan, W. J. et al. Lack of a clinically significant pharmacokinetic interaction between fenofibrate and pravastatin in healthy volunteers. J. Clin. Pharmacol. 40, 316-323 (2000).
    • (2000) J. Clin. Pharmacol. , vol.40 , pp. 316-323
    • Pan, W.J.1
  • 80
    • 0037292311 scopus 로고    scopus 로고
    • An open-label, randomized, three-way crossover trial of the effects of coadministration of rosuvastatin and fenofibrate on the pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteers
    • Martin, P. D., Dane, A. L., Schneck, D. W. & warwick, M. J. An open-label, randomized, three-way crossover trial of the effects of coadministration of rosuvastatin and fenofibrate on the pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteers. Clin. Ther. 25, 459-471 (2003).
    • (2003) Clin. Ther. , vol.25 , pp. 459-471
    • Martin, P.D.1    Dane, A.L.2    Schneck, D.W.3    Warwick, M.J.4
  • 81
    • 58149181570 scopus 로고    scopus 로고
    • ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans
    • Zhu, T. et al. ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans. J. Clin. Pharmacol. 49, 63-71 (2008).
    • (2008) J. Clin. Pharmacol. , vol.49 , pp. 63-71
    • Zhu, T.1
  • 82
    • 0037534010 scopus 로고    scopus 로고
    • Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
    • DOI 10.1016/S0009-9236(03)00052-3
    • Kyrklund, C., Backman, J. T., Neuvonen, M. & Neuvonen, P. J. Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin. Pharmacol. Ther. 73, 538-544 (2003). (Pubitemid 37249124)
    • (2003) Clinical Pharmacology and Therapeutics , vol.73 , Issue.6 , pp. 538-544
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 83
    • 0035337643 scopus 로고    scopus 로고
    • Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate
    • Kyrklund, C. et al. Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate. Clin. Pharmacol. Ther. 69, 340-345 (2001).
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 340-345
    • Kyrklund, C.1
  • 85
    • 1842559795 scopus 로고    scopus 로고
    • Rosuvastatin and fenofibrate alone and in combination in type 2 diabetes patients with combined hyperlipidaemia
    • Durrington, P. N., Tuomilehto, J., Hamann, A., Kallend, D. & smith, K. Rosuvastatin and fenofibrate alone and in combination in type 2 diabetes patients with combined hyperlipidaemia. Diabetes Res. Clin. Pract. 64, 137-151 (2004).
    • (2004) Diabetes Res. Clin. Pract. , vol.64 , pp. 137-151
    • Durrington, P.N.1    Tuomilehto, J.2    Hamann, A.3    Kallend, D.4    Smith, K.5
  • 86
    • 33846199963 scopus 로고    scopus 로고
    • Efficacy and safety of the coadministration of ezetimibe/simvastatin with fenofibrate in patients with mixed hyperlipidemia
    • Farnier, M. et al. Efficacy and safety of the coadministration of ezetimibe/simvastatin with fenofibrate in patients with mixed hyperlipidemia. Am. Heart J. 153, 335e1-335e8 (2007).
    • (2007) Am. Heart J. , vol.153
    • Farnier, M.1
  • 87
  • 88
    • 13844272245 scopus 로고    scopus 로고
    • Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the sAFAri trial)
    • Grundy, S. M. et al. Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the sAFAri trial). Am. J. Cardiol. 95, 462-468 (2005).
    • (2005) Am. J. Cardiol. , vol.95 , pp. 462-468
    • Grundy, S.M.1
  • 89
    • 18944381282 scopus 로고    scopus 로고
    • Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia
    • Koh, K. K. et al. Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia. J. Am. Coll. Cardiol. 45, 1649-1653 (2005).
    • (2005) J. Am. Coll. Cardiol. , vol.45 , pp. 1649-1653
    • Koh, K.K.1
  • 90
    • 10444268083 scopus 로고    scopus 로고
    • Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: A 12-month, randomized, double-blind, controlled trial
    • Derosa, G. et al. Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial. Clin. Ther. 26, 1599-1607 (2004).
    • (2004) Clin. Ther. , vol.26 , pp. 1599-1607
    • Derosa, G.1
  • 91
    • 0037446467 scopus 로고    scopus 로고
    • Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome
    • Vega, G. L. et al. Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome. Am. J. Cardiol. 91, 956-960 (2003).
    • (2003) Am. J. Cardiol. , vol.91 , pp. 956-960
    • Vega, G.L.1
  • 92
    • 0033985113 scopus 로고    scopus 로고
    • Effect of combined fluvastatin-fenofibrate therapy compared with fenofibrate monotherapy in severe primary hypercholesterolemia. French Fluvastatin study Group
    • Farnier, M. & Dejager, S. Effect of combined fluvastatin-fenofibrate therapy compared with fenofibrate monotherapy in severe primary hypercholesterolemia. French Fluvastatin study Group. Am. J. Cardiol. 85, 53-57 (2000).
    • (2000) Am. J. Cardiol. , vol.85 , pp. 53-57
    • Farnier, M.1    Dejager, S.2
  • 93
    • 0032938465 scopus 로고    scopus 로고
    • Effectiveness and safety of alternate-day simvastatin and fenofibrate on mixed hyperlipidemia
    • Kayikçiolu, M., Ozerkan, F. & soydan, I. Effectiveness and safety of alternate-day simvastatin and fenofibrate on mixed hyperlipidemia. Am. J. Cardiol. 83, 1135-1137 (1999).
    • (1999) Am. J. Cardiol. , vol.83 , pp. 1135-1137
    • Kayikçiolu, M.1    Ozerkan, F.2    Soydan, I.3
  • 94
    • 0032568095 scopus 로고    scopus 로고
    • Long-term efficacy and safety of fenofibrate and a statin in the treatment of combined hyperlipidemia
    • Ellen, R. L. & McPherson, R. Long-term efficacy and safety of fenofibrate and a statin in the treatment of combined hyperlipidemia. Am. J. Cardiol. 81, 60B-65B (1998).
    • (1998) Am. J. Cardiol. , vol.81
    • Ellen, R.L.1    McPherson, R.2
  • 95
    • 0030712388 scopus 로고    scopus 로고
    • Fenofibrate plus simvastatin therapy versus simvastatin plus cholestyramine therapy for familial hypercholesterolaemia
    • Wierzbicki, A. S., Lumb, P. J., Cheung, J. & Crook, M. A. Fenofibrate plus simvastatin therapy versus simvastatin plus cholestyramine therapy for familial hypercholesterolaemia. QJM 90, 631-634 (1997).
    • (1997) QJM , vol.90 , pp. 631-634
    • Wierzbicki, A.S.1    Lumb, P.J.2    Cheung, J.3    Crook, M.A.4
  • 96
    • 0038637253 scopus 로고    scopus 로고
    • Efficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia
    • Wägner, A. M., Jorba, O., Bonet, R., Ordóñez-Llanos, J. & Pérez, A. Efficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia. J. Clin. Endocrinol. Metab. 88, 3212-3217 (2003).
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 3212-3217
    • Wägner, A.M.1    Jorba, O.2    Bonet, R.3    Ordóñez-Llanos, J.4    Pérez, A.5
  • 97
    • 0002042353 scopus 로고    scopus 로고
    • Combined treatment of hypercholesterolemia of renal transplant allograft recipients with fluvastatin and gemfibrozil
    • Vergoulas, G. et al. Combined treatment of hypercholesterolemia of renal transplant allograft recipients with fluvastatin and gemfibrozil. Transpl. Int. 13 (Suppl. 1), s64-s67 (2000).
    • (2000) Transpl. Int. , vol.13 , Issue.SUPPL. 1
    • Vergoulas, G.1
  • 98
    • 0032788490 scopus 로고    scopus 로고
    • Long-term safety and efficacy of combination gemfibrozil and HMG-CoA reductase inhibitors for the treatment of mixed lipid disorders
    • Murdock, D. K. et al. Long-term safety and efficacy of combination gemfibrozil and HMG-CoA reductase inhibitors for the treatment of mixed lipid disorders. Am. Heart J. 138, 151-155 (1999).
    • (1999) Am. Heart J. , vol.138 , pp. 151-155
    • Murdock, D.K.1
  • 99
    • 0032959122 scopus 로고    scopus 로고
    • Long-term safety of pravastatin-gemfibrozil therapy in mixed hyperlipidemia
    • Iliadis, E. A. & rosenson, R. S. Long-term safety of pravastatin-gemfibrozil therapy in mixed hyperlipidemia. Clin. Cardiol. 22, 25-28 (1999).
    • (1999) Clin. Cardiol. , vol.22 , pp. 25-28
    • Iliadis, E.A.1    Rosenson, R.S.2
  • 100
    • 0029003602 scopus 로고
    • Treatment of combined hyperlipidemia with fluvastatin and gemfibrozil, alone or in combination, does not induce muscle damage
    • Smit, J. W. et al. Treatment of combined hyperlipidemia with fluvastatin and gemfibrozil, alone or in combination, does not induce muscle damage. Am. J. Cardiol. 76, 126A-128A (1995).
    • (1995) Am. J. Cardiol. , vol.76
    • Smit, J.W.1
  • 101
    • 0028033548 scopus 로고
    • Safety of combined pravastatin-gemfibrozil therapy
    • Rosenson, R. S. & Frauenheim, W. A. Safety of combined pravastatin-gemfibrozil therapy. Am. J. Cardiol. 74, 499-500 (1994).
    • (1994) Am. J. Cardiol. , vol.74 , pp. 499-500
    • Rosenson, R.S.1    Frauenheim, W.A.2
  • 102
    • 0027400118 scopus 로고
    • Pravastatin and gemfibrozil alone and in combination for the treatment of hypercholesterolemia
    • Wiklund, O. et al. Pravastatin and gemfibrozil alone and in combination for the treatment of hypercholesterolemia. Am. J. Med. 94, 13-20 (1993).
    • (1993) Am. J. Med. , vol.94 , pp. 13-20
    • Wiklund, O.1
  • 103
    • 0027194085 scopus 로고
    • Treatment of hyperlipidemia in heart transplant recipients with gemfibrozil ± lovastatin
    • Peters, J. R., Kubo, S. H., Olivari, M. T. , Knutson, K. R. & Hunninghake, D. B. Treatment of hyperlipidemia in heart transplant recipients with gemfibrozil ± lovastatin. Am. J. Cardiol. 71, 1485-1488 (1993).
    • (1993) Am. J. Cardiol. , vol.71 , pp. 1485-1488
    • Peters, J.R.1    Kubo, S.H.2    Olivari, M.T.3    Knutson, K.R.4    Hunninghake, D.B.5
  • 104
    • 0026484780 scopus 로고
    • The influence of simvastatin alone or in combination with gemfibrozil on plasma lipids and lipoproteins in patients with type iii hyperlipoproteinemia
    • Feussner, G., Eichinger, M. & Ziegler, R. The influence of simvastatin alone or in combination with gemfibrozil on plasma lipids and lipoproteins in patients with type iii hyperlipoproteinemia. Clin. Investig. 70, 1027-1035 (1992).
    • (1992) Clin. Investig. , vol.70 , pp. 1027-1035
    • Feussner, G.1    Eichinger, M.2    Ziegler, R.3
  • 105
    • 0025309850 scopus 로고
    • Safety and efficacy of combined gemfibrozil-lovastatin therapy for primary dyslipoproteinemias
    • Glueck, C. J., Speirs, J. & Tracy, T. Safety and efficacy of combined gemfibrozil-lovastatin therapy for primary dyslipoproteinemias. J. Lab. Clin. Med. 115, 603-609 (1990).
    • (1990) J. Lab. Clin. Med. , vol.115 , pp. 603-609
    • Glueck, C.J.1    Speirs, J.2    Tracy, T.3
  • 106
    • 0024514075 scopus 로고
    • Influence of lovastatin plus gemfibrozil on plasma lipids and lipoproteins in patients with heterozygous familial hypercholesterolemia
    • Illingworth, D. R. & Bacon, S. Influence of lovastatin plus gemfibrozil on plasma lipids and lipoproteins in patients with heterozygous familial hypercholesterolemia. Circulation 79, 590-596 (1989). (Pubitemid 19087710)
    • (1989) Circulation , vol.79 , Issue.3 , pp. 590-596
    • Illingworth, D.R.1    Bacon, S.2
  • 107
    • 67349119255 scopus 로고    scopus 로고
    • Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: A phase 3 study
    • Jones, P. H. et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: a phase 3 study. Atherosclerosis 204, 208-215 (2009).
    • (2009) Atherosclerosis , vol.204 , pp. 208-215
    • Jones, P.H.1
  • 108
    • 33645872390 scopus 로고    scopus 로고
    • Statin safety: An appraisal from the adverse event reporting system
    • Davidson, M. H., Clark, J. A., Glass, L. M. & Kanumalla, A. Statin safety: an appraisal from the adverse event reporting system. Am. J. Cardiol. 97, 32C-43C (2006).
    • (2006) Am. J. Cardiol. , vol.97
    • Davidson, M.H.1    Clark, J.A.2    Glass, L.M.3    Kanumalla, A.4
  • 110
    • 11144239674 scopus 로고    scopus 로고
    • Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin
    • Jones, P. H. & Davidson, M. H. Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin. Am. J. Cardiol. 95, 120-122 (2005).
    • (2005) Am. J. Cardiol. , vol.95 , pp. 120-122
    • Jones, P.H.1    Davidson, M.H.2
  • 111
    • 37449001912 scopus 로고    scopus 로고
    • Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use
    • Holoshitz, N., Alsheikh-Ali, A. A. & Karas, R. H. Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use. Am. J. Cardiol. 101, 95-97 (2008).
    • (2008) Am. J. Cardiol. , vol.101 , pp. 95-97
    • Holoshitz, N.1    Alsheikh-Ali, A.A.2    Karas, R.H.3
  • 112
    • 3042623891 scopus 로고    scopus 로고
    • Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy
    • Chang, J. T. , staffa, J. A., Parks, M. & Green, L. Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy. Pharmacoepidemiol. Drug Saf. 13, 417-426 (2004).
    • (2004) Pharmacoepidemiol. Drug Saf. , vol.13 , pp. 417-426
    • Chang, J.T.1    Staffa, J.A.2    Parks, M.3    Green, L.4
  • 113
    • 0033863264 scopus 로고    scopus 로고
    • Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro
    • Wandel, C., Kim, R. B., Guengerich, F. P. & wood, A. J. Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. Drug Metab. Dispos. 28, 895-898 (2000).
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 895-898
    • Wandel, C.1    Kim, R.B.2    Guengerich, F.P.3    Wood, A.J.4
  • 114
    • 0037310871 scopus 로고    scopus 로고
    • Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin
    • Shitara, Y. , itoh, T. , sato, H., Li, A. P. & sugiyama, Y. Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A. J. Pharmacol. Exp. Ther. 304, 610-616 (2003).
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 610-616
    • Shitara, Y.1    Itoh, T.2    Ssato Li H, A.P.3    Sugiyama, Y.4
  • 115
    • 25844438751 scopus 로고    scopus 로고
    • Cyclosporine markedly raises the plasma concentrations of repaglinide
    • Kajosaari, L. I. et al. Cyclosporine markedly raises the plasma concentrations of repaglinide. Clin. Pharmacol. Ther. 78, 388-399 (2005).
    • (2005) Clin. Pharmacol. Ther. , vol.78 , pp. 388-399
    • Kajosaari, L.I.1
  • 116
    • 14944386980 scopus 로고    scopus 로고
    • Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin
    • Ejendal, K. F. & Hrycyna, C. A. Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A. Mol. Pharmacol. 67, 902-911 (2005).
    • (2005) Mol. Pharmacol. , vol.67 , pp. 902-911
    • Ejendal, K.F.1    Hrycynac., A.2
  • 117
    • 33744982042 scopus 로고    scopus 로고
    • AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update, endorsed by the National Heart, Lung, and Blood institute
    • Smith, S. C. Jr. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update, endorsed by the National Heart, Lung, and Blood institute. Circulation 113, 2363-2372 (2006)
    • (2006) Circulation , vol.113 , pp. 2363-2372
    • Smith Jr., S.C.1    Jacobson, T.A.2
  • 118
    • 44949180810 scopus 로고    scopus 로고
    • Managing dyslipidemia in chronic kidney disease
    • Harper, C. R. & Jacobson, T. A. Managing dyslipidemia in chronic kidney disease. J. Am. Coll. Cardiol. 51, 2375-2384 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 2375-2384
    • Harper, C.R.1    Jacobson, T.A.2
  • 119
    • 32444444724 scopus 로고    scopus 로고
    • Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients- the PriMO study
    • Bruckert, E., Hayem, G., Dejager, S., Yau, C. & Bégaud, B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients- the PriMO study. Cardiovasc. Drugs Ther. 19, 403-414 (2005).
    • (2005) Cardiovasc. Drugs Ther. , vol.19 , pp. 403-414
    • Bruckert, E.1    Hayem, G.2    Dejager, S.3    Yau, C.4    Bégaud, B.5
  • 120
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
    • Rubins, H. B. et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol intervention Trial study Group. N. Engl. J. Med. 341, 410-418 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 410-418
    • Rubins, H.B.1
  • 121
    • 0042669791 scopus 로고    scopus 로고
    • Insulin resistance and cardiovascular events with low HDL cholesterol: The veterans Affairs HDL intervention Trial (vA-HiT)
    • Robins, S. J. et al. Insulin resistance and cardiovascular events with low HDL cholesterol: the veterans Affairs HDL intervention Trial (vA-HiT). Diabetes Care 26, 1513-1517 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 1513-1517
    • Robins, S.J.1
  • 122
    • 34250753275 scopus 로고    scopus 로고
    • Evolution of the lipid trial protocol of the Action to Control Cardiovascular risk in Diabetes (ACCOrD) trial
    • Ginsberg, H. N. et al. Evolution of the lipid trial protocol of the Action to Control Cardiovascular risk in Diabetes (ACCOrD) trial. Am. J. Cardiol. 99 (Part A), 56i-67i (2007).
    • (2007) Am. J. Cardiol. , vol.99 , Issue.PART A
    • Ginsberg, H.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.