Modalities in prevention of flexor tendon adhesion in the hand: What have we achieved so far?

Acta Orthopaedica Belgica

Volumn 75, Issue 4, 2009, Pages 433-444

  Khanna, Anil ^a   Gougoulias, Nikolaos ^b   Maffulli, Nicola ^a,c  

^a Centre for Sports and Exercise Medicine   (United Kingdom)

^b UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adhesions; Hand; Lexor tendons

Indexed keywords

ANIMAL; HAND INJURY; HUMAN; ORTHOPEDIC SURGERY; REVIEW; SUTURING METHOD; TENDON INJURY; TISSUE ADHESION;

ANIMALS; HAND INJURIES; HUMANS; ORTHOPEDIC PROCEDURES; SUTURE TECHNIQUES; TENDON INJURIES; TISSUE ADHESIONS;

EID: 70349319577     PISSN: 00016462     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Abrahamsson SO, Gelberman RH, Lohmander SL. Variations in cellular proliferation and matrix synthesis in intrasynovial and extrasynovial tendons: an in vitro study in dogs. J Hand Surg 1994; 19-A: 259-265.
2. (Pubitemid 26067991) Adolfsson L, Soderberg G, Larsson M, Karlander LE. The effects of a shortened postoperative mobilization programme after flexor tendon repair in zone 2. J Hand Surg 1996; 21-B: 67-71.
3. (Pubitemid 29018844) Akali A, Khan U, Khaw P T, McGrouther AD. Decrease in adhesion formation by a single application of 5-fluorouracil after flexor tendon injury. Plast Reconstr Surg 1999; 103: 151-158.
4. (Pubitemid 40126461) Akasaka T, Nishida J, Araki S et al. Hyaluronic acid diminishes the resistance to excursion after flexor tendon repair: an in vitro biomechanical study. J Biomech 2005; 38:503-507.
5. Amadio PC. Friction of the gliding surface. Implications for tendon surgery and rehabilitation. J Hand Ther 2005; 18: 112-119.
6. Amadio PC, Hunter JM, Jaeger SH, Wehbe MA, Schneider LH. The effect of vincular injury on the results of flexor tendon surgery in zone 2. J Hand Surg 1985; 10-B: 626-632.
7. Aoki M, Manske PR, Pruitt DL, Larson BJ. Work of flexion after tendon repair with various suture methods. A human cadaveric study. J Hand Surg 1995; 20-B: 310-313.
8. (Pubitemid 24105116) Ark JW, Gelberman RH, Abrahamsson SO, Seiler JG 3rd, Amiel D. Cellular survival and proliferation in autogenous flexor tendon grafts. J Hand Surg 1994; 19-A: 249-258.
9. (Pubitemid 30354310) Barrie KA, Wolfe SW, Shean C et al. A biomechanical comparison of multistrand flexor tendon repairs using an in situ testing model. J Hand Surg 2000; 25-A: 499-506.
10. Boyer MI, Gelberman RH, Burns ME et al. Intrasynovial flexor tendon repair: an experimental study comparing low and high levels of in vivo force during rehabilitation in canines. J Bone Joint Surg 2001; 83: 891-899.
11. Boyer MI, Goldfarb CA, Gelberman RH. Recent progress in flexor tendon healing. The modulation of tendon healing with rehabilitation variables. J Hand Ther 2005; 18: 80-85.
12. (Pubitemid 29501509) Carpenter JE, Thomopoulos S, Soslowsky LJ. Animal models of tendon and ligament injuries for tissue engineering applications. Clin Orthop Relat Res 1999; 367: 296-311.
13. (Pubitemid 30027042) Chang J, Thunder R, Most D, Longaker MT, Lineaweaver WC. Studies in flexor tendon wound healing: neutralizing antibody to TGF-betal increases postoperative range of motion. Plast Reconstr Surg 2000; 105:148-155.
14. Dinopoulos HT, Boyer MI, Burns ME, Gelberman RH, Silva MJ. The resistance of a four-and eight-strand suture technique to gap formation during tensile testing: an experimental study of repaired canine flexor tendons after 10 days of in vivo healing. J Hand Surg 2000; 25-A: 489-498.
15. (Pubitemid 20093917) Dunlap J, McCarthy JA, Joyce ME, Manske PR. Biomechanical and histologic evaluations of pulley reconstructions in non-human primates. J Hand Surg 1990; 15-A: 57-63.
16. (Pubitemid 38673751) Ferguson M W, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci 2004; 359: 839-850.
17. Gelberman RH, Manske PR. Factors influencing flexor tendon adhesions. Hand Clin 1985; 1: 35-42.
18. Gelberman RH, Nunley JA 2nd, Osterman AL et al. Influences of the protected passive mobilization interval on flexor tendon healing. A prospective randomized clinical study. Clin Orthop Relat Res 1991; 264: 189-196.
19. Gelberman RH, VandeBerg JS, Lundborg GN, Akeson WH. Flexor tendon healing and restoration of the gliding surface: an ultrastructural study in dogs. J Bone Joint Surg 1983; 65-A: 70-80.
20. (Pubitemid 20093919) Gelberman RH, Woo SL-Y, Amiel D, Horibe S, Lee D. Influences of flexor sheath continuity and early motion on tendon healing in dogs. J Hand Surg 1990; 15-A: 69-77.
21. Gelberman RH, Woo SLY, Lothringer K, Akeson WH, Amiel D. Effects of early intermittent passive mobilization on healing canine flexor tendons. J Hand Surg 1982; 7-A: 170-175.
22. Gill RS, Lim BH, Shatford RA et al. A comparative analysis of the six-strand double-loop flexor tendon repair and three other techniques: a human cadaveric study. J Hand Surg 1999; 24-A: 1315-1322.
23. (Pubitemid 26421326) Greenough CG. The effect of pulsed electromagnetic fields on flexor tendon healing in the rabbit. J Hand Surg 1996; 21-B: 808-812.
24. (Pubitemid 40569571) Groth GN. Current practice patterns of flexor tendon rehabilitation. J Hand Ther 2005; 18: 169-174.
25. (Pubitemid 46198080) Hackam DG. Translating animal research into clinical benefit. BMJ 2007; 27: 163-164.
26. (Pubitemid 29098716) Hagberg L. Exogenous hyaluronate as an adjunct in the prevention of adhesions after flexor tendon surgery: a controlled clinical trial. J Hand Surg 1992; 17: 132-136.
27. Hagberg L, Abrahamsson S, Philstrom S, Carlsson I. Active flexion versus rubber band traction for early controlled mobilization following flexor tendon repair in zone II. A controlled clinical study. J Hand Surg 2000; 25-B (Suppl): 52.
28. (Pubitemid 34863356) Hanff G, Dahlin LB, Lundborg G. Reconstruction of flexor tendon pulley with expanded polytetrafluoroethylene (e-PTFE). Scand J Plastic Reconstr Surg 1991; 25: 25-30.
29. Hanff G, Hagberg L. Prevention of restrictive adhesions with expanded polytetrafluoroethylene diffusible membrane following flexor tendon repair: an experimental study in rabbits. J Hand Surg 1998; 23-A: 658-664.
30. Horii E, Lin GT, Cooney WP, Linscheid RL, An KN. Comparative flexor tendon excursion after passive mobilization: an in vitro study. J Hand Surg 1992; 17: 559-566.
31. Işik S, Oztürk S, Gürses S et al. Prevention of restrictive adhesions in primary tendon repair by HA-membrane: experimental research in chickens. Br J Plast Surg 1999; 52: 373-379.
32. Jones ME, Burnett S, Southgate A et al. The role of human-derived fibrin sealant in the reduction of postoperative flexor tendon adhesion formation in rabbits. J Hand Surg 2002; 27-B: 78-82.
33. Karakurum G, Buyukbebeci O, Kalender M, Gulec A. Seprafilm interposition for preventing adhesion formation after tenolysis. An experimental study on the chicken flexor tendons. J Surg Res 2003; 113: 195-200.
34. Kneafsey B, O'Shaughnessy M, Vidal P, Milling MA, Sykes PJ. Controlled mobilization after flexor tendon repair: a prospective comparison of two methods. J Hand Surg 1994; 19 (Suppl 1): 37-38.
35. (Pubitemid 32982270) Kobayashi M, Toguchida J, Oka M. Development of polyvinyl alcohol-hydrogel (PVA-H) shields with a high water content for tendon injury repair. J Hand Surg 2001; 26-B: 436-440.
36. (Pubitemid 15222995) Kulick MI, Brazlow R, Smith S, Hentz VR. Injectable ibuprofen: preliminary evaluation of its ability to decrease peritendinous adhesions. Ann Plast Surg 1984; 13: 459-467.
37. (Pubitemid 16187934) Kulick MI, Smith S, Hadler K. Oral ibuprofen: evaluation of its effect on peritendinous adhesions and the breaking strength of a tenorrhaphy. J Hand Surg 1986; 11-A: 110-120.
38. (Pubitemid 40613646) Kusano N, Zaegel MA, Placzek JD, Gelberman RH, Silva MJ. Supplementary core sutures increase resistance to gapping for flexor digitorum profundus tendon to bone surface repair - an in vitro biomechanical analysis. J Hand Surg 2005; 30: 288-293.
39. Lundborg G. Experimental flexor tendon healing without adhesion formation: a new concept of tendon nutrition and intrinsic healing mechanisms. Hand 1976; 8: 235-238.
40. Lundborg G, Holm S, Myrhage R. The role of the synovial fluid and tendon sheath for flexor tendon nutrition. Scand J Plast Reconstr Surg 1980; 14: 99-107.
41. (Pubitemid 8283399) Lundborg G, Rank F. Experimental intrinsic healing of flexor tendon based upon synovial fluid nutrition. J Hand Surg 1978; 3-A: 21-31.
42. (Pubitemid 43943721) Maiti SK, Kumar N, Singh GR, Hoque M, Singh R. Ultrasound therapy in tendinous injury healing in goats. J Vet Med A Physiol Pathol Clin Med 2006; 53: 249-258.
43. Manske PR, Lesker PA. Comparative nutrient pathways to the flexor profundus tendon in zone II of various experimental animals. J Surg Res 1983; 34: 83-93.
44. (Pubitemid 44511336) McCombe D, Kubicki M, Witschi C, Williams J, Thompson EW. A collagen prolyl 4-hydroxylase inhibitor reduces adhesions after tendon injury. Clin Orthop Rel Res 2006; 451: 251-256.
45. (Pubitemid 30165587) Moran SL, Ryan CK, Orlando GS, Pratt CE, Michalko KB. Effects of 5-fluorouracil on flexor tendon repair. J Hand Surg 2000; 25-A: 242-251.
46. (Pubitemid 46034432) Namba J, Shimada K, Saito M et al. Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model. J Biomed Mater Res B Appl Biomater 2007; 80: 273-279.
47. (Pubitemid 23234192) Noguchi M, Seiler JG III, Gelberman RH, Sofranko RA, Woo SL-Y. In vitro biomechanical analysis of suture methods for flexor tendon repair. J Orthop Res 1993; 11: 603-611.
48. (Pubitemid 27103299) Nyska M, Nyska A, Rivlin E et al. Topically applied halofuginone, an inhibitor of collagen type I transcription, reduces peritendinous fibrous adhesions following surgery. Connect Tissue Res 1996; 34: 97-103.
49. (Pubitemid 32244888) Ozgenel GY, Samli B, Ozcan M. Effects of human amniotic fluid on peritendinous adhesion formation and tendon healing after flexor tendon surgery in rabbits. J Hand Surg 2001; 26-A: 332-329.
50. Percival NJ, Sykes PJ. Flexor pollicis longus tendon repair: a comparison between dynamic and static splintage. J Hand Surg 1989; 14-B: 412-415.
51. (Pubitemid 20093916) Peterson WW, Manske PR, Dunlap J, Horwitz DS, Kahn B. Effect of various methods of restoring flexor sheath integrity on the formation of adhesions after tendon surgery. J Hand Surg 1990; 15-A: 48-56.
52. Peterson WW, Manske PR, Kain CC, Lesker PA. Effect of flexor sheath integrity on tendon gliding: a biomechanical and histologic study. J Orthop Res 1986; 4: 458-465.
53. (Pubitemid 10145152) Porat S, Rousso M, Shoshan S. Improvement of gliding function of flexor tendons by topically applied enriched collagen solution. J Bone Joint Surg 1980; 62-B: 208-213.
54. (Pubitemid 29084349) Robotti E, Zimbler AG, Kenna D, Grossman JA. The effect of pulsed electromagnetic fields on flexor tendon healing in chickens. J Hand Surg 1999; 24-B: 56-58.
55. Rothkopf DM, Webb S, Szabo RM, Gelberman RH, May JWJr. An experimental model for the study of canine flexor tendon adhesions. J Hand Surg 1991; 16-A: 694-700.
56. Saldana MJ, Ho PK, Lichtman DM et al. Flexor tendon repair and rehabilitation in zone II: open sheath technique versus closed sheath technique. J Hand Surg 1987; 12-A: 1110-1114.
57. Siddiqi NA, Hamada Y, Ide T, Akamatsu N. Effects of hydroxyapatite and alumina sheaths on postoperative peritendinous adhesions in chickens. J Appl Biomater 1995; 6: 43-53.
58. Siddiqi NA, Hamada Y, Yamaguchi T, Toshima T. An experimental study on the application of a hydroxyapatite artificial tendon sheath to prevent adhesions after tendon repair (Part 1). Nippon Seikeigeka Gakkai Zasshi 1991; 65: 561-570.
59. Smith A M, Forder JA, Annapureddy SR, Reddy KS, Amis AA. The porcine forelimb as a model for human flexor tendon surgery. J Hand Surg 2005; 30-B: 307-309.
60. (Pubitemid 15119416) Speer D P, Feldman S, Chvapil M. The control of peritendinous adhesions using topical beta-aminopropionitrile base. J Surg Res 1985; 38: 252-257.
61. (Pubitemid 17173474) Strauch B, de Moura W, Ferder M et al. The fate of tendon healing after restoration of the integrity of the tendon sheath with autogenous vein grafts. J Hand Surg 1985; 10-A: 790-795.
62. (Pubitemid 38146396) Strick MJ, Filan SL, Hile M et al. Adhesion formation after flexor tendon repair: a histologic and biomechanical comparison of 2- and 4-strand repairs in a chicken model. J Hand Surg 2004; 29-A: 15-21.
63. Strickland JW. Development of flexor tendon surgery: twenty-five years of progress. J Hand Surg 2000; 25-A: 214-235.
64. Strickland JW, Glogovac SV. Digital function following flexor tendon repair in Zone II: a comparison of immobilization and controlled passive motion techniques. J Hand Surg 1980; 5-A: 537-543.
65. Sueoka SS, Lastayo PC. Zone II flexor tendon rehabilitation: a proposed algorithm. J Hand Ther 2008; 21: 410-413.
66. (Pubitemid 44973322) Sungur N, Uysal A, Koçer U et al. Prevention of tendon adhesions by the reconstruction of the tendon sheath with solvent dehydrated bovine pericard: An experimental study. J Trauma 2006; 61: 1467-1472.
67. (Pubitemid 20231140) Szabo RM, Younger E. Effects of indomethacin on adhesion formation after repair of zone II tendon lacerations in the rabbit. J Hand Surg 1990; 15-A: 480-483.
68. (Pubitemid 46991156) Tanaka T, Zhao C, Sun YL et al. The effect of carbodiimide-derivatized hyaluronic acid and gelatin surface modification on peroneus longus tendon graft in a shortterm canine model in vivo. J Hand Surg 2007; 32-A: 876-881.
69. (Pubitemid 40692392) Tang JB. Clinical outcomes associated with flexor tendon repair. Hand Clin 2005; 21: 199-210.
70. (Pubitemid 351632653) Tang JB, Cao Y, Zhu B et al. Adeno-associated virus-2-mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength. An in vivo study. J Bone Joint Surg 2008; 90-A: 1078-1089.
71. (Pubitemid 24233588) Tang JB, Ishii S, Usui M, Yamamura T. Flexor sheath closure during delayed primary tendon repair. J Hand Surg 1994; 19-A: 636-640.
72. Thurman RT, Trumble TE, Hand DP, Tencer AF, Kiser PK. Two-, four-, and six-strand zone II flexor tendon repairsan in situ biomechanical comparison using a cadaver model. J Hand Surg 1998; 23-A: 261-265.
73. (Pubitemid 33117456) Walbeehm ET, De Wit T, Hovius SE, McGrouther DA. Influence of core suture geometry on tendon deformation and gap formation in porcine flexor tendons. J Hand Surg Eur Vol 2009; 34:190-195.
74. Wang ED. Tendon repair. J Hand Therapy 1998; 11: 105-110.
75. (Pubitemid 34207975) Zhao C, Amadio P C, Momose T et al. The effect of suture technique on adhesion formation after flexor tendon repair for partial lacerations in a canine model. J Trauma 2001; 51: 917-921.
76. (Pubitemid 44834571) Zhao C, Amadio PC, Zobitz ME et al. Effect of synergistic motion on flexor digitorum profundus tendon excursion. Clin Orthop Relat Res 2002; 396: 223-230.
77. (Pubitemid 46687084) Zhao C, Sun Y L, Amadio PC et al. Surface treatment of flexor tendon autografts with carbodiimide-derivatized hyaluronic acid. An in vivo canine model. J Bone Joint Surg 2006; 88-A: 2181-2191.
78. Zhu B, Cao Y, Xin KQ et al. Tissue reactions of adenoviral, adeno-associated viral, and liposome-plasmid vectors in tendons and comparison with early-stage healing responses of injured flexor tendons. J Hand Surg 2006; 31-B: 1652-1260.