Tissue Reactions of Adenoviral, Adeno-Associated Viral, and Liposome-Plasmid Vectors in Tendons and Comparison With Early-Stage Healing Responses of Injured Flexor Tendons

Journal of Hand Surgery

Volumn 31, Issue 10, 2006, Pages 1652-1660

  Zhu, Bei ^a   Cao, Yi ^a   Xin, Ke Qin ^a   Wang, Xiao Tian ^a   Summerhayes, Ian C ^a   Liu, Paul Y ^a   Tang, Jin Bo ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

adeno associated viral vectors; adenoviral vectors; Flexor tendon; gene therapy; healing response; tissue reactions

Indexed keywords

LIPOSOME; LUCIFERASE;

ADENOVIRUS VECTOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FLEXOR TENDON INJURY; HEALING; INFLAMMATION; INTERMETHOD COMPARISON; NEW ZEALAND; NONHUMAN; PARVOVIRUS VECTOR; PLASMID VECTOR; PRIORITY JOURNAL; RABBIT; TISSUE REACTION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BETA-GALACTOSIDASE; CELL PROLIFERATION; CYTOMEGALOVIRUS; GENETIC VECTORS; INFLAMMATION; LIPOSOMES; LUCIFERASES; LYMPHOCYTES; NEUTROPHILS; PLASMIDS; RABBITS; TENDON INJURIES; TENDONS; WOUND HEALING;

EID: 33751520377     PISSN: 03635023     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhsa.2006.09.007     Document Type: Article

References (27)

1. Chan B.P., Chan K.M., Maffulli N., Webb S., and Lee K.K. Effect of basic fibroblast growth factor. An in vitro study of tendon healing. Clin Orthop 342 (1997) 239-247
2. Chang J., Most D., Thunder R., Mehrara B., Longaker M.T., and Lineaweaver W.C. Molecular studies in flexor tendon wound healing: the role of basic fibroblast growth factor gene expression. J Hand Surg 23A (1998) 1052-1058
3. Yoshikawa Y., and Abrahamsson S.O. Dose-related cellular effects of platelet-derived growth factor-BB differ in various types of rabbit tendons in vitro. Acta Orthop Scand 72 (2001) 287-292
4. Tang J.B., Xu Y., Ding F., and Wang X.T. Tendon healing in vitro: promotion of collagen gene expression by bFGF with NF-κB gene activation. J Hand Surg 28A (2003) 215-220
5. Klein M.B., Yalamanchi N., Pham H., Longaker M.T., and Chang J. Flexor tendon healing in vitro: effects of TGF-β on tendon cell collagen production. J Hand Surg 27A (2002) 615-620
6. Lou J. In vivo gene transfer into tendon by recombinant adenovirus. Clin Orthop 379 suppl (2000) 252-255
7. Lou J., Kubota H., Hotokezaka S., Ludwig F.J., and Manske P.R. In vivo gene transfer and overexpression of focal adhesion kinase (pp125 FAK) mediated by recombinant adenovirus- induced tendon adhesion formation and epitenon cell change. J Orthop Res 15 (1997) 911-918
8. Lou J., Manske P.R., Aoki M., and Joyce M.E. Adenovirus-mediated gene transfer into tendon and tendon sheath. J Orthop Res 14 (1996) 513-517
9. Wang X.T., Liu P.Y., and Tang J.B. Tendon healing in vitro: genetic modification of tenocytes with exogenous PDGF gene and promotion of collagen gene expression. J Hand Surg 29A (2004) 884-890
10. Mehta V., Kang Q., Luo J., He T.C., Haydon R.C., and Mass D.P. Characterization of adenovirus-mediated gene transfer in rabbit flexor tendons. J Hand Surg 30A (2005) 136-141
11. Wang X.T., Liu P.Y., Xin K.Q., and Tang J.B. Tendon healing in vitro: bFGF gene transfer to tenocytes by adeno-associated viral vectors promotes expression of collagen genes. J Hand Surg 30A (2005) 1255-1261
12. McMahon J.M., Wells K.E., Bamfo J.E., Cartwright M.A., and Wells D.J. Inflammatory responses following direct injection of plasmid DNA into skeletal muscle. Gene Ther 5 (1998) 1283-1290
13. Liu Q., and Muruve D.A. Molecular basis of the inflammatory response to adenovirus vectors. Gene Ther 10 (2003) 935-940
14. Nickerson H.D., and Colledge W.H. A comparison of gene repair strategies in cell culture using a lacZ reporter system. Gene Ther 10 (2003) 1584-1591
15. Martinek V., Latterman C., Usas A., Abramowitch S., Woo S.L., Fu F.H., and Huard J. Enhancement of tendon-bone integration of anterior cruciate ligament grafts with bone morphogenetic protein-2 gene transfer: a histological and biomechanical study. J Bone Joint Surg 84A (2002) 1123-1131
16. Rickert M., Wang H., Wieloch P., Lorenz H., Steck E., Sabo D., and Richter W. Adenovirus-mediated gene transfer of growth and differentiation factor-5 into tenocytes and the healing rat Achilles tendon. Connect Tissue Res 46 (2005) 175-183
17. Yokoo N., Saito T., Uesugi M., Kobayashi N., Xin K.Q., Okuda K., et al. Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector. Arthritis Rheum 52 (2005) 164-170
18. Liu P.Y., Tong W., Liu K., Han S.H., Wang X.T., Badiavas E., et al. Liposome-mediated transfer of vascular endothelial growth factor cDNA augments survival of random-pattern skin flaps in the rat. Wound Repair Regen 12 (2004) 80-85
19. Wang X.T., Liu P.Y., and Tang J.B. PDGF gene therapy enhances expression of VEGF and bFGF genes and activates the NF-κB gene in signal pathways in ischemic flaps. Plast Reconstr Surg 117 (2006) 129-137
20. Liu P.Y., Liu K., Wang X.T., Badiavas E., Rieger-Christ K.M., Tang J.B., and Summerhayes I.C. Efficacy of combination gene therapy with multiple growth factor cDNAs to enhance skin flap survival in a rat model. DNA Cell Biol 24 (2005) 751-757
21. Yang K., Clifton G.L., and Hayes R.L. Gene therapy for central nervous system injury: the use of cationic liposomes: an invited review. J Neurotrauma 14 (1997) 281-297
22. Pleyer U., Groth D., Hinz B., Keil O., Bertelmann E., Rieck P., and Reszka R. Efficiency and toxicity of liposome-mediated gene transfer to corneal endothelial cells. Exp Eye Res 73 (2001) 1-7
23. Brenner M. Gene transfer by adenovectors. Blood 94 (1999) 3965-3967
24. Schwarz E.M. The adeno-associated virus vector for orthopaedic gene therapy. Clin Orthop 379 suppl (2000) 31-39
25. Erles K., Sebokova P., and Schlehofer J.R. Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus (AAV). J Med Virol 59 (1999) 406-411
26. Daly T.M. AAV-mediated gene transfer to the liver. Methods Mol Biol 246 (2004) 195-199
27. Daly T.M. Overview of adeno-associated viral vectors. Methods Mol Biol 246 (2004) 157-165