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Volumn 53, Issue 10, 2009, Pages 4441-4449

High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete

Author keywords

[No Author keywords available]

Indexed keywords

ANTISPIROCHETAL AGENT; DNA; RESOLVASE; REST INHIBITOR; UNCLASSIFIED DRUG;

EID: 70349317380     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00529-09     Document Type: Article
Times cited : (8)

References (39)
  • 1
    • 4644325594 scopus 로고    scopus 로고
    • Mixing active site components: A recipe for the unique enzymatic activity of a telomere resolvase
    • Bankhead, T., and G. Chaconas. 2004. Mixing active site components: a recipe for the unique enzymatic activity of a telomere resolvase. Proc. Natl. Acad. Sci. USA 101:13768-13773.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13768-13773
    • Bankhead, T.1    Chaconas, G.2
  • 2
    • 33749991551 scopus 로고    scopus 로고
    • Unexpected twist: Harnessing the energy in positive supercoils to control telomere resolution
    • Bankhead, T., K. Kobryn, and G. Chaconas. 2006. Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution. Mol. Microbiol. 62:895-905.
    • (2006) Mol. Microbiol. , vol.62 , pp. 895-905
    • Bankhead, T.1    Kobryn, K.2    Chaconas, G.3
  • 3
    • 0023663587 scopus 로고
    • Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends
    • Barbour, A. G., and C. F. Garon. 1987. Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science 237:409-411.
    • (1987) Science , vol.237 , pp. 409-411
    • Barbour, A.G.1    Garon, C.F.2
  • 4
    • 21244445445 scopus 로고    scopus 로고
    • Mapping of essential replication functions of the linear plasmid lp17 of B. burgdorferi by targeted deletion walking
    • Beaurepaire, C., and G. Chaconas. 2005. Mapping of essential replication functions of the linear plasmid lp17 of B. burgdorferi by targeted deletion walking. Mol. Microbiol. 57:132-142.
    • (2005) Mol. Microbiol. , vol.57 , pp. 132-142
    • Beaurepaire, C.1    Chaconas, G.2
  • 6
    • 0035227131 scopus 로고    scopus 로고
    • Synthesis and use of DNA containing a 5′-bridging phosphorothioate as a suicide substrate for type I DNA topoisomerases
    • Burgin, A. B. 2001. Synthesis and use of DNA containing a 5′-bridging phosphorothioate as a suicide substrate for type I DNA topoisomerases. Methods Mol. Biol. 95:119-128.
    • (2001) Methods Mol. Biol. , vol.95 , pp. 119-128
    • Burgin, A.B.1
  • 7
    • 2442645223 scopus 로고    scopus 로고
    • The essential nature of the ubiquitous 26-kilobase circular replicon of Borrelia burgdorferi
    • Byram, R., P. E. Stewart, and P. Rosa. 2004. The essential nature of the ubiquitous 26-kilobase circular replicon of Borrelia burgdorferi. J. Bacteriol. 186:3561-3569.
    • (2004) J. Bacteriol. , vol.186 , pp. 3561-3569
    • Byram, R.1    Stewart, P.E.2    Rosa, P.3
  • 8
    • 0030696878 scopus 로고    scopus 로고
    • Telomeres of the linear chromosomes of Lyme disease spirochaetes: Nucleotide sequence and possible exchange with linear plasmid telomeres
    • Casjens, S., M. Murphy, M. DeLange, L. Sampson, R. van Vugt, and W. M. Huang. 1997. Telomeres of the linear chromosomes of Lyme disease spirochaetes: nucleotide sequence and possible exchange with linear plasmid telomeres. Mol. Microbiol. 26:581-596.
    • (1997) Mol. Microbiol. , vol.26 , pp. 581-596
    • Casjens, S.1    Murphy, M.2    Delange, M.3    Sampson, L.4    Van Vugt, R.5    Huang, W.M.6
  • 10
    • 27444436381 scopus 로고    scopus 로고
    • Hairpin telomere and genome plasticity in Borrelia: All mixed up in the end
    • Chaconas, G. 2005. Hairpin telomere and genome plasticity in Borrelia: all mixed up in the end. Mol. Microbiol. 58:625-635.
    • (2005) Mol. Microbiol. , vol.58 , pp. 625-635
    • Chaconas, G.1
  • 11
    • 0035875922 scopus 로고    scopus 로고
    • Telomere resolution in the Lyme disease spirochete
    • DOI 10.1093/emboj/20.12.3229
    • Chaconas, G., P. E. Stewart, K. Tilly, J. L. Bono, and P. Rosa. 2001. Telomere resolution in the Lyme disease spirochete. EMBO J. 20:3229-3237. (Pubitemid 32612010)
    • (2001) EMBO Journal , vol.20 , Issue.12 , pp. 3229-3237
    • Chaconas, G.1    Stewart, P.E.2    Tilly, K.3    Bono, J.L.4    Rosa, P.5
  • 12
    • 11144237450 scopus 로고    scopus 로고
    • Catalytic residues of the telomere resolvase ResT: A pattern similar to, but distinct from tyrosine recombinases and type IB topoisomerases
    • Deneke, J., A. B. Burgin, S. L. Wilson, and G. Chaconas. 2004. Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from tyrosine recombinases and type IB topoisomerases. J. Biol. Chem. 279:53699-53706.
    • (2004) J. Biol. Chem. , vol.279 , pp. 53699-53706
    • Deneke, J.1    Burgin, A.B.2    Wilson, S.L.3    Chaconas, G.4
  • 13
  • 14
    • 0033535579 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics
    • Dragovich, P. S., T. J. Prins, R. Zhou, S. A. Fuhrman, A. K. Patick, D. A. Matthews, C. E. Ford, J. W. Meador III, R. A. Ferre, and S. T. Worland. 1999. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J. Med. Chem. 42:1203-1212.
    • (1999) J. Med. Chem. , vol.42 , pp. 1203-1212
    • Dragovich, P.S.1    Prins, T.J.2    Zhou, R.3    Fuhrman, S.A.4    Patick, A.K.5    Matthews, D.A.6    Ford, C.E.7    Meador III, J.W.8    Ferre, R.A.9    Worland, S.T.10
  • 16
    • 0025746558 scopus 로고
    • Linear plasmids of Borrelia burgdorferi have a telomeric structure and sequence similar to those of a eukaryotic virus
    • Hinnebusch, J., and A. G. Barbour. 1991. Linear plasmids of Borrelia burgdorferi have a telomeric structure and sequence similar to those of a eukaryotic virus. J. Bacteriol. 173:7233-7239.
    • (1991) J. Bacteriol. , vol.173 , pp. 7233-7239
    • Hinnebusch, J.1    Barbour, A.G.2
  • 17
    • 33845683283 scopus 로고    scopus 로고
    • Antimicrobial susceptibility of Borrelia burgdorferi sensu lato: What we know, what we don't know, and what we need to know
    • Hunfeld, K. P., and V. Brade. 2006. Antimicrobial susceptibility of Borrelia burgdorferi sensu lato: what we know, what we don't know, and what we need to know. Wien Klin. Wochenschr. 118:659-668.
    • (2006) Wien Klin. Wochenschr. , vol.118 , pp. 659-668
    • Hunfeld, K.P.1    Brade, V.2
  • 18
    • 22844437553 scopus 로고    scopus 로고
    • Uncoupling the chemical steps of telomere resolution by ResT
    • Kobryn, K., A. B. Burgin, and G. Chaconas. 2005. Uncoupling the chemical steps of telomere resolution by ResT. J. Biol. Chem. 280:26788-26795.
    • (2005) J. Biol. Chem. , vol.280 , pp. 26788-26795
    • Kobryn, K.1    Burgin, A.B.2    Chaconas, G.3
  • 19
    • 15244346495 scopus 로고    scopus 로고
    • Fusion of hairpin telomeres by the B. burgdorferi telomere resolvase ResT: Implications for shaping a genome in flux
    • Kobryn, K., and G. Chaconas. 2005. Fusion of hairpin telomeres by the B. burgdorferi telomere resolvase ResT: implications for shaping a genome in flux. Mol. Cell 17:783-791.
    • (2005) Mol. Cell , vol.17 , pp. 783-791
    • Kobryn, K.1    Chaconas, G.2
  • 20
    • 0036161673 scopus 로고    scopus 로고
    • ResT, a telomere resolvase encoded by the Lyme disease spirochete
    • DOI 10.1016/S1097-2765(01)00433-6
    • Kobryn, K., and G. Chaconas. 2002. ResT, a telomere resolvase encoded by the Lyme disease spirochete. Mol. Cell 9:195-201. (Pubitemid 34127783)
    • (2002) Molecular Cell , vol.9 , Issue.1 , pp. 195-201
    • Kobryn, K.1    Chaconas, G.2
  • 22
    • 0037061628 scopus 로고    scopus 로고
    • A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
    • McGovern, S. L., E. Caselli, N. Grigorieff, and B. K. Shoichet. 2002. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 45:1712-1722.
    • (2002) J. Med. Chem. , vol.45 , pp. 1712-1722
    • McGovern, S.L.1    Caselli, E.2    Grigorieff, N.3    Shoichet, B.K.4
  • 26
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne, D. J., M. N. Gwynn, D. J. Holmes, and D. L. Pompliano. 2007. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6:29-40.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 27
    • 0032898516 scopus 로고    scopus 로고
    • Physical mapping of an origin of bidirectional replication at the centre of the Borrelia burgdorferi linear chromosome
    • Picardeau, M., J. R. Lobry, and B. J. Hinnebusch. 1999. Physical mapping of an origin of bidirectional replication at the centre of the Borrelia burgdorferi linear chromosome. Mol. Microbiol. 32:437-445.
    • (1999) Mol. Microbiol. , vol.32 , pp. 437-445
    • Picardeau, M.1    Lobry, J.R.2    Hinnebusch, B.J.3
  • 28
    • 33646350750 scopus 로고    scopus 로고
    • Strategies for reducing the risk of Lyme borreliosis in North America
    • Piesman, J. 2006. Strategies for reducing the risk of Lyme borreliosis in North America. Int. J. Med. Microbiol. 296(Suppl. 40):17-22.
    • (2006) Int. J. Med. Microbiol. , vol.296 , Issue.SUPPL. 40 , pp. 17-22
    • Piesman, J.1
  • 29
    • 0034610332 scopus 로고    scopus 로고
    • Correlation between plasmid content and infectivity in Borrelia burgdorferi
    • Purser, J. E., and S. J. Norris. 2000. Correlation between plasmid content and infectivity in Borrelia burgdorferi. Proc. Natl. Acad. Sci. USA 97:13865-13870.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13865-13870
    • Purser, J.E.1    Norris, S.J.2
  • 30
    • 0028641494 scopus 로고
    • The emergence of Lyme disease and human babesiosis in a changing environment
    • Spielman, A. 1994. The emergence of Lyme disease and human babesiosis in a changing environment. Ann. N. Y. Acad. Sci. 740:146-156.
    • (1994) Ann. N. Y. Acad. Sci. , vol.740 , pp. 146-156
    • Spielman, A.1
  • 31
    • 42949156146 scopus 로고    scopus 로고
    • Lyme disease: European perspective
    • Stanek, G., and F. Strle. 2008. Lyme disease: European perspective. Infect. Dis. Clin. N. Am. 22:327-339.
    • (2008) Infect. Dis. Clin. N. Am. , vol.22 , pp. 327-339
    • Stanek, G.1    Strle, F.2
  • 35
    • 65449144783 scopus 로고    scopus 로고
    • Characterization and in vitro reaction properties of 19 unique hairpin telomeres from the linear plasmids of the Lyme disease spirochete
    • Tourand, Y., J. Deneke, T. J. Moriarty, and G. Chaconas. 2009. Characterization and in vitro reaction properties of 19 unique hairpin telomeres from the linear plasmids of the Lyme disease spirochete. J. Biol. Chem. 284:7264-7272.
    • (2009) J. Biol. Chem. , vol.284 , pp. 7264-7272
    • Tourand, Y.1    Deneke, J.2    Moriarty, T.J.3    Chaconas, G.4
  • 36
    • 0037678809 scopus 로고    scopus 로고
    • Sequence-specific recognition but position-dependent cleavage of two distinct telomeres by the Borrelia burgdorferi telomere resolvase, ResT
    • Tourand, Y., K. Kobryn, and G. Chaconas. 2003. Sequence-specific recognition but position-dependent cleavage of two distinct telomeres by the Borrelia burgdorferi telomere resolvase, ResT. Mol. Microbiol. 48:901-911.
    • (2003) Mol. Microbiol. , vol.48 , pp. 901-911
    • Tourand, Y.1    Kobryn, K.2    Chaconas, G.3
  • 37
    • 34247512061 scopus 로고    scopus 로고
    • Telomere resolution by Borrelia burgdorferi ResT through the collaborative efforts of tethered DNA binding domains
    • Tourand, Y., L. Lee, and G. Chaconas. 2007. Telomere resolution by Borrelia burgdorferi ResT through the collaborative efforts of tethered DNA binding domains. Mol. Microbiol. 64:580-590.
    • (2007) Mol. Microbiol. , vol.64 , pp. 580-590
    • Tourand, Y.1    Lee, L.2    Chaconas, G.3
  • 38
    • 11144238722 scopus 로고    scopus 로고
    • An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
    • Tsao, J. I., J. T. Wootton, J. Bunikis, M. G. Luna, D. Fish, and A. G. Barbour. 2004. An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proc. Natl. Acad. Sci. USA 101:18159-18164.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 18159-18164
    • Tsao, J.I.1    Wootton, J.T.2    Bunikis, J.3    Luna, M.G.4    Fish, D.5    Barbour, A.G.6
  • 39
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang, J. H., T. D. Chung, and K. R. Oldenburg. 1999. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4:67-73.
    • (1999) J. Biomol. Screen. , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.