Review of virulence factors of enterococcus : AAAn emerging nosocomial pathogen

Indian Journal of Medical Microbiology

Volumn 27, Issue 4, 2009, Pages 301-305

  Upadhyaya, Giridhara P M ^a   Ravikumar, K L ^a   Umapathy, B L ^b,c  

^a Department of Microbiology ^*  (India)

^b BSK II Stage   (India)

^c Adichunchungiri Medical College Bellur   (India)

Author keywords

Enterococci; Nosocomial infection; Virulence factors

Indexed keywords

BACTERIAL POLYSACCHARIDE; BACTERIAL PROTEIN; CARBOHYDRATE; COLLAGEN; GELATINASE; HEMOLYSIN; MEMBRANE PROTEIN; SCLEROPROTEIN; SUPEROXIDE; VIRULENCE FACTOR;

BACTERIAL CELL WALL; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; ENTEROCOCCAL INFECTION; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; GENE SEQUENCE; HOSPITAL INFECTION; HUMAN; MULTILOCUS SEQUENCE TYPING; NONHUMAN; OPEN READING FRAME; PATHOGENICITY ISLAND; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; REVIEW;

EID: 70349317145     PISSN: 02550857     EISSN: 19983646     Source Type: Journal    
DOI: 10.4103/0255-0857.55437     Document Type: Review

References (47)

1. Schaberg DR, Culver DH, Gaynes RP. Major trends in microbial aetiology of nosocomial infection. Am J Med 1991;91:72s-5s.
2. Mollering RC Jr. Emergence of Enterococcus as significant pathogen. Clin Infect Dis 1992;14:1173-1178
3. Murray BE. The life and times of Enterococcus. Clin Microbial Rev 1990;3:45-65.
4. Tendulkar PM, Baghdayan AS, Shankar N. Pathogenic Enterococci: New developments in the 21st Century. Cell Mole Life Sci 2003;60:2622-2636
5. Ike Y, Hashimoto H, Clewell DB. Haemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice. Infect Immun 1984;45:528-530
6. Pearson H. Superbug. hurdles key drug barrier. Nature 2002;418:469.
7. Marion AK, Rose AD, Timothy FJ, Bryan PS, Kelly M, Susan C et al. Response to emerging infection leading to outbreak of Linezolid-resistant Enterococci. Emerg Infect Dis 2007;13:1024-1030
8. Paulson IT, Banerjee L, Myers GS, Nelson KE, Seshadri R, Read TD, et al. Role of mobile DNA in the evolution of Vancomycin-resistant Enterococcus faecalis. Science 2003;299:2071-2074
9. Hacker J, Kaper JB. Pathogenicity islands and the evolution of microbes. Annu Rev Microbial 2000;54:641-679
10. Huycke MM, Spiegel CA, Gilmore MS. Bacteraemia caused by haemolytic high level gentamycin-resistant Enterococcus faecalis. Antimicrob Agents Chemother 1991;35:1626-1634
11. Sahm DF, Kissinger J, Gilmore MS, Murray PR, Mulder R, Solliday J, et al. Invitro susceptibility studies of Vancomycin- resistant Enterococcus faecalis. Antimicrob Agents Chemother 1989;33:1588-1591
12. Shankar N, Baghdayan AS, Gilmore MS. Modulation of virulence within a pathogenicity island in Vancomycin- resistant Enterococcus faecalis. Nature 2002;417:746-750
13. Hancock LE, Gilmore MS. Pathogenicity of Enterococci: In gram positive pathogens. Am Soc Microbiol 2000;:251-258
14. Garsin AD, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, et al A simple model host for identifying gram positive virulence factors. Proc Natl Acnd Sci 2001;98:10892-10897
15. Jett BD, Huycke MM, Gilmore MS. Virulence of Enterococci. Clin Microbial Rev 1994;7:462-478
16. Nallapareddy SR, Qin X, Weinstock GM, Hook M, Murray BE. Enterococcus faecalis adhesion, Ace mediates attachment to extracellular matrix proteins collagen type IV and laminin as well as collagen Type I. Infect Immun 2000;68:5218-5224
17. Sartingen S, Rozdzinski E, Muscholl-Silberhorn A. Aggregation substances increases adherence and internalization but not translocation of Enterococcus faecalis through different intestinal epithelial cells invitro. Infect Immun 2000;68:6044-6047
18. Shankar V, Baghdayan AS, Huycke MM, Lendahl G, Gilmore MS. Infection derived Enterococcus faecalis strains are enriched in esp, a gene encoding a novel surface protein Infect Immun 1999;67:193-200.
19. Hass W, Shepard BD, Gilmore MS. Two-component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction. Nature 2002;415:84-87
20. Huycke MM, Abrams V, Moore DR. Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA. Carcinogenesis 2002;23:529-536
21. Chow JW, Thal LA, Perri MB, Vazquez JA, Donabedian SM, Clewell DB, et al. Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental Enterococcal endocarditis. Antimicrob Agents Chemother 1993;37:2474-2477
22. Ike Y, Hashimoto H, Clewell DB. High incidence of hemolysin production by Enterococcus (Streptococcus) faecalis strains associated with human parenteral infections. J Clin Microbiol 1987;25:1524-1528
23. Johnson AP. The pathogenicity of Enterococci. J Antimicrob Chemother 1994;33:1083-1089
24. Vergis EN, Nathan S, Joseph WC, Hayden MK, Syndman DR, Zervos, et al. Association between the presence of Enterococcal virulence factors gelatinase, haemolysin and enterococcal surface protein and mortality among patients with bacteremia due to Enterococcus faecalis. Clin Infect Dis 2002;35:570-575
25. Kreft B, Marre R, Schramm U, Wirth R. Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells. Infect Immun 1992;60:25-30.
26. Gutschik E, Moller S, Christensen N. Experimental endocarditis in rabbits, 3: Significance of the proteolytic capacity of the infecting strains of Streptococcus faecalis. Acta Pathol Microbiol Scand 1979;87:353-362
27. Peng HL, Novick RP, Kreiswirth B, Kornblum J, Schlievert P. Cloning, characterization and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus. J Bacteriol 1988;170:4365-4372
28. Shankar N, Lockatell CV, Baghdayan AS, Drachenberg C, Gilmore MS, Johnson DE. Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection. Infect Immun 2001;69:4366-4372
29. Clewell DB. Bacterial sex pheromone-induced plasmid transfer. Cell 1993;73:9-12.
30. Mundy LM, Sahm DF, Gilmore MS. Relationship between enterococcal virulence and antimicrobial resistance. J Clin Microbiol 2000;13:513-522
31. Sussmuth SD, Muscholl-Silberhorn A, Wirth R, Susa M, Marre R, Rozdzinski E. Aggregation substance promotes adherence, phagocytosis and intracellular survival of Enterococcus faecalis within human macrophages and suppresses respiratory burst. Infect Immun 2000;68:4900-4906
32. McCormick JK, Hirt H, Waters CM, Tripp TJ, Dunny GM, Schlievert PM. Antibodies to a surface-exposed, N-terminal domain of aggregation substance are not protective in the rabbit model of Enterococcus faecalis infective endocarditis. Infect Immun 2001;69:3305-3314
33. Vanek NN, Simon SI, Jacques-Palaz K, Mariscalco MM, Dunny GM, Rakita RM. Enterococcus faecalis aggregation substance promotes opsonin-independent binding to human neutrophils via a complement receptor type 3-mediated mechanism. FEMS Immunol Med Microbiol 1999;26:49-60
34. Rich RL, Kreikemeyer B, Owens RT, LaBrenz S, Narayana SV, Weinstock GM, et al. Ace is a collagen-binding MSCRAMM from Enterococcus faecalis. J Biol Chem 1999;274:26939-26945
35. Duh RW, Singh KV, Malathum K, Murray BE. In vitro activity of 19 antimicrobial agents against Enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification. Microb Drug Resist 2001;7:39-46.
36. Nallapareddy SR, Singh KV, Duh RW, Weinstock GM, Murray BE. Diversity of ace, a gene encoding a microbial surface component recognizing adhesive matrix molecules, from different strains of Enterococcus faecalis and evidence for production of ace during human infections. Infect Immun 2000;68:5210-5217
37. Nallapareddy SR, Weinstock GM, Murray BE. Clinical isolates of Enterococcus faecium exhibit strain-specific collagen binding mediated by Acm, a new member of the MSCRAMM family. Mol Microbiol 2003;47:1733-1747
38. Hancock LE, Gilmore MS. The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall. Proc Natl Acad Sci 2002;99:1574-1579
39. Huebner J, Wang Y, Krueger WA, Madoff LC, Martirosian G, Boisot S, et al. Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium. Infect Immun 1999;67:1213-1219
40. Huebner J, Quaas A, Krueger WA, Goldmann DA, Pier GB. Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among Vancomycin-sensitive and -resistant enterococci. Infect Immun 2000;68:4631-4636
41. Huycke MM, Moore D, Joyce W, Wise P, Shepard L, Kotake Y, et al. Extracellular superoxide production by Enterococcus faecalis requires Demethylmenaquinone and is attenuated by functional terminal quinol oxidases. Mol Microbiol 2001;42:729-740
42. Huycke MM, Gilmore MS. In vivo survival of Enterococcus faecalis is enhanced by extracellular superoxide production. Adv Exp Med Bio 1997;418:781-784
43. Tenover FC, Arbeit RD, Goering RV. How to select and interpret molecular strain typing methods for epidemiological studies of bacterial infections: A review for healthcare epidemiologists. Infect Control Hosp Epidemiol 1997;18:426-439
44. Tenover FC, Arbeit FR, Goering R, Mickelsen PA, Murray BE, Persing DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: Criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233-2239
45. Coque TM, Patterson JE, Steckelberg JM, Murray BE. Incidence of hemolysin, Gelatinase and aggregation substance among Enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons. J Infect Dis 1995;171:223-229
46. Garbutt J, Ventrapragada M, Littenberg B, Mundy LM. Association between resistance to vancomycin and death in cases of Enterococcus faecium bacteremia. Clin Infect Dis 2000;30:466-472
47. Lautenbach E, Bilker WB, Brennan PJ. Enterococcal bacteremia: Risk factors for Vancomycin resistance and predictors of mortality. Infect Control Hosp Epidemiol 1999;20:318-323