-
1
-
-
0020696384
-
Renal cell carcinoma antitumor effects of leukocyte interferon
-
Quesada JR, Swanson DA, Trindale A, et al. Renal cell carcinoma antitumor effects of leukocyte interferon. Cancer Res 1983, 43:940-7.
-
(1983)
Cancer res
, vol.43
, pp. 940-947
-
-
Quesada, J.R.1
Swanson, D.A.2
Trindale, A.3
-
2
-
-
0036271549
-
Randomized clinical trial of long-term outcome after resection of hepatitis C virus-related hepatocellular carcinoma by postoperative interferon therapy
-
DOI 10.1046/j.0007-1323.2001.02054.x
-
(Pubitemid 34595504) Kubo S, Nishiguchi S, Hirohashi K, et al. Randomized clinical trial of long-term outcome after resection of hepatitis C virus-related hepatocellular carcinoma by postoperative interferon therapy. Br J Surg 2002;89:418-22
-
(2002)
British Journal of Surgery
, vol.89
, Issue.4
, pp. 418-422
-
-
Kubo, S.1
Nishiguchi, S.2
Hirohashi, K.3
Tanaka, H.4
Shuto, T.5
Kinoshita, H.6
-
3
-
-
0003162005
-
Molecular mechanisms of immune dysfunction in renal cell carcinoma
-
Eds: Bukowski rm, novick ac. Totowa, new jersey: Humana press
-
Uzzo RG, Rayman P, Novick AC, et al. Molecular Mechanisms of Immune Dysfunction in Renal Cell Carcinoma. In: Renal Cell Carcinoma: Molecular Biology, Immunology, and Clinical Management. Eds: Bukowski RM, Novick AC. Totowa, New Jersey: Humana Press, 2000. pp 63-78.
-
(2000)
Renal cell carcinoma: Molecular biology, immunology, and Clinical management
, pp. 63-78
-
-
Uzzo, R.G.1
Rayman, P.2
Novick, A.C.3
-
4
-
-
0037022602
-
Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression
-
DOI 10.1073/pnas.052705299
-
(Pubitemid 34240546) Shou J, Soriano R, Hayward SW, et al. Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression. Proc Natl Acad Sci U S A 2002;99:2830-5.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.5
, pp. 2830-2835
-
-
Shou, J.1
Soriano, R.2
Hayward, S.W.3
Cunha, G.R.4
Williams, P.M.5
Gao, W.-Q.6
-
5
-
-
33645050917
-
Expression of rassf1a, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons
-
Reu FJ, Leaman DW, Maitra RR, et al. Expression of RASSFIA, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons. Cancer Res 2006;66:2785-93.
-
(2006)
Cancer res
, vol.66
, pp. 2785-2793
-
-
Reu, F.J.1
Leaman, D.W.2
Maitra, R.R.3
-
6
-
-
0019853949
-
Evidence that types I and II interferons have different receptors
-
(Pubitemid 12174452) Branca AA, Baglioni C. Evidence that types I and II interferons have different receptors. Nature 1981;294:768-70.
-
(1981)
Nature
, vol.294
, Issue.5843
, pp. 768-770
-
-
Branca, A.A.1
Baglioni, C.2
-
7
-
-
0021831193
-
125I-Labeled human interferons alpha, beta and gamma: Comparative receptor-binding data
-
(Pubitemid 15067117) Merlin G, Falcoff E, Aguet M. 125I-labelled human interferons alpha, beta and gamma: comparative receptor-binding data. J Gen Virol 1985;66:1149-52.
-
(1985)
Journal of General Virology
, vol.66
, Issue.5
, pp. 1149-1152
-
-
Merlin, G.1
Falcoff, E.2
Aguet, M.3
-
8
-
-
0023160234
-
Variation in the binding of 125i-labeled interferon-beta ser to cellular receptors during growth of human renal and bladder carcinoma cells in vitro
-
Ruzicka FJ, Schmid SM, Groveman DS, et al. Variation in the binding of 125I-labeled interferon-beta ser to cellular receptors during growth of human renal and bladder carcinoma cells in vitro. Cancer Res 1987;47:4582-9.
-
(1987)
Cancer Res
, vol.47
, pp. 4582-4589
-
-
Ruzicka, F.J.1
Schmid, S.M.2
Groveman, D.S.3
-
9
-
-
0029148972
-
Cloning and expression of a long form of the beta subunit of the Interferon alpha beta receptor that is required for signaling
-
Domanski P, Witte M, Kellum M, et al. Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J Biol Chem 1995;270:21606-11.
-
(1995)
J Biol Chem
, vol.270
, pp. 21606-21611
-
-
Domanski, P.1
Witte, M.2
Kellum, M.3
-
10
-
-
0037138370
-
Signaling through the JAK/STAT pathway, recent advances and future challenges
-
DOI 10.1016/S0378-11190200398-0, PII S0378111902003980
-
(Pubitemid 34246317) Kisseleva T, Bhattacharya S, Braunstein J, et al. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002;285:1-24.
-
(2002)
Gene
, vol.285
, Issue.1-2
, pp. 1-24
-
-
Kisseleva, T.1
Bhattacharya, S.2
Braunstein, J.3
Schindler, C.W.4
-
11
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
-
Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-21.
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell, Jr.J.E.1
Kerr, I.M.2
Stark, G.R.3
-
12
-
-
32144453842
-
JAK/STAT signal transduction: Regulators and implication in hematological malignancies
-
DOI 10.1016/j.bcp.2005.12.017, PII S0006295205008464
-
(Pubitemid 43208827) Valentino L, Pierre J. JAK-STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 2006;71:713-21.
-
(2006)
Biochemical Pharmacology
, vol.71
, Issue.6
, pp. 713-721
-
-
Valentino, L.1
Pierre, J.2
-
14
-
-
0023160237
-
Inhibition of angiogenesis by interferons: Effects on tumorand lymphocyte-induced vascular responses
-
Sidky YA, Borden EC. Inhibition of angiogenesis by interferons: effects on tumorand lymphocyte-induced vascular responses. Cancer Res 1987;47:5155-65.
-
(1987)
Cancer Res
, vol.47
, pp. 5155-5165
-
-
Sidky, Y.A.1
Borden, E.C.2
-
15
-
-
0032519590
-
Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon administration
-
(Pubitemid 28099496) Dinney CP, Bielenberg DR, Perrotte P, et al. Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration. Cancer Res 1998;58:808-14.
-
(1998)
Cancer Research
, vol.58
, Issue.4
, pp. 808-814
-
-
Dinney, C.P.N.1
Bielenberg, D.R.2
Perrotte, P.3
Reich, R.4
Eve, B.Y.5
Bucana, C.D.6
Fidler, I.J.7
-
16
-
-
0032710319
-
Clinical applications of angiogenic growth factors and Their inhibitors
-
Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 1999;5:1359-64.
-
(1999)
Nat Med
, vol.5
, pp. 1359-1364
-
-
Ferrara, N.1
Alitalo, K.2
-
17
-
-
0037454239
-
Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis
-
(Pubitemid 36432418) von Marschall Z, Scholz A, Cramer T, et al. Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Natl Cancer Inst 2003;95:437-48.
-
(2003)
Journal of the National Cancer Institute
, vol.95
, Issue.6
, pp. 437-448
-
-
Von Marschall, Z.1
Scholz, A.2
Cramer, T.3
Schafer, G.4
Schirner, M.5
Oberg, K.6
Wiedenmann, B.7
Hocker, M.8
Rosewicz, S.9
-
18
-
-
0028886747
-
Synergistic role of type I Interferons in the induction of protective cytotoxic t lymphocytes
-
von Hoegen P. Synergistic role of type I interferons in the induction of protective cytotoxic T lymphocytes. Immunol Lett 1995;47:157-62.
-
(1995)
Immunol Lett
, vol.47
, pp. 157-162
-
-
Von P. Hoegen1
-
19
-
-
0018743735
-
Activation of human natural killer cells cytotoxic for human leukemia cells by purified interferon
-
(Pubitemid 9213546) Zarling JM, Eskra L, Borden EC, et al. Activation of human natural killer cells cytotoxic for human leukemia cells by purified interferon. J Immunol 1979;123:63-70.
-
(1979)
Journal of Immunology
, vol.123
, Issue.1
, pp. 63-70
-
-
Zarling, J.M.1
Eskra, L.2
Borden, E.C.3
-
20
-
-
0032529213
-
Type I IFNs enhance the terminal differentiation of dendritic cells
-
(Pubitemid 28387618) Luft T, Pang KC, Thomas E, et al. Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol 1998;161:1947-53.
-
(1998)
Journal of Immunology
, vol.161
, Issue.4
, pp. 1947-1953
-
-
Luft, T.1
Pang, K.C.2
Thomas, E.3
Hertzog, P.4
Hart, D.N.J.5
Trapani, J.6
Cebon, J.7
-
21
-
-
0031895637
-
Mechanisms of MHC class I-restricted antigen processing
-
DOI 10.1146/annurev.immunol.16.1.323
-
(Pubitemid 28183368) Pamer E, Cresswell P. Mechanisms of MHC class I-restricted antigen processing. Annu Rev Immunol 1998;16:323-58.
-
(1998)
Annual Review of Immunology
, vol.16
, pp. 323-358
-
-
Pamer, E.1
Cresswell, P.2
-
22
-
-
33645401291
-
Transcriptional program associated with IFN-alpha response of renal cell carcinoma
-
Banerjee D, Chadalavada RS, Bourdon V, et al. Transcriptional program associated with IFN-alpha response of renal cell carcinoma. J Interferon Cytokine Res 2006;26:156-70.
-
(2006)
J Interferon Cytokine Res
, vol.26
, pp. 156-170
-
-
Banerjee, D.1
Chadalavada, R.S.2
Bourdon, V.3
-
23
-
-
0021049597
-
The treatment of renal cell carcinoma with human leukocyte alpha-interferon
-
(Pubitemid 14211183) DeKernion JB, Sarna JB, Figlin R, et al. The treatment of renal cell carcinoma with human leukocyte alpha-interferon. J Urol 1983;130:1063-66.
-
(1983)
Journal of Urology
, vol.130
, Issue.6
, pp. 1063-1066
-
-
DeKernion, J.B.1
Sarna, G.2
Figlin, R.3
-
24
-
-
24044437298
-
Clinical practice guidelines: Renal cell carcinoma
-
Bukowski RM, Novick AC. Clinical practice guidelines: renal cell carcinoma. Cleve Clin J Med 1997; 64:S1-48.
-
(1997)
Cleve Clin J Med
, vol.64
-
-
Bukowski, R.M.1
Novick, A.C.2
-
25
-
-
2442737061
-
Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer
-
(Pubitemid 29415245) Pyrhonen S, Salminen E, Ruuru M, et al. Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer. J Clin Oncol 1999;17:2859-67.
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.9
, pp. 2859-2867
-
-
Pyrhonen, S.1
Salminen, E.2
Ruutu, M.3
Lehtonen, T.4
Nurmi, M.5
Tammela, T.6
Juusela, H.7
Rintala, E.8
Hietanen, P.9
Kellokumpu-Lehtinen, P.-L.10
-
26
-
-
0033514050
-
Medical research council renal cancer collaborators
-
Interferon α And sur vival in metastatic renal cell carcinoma: Early results of randomized trial
-
Medical Research Council Renal Cancer Collaborators. Interferon α and sur vival in metastatic renal cell carcinoma: Early results of randomized trial. Lancet 1999;353:14-7
-
(1999)
Lancet
, vol.353
, pp. 14-17
-
-
-
27
-
-
62849127717
-
Interferon-α (IFN), interleukin-2 (IL-2), and 5-fluorouracil (5-FU) vs IFN alone in patients with metastatic renal cell carcinoma (mRCC) : Results of the randomized mrc/eortc re043 trial
-
Abstract 5039
-
Gore ME. Interferon-α (IFN), interleukin-2 (IL-2), and 5-fluorouracil (5-FU) vs IFN alone in patients with metastatic renal cell carcinoma (mRCC) : Results of the randomized MRC/EORTC RE043 trial. J Clin Oncol 2008;26(15 suppl):259s (Abstract 5039).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.15 SUPPL.
-
-
Gore, M.E.1
-
28
-
-
0033902999
-
Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma
-
(Pubitemid 30644121) Motzer RJ, Murphy BA, Bacik J, et al. Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma. J Clin Oncol 2000;18:2972-80.
-
(2000)
Journal of Clinical Oncology
, vol.18
, Issue.16
, pp. 2972-2980
-
-
Motzer, R.J.1
Murphy, B.A.2
Bacik, J.3
Schwartz, L.H.4
Nanus, D.M.5
Mariani, T.6
Loehrer, P.7
Wilding, G.8
Fairclough, D.L.9
Cella, D.10
Mazumdar, M.11
-
29
-
-
7144227930
-
Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma
-
DOI 10.1056/NEJM199804303381805
-
(Pubitemid 28216581) Negrier S, Escudier B, Lasset C, et al. Recombinant human interleukin-2, recombinant interferon alfa-2a, or both in metastatic renal cell carcinoma. Groupe Francaise d-Immunotherapie. N Engl J Med 1998;338:1272-8.
-
(1998)
New England Journal of Medicine
, vol.338
, Issue.18
, pp. 1272-1278
-
-
Negrier, S.1
Escudier, B.2
Lasset, C.3
Douillard, J.-Y.4
Savary, J.5
Chevreau, C.6
Ravaud, A.7
Mercatello, A.8
Peny, J.9
Mousseau, M.10
Philip, T.11
Tursz, T.12
-
30
-
-
33750532947
-
Improved tolerability and quality of life with maintained efficacy using twice-daily low-dose interferon-2b: Results of a randomized phase II trial of low-dose versus intermediate-dose interferon-2b in patients with metastatic renal cell carcinoma
-
DOI 10.1002/cncr.22253
-
(Pubitemid 44665661) Tannir NM, Cohen L, Wang X, et al. Improved tolerability and quality of life with maintained efficacy using twice daily low-dose Interferon-alpha-2b: results of a randomized phase II trial of low dose versus intermediate-dose interferon-alpha-2b in patients with metastatic renal cell carcinoma. Cancer 2006: 107:2254-61.
-
(2006)
Cancer
, vol.107
, Issue.9
, pp. 2254-2261
-
-
Tannir, N.M.1
Cohen, L.2
Wang, X.3
Thall, P.4
Mathew, P.F.5
Jonasch, E.6
Siefker-Radtke, A.7
Pagliaro, L.C.8
Ng, C.S.9
Logothetis, C.10
-
31
-
-
0035818877
-
Nephrectomy followed by Interferon alfa-2b compared with Interferon alfa-2b alone for metastatic renal cell carcinoma
-
Flannigan RC, Salmon E, Blumenstein BA, et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal cell carcinoma. N Engl J Med 2001;345:1655-9.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1655-1659
-
-
Flannigan, R.C.1
Salmon, E.2
Blumenstein, B.A.3
-
32
-
-
0035934596
-
Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: A randomised trial
-
DOI 10.1016/S0140-67360106103-7
-
(Pubitemid 32913522) Mickisch GH, Garin A, van Poppel H, et al. Radical nephrectomy plus interferonalfa-based immunotherapy compared with interferon alfa alone in metastatic renal cell carcinoma: a randomized trial. Lancet 2001;358:966-70.
-
(2001)
Lancet
, vol.358
, Issue.9286
, pp. 966-970
-
-
Mickisch, G.H.J.1
Garin, A.2
Van Poppel, H.3
De Prijck, L.4
Sylvester, R.5
-
34
-
-
0037106366
-
Pegylated interferon alfa-2b treatment for patients with solid tumors: A phase I/II study
-
DOI 10.1200/JCO.2002.02.051
-
(Pubitemid 35050837) Bukowski R, Ernstoff MS, Gore ME, et al. Pegylated interferon alfa-2b treatment for patients with solid tumors: A phase I/II study. J Clin Oncol 2002;20:3841-9.
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.18
, pp. 3841-3849
-
-
Bukowski, R.1
Ernstoff, M.S.2
Gore, M.E.3
Nemunaitis, J.J.4
Amato, R.5
Gupta, S.K.6
Tendler, C.L.7
-
35
-
-
0032772880
-
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
-
(Pubitemid 29368255) Motzer RJ, Mazumadar M, Bacik J, et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999;17:2530-40.
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.8
, pp. 2530-2540
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
Berg, W.4
Amsterdam, A.5
Ferrara, J.6
-
36
-
-
14144252047
-
Validation and extension of the memorial sloan kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
-
Mekhail TM, Abou-Jawde RM, Boumerhi G, et al. Validation and extension of the Memorial Sloan Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol 2005;23:832-41.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 832-841
-
-
Mekhail, T.M.1
Abou-Jawde, R.M.2
Boumerhi, G.3
-
37
-
-
36448930484
-
Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: Results of a randomized controlled trial
-
DOI 10.1002/cncr.23056
-
(Pubitemid 350174932) Negrier S, Perol D, Ravaud A, et al. Medroxyprogesterone, interferon alfa-2a, Interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: results of a randomized controlled trial. Cancer 2007;110:2468-77.
-
(2007)
Cancer
, vol.110
, Issue.11
, pp. 2468-2477
-
-
Negrier, S.1
Perol, D.2
Ravaud, A.3
Chevreau, C.4
Bay, J.-O.5
Delva, R.6
Sevin, E.7
Caty, A.8
Escudier, B.9
-
38
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
DOI 10.1056/NEJMoa065044
-
(Pubitemid 46089672) Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115-24.
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
39
-
-
35548931472
-
Randomized phase II trial of first-line treatment with sorafenib versus Interferon in patients with advanced renal cell carcinoma: Final results
-
Abstract 5025
-
Szczylik C, Demkow T, Staehler M, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. J Clin Oncol 2007;25(18 suppl):241s (Abstract 5025).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.18 SUPPL.
-
-
Szczylik, C.1
Demkow, T.2
Staehler, M.3
-
40
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
-
DOI 10.1016/S0140-67360761904-7, PII S0140673607619047
-
(Pubitemid 350296300) Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab in combination with interferon alfa-2a as first-line therapy for metastatic renal-cell carcinoma. Lancet 2007;370:2103-11.
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
Ravaud, A.4
Bracarda, S.5
Szczylik, C.6
Chevreau, C.7
Filipek, M.8
Melichar, B.9
Bajetta, E.10
Gorbunova, V.11
Bay, J.-O.12
Bodrogi, I.13
Jagiello-Gruszfeld, A.14
Moore, N.15
-
41
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
DOI 10.1056/NEJMoa065044
-
(Pubitemid 46089672) Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271-81.
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
42
-
-
0030856731
-
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
-
(Pubitemid 27441066) Presta LG, Chen H, O-Connor SJ, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997;57:4593-9.
-
(1997)
Cancer Research
, vol.57
, Issue.20
, pp. 4593-4599
-
-
Presta, L.G.1
Chen, H.2
O'Connor, S.J.3
Chisholm, V.4
Meng, Y.G.5
Krummen, L.6
Winkler, M.7
Ferrara, N.8
-
43
-
-
35648938219
-
Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer
-
Bukowski RM, Kabbinavar FF, Figlin RA, et al. Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer. J Clin Oncol 2007;25:4536-41.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 4536-4541
-
-
Bukowski, R.M.1
Kabbinavar, F.F.2
Figlin, R.A.3
-
44
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
DOI 10.1056/NEJMoa021491
-
(Pubitemid 36910021) Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427-34.
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.5
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
Steinberg, S.M.7
Chen, H.X.8
Rosenberg, S.A.9
-
45
-
-
43249085165
-
Calgb 90206: A phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma
-
gastrointestinal cancers symposium; January 25-27, Orlando, Florida. Abstract 350
-
Rini BI, Halabi S, Rosenberg JE, et al. CALGB 90206: A phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma. Presented at: the American Society of Clinical Oncology: 2008 Gastrointestinal Cancers Symposium; January 25-27, 2008; Orlando, Florida. Abstract 350.
-
(2008)
Presented at: The American Society of Clinical Oncology
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
46
-
-
48749092867
-
First-line bevacizumab combined with reduced dose interferon-{alpha}2a is active in patients with metastatic renal cell carcinoma
-
Melichar B, Koralewski P, Ravaud A, et al. First-line bevacizumab combined with reduced dose interferon-{alpha}2a is active in patients with metastatic renal cell carcinoma. Ann Oncol 2008;19:1470-6.
-
(2008)
Ann Oncol
, vol.19
, pp. 1470-1476
-
-
Melichar, B.1
Koralewski, P.2
Ravaud, A.3
-
47
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
DOI 10.1158/0008-5472.CAN-04-1443
-
(Pubitemid 39331023) Wilhelm SM, Carte C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral anti-tumor activity and targets the Raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109.
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
48
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
(Pubitemid 46089673) Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356:125-34.
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
49
-
-
34250168681
-
Phase I trial of sorafenib in combination with IFN 2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma
-
DOI 10.1158/1078-0432.CCR-06-1432
-
(Pubitemid 46952949) Escudier B, Lassau N, Angevin E, et al. Phase 1 trial of sorafenib in combination with IFN alpha-2b in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma. Clin Cancer Res 2007;13:1801-9.
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.6
, pp. 1801-1809
-
-
Escudier, B.1
Lassau, N.2
Angevin, E.3
Soria, J.C.4
Chami, L.5
Lamuraglia, M.6
Zafarana, E.7
Landreau, V.8
Schwartz, B.9
Brendel, E.10
Armand, J.-P.11
Robert, C.12
-
50
-
-
34548229506
-
Sorafenib with Interferon alfa-2b as first line treatment of advanced renasl cell carcinoma: A phase II study of the southwest oncology group
-
Ryan CW, Goldman BH, Lara PN, et al. Sorafenib with interferon alfa-2b as first line Treatment of Advanced Renasl Cell Carcinoma: a phase II study of the Southwest Oncology Group. J Clin Oncol 2007;25:3296-301.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3296-3301
-
-
Ryan, C.W.1
Goldman, B.H.2
Lara, P.N.3
-
51
-
-
34548263735
-
Phase II trial of sorafenib plus Interferon alfa-2b as first or second-line therapy in patients with metastatic renal cell cancer
-
Gollob JA, Rathmell WK, Richmond TM, et al. Phase II trial of sorafenib plus interferon Alfa-2b as first or second-line therapy in patients with metastatic renal cell cancer. J Clin Oncol 2007;25:3288-95.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3288-3295
-
-
Gollob, J.A.1
Rathmell, W.K.2
Richmond, T.M.3
-
52
-
-
35548959952
-
Randomized phase II study of sorafenib with or without low-dose IFN in patients with metastatic renal cell carcinoma
-
Abstract 5104
-
Jonasch E, Corn P, Ashe RG, et al. Randomized phase II study of sorafenib with or without low-dose IFN in patients with metastatic renal cell carcinoma. J Clin Oncol 2007;25(18 suppl):260s (Abstract 5104).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.18 SUPPL.
-
-
Jonasch, E.1
Corn, P.2
Ashe, R.G.3
-
53
-
-
57449084262
-
A randomized phase II trial of sorafenib versus sorafenib plus low-dose interferon-alfa: Clinical results and biomarker analysis
-
Abstract 5093
-
Tannir NM, Zurita AJ, Heymach J V, et al. A randomized phase II trial of sorafenib versus sorafenib plus low-dose interferon-alfa: Clinical results and biomarker analysis. J Clin Oncol 2008;26(15 suppl):272s (Abstract 5093).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.15 SUPPL.
-
-
Tannir, N.M.1
Zurita, A.J.2
Heymach, J.V.3
-
55
-
-
44449155614
-
Sunitinib malate (SU) plus Interferon (IFN) in first line metastatic renal cell carcinoma (mRCC) : Results of a dose finding study
-
Abstract 5101
-
Kondagunta GV, Hudes GR, Figlin R, et al. Sunitinib malate (SU) plus Interferon (IFN) in first line metastatic renal cell carcinoma (mRCC) : Results of a dose finding study. J Clin Oncol 2007;25(18 suppl):260s (Abstract 5101).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.18 SUPPL.
-
-
Kondagunta, G.V.1
Hudes, G.R.2
Figlin, R.3
-
56
-
-
2342559981
-
The tor pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004;4:335-48.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
57
-
-
33745242315
-
Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
-
DOI 10.1158/0008-5472.CAN-05-2825
-
(Pubitemid 43927103) Del Bufalo D, Cuffrede L, Trisciuoglio D, et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 2006;66:5549-54.
-
(2006)
Cancer Research
, vol.66
, Issue.11
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
Desideri, M.4
Cognetti, F.5
Zupi, G.6
Milella, M.7
-
58
-
-
17944368972
-
+/- mice
-
DOI 10.1073/pnas.171060098
-
(Pubitemid 32803018) Podsypasnina K, Lee RT, Politis C, et al. An inhibitor of m TOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten +/-mice. Proc Natl Acad Sci U S A 2001;98:10320-5.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.18
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
Frost, P.11
Dreisbach, V.12
Blenis, J.13
Gaciong, Z.14
Fisher, P.15
Sawyers, C.16
Hedrick-Ellenson, L.17
Parsons, R.18
-
59
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
DOI 10.1200/JCO.2004.08.185
-
(Pubitemid 41103603) Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22:909-18.
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
Logan, T.F.4
Dutcher, J.P.5
Hudes, G.R.6
Park, Y.7
Liou, S.-H.8
Marshall, B.9
Boni, J.P.10
Dukart, G.11
Sherman, M.L.12
-
60
-
-
70349318496
-
CCI-779 potentiates the inhibitory effect of the anti-angiogenesis drug interferon-alpha on the growth of a human renal cell carcinoma in nude mice
-
Rpt-49843. Pearl river, ny
-
Gibbons JJ. CCI-779 potentiates the inhibitory effect of the anti-angiogenesis drug interferon-alpha on the growth of a human renal cell carcinoma in nude mice. RPT-49843. Pearl River, NY, Wyeth Research, 2006.
-
(2006)
Wyeth Research
-
-
Gibbons, J.J.1
-
61
-
-
34548528069
-
Temsirolimus plus Interferon alfa phase I trial in patients with advanced renal cell carcinoma
-
Motzer RJ, Hudes GR, Curti BD, et al. Temsirolimus plus interferon alfa phase I trial in patients with advanced renal cell carcinoma. J Clin Oncol 2007;25:3958-64.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3958-3964
-
-
Motzer, R.J.1
Hudes, G.R.2
Curti, B.D.3
|