Roles of the genetic polymorphisms of alcohol-metabolizing enzymes on the immunology in high-risk drinkers

Toxicological Sciences

Volumn 111, Issue 2, 2009, Pages 267-276

  Tseng, Yang Ming ^a,b   Tsai, Shih Meng ^a   Chen, Sheng Yi ^a   Lin, Chun Chin ^a,b   Jin, Yi Ru ^b   Yeh, Wei Hao ^a   Wu, Yi Ru ^a   Chen, Ing Jun ^c   Lee, Jang Hwa ^b   Tsai, Li Yu ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Alcohol metabolizing enzymes; Genetic variations; High risk drinkers; Immunology

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CATALASE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; CYTOCHROME P450 2E1; GAMMA GLUTAMYLTRANSFERASE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 6;

ADULT; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CD4 CD8 RATIO; CD4 LYMPHOCYTE PERCENTAGE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LEUKOCYTE COUNT; LIFESTYLE; LIVER; LIVER FUNCTION TEST; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SMOKING;

ADULT; AGED; ALCOHOL DRINKING; ENZYMES; ETHANOL; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS;

PIPER BETEL;

EID: 70349289560     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp143     Document Type: Article

References (33)

1. Arosa, F. A., Porto, G., Cabeda, J. M., Lacerda, R., Resende, D., Cruz, E., Cardoso, C., Fonseca, M., Simoes, C., Rodrigues, P., et al. (2000). Expansions of CD8+CD28- and CD8+TcRVbeta5.2+ T cells in peripheral blood of heavy alcohol drinkers. Alcohol Clin. Exp. Res. 24, 519-527.
2. Bataille, V., Ruidavets, J. B., Arveiler, D., Amouyel, P., Ducimetiere, P., Perret, B., and Ferrieres, J. (2003). Joint use of clinical parameters, biological markers and CAGE questionnaire for the identification of heavy drinkers in a large population-based sample. Alcohol Alcohol 38, 121-127.
3. Brown, L. A., Cook, R. T., Jerrells, T. R., Kolls, J. K., Nagy, L. E., Szabo, G., Wands, J. R., and Kovacs, E. J. (2006). Acute and chronic alcohol abuse modulate immunity. Alcohol Clin. Exp. Res. 30, 1624-1631.
4. Chang, M. C., Chiang, C. P., Lin, C. L., Lee, J. J., Hahn, L. J., and Jeng, J. H. (2005). Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol. 41, 757-775.
5. Cook, R. T. (1998). Alcohol abuse, alcoholism, and damage to the immune system - A review. Alcohol Clin. Exp. Res. 22, 1927-1942.
6. Crews, F. T., Bechara, R., Brown, L. A., Guidot, D. M., Mandrekar, P., Oak, S., Qin, L., Szabo, G., Wheeler, M., and Zou, J. (2006). Cytokines and alcohol. Alcohol Clin. Exp. Res. 30, 720-730.
7. Dawson, D. A., Grant, B. F., Stinson, F. S., and Zhou, Y. (2005). Effectiveness of the derived Alcohol Use Disorders Identification Test (AUDIT-C) in screening for alcohol use disorders and risk drinking in the US general population. Alcohol Clin. Exp. Res. 29, 844-854.
8. Forsberg, L., Lyrenas, L., de Faire, U., and Morgenstern, R. (2001). A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels. Free Radic. Biol. Med. 30, 500-505.
9. Goulas, A., Fidani, L., Kotsis, A., Mirtsou, V., Petersen, R. C., Tangalos, E., and Hardy, J. (2002). An association study of a functional catalase gene polymorphism, -262C→ T, and patients with Alzheimer's disease. Neurosci. Lett. 330, 210-213.
10. Grimbaldeston, M. A., Nakae, S., Kalesnikoff, J., Tsai, M., and Galli, S. J. (2007). Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat. Immunol. 8, 1095-1104.
11. Gul, S., Akvardar, Y., Tas, G., and Tuncel, P. (2005). [The diagnostic validity of screening tests and laboratory markers in alcohol use disorders]. Turk Psikiyatri Derg. 16, 3-12.
12. Kaliappan, S., Jha, P., Lyzogubov, V. V., Tytarenko, R. G., Bora, N. S., and Bora, P. S. (2008). Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system. FEBS Lett. 582, 3451-3458.
13. Lieber, C. S. (2000). Alcoholic liver disease: New insights in pathogenesis lead to new treatments. J. Hepatol. 32, 113-128.
14. Matsuo, K., Wakai, K., Hirose, K., Ito, H., Saito, T., Suzuki, T., Kato, T., Hirai, T., Kanemitsu, Y., Hamajima, H., and Tajima, K. (2006). A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan. Carcinogenesis 27, 1018-1023.
15. McBride, W. J., Le, A. D., and Noronha, A. (2002). Central nervous system mechanisms in alcohol relapse. Alcohol Clin. Exp. Res. 26, 280-286.
16. McClain, C. J., Barve, S., Deaciuc, I., Kugelmas, M., and Hill, D. (1999). Cytokines in alcoholic liver disease. Semin. Liver Dis. 19, 205-219.
17. McClain, C. J., and Cohen, D. A. (1989). Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9 349-351.
18. Nicolaou, C., Chatzipanagiotou, S., Tzivos, D., Tzavellas, E. O., Boufidou, F., and Liappas, I. A. (2004). Serum cytokine concentrations in alcohol-dependent individuals without liver disease. Alcohol 32, 243-247.
19. Pennington, J. S., Shuvaeva, T. I., and Pennington, S. N. (2002). Maternal dietary ethanol consumption is associated with hypertriglyceridemia in adult rat offspring. Alcohol Clin. Exp. Res. 26, 848-855.
20. Pownall, H. J., Ballantyne, C. M., Kimball, K. T., Simpson, S. L., Yeshurun, D., and Gotto, A. M., Jr. (1999). Effect of moderate alcohol consumption on hypertriglyceridemia: A study in the fasting state. Arch Intern. Med. 159, 981-987.
21. Sakamoto, T., Hara, M., Higaki, Y., Ichiba, M., Horita, M., Mizuta, T., Eguchi, Y., Yasutake, T., Ozaki, I., Yamamoto, K., et al. (2006). Influence of alcohol consumption and gene polymorphisms of ADH2 and ALDH2 on hepatocellular carcinoma in a Japanese population. Int. J. Cancer 118, 1501-1507.
22. Schleifer, S. J., Keller, S. E., and Czaja, S. (2006). Major depression and immunity in alcohol-dependent persons. Brain Behav. Immun. 20, 80-91.
23. Sun, F., Tsuritani, I., Honda, R., Ma, Z. Y., and Yamada, Y. (1999). Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. Hum. Genet. 105, 295-300.
24. Szabo, G. (1997). Alcohol's contribution to compromised immunity. Alcohol Health Res. World 21, 30-41.
25. Tsai, J. F., Chuang, L. Y., Jeng, J. E., Ho, M. S., Hsieh, M. Y., Lin, Z. Y., and Wang, L. Y. (2001). Betel quid chewing as a risk factor for hepatocellular carcinoma: A case-control study. Br. J. Cancer 84, 709-713.
26. Tseng, Y. M., Chen, S. Y., Chen, C. H., Jin, Y. R., Tsai, S. M., Chen, I. J., Lee, J. H., Chiu, C. C., and Tsai, L. Y. (2008a). Effects of alcohol-induced human peripheral blood mononuclear cell (PBMC) pretreated whey protein concentrate (WPC) on oxidative damage. J. Agric. Food Chem. 56, 8141-8147.
27. Tseng, Y. M., Hu, B. W., Tsai, S. M., Chen, I. J., Jin, Y. R., Lee, J. H., Huang, F. D., Wu, S. H., Yeh, F. L., and Tsai, L. Y. (2007). Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department. Clin. Biochem. 40, 370-376.
28. Tseng, Y.M., Jin, Y. R., Chen, I. J., Huang, F. D.,Wu, S. H.,Ma, H., Chen, S. Y., Tsai, L. Y., Tsai, S.M., and Lee, J. H. (2008b). Roles of the genetic variation of alcohol-metabolizing enzymes on biomarkers in trauma patients with excessive alcohol intake at emergency department. Clin. Chim. Acta 389, 14-18.
29. Tsoumakidou, M., Elston, W., Zhu, J., Wang, Z., Gamble, E., Siafakas, N. M., Barnes, N. C., and Jeffery, P. K. (2007). Cigarette smoking alters bronchial mucosal immunity in asthma. Am. J. Respir. Crit. Care Med. 175, 919-925.
30. World Health Organization (WHO). (2000). International Guide for Monitoring Alcohol Consumption and Related Harm. World Health Organization, Switzerland.
31. Wu, G. H., Boucher, B. J., Chiu, Y. H., Liao, C. S., and Chen, T. H. (2009). Impact of chewing betel-nut (Areca catechu) on liver cirrhosis and hepatocellular carcinoma: A population-based study from an area with a high prevalence of hepatitis B and C infections. Public Health Nutr. 12, 129-135.
32. Wu, M. T., Lee, Y. C., Chen, C. J., Yang, P. W., Lee, C. J., Wu, D. C., Hsu, H. K., Ho, C. K., Kao, E. L., and Lee, J. M. (2001). Risk of betel chewing for oesophageal cancer in Taiwan. Br. J. Cancer 85, 658-660.
33. Zhang, F. F., Hou, L., Terry, M. B., Lissowska, J., Morabia, A., Chen, J., Yeager, M., Zatonski, W., Chanock, S., and Chow, W. H. (2007). Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland. Int. J. Cancer 121, 2060-2064.