Influence of luminal monosaccharides on secretion of glutathione conjugates from rat small intestine in vitro

International Journal of Pharmaceutics

Volumn 381, Issue 2, 2009, Pages 199-204

  Uršič, Darko ^a   Berginc, Katja ^b   Žakelj, Simon ^b   Kristl, Albin ^b  

^a KRKA D D   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Glucose; Glutathione conjugates; Hypoosmolarity; MRP2; SGLT

Indexed keywords

ALPHA METHYLGLUCOSIDE; BENZBROMARONE; BREAST CANCER RESISTANCE PROTEIN; FRUCTOSE; FUROSEMIDE; GALACTOSE; GLUCOSE; GLUTATHIONE; MANNITOL; MONOSACCHARIDE; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELIMINATION REACTION; IN VITRO STUDY; MALE; NONHUMAN; OSMOLARITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SMALL INTESTINE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BENZBROMARONE; CELL POLARITY; DINITROCHLOROBENZENE; ENTEROCYTES; FUROSEMIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INTESTINE, SMALL; MALE; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; METHYLGLUCOSIDES; MONOSACCHARIDES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OSMOLAR CONCENTRATION; PERMEABILITY; RATS; RATS, WISTAR; SECRETORY PATHWAY; SODIUM-GLUCOSE TRANSPORT PROTEINS; SUCCINIMIDES; SULFANILAMIDES;

EID: 70349272261     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.03.011     Document Type: Article

References (23)

1. Awasthi S., Sharma R., Singhal S.S., Zimniak P., and Awasthi Y.C. RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug. Metab. Dispos. 30 (2002) 1300-1310
2. Bell G.I., Burant C.F., Takeda J., and Gould G.W. Structure and function of mammalian facilitative sugar transporters. J. Biol. Chem. 268 (1993) 19161-19164
3. Benjamini Y., and Hochberg Y. On the adaptive control of the false discovery rate in multiple testing with independent statistics. J. Educ. Behav. Stat. 25 (2000) 60-83
4. Chan L.M.S., Lowes S., and Hirst B.H. The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur. J. Pharm. Sci. 21 (2004) 25-51
5. Dombrowski F., Kubitz R., Chittattu A., Wettstein M., Saha N., and Haussinger D. Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide. Biochem. J. 348 (2000) 183-188
6. Gerk P.M., and Vore M. Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J. Pharmacol. Exp. Ther. 302 (2002) 407-415
7. Gregory J.D. The stability of N-ethylmaleimide and its reaction with sulfhydryl groups. J. Am. Chem. Soc. 77 (1955) 3922-3923
8. Hasegawa M., Kusuhara H., Adachi M., Schuetz J.D., Takeuchi K., and Sugiyama Y. Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide. J. Am. Soc. Nephrol. 18 (2007) 37-45
9. Hinchman C.A., Matsumoto H., Simmons T.W., and Ballatori N. Intrahepatic conversion of a glutathione conjugate to its mercapturic acid. Metabolism of 1-chloro-2,4-dinitrobenzene in isolated perfused rat and guinea pig livers. J. Biol. Chem. 266 (1991) 22179-22185
10. Hinchman C.A., Rebbeor J.F., and Ballatori N. Efficient hepatic uptake and concentrative biliary excretion of a mercapturic acid. Am. J. Physiol. Gastrointest. Liver Physiol. 275 (1998) G612-G619
11. Kellett G.L., and Brot-Laroche E. Apical GLUT2: a major pathway of intestinal sugar absorption. Diabetes 54 (2005) 3056-3062
12. Kubitz R., Warskulat U., Schmitt M., and Haussinger D. Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes. Biochem. J. 340 (1999) 585-591
13. Kuninori T., and Nishiyama J. Measurement of biological thiols and disulfides by high-performance liquid chromatography and electrochemical detection of silver mercaptide formation. Anal. Biochem. 197 (1991) 19-24
14. 2+ in glucose-stimulated pancreatic beta-cells. Biochem. J. 314 (1996) 91-94
15. Polentarutti B.I., Peterson A.L., Sjaberg K., Anderberg E.K., Utter L.M., and Ungell A.L. Evaluation of viability of excised rat intestinal segments in the Ussing chamber: investigation of morphology, electrical parameters, and permeability characteristics. Pharm. Res. 16 (1999) 446-454
16. Rolland F., Winderickx J., and Thevelein J.M. Glucose-sensing mechanisms in eukaryotic cells. Trends Biochem. Sci. 26 (2001) 310-317
17. Swaan P.W., Stehouwer M.C., and Tukker J.J. Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril. Biochim. Biophys. Acta 1236 (1995) 31-38
18. Tanaka Y., Kobayashi Y., Gabazza E.C., Higuchi K., Kamisako T., Kuroda M., Takeuchi K., Iwasa M., Kaito M., and Adachi Y. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Am. J. Physiol. Gastrointest. Liver Physiol. 282 (2002) G656-G662
19. Turner J.R., Cohen D.E., Mrsny R.J., and Madara J.L. Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na-glucose cotransport. Dig. Dis. Sci. 45 (2000) 2122-2126
20. Wright E.M., Loo D.D.F., Hirayama B.A., and Turk E. Surprising versatility of Na-Glucose cotransporters: SLC5. Physiology 19 (2004) 370-376
21. Zamek-Gliszczynski M.J., Hoffmaster K.A., Nezasa K.I., Tallman M.N., and Brouwer K.L.R. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur.J. Pharm. Sci. 27 (2006) 447-486
22. Zelcer N., Huisman M.T., Reid G., Wielinga P., Breedveld P., Kuil A., Knipscheer P., Schellens J.H.M., Schinkel A.H., and Borst P. Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J. Biol. Chem. 278 (2003) 23538-23544
23. Žakelj S., Legen I., Veber M., and Kristl A. The influence of buffer composition on tissue integrity during permeability experiments "in vitro". Int. J. Pharm. 272 (2004) 173-180