Genetic mapping of fixed phenotypes: Disease frequency as a breed characteristic

Journal of Heredity

Volumn 100, Issue , 2009, Pages S37-S41

  Chase, Kevin ^a   Jones, Paul ^b   Martin, Alan ^b   Ostrander, Elaine A ^c   Lark, Karl G ^a  

^a UNIVERSITY OF UTAH   (United States)

^b WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Association; Canine; Disease; Longevity; Morphology; QTL

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; BODY SIZE; BREEDING; CHROMOSOME MAP; DOG; DOG DISEASE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LONGEVITY; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BODY SIZE; BREEDING; CHROMOSOME MAPPING; DOGS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HIP DYSPLASIA, CANINE; LONGEVITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 70349251589     PISSN: 00221503     EISSN: 14657333     Source Type: Journal    
DOI: 10.1093/jhered/esp011     Document Type: Article

References (17)

1. Bartke A. 2005. Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology. 146:3718-3723.
2. Calboli FC, Sampson J, Fretwell N, Balding DJ. 2008. Population structure and inbreeding from pedigree analysis of purebred dogs. Genetics. 179:593-601.
3. Conover WJ. 1971. Two-sample "Smirnov" test. Practical nonparametric statistics. New York: John Wiley And Sons, 309-314.
4. Dembinski A, Warzecha Z, Ceranowicz P, Cieszkowski J, Pawlik WW, Tomaszewska R, Kusnierz-Cabala B, Naskalski JW, Kuwahara A, Kato I. 2006. Role of growth hormone and insulin-like growth factor-1 in the protective effect of ghrelin in ischemia/reperfusion-induced acute pancreatitis. Growth Horm IGF Res. 16:348-356.
5. Egenvall A, Bonnett BN, Hedhammar A, Olson P. 2005. Mortality in over 350, 000 insured Swedish dogs from 1995-2000: II. Breed-specific age and survival patterns and relative risk for causes of death. Acta Vet Scand. 46:121-136.
6. Galis F, Van der Sluijs I, Van Dooren TJ, Metz JA, Nussbaumer M. 2007. Do large dogs die young? J Exp Zoolog B Mol Dev Evol. 308:119-126.
7. Housley DJ, Venta PJ. 2006. The long and the short of it: evidence that FGF5 is a major determinant of canine 'hair'-itability. Anim Genet. 37:309-315.
8. Jones P, Chase K, Martin A, Davern P, Ostrander EA, Lark KG. 2008. Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics. 179:1033-1044.
9. Kenyon C. 2001. A conserved regulatory system for aging. Cell. 105:165-168.
10. Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ 3rd, Zody MC, et al. 2005. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature. 438:803-819.
11. Ostrander EA, Wayne RK. 2005. The canine genome. Genome Res. 15:1706-1716.
12. Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. 2004. Genetic structure of the purebred domestic dog. Science. 304:1160-1164.
13. R Development Core Team. 2006. R: A language and environment for statistical computing. ISBN 3-900051-07-0 [Internet]. Vienna (Austria): R Foundation for Statistical Computing, Available from: URL http://www.Rproject.org.
14. Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao K, Zhu L, et al. 2007. A single IGF1 allele is a major determinant of small size in dogs. Science 316:112-115.
15. Sutter NB, Ostrander EA. 2004. Dog star rising: The canine genetic system. Nat Rev Genet. 5:900-910.
16. Warzecha Z, Dembinski A, Ceranowicz P, Konturek SJ, Tomaszewska R, Stachura J, Konturek PC. 2003. IGF-1 stimulates production of interleukin- 10 and inhibits development of caerulein-induced pancreatitis. J Physiol Pharmacol. 54:575-590.
17. Wuertz D. 2006. fExtremes: Rmetrics-extreme financial market data. R package version 240.10068. Available from: URL http://www.rmetrics.org.