Peripheral Thy1+ lymphocytes rearranging TCR-γδ genes in LAT-deficient mice

European Journal of Immunology

Volumn 39, Issue 9, 2009, Pages 2596-2605

  Miazek, Arkadiusz ^a,b   Macha, Kornelia ^a   Łaszkiewicz, Agnieszka ^a   Kissenpfennig, Adrien ^b,c   Malissen, Bernard ^b   Kisielow, Pawel ^a  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

T cells; Extrathymic lymphopoiesis; LAT; Thy; Thymopoiesis

Indexed keywords

ALPHA2 INTEGRIN; CD3 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; LAT PROTEIN; RAG1 PROTEIN; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; LAT PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; THY 1 ANTIGEN;

ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE REARRANGEMENT; HETEROZYGOSITY; LYMPH NODE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; LYMPHOID ORGAN; LYMPHOID TISSUE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; ALLELE; ANIMAL; BIOSYNTHESIS; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; ANIMALS; ANTIGENS, THY-1; GENE REARRANGEMENT, DELTA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

EID: 70349248364     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939252     Document Type: Article

References (34)

1. Horejsi, V., Zhang, W. and Schraven, B., Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat. Rev. Immunol. 2004. 4: 603-616.
2. Malissen, B., Aguado, E. and Malissen, M., Role of the LAT adaptor in T-cell development and Th2 differentiation. Adv. Immunol. 2005. 87: 1-25.
3. Zhang,W., Sloan-Lancaster, J., Kitchen, J., Trible, R. P. and Samelson, L. E., LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998. 92: 83-92. (Pubitemid 28053300)
4. Oya, K.,Wang, J.,Watanabe, Y., Koga, R. andWatanabe, T., Appearance of the LAT protein at an early stage of B-cell development and its possible role. Immunology 2003. 109: 351-359.
5. Jevremovic, D., Billadeau, D. D., Schoon, R. A., Dick, C. J., Irvin, B. J., Zhang, W., Samelson, L. E. et al., Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J. Immunol. 1999. 162: 2453-2456. (Pubitemid 29309259)
6. Pasquet, J. M., Gross, B., Quek, L., Asazuma, N., Zhang,W., Sommers, C. L., Schweighoffer, E. et al. LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. Mol. Cell Biol. 1999. 19: 8326-8334.
7. Saitoh,S., Arudchandran,R., Manetz,T. S., Zhang,W., Sommers,C. L., Love,P. E., Rivera,J. and Samelson,L. E., LAT is essential for Fc(epsilon) RI-mediated mast cell activation. Immunity 2000. 12: 525-535.
8. Zhang,W., Sommers, C. L., Burshtyn, D. N., Stebbins, C. C., DeJarnette, J. B., Trible, R. P., Grinberg, A. et al. Essential role of LAT in T cell development. Immunity 1999. 10: 323-332. (Pubitemid 29165287)
9. Su, Y. W. and Jumaa, H., LAT links the pre-BCR to calcium signaling. Immunity 2003. 19: 295-305. (Pubitemid 37011343)
10. Wang, Y., Horvath, O., Hamm-Baarke, A., Richelme, M., Gregoire, C., Guinamard, R., Horejsi, V. et al. Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function. Mol. Cell Biol. 2005. 25: 4455-4465.
11. Prinz, I., Sansoni, A., Kissenpfennig, A., Ardouin, L., Malissen, M. and Malissen, B., Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nat. Immunol. 2006. 7: 995-1003.
12. Livak, F., Tourigny, M., Schatz, D. G. and Petrie, H. T., Characterization of TCR gene rearrangements during adult murine T cell development. J. Immunol. 1999. 162: 2575-2580. (Pubitemid 29309276)
13. Capone, M., Hockett, R. D., Jr. and Zlotnik, A., Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(1)CD25(1) Pro-T thymocytes. Proc. Natl. Acad. Sci. USA 1998. 95: 12522-12527.
14. Godfrey, D. I., Kennedy, J., Suda, T. and Zlotnik, A., A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 1993. 150: 4244-4252. (Pubitemid 23133699)
15. Kennedy, J. D., Pierce, C.W. and Lake, J. P., Extrathymic T cell maturation. phenotypic analysis of T cell subsets in nude mice as a function of age. J. Immunol. 1992. 148: 1620-1629.
16. Clegg, C. H., Haugen, H. S., Rulffes, J. T., Friend, S. L. and Farr, A. G., Oncostatin M transforms lymphoid tissue function in transgenic mice by stimulating lymph node T-cell development and thymus autoantibody production. Exp. Hematol. 1999. 27: 712-725.
17. Lancrin, C., Schneider, E., Lambolez, F., Arcangeli, M. L., Garcia-Cordier, C., Rocha, B. and Ezine, S., Major T cell progenitor activity in bone marrow-derived spleen colonies. J. Exp. Med. 2002. 195: 919-929.
18. Guy-Grand, D., Azogui, O., Celli, S., Darche, S., Nussenzweig, M. C., Kourilsky, P. and Vassalli, P., Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J. Exp. Med. 2003. 197: 333-341.
19. Guy-Grand, D., Azogui, O., Celli, S., Darche, S., Nussenzweig, M. C., Kourilsky, P. and Vassalli, P., Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J. Exp. Med. 2003. 197: 333-341.
20. Lambolez, F., Arcangeli, M. L., Joret, A. M., Pasqualetto, V., Cordier, C., Di Santo, J. P., Rocha, B. and Ezine, S., The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat. Immunol. 2006. 7: 76-82.
21. Veinotte, L. L., Halim, T. Y. and Takei, F., Unique subset of natural killer cells develops from progenitors in lymph node. Blood 2008. 111: 4201-4208.
22. Rothenberg, E. V., Moore, J. E. and Yui, M. A., Launching the T-cell-lineage developmental programme. Nat. Rev. Immunol. 2008. 8: 9-21.
23. Zhao, Y., Ohdan, H., Manilay, J. O. and Sykes, M., NK cell tolerance in mixed allogeneic chimeras. J. Immunol. 2003. 170: 5398-5405. (Pubitemid 36617825)
24. Kim, S., Iizuka, K., Kang, H. S., Dokun, A., French, A. R., Greco, S. and Yokoyama,W. M., In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol. 2002. 3: 523-528.
25. Di Santo, J. P., Natural killer cell developmental pathways: a question of balance. Annu. Rev. Immunol. 2006. 24: 257-286.
26. Nunez-Cruz, S., Aguado, E., Richelme, S., Chetaille, B., Mura, A. M., Richelme, M., Pouyet, L. et al. LAT regulates gammadelta T cell homeostasis and differentiation. Nat. Immunol. 2003. 4: 999-1008.
27. Veinotte, L. L., Greenwood, C. P., Mohammadi, N., Parachoniak, C. A. and Takei, F., Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment. Blood 2006. 107: 2673-2679.
28. Terra, R., Louis, I., Le, B. R., Ouellet, S., Zuniga-Pflucker, J. C. and Perreault, C., T-cell generation by lymph node resident progenitor cells. Blood 2005. 106: 193-200. (Pubitemid 40967192)
29. Falk, I., Potocnik, A. J., Barthlott, T., Levelt, C. N. and Eichmann, K., Immature T cells in peripheral lymphoid organs of recombinase-activating gene-1/-2-deficient mice. Thymus dependence and responsiveness to anti-CD3 epsilon antibody. J. Immunol. 1996. 156: 1362-1368.
30. Guy-Grand, D., Azogui, O., Celli, S., Darche, S., Nussenzweig, M. C., Kourilsky, P. and Vassalli, P., Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J. Exp. Med. 2003. 197: 333-341.
31. Aguado, E., Richelme, S., Nunez-Cruz, S., Miazek, A., Mura, A. M., Richelme, M., Guo, X. J. et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 2002. 296: 2036-2040. (Pubitemid 34627528)
32. Kress, C., Vandormael-Pournin, S., Baldacci, P., Cohen-Tannoudji, M. and Babinet, C., Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation. Mamm. Genome 1998. 9: 998-1001. (Pubitemid 29030903)
33. Gagneten, S., Le, Y., Miller, J. and Sauer, B., Brief expression of a GFP cre fusion gene in embryonic stem cells allows rapid retrieval of site-specific genomic deletions. Nucleic Acids Res. 1997. 25: 3326-3331. (Pubitemid 27338694)
34. Whitehurst, C. E., Chattopadhyay, S. and Chen, J., Control of V(D) J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter. Immunity 1999. 10: 313-322.