Structural identification and characterization of potential degradants of zotarolimus on zotarolimus-coated drug-eluting stents

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 5, 2009, Pages 778-786

  Chen, Quan ^a   Zielinski, Dorota ^a   Chen, Jenny ^a   Nowak, Steve ^a   Zhou, Casey Chun ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Degradation products; Drug eluting stents; HPLC; Impurity identification; LC MS; NMR; Zotarolimus (ABT 578)

Indexed keywords

ZOTAROLIMUS;

ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG ELUTING STENT; DRUG IMPURITY; DRUG STRUCTURE; PRIORITY JOURNAL; SEPARATION TECHNIQUE;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUG-ELUTING STENTS; HOT TEMPERATURE; HUMIDITY; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR CONFORMATION; OXYGEN; PYRANS; SIROLIMUS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 70349240297     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.06.024     Document Type: Article

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