An intramolecular ionic hydrogen bond stabilizes a cis amide bond rotamer of a ring-opened rapamycin-degradation product

Magnetic Resonance in Chemistry

Volumn 43, Issue 1, 2005, Pages 41-46

  Zhou, Casey Chun ^a   Stewart, Kent D ^a   Dhaon, Madhup K ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

13C NMR; 1H NMR; Amide bond rotamers; Ionic hydrogen bond; NMR; Rapamycin degradation product

Indexed keywords

AMIDES; CARBOXYLATION; CONFORMATIONS; DEGRADATION; HYDROGEN BONDS; ORGANIC SOLVENTS;

13C NMR; 1H NMR; AMIDE BOND; AMIDE BOND ROTAMER; DEGRADATION PRODUCTS; IONIC HYDROGEN BOND; RAPAMYCIN; RAPAMYCIN DEGRADATION PRODUCT; ROTAMERS; TRANS CONFORMATIONS;

DIMETHYL SULFOXIDE;

ALCOHOL; AMIDE; CARBOXYLIC ACID DERIVATIVE; DIMETHYL SULFOXIDE; MACROLIDE; RAPAMYCIN; TRIETHYLAMINE; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; CIS ISOMER; DRUG CONFORMATION; DRUG DEGRADATION; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RING OPENING; TRANS ISOMER; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG STABILITY; METHODOLOGY; SOLUTION AND SOLUBILITY;

DRUG STABILITY; HYDROGEN BONDING; IMMUNOSUPPRESSIVE AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SIROLIMUS; SOLUTIONS;

EID: 16644401549     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrc.1501     Document Type: Article

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