Extracts of marine sponge Polymastia janeirensis induce oxidative cell death through a caspase-9 apoptotic pathway in human U138MG glioma cell line

Investigational New Drugs

Volumn 27, Issue 5, 2009, Pages 440-446

  Conte Da Frota Jr , Mario Luiz ^a   Braganhol, Elizandra ^a   Delgado Canedo, Andrés ^b   Klamt, Fabio ^a   Apel, Miriam Anders ^c   Mothes, Beatriz ^d   Lerner, Cléa ^d   Oliveira Battastini, Ana Maria ^a   Henriques, Amélia Teresinha ^c   Fonseca Moreira, José Cláudio ^a  

^a Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

^b Laboratório de Cardiologia Molecular e Celular IC FUC   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d Museu de Ciencias Naturais   (Brazil)

Author keywords

Apoptosis; Cancer; Marine sponges; Polymastia janeirensis; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; CASPASE 9; NATURAL PRODUCT; POLYMASTIA JANEIRENSIS EXTRACT; REACTIVE OXYGEN METABOLITE; TROLOX C; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ANTAGONISM; DRUG EXPOSURE; ENZYME INHIBITION; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; MARINE SPECIES; OXIDATION; POLYMASTIA JANEIRENSIS; PRIORITY JOURNAL; SPONGE (PORIFERA);

ANIMALS; APOPTOSIS; BRAIN NEOPLASMS; CASPASE 9; FLOW CYTOMETRY; GLIOMA; HUMANS; PORIFERA; REACTIVE OXYGEN SPECIES; TISSUE EXTRACTS; TUMOR CELLS, CULTURED;

EID: 70349235778     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9198-0     Document Type: Article

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