Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

Investigational New Drugs

Volumn 27, Issue 1, 2009, Pages 13-20

  Da Frota Jr , Mario Luiz Conte ^a   Braganhol, Elizandra ^a   Canedo, Andrés Delgado ^b   Klamt, Fabio ^a   Apel, Miriam Anders ^c   Mothes, Beatriz ^d   Lerner, Cléa ^d   Battastini, Ana Maria Oliveira ^a   Henriques, Amélia Teresinha ^c   Moreira, José Cláudio Fonseca ^a  

^a Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

^b IC/FUC   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d Museu de Ciencias Naturais   (Brazil)

Author keywords

Apoptosis; Cancer; Glioma cells; Marine sponges; New drugs; Polymastia janeirensis

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; POLYMASTIA JANEIRENSIS EXTRACT; PROPIDIUM IODIDE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; DACARBAZINE; DRUG DERIVATIVE; PEPTIDE CHLOROMETHYL KETONE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; CANCER RESEARCH; CELL COUNT; CELL STRAIN U138MG; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; POLYMASTIA JANEIRENSIS; PRIORITY JOURNAL; RAT; SPONGE (PORIFERA); ANIMAL; BRAZIL; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MIXTURE; GLIOMA; TUMOR CELL LINE;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASTROCYTES; BRAZIL; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; COMPLEX MIXTURES; DACARBAZINE; GLIOMA; HUMANS; PORIFERA;

EID: 62749126751     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9134-3     Document Type: Article

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