Supranormal electroretinogram in fat-1 mice with retinas enriched in docosahexaenoic acid and n-3 very long chain fatty acids (C24-C36)

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 9, 2009, Pages 4394-4401

  Suh, Miyoung ^a   Sauvé, Yves ^b   Merrells, Krystal J ^a   Kang, Jing X ^c   Ma, David W L ^d,e  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYETHYLPYRROLE; DOCOSAHEXAENOIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; OMEGA 3 FATTY ACID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID; ACYL COENZYME A DESATURASE; CAENORHABDITIS ELEGANS PROTEIN; FAT 1 PROTEIN, C ELEGANS; FAT-1 PROTEIN, C ELEGANS; FATTY ACID; OMEGA 6 FATTY ACID; SAFFLOWER OIL;

ALPHA RHYTHM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA RHYTHM; CONTROLLED STUDY; ELECTRORETINOGRAM; MALE; MOUSE; MUELLER CELL; NIGHT VISION; NONHUMAN; OXIDATIVE STRESS; PHOTOPIC VISION; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA; TISSUE LEVEL; ANIMAL; C3H MOUSE; C57BL MOUSE; DIET; ELECTRORETINOGRAPHY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLIA; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS PROTEINS; DIET; DOCOSAHEXAENOIC ACIDS; ELECTRORETINOGRAPHY; FATTY ACID DESATURASES; FATTY ACIDS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROGLIA; PHOSPHOLIPIDS; RETINA; SAFFLOWER OIL;

EID: 70349230976     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2565     Document Type: Article

References (39)

1. Fliesler SJ, Anderson RE. Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipids Res. 1983;22:79-131.
2. Anderson RE, Andrews LD. Biochemistry of retinal photoreceptor membranes in vertebrate and invertebrate. In: Westfall JA, ed. Visual Cells in Evolution. New York: Raven Press; 1982;1-22.
3. Anderson RE, Risk M. Lipids of ocular tissues IX: the phospholipids of frog photoreceptor membranes. Vision Res. 1974;14:129-131.
4. Suh M, Wierzbicki AA, Clandinin MT. Dietary n-3 FA modulate long and very long chain FA content, rhodopsin content and rhodopsin phosphorylation in rat rod outer segment after light exposure. Lipids. 2002;37:253-260.
5. Aveldano MI. Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes. Biochemistry. 1988;27:1229-1239.
6. Suh M, Wierzbicki AA, Lien E, Clandinin MT. Dietary 20:4n-6 and 22:6n-3 modulates the profile of long- and very-long-chain fatty acids (C24-C36), rhodopsin content and kinetics in developing photoreceptor cells. Pediatr Res. 2000;48:524-530.
7. Rotstein NP, Politi LE, Aveldaño MI. Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture. Invest Ophthalmol Vis Sci. 1998;39:2750-2758.
8. Rotstein NP, Aveldaño MI, Barrantes FJ, Roccamo AM, Politi LE. Apoptosis of retinal photoreceptors during development in vitro: protective effect of docosahexaenoic acid. J Neurochem. 1997;69: 504-513.
9. Polit L, Rotstein N, Carri N. Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. Lipids. 2001; 36:927-935.
10. Bazan NG. Neuroprotecting D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain Pathol. 2005;15:159-166.
11. Mukherjee P, Marcheselli V, de Rivero Vacari J, Gordon W, Jackson F, Bazan N. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotecting D1 synthesis. Proc Natl Acad Sci USA. 2007;104:13158-13163.
12. Connor K, San Giovanni J, Lofgvist C, et al. Increased dietary intake of w-3-polyunsaturated fatty acids reduced pathological retinal angiogenesis. Nat Med. 2007;13:868-873.
13. Neuringer M, Connor WE, Lin PS, Barstad L, Luck S. Biochemical and functional effects of prenatal and postnatal ω3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci USA. 1986;3:4021-4025.
14. Martinez M. Dietary polyunsaturated fatty acids in relation to neural development in human. In: Claudio G, Simopoulos AP, eds. Dietary ω3 and ω6 Fatty Acids: Biological Effects and Nutritional Essentiality. New York: Plenum Press; 1988;171:123-133.
15. Pawlosky RJ, Denkins Y, Ward G, Salem N Jr. Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: the effects of corn oil- based maternal diets. Am J Clin Nutr. 1997;65:465-472.
16. Kang JX, Wang J, Wu L, Kang ZB. Transgenic mice: Fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004;427-504.
17. Ma D, Ngo V, Huot P, Kang J. N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland. Lipids. 2006;41:35-39.
18. Spychalla JP, Kinney AJ, Browse J. Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis. Proc Natl Acad Sci U S A. 1997;94:1142-1147.
19. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497-509.
20. Touchstone JC, Chen JC, Beaver KM. Improved separation of phospholipids in thin-layer chromatography. Lipids. 1980;15:61-62.
21. Morrison WR, Smith LM. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res. 1964;5:600-608.
22. Sauvé Y, Karan G, Yang Z, Li C, Hu J, Zhang K. Treatment with carbonic anhydrase inhibitors depresses electroretinogram responsiveness in mice. Adv Exp Med Biol. 2006;572:439-446.
23. Smith SB, Brodjian S, Desai S, Sarthy V. Glial fibrillary acidic protein (GFAP) is synthesized in the early stages of the photoreceptor cell degeneration of the mivit/mivit (vitiligo) mouse. Exp Eye Res. 1997;64:645-650.
24. Alvarez BV, Gilmour GS, Mema SC, et al. Blindness caused by deficiency in AE3 chloride/bicarbonate exchanger. PLoS ONE. 2007;2:e839.
25. Gu X, Meer S, Miyagi M, et al. Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J Biol Chem. 2003;278:42027-42035.
26. Crabb JW, Miyagi M, Gu X, et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A. 2002;99:14682-14687.
27. Zhang K, Kniazeva M, Han M, et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet. 2001;27:89-93.
28. Maugeri A, Meire F, Hoyng CB, et al. A novel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophy. Invest Ophthalmol Vis Sci. 2004;45:4263-4267.
29. McMahon A, Jackson SN, Woods AS, Kedzierski W. A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32-C36 acyl: phosphatidylcholines. FEBS Lett. 2007; 581:5459-5463.
30. Karan G, Lillo C, Yang Z, et al. Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci U S A. 2005;102:4164-4169.
31. MacDonald IM, Hebert M, Yau RJ, et al. Effect of docosahexaenoic acid supplementation on retinal function in a patient with autosomal dominant Stargardt-like retinal dystrophy. Br J Ophthalmol. 2004;88:305-306.
32. Martin R, Ranchon-Cole I, Brush R, et al. P23H and S334ter opsin mutations: Increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration. Mol Vis. 2004;10:199-207.
33. Jeffrey BG, Mitchell DC, Hibbeln JR, Gibson RA, Chedester AL, Salem N Jr. Visual acuity and retinal function in infant monkeys fed long-chain PUFA. Lipids. 2002;37:839-848.
34. Suh M. Relationship between Dietary Fat, Membrane Fatty Acid Composition and Function of the Photoreceptor Cells: Role of Very Long Chain (C24-C36) Polyenoic Fatty Acids. PhD Thesis. Edmunton, AL, Canada: University of Alberta; 1998.
35. Heckenlively JR, Tanji T, Logani S. Retrospective study of hyperabnormal (supranormal) electroretinographic responses in 104 patients. Trans Am Ophthalmol Soc. 1994;92:217-231.
36. Ransom BR, Orkand RK. Glial-neuronal interactions in non-synaptic areas of the brain: studies in the optic nerve. Trends Neurosci. 1996;19:352-358.
37. Aschner M. Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal dysfunction. Neurotoxicology. 1998;19:7-17.
38. Eddleston M, Mucke L. Molecular profile of reactive astrocytes: implications for their role in neurologic disease. Neuroscience. 1993;54:15-36.
39. Hollyfield JG, Bonilha VL, Rayborn ME, et al. Oxidative damageinduced inflammation initiates age-related macular degeneration. Nat Med. 2008;14:194-198.