Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 13, 2007, Pages 3686-3689

  Lebouvier, Nicolas ^a   Pagniez, Fabrice ^a   Duflos, Muriel ^a   Le Pape, Patrice ^a   Na, Young Min ^b   Le Baut, Guillaume ^a   Le Borgne, Marc ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b Yang Ji Chemical Co Ltd   (South Korea)

Author keywords

Antifungal; Azaheterocycle; Candida albicans; Indole; Microwave irradiation; Oxirane; Triazole

Indexed keywords

3 ETHOXYCARBONYLETHYL 1H INDOLE; 3 ETHOXYCARBONYLMETHYL 1H INDOLE; 3 FORMYL 1H INDOLE; 4 OXO 4,5,6,7 TETRAHYDRO 1H INDOLE; 5 AMINOINDOLE; 7 AZAINDOLE; BENZIMIDAZOLE; ETHYLENE OXIDE; FLUCONAZOLE; INDOLE; INDOLINE; N1 BENZOTRIAZOLE; N1 INDAZOLE; N2 BENZOTRIAZOLE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; MICROWAVE IRRADIATION; NONHUMAN; NUCLEOTIDE SEQUENCE;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG RESISTANCE, FUNGAL; FLUCONAZOLE; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; TIME FACTORS; TRIAZOLES;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; FUNGI;

EID: 34250335109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.038     Document Type: Article

References (21)

1. Eggimann P., Garbino J., and Pittet D. Lancet Infect. Dis. 3 (2003) 772
2. Tortorano A.M., Caspani L., Rigoni A.L., Biraghi E., Sicignano A., and Viviani M.A. J. Hosp. Infect. 57 (2004) 8
3. Patterson T.F. Lancet 366 (2005) 1013
4. Masia Canuto M., and Gutierrez Rodero F. Lancet Infect. Dis. 2 (2002) 550
5. Sims C.R., Ostrosky-Zeichner L., and Rex J.H. Arch. Med. Res. 36 (2005) 660
6. Montravers P., and Jabbour K. Int. J. Antimicrob. Agents 27 (2006) 1
7. Na Y.M., Le Borgne M., Pagniez F., Le Baut G., and Le Pape P. Eur. J. Med. Chem. 38 (2003) 75
8. Lebouvier N., Giraud F., Corbin T., Na Y.M., Le Baut G., Marchand P., and Le Borgne M. Tetrahedron Lett. 47 (2006) 6479
9. Zervos M., and Meunier F. Int. J. Antimicrob. Agents 3 (1993) 147
10. Cavrini V., Gatti R., Roveri P., and Cesaroni M.R. Arch. Pharm. 317 (1984) 662
11. Gatti R., Cavrini V., Roveri P., and Luglio G. Arch. Pharm. 318 (1985) 157
12. Sugiyama M., Yokokawa F., Aoyama T., and Shioiri T. Tetrahedron Lett. 42 (2001) 7277
13. Dandia A., Singh R., Khaturia S., Mérienne C., Morgant G., and Loupy A. Bioorg. Med. Chem. 14 (2006) 2409
14. Tiwari R.K., Verma A.K., Chhillard A.K., Singh D., Singh J., Sankar V.K., Yadav V., Sharma G.L., and Chandra R. Bioorg. Med. Chem. 14 (2006) 2747
15. +), 242, 131, 82.
16. +), 242, 131, 82.
17. +).
18. +), 399, 327, 216, 82.
19. Shaffer C.L., Gunduz M., O'Connell T.N., Obach R.S., and Yee S. Drug Metab. Dispos. 33 (2005) 1688
20. Pagniez F., and Le Pape P. J. Mycol. Med. 11 (2001) 73
21. Pagniez, F.; Lebouvier, N.; Na, Y. M.; Le Borgne, M.; Palzer, M.; Hartmann, R. W.; Le Pape, P. Abstract of papers, 17th European Congress of Clinical Microbiology and Infectious Diseases and 25th International Congress of Chemotherapy, Munich, Germany; European Society of Clinical Microbiology and Infectious Diseases: Basel, Switzerland, 2007; Abstract P1674.