Overexpression of the novel oncogene SALL4 and activation of the Wnt/β-catenin pathway in myelodysplastic syndromes

Cancer Genetics and Cytogenetics

Volumn 194, Issue 2, 2009, Pages 119-124

  Shuai, Xiao ^a,b   Zhou, Daobin ^a   Shen, Ti ^a   Wu, Yongji ^a   Zhang, Jieping ^a   Wang, Xuan ^a   Li, Qian ^c  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b SICHUAN UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; MYC PROTEIN; ONCOPROTEIN; SALL4 PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; BETA CATENIN; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; ONCOGENES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TUMOR CELLS, CULTURED; UP-REGULATION; WNT1 PROTEIN; YOUNG ADULT;

MUS MUSCULUS;

EID: 70349210687     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.06.006     Document Type: Article

References (20)

1. Greenberg P.L. Myelodysplastic syndrome. In: Hoffman R., and Benz E.J. (Eds). Hematology: basic principles and practice. 3rd ed (2000), Churchill Livingstone, New York 1106-1129
2. Nishino H.T., and Chang C.C. Myelodysplastic syndromes: clinicopathologic features, pathobiology, and molecular pathogenesis. Arch Pathol Lab Med 129 (2005) 1299-1310
3. Ma Y., Cui W., Yang J., Qu J., Di C., Amin H.M., Lai R., Ritz J., Krause D.S., and Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 108 (2006) 2726-2735
4. Al-Baradie R., Yamada K., St Hilaire C., Chan W.M., Andrews C., McIntosh N., Nakano M., Martonyi E.J., Raymond W.R., Okumura S., Okihiro M.M., and Engle E.C. Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Am J Hum Genet 71 (2002) 1195-1199
5. Jürgens G. Head and tail development of the Drosophila embryo involves spalt, a novel homeotic gene. EMBO J 7 (1988) 189-196
6. Kohlhase J., Schuh R., Dowe G., Kühnlein R.P., Jäckle H., Schroeder B., Schulz-Schaeffer W., Kretzschmar H.A., Köhler A., Müller U., Raab-Vetter M., Burkhardt E., Engel W., and Stick R. Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt. Genomics 38 (1996) 291-298
7. Kohlhase J., Hausmann S., Stojmenovic G., Dixkens C., Bink K., Schulz-Schaeffer W., Altmann M., and Engel W. SALL3, a new member of the human spalt-like gene family, maps to 18q23. Genomics 62 (1999) 216-222
8. Zhang J., Tam W.L., Tong G.Q., Wu Q., Chan H.Y., Soh B.S., Lou Y., Yang J., Ma Y., Chai L., Ng H.H., Lufkin T., Robson P., and Lim B. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol 8 (2006) 1114-1123
9. Elling U., Klasen C., Eisenberger T., Anlag K., and Treier M. Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A 103 (2006) 16319-16324
10. Wu Q., Chen X., Zhang J., Loh Y.H., Low T.Y., Zhang W., Zhang W., Sze S.K., Lim B., and Ng H.H. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem 281 (2006) 24090-24094
11. Kohlhase J., Heinrich M., Schubert L., Liebers M., Kispert A., Laccone F., Turnpenny P., Winter R.M., and Reardon W. Okihiro syndrome is caused by SALL4 mutations. Hum Mol Genet 11 (2002) 2979-2987
12. Cui W., Kong N.R., Ma Y., Amin H.M., Lai R., and Chai L. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol 19 (2006) 1585-1592
13. Yang J., Chai L., Gao C., Fowles T.C., Alipio Z., Dang H., Xu D., Fink L.M., Ward D.C., and Ma Y. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood 112 (2008) 805-813
14. Yang J., Chai L., Liu F., Fink L.M., Lin P., Silberstein L.E., Amin H.M., Ward D.C., and Ma Y. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci U S A 104 (2007) 10494-10499
15. Reya T., Duncan A.W., Ailles L., Domen J., Scherer D.C., Willert K., Hintz L., Nusse R., and Weissman I.L. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 423 (2003) 409-414
16. Reya T., and Clevers H. Wnt signalling in stem cells and cancer. Nature 434 (2005) 843-850
17. Lustig B., and Behrens J. The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 129 (2003) 199-221
18. Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A., Gralnick H.R., and Sultan C. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51 (1982) 189-199
19. Watt R., Stanton L.W., Marcu K.B., Gallo R.C., Croce C.M., and Rovera G. Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature 303 (1983) 725-728
20. Motokura T., Bloom T., Kim H.G., Jüppner H., Ruderman J.V., Kronenberg H.M., and Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350 (1991) 512-515