Synthesis and in vitro and in vivo evaluation of a series of dihydroisocoumarin derivatives conjugated with fatty acids, alcohols, and amines as potential anticancer agents

Bioconjugate Chemistry

Volumn 20, Issue 9, 2009, Pages 1737-1751

  Higgins, Catherine A ^a   Delbederi, Zoica ^b   McGarel, Kelly ^b   Mills, Timothy ^b   McGrath, Owen ^a   Feutren Burton, Stephanie ^b   Watters, William ^b   Armstrong, Paul ^b   Johnston, Patrick G ^a   Waugh, David ^a   Van Den Berg, Hendrik ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Almac Sciences   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 HYDROXY 3 OXO 1,3 DIHYDROISOBENZOFURAN 5 CARBOXYLIC ACID OCTADECA 6,9,12 TRIENYL ESTER DERIVATIVE; ALCOHOL; AMINE; ANTINEOPLASTIC AGENT; DIHYDROISOCOUMARIN DERIVATIVE; FATTY ACID; FATTY ALCOHOL; GAMMA LINOLENYL; HENEICOSANOIC ACID; HYDROCARBON; KIGELIN; MELLEIN; OCHRATOXIN ACID GAMMA LINOLENYL ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA CELL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

EID: 70349203960     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc900122g     Document Type: Article

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