Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients

Neuroscience Letters

Volumn 465, Issue 1, 2009, Pages 1-5

  Saito, Yoshiro ^a,b   Hamakubo, Takao ^c   Yoshida, Yasukazu ^a   Ogawa, Yoko ^a   Hara, Yasuo ^d   Fujimura, Harutoshi ^e   Imai, Yasuharu ^d   Iwanari, Hiroko ^c   Mochizuki, Yasuhiro ^c   Shichiri, Mototada ^a   Nishio, Keiko ^a   Kinumi, Tomoya ^a   Noguchi, Noriko ^b   Kodama, Tatsuhiko ^c   Niki, Etsuo ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d IKEDA MUNICIPAL HOSPITAL   (Japan)

^e TONEYAMA NATIONAL HOSPITAL   (Japan)

Author keywords

Biomarker; DJ 1; Enzyme linked immunosorbent assay; Erythrocytes; Oxidative stress; Parkinson's disease

Indexed keywords

DJ 1 PROTEIN; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; MONOCLONAL ANTIBODY;

ADULT; AGED; ANTIBODY ENGINEERING; ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; FEMALE; HUMAN; MALE; OXIDATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN MODIFICATION; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

AGED; ANALYSIS OF VARIANCE; ANTIBODIES; ANTIPARKINSON AGENTS; BACULOVIRIDAE; BLOTTING, WESTERN; CELL LINE, TUMOR; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTES; FEMALE; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; ONCOGENE PROTEINS; OXIDATION-REDUCTION; PARKINSON DISEASE; TIME FACTORS;

EID: 70349152584     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.08.074     Document Type: Article

References (34)

1. Allard L., Burkhard P.R., Lescuyer P., Burgess J.A., Walter N., Hochstrasser D.F., and Sanchez J.C. PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clin. Chem. 51 (2005) 2043-2051
2. Bandopadhyay R., Kingsbury A.E., Cookson M.R., Reid A.R., Evans I.M., Hope A.D., Pittman A.M., Lashley T., Canet-Aviles R., Miller D.W., McLendon C., Strand C., Leonard A.J., Abou-Sleiman P.M., Healy D.G., Ariga H., Wood N.W., de Silva R., Revesz T., Hardy J.A., and Lees A.J. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain 127 (2004) 420-430
3. Biskup S., Gerlach M., Kupsch A., Reichmann H., Riederer P., Vieregge P., Wullner U., and Gasser T. Genes associated with Parkinson syndrome. J. Neurol. 255 Suppl. 5 (2008) 8-17
4. Bogdanov M., Matson W.R., Wang L., Matson T., Saunders-Pullman R., Bressman S.S., and Flint Beal M. Metabolomic profiling to develop blood biomarkers for Parkinson's disease. Brain 131 (2008) 389-396
5. Bonifati V., Rizzu P., van Baren M.J., Schaap O., Breedveld G.J., Krieger E., Dekker M.C., Squitieri F., Ibanez P., Joosse M., van Dongen J.W., Vanacore N., van Swieten J.C., Brice A., Meco G., van Duijn C.M., Oostra B.A., and Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science (2003) 256-259
6. Calne D.B., Snow B.J., and Lee C. Criteria for diagnosing Parkinson's disease. Ann. Neurol. 32 Suppl. (1992) S125-127
7. Canet-Aviles R.M., Wilson M.A., Miller D.W., Ahmad R., McLendon C., Bandyopadhyay S., Baptista M.J., Ringe D., Petsko G.A., and Cookson M.R. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 9103-9108
8. Cha S.S., Jung H.I., Jeon H., An Y.J., Kim I.K., Yun S., Ahn H.J., Chung K.C., Lee S.H., Suh P.G., and Kang S.O. Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. J. Biol. Chem. 283 (2008) 34069-34075
9. Choi J., Sullards M.C., Olzmann J.A., Rees H.D., Weintraub S.T., Bostwick D.E., Gearing M., Levey A.I., Chin L.S., and Li L. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J. Biol. Chem. 281 (2006) 10816-10824
10. El-Agnaf O.M., Salem S.A., Paleologou K.E., Curran M.D., Gibson M.J., Court J.A., Schlossmacher M.G., and Allsop D. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J. 20 (2006) 419-425
11. Forno L.S. Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55 (1996) 259-272
12. Hoehn M.M., and Yahr M.D. Parkinsonism: onset, progression and mortality. Neurology 17 (1967) 427-442
13. Junn E., Jang W.H., Zhao X., Jeong B.S., and Mouradian M.M. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J. Neurosci. Res. 87 (2009) 123-129
14. Kinumi T., Kimata J., Taira T., Ariga H., and Niki E. Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 317 (2004) 722-728
15. Lang A.E., and Lozano A.M. Parkinson's disease. First of two parts. N. Eng. J. Med. 339 (1998) 1044-1053
16. Le Naour F., Misek D.E., Krause M.C., Deneux L., Giordano T.J., Scholl S., and Hanash S.M. Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin. Cancer Res. 7 (2001) 3328-3335
17. Maita C., Tsuji S., Yabe I., Hamada S., Ogata A., Maita H., Iguchi-Ariga S.M., Sasaki H., and Ariga H. Secretion of DJ-1 into the serum of patients with Parkinson's disease. Neurosci. Lett. 431 (2008) 86-89
18. Moore D.J., West A.B., Dawson V.L., and Dawson T.M. Molecular pathophysiology of Parkinson's disease. Ann. Rev. Neurosci. 28 (2005) 57-87
19. Nagakubo D., Taira T., Kitaura H., Ikeda M., Tamai K., Iguchi-Ariga S.M., and Ariga H. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem. Biophys. Res. Commun. 231 (1997) 509-513
20. Olanow C.W. The scientific basis for the current treatment of Parkinson's disease. Annu. Rev. Med. 55 (2004) 41-60
21. Ooe H., Iguchi-Ariga S.M., and Ariga H. Establishment of specific antibodies that recognize C106-oxidized DJ-1. Neurosci. Lett. 404 (2006) 166-169
22. Saito Y., Nishio K., Ogawa Y., Kimata J., Kinumi T., Yoshida Y., Noguchi N., and Niki E. Turning point in apoptosis/necrosis induced by hydrogen peroxide. Free Radic. Res. 40 (2006) 619-630
23. Saitoh R., Ohtomo T., Yamada Y., Kamada N., Nezu J., Kimura N., Funahashi S., Furugaki K., Yoshino T., Kawase Y., Kato A., Ueda O., Jishage K., Suzuki M., Fukuda R., Arai M., Iwanari H., Takahashi K., Sakihama T., Ohizumi I., Kodama T., Tsuchiya M., and Hamakubo T. Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus. J. Immunol. Methods 322 (2007) 104-117
24. Taira T., Saito Y., Niki T., Iguchi-Ariga S.M., Takahashi K., and Ariga H. DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep. 5 (2004) 213-218
25. Takahashi K., Taira T., Niki T., Seino C., Iguchi-Ariga S.M., and Ariga H. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. 276 (2001) 37556-37563
26. Tanaka T., Takeno T., Watanabe Y., Uchiyama Y., Murakami T., Yamashita H., Suzuki A., Aoi R., Iwanari H., Jiang S.Y., Naito M., Tachibana K., Doi T., Shulman A.I., Mangelsdorf D.J., Reiter R., Auwerx J., Hamakubo T., and Kodama T. The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J. Atheroscler. Thromb. 9 (2002) 233-242
27. Tokuda T., Salem S.A., Allsop D., Mizuno T., Nakagawa M., Qureshi M.M., Locascio J.J., Schlossmacher M.G., and El-Agnaf O.M. Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochem. Biophys. Res. Commun. 349 (2006) 162-166
28. Tsuboi Y., Munemoto H., Ishikawa S., Matsumoto K., Iguchi-Ariga S.M., and Ariga H. DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains. FEBS Lett. 582 (2008) 2643-2649
29. Vila M., and Przedborski S. Genetic clues to the pathogenesis of Parkinson's disease. Nat. Med. 10 Suppl. (2004) S58-62
30. Wagenfeld A., Gromoll J., and Cooper T.G. Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization. Biochem. Biophys. Res. Commun. 251 (1998) 545-549
31. Waragai M., Nakai M., Wei J., Fujita M., Mizuno H., Ho G., Masliah E., Akatsu H., Yokochi F., and Hashimoto M. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease. Neurosci. Lett. 425 (2007) 18-22
32. Waragai M., Wei J., Fujita M., Nakai M., Ho G.J., Masliah E., Akatsu H., Yamada T., and Hashimoto M. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochem. Biophys. Res. Commun. 345 (2006) 967-972
33. Younes-Mhenni S., Frih-Ayed M., Kerkeni A., Bost M., and Chazot G. Peripheral blood markers of oxidative stress in Parkinson's disease. Eur. Neurol. 58 (2007) 78-83
34. Zhou W., Zhu M., Wilson M.A., Petsko G.A., and Fink A.L. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J. Mol. Biol. 356 (2006) 1036-1048