Stereocontrolled synthesis and pharmacological evaluation of cis-2, 6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues

Journal of Organic Chemistry

Volumn 74, Issue 16, 2009, Pages 6072-6076

  Zheng, Guangrong ^a   Dwoskin, Linda P ^a   Deaciuc, Agripina G ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL REACTIONS;

BINDING MODES; CHEMICAL EQUATIONS; QUINUCLIDINES; STEREOCONTROLLED SYNTHESIS;

BINDING SITES;

2, 6 DIPHENETHYL 1 AZABICYCLO[2.2.2]OCTANE; ENDO 2,6 DIPHENETHYL 1 AZABICYCLO[2.2.2]OCTANE; EXO 2,6 DIPHENETHYL 1 AZABICYCLO[2.2.2]OCTANE; LOBELANE; PROTEIN INHIBITOR; QUINUCLIDINE DERIVATIVE; TETRABENAZINE; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2; CYCLOOCTANE DERIVATIVE; LOBELINE; VESICULAR MONOAMINE TRANSPORTER;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GEOMETRY; NONHUMAN; RAT; STEREOCHEMISTRY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; CONFORMATION; METABOLISM; STEREOISOMERISM; SYNTHESIS;

ANIMALS; BINDING SITES; CYCLOOCTANES; LOBELINE; MOLECULAR CONFORMATION; RATS; STEREOISOMERISM; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 70349152205     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo901082r     Document Type: Article

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